JP2022543767A5 - - Google Patents
Info
- Publication number
- JP2022543767A5 JP2022543767A5 JP2022506075A JP2022506075A JP2022543767A5 JP 2022543767 A5 JP2022543767 A5 JP 2022543767A5 JP 2022506075 A JP2022506075 A JP 2022506075A JP 2022506075 A JP2022506075 A JP 2022506075A JP 2022543767 A5 JP2022543767 A5 JP 2022543767A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkylamino
- alkoxy
- membered heterocycloalkyl
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910712388.0 | 2019-08-02 | ||
| CN201910712388 | 2019-08-02 | ||
| CN201910899724 | 2019-09-23 | ||
| CN201910899724.7 | 2019-09-23 | ||
| CN201911157922.2 | 2019-11-22 | ||
| CN201911157922 | 2019-11-22 | ||
| CN202010054185 | 2020-01-17 | ||
| CN202010054185.X | 2020-01-17 | ||
| PCT/CN2020/106573 WO2021023154A1 (zh) | 2019-08-02 | 2020-08-03 | 四并环类化合物及其制备方法和应用 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022543767A JP2022543767A (ja) | 2022-10-14 |
| JP2022543767A5 true JP2022543767A5 (https=) | 2023-08-16 |
| JP7756069B2 JP7756069B2 (ja) | 2025-10-17 |
| JP7756069B6 JP7756069B6 (ja) | 2025-11-27 |
Family
ID=74483410
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022506075A Active JP7756069B6 (ja) | 2019-08-02 | 2020-08-03 | 四環式化合物、その調製と使用の方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20220298174A1 (https=) |
| EP (1) | EP4011886A4 (https=) |
| JP (1) | JP7756069B6 (https=) |
| KR (1) | KR20220079521A (https=) |
| CN (1) | CN112300195B (https=) |
| AU (1) | AU2020325477A1 (https=) |
| CA (1) | CA3149403A1 (https=) |
| IL (1) | IL290276B1 (https=) |
| MX (1) | MX2022001421A (https=) |
| WO (1) | WO2021023154A1 (https=) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019217307A1 (en) | 2018-05-07 | 2019-11-14 | Mirati Therapeutics, Inc. | Kras g12c inhibitors |
| JP2022500385A (ja) | 2018-09-10 | 2022-01-04 | ミラティ セラピューティクス， インコーポレイテッド | 組み合わせ療法 |
| EA202190749A1 (ru) | 2018-09-10 | 2021-07-09 | Мирати Терапьютикс, Инк. | Способы комбинированной терапии |
| EP3849535A4 (en) | 2018-09-10 | 2022-06-29 | Mirati Therapeutics, Inc. | Combination therapies |
| EP3849537B1 (en) | 2018-09-10 | 2024-10-23 | Mirati Therapeutics, Inc. | Combination therapies |
| WO2020085504A1 (ja) | 2018-10-26 | 2020-04-30 | 大鵬薬品工業株式会社 | 光照射ザンドマイヤー反応を用いたクロロアゾールカルボキシレート誘導体の製造方法 |
| MX2021002804A (es) | 2018-12-05 | 2021-07-15 | Mirati Therapeutics Inc | Terapias de combinacion. |
| EP3908283A4 (en) | 2019-01-10 | 2022-10-12 | Mirati Therapeutics, Inc. | KRAS G12C INHIBITORS |
| CN112390818B (zh) * | 2019-08-12 | 2023-08-22 | 劲方医药科技(上海)有限公司 | 取代的杂芳环并二氢嘧啶酮衍生物，其制法与医药上的用途 |
| MX2022002465A (es) | 2019-08-29 | 2022-05-19 | Mirati Therapeutics Inc | Inhibidores de kras g12d. |
| US12122787B2 (en) | 2019-09-20 | 2024-10-22 | Shanghai Jemincare Pharmaceuticals Co., Ltd | Fused pyridone compound, and preparation method therefor and use thereof |
| WO2021061749A1 (en) | 2019-09-24 | 2021-04-01 | Mirati Therapeutics, Inc. | Combination therapies |
| UA129778C2 (uk) | 2019-10-28 | 2025-07-30 | Мерк Шарп Енд Доум Елелсі | Низькомолекулярні інгібітори g12c-мутантного kras |
| EP4067343A4 (en) | 2019-11-29 | 2024-01-03 | Taiho Pharmaceutical Co., Ltd. | NEW PHENOLIC COMPOUND OR SALT THEREOF |
| PH12022551513A1 (en) | 2019-12-20 | 2023-04-24 | Mirati Therapeutics Inc | Sos1 inhibitors |
| CN113929676A (zh) * | 2020-07-14 | 2022-01-14 | 浙江海正药业股份有限公司 | 吡啶并杂环类衍生物及其制备方法和用途 |
| CN113980032B (zh) * | 2020-07-27 | 2023-06-16 | 江苏恒瑞医药股份有限公司 | 稠合四环类衍生物、其制备方法及其在医药上的应用 |
| EP4210833A4 (en) | 2020-09-11 | 2024-09-11 | Mirati Therapeutics, Inc. | CRYSTALLINE FORMS OF A KRAS G12C INHIBITOR |
| JP2023553492A (ja) | 2020-12-15 | 2023-12-21 | ミラティ セラピューティクス， インコーポレイテッド | アザキナゾリン汎ＫＲａｓ阻害剤 |
| EP4262803A4 (en) | 2020-12-16 | 2025-03-12 | Mirati Therapeutics, Inc. | Tetrahydropyridopyrimidine pan-kras inhibitors |
| CN114716435A (zh) * | 2021-01-04 | 2022-07-08 | 广州百霆医药科技有限公司 | Kras g12c突变抑制剂 |
| US20240199644A1 (en) * | 2021-03-07 | 2024-06-20 | Jacobio Pharmaceuticals Co., Ltd. | Fused Ring Derivatives Useful as KRAS G12D Inhibitors |
| WO2023001141A1 (en) * | 2021-07-23 | 2023-01-26 | Shanghai Zion Pharma Co. Limited | Kras g12d inhibitors and uses thereof |
| KR20240055778A (ko) | 2021-09-01 | 2024-04-29 | 노파르티스 아게 | Tead 억제제를 포함하는 제약 조합물 및 암의 치료를 위한 이의 용도 |
| US20250034166A1 (en) * | 2021-09-27 | 2025-01-30 | Jacobio Pharmaceuticals Co., Ltd. | Polycyclic fused ring derivatives and use thereof |
| MX2024004846A (es) * | 2021-10-22 | 2024-05-03 | Jiangsu Hengrui Pharmaceuticals Co Ltd | Compuesto tetraciclico que contiene nitrogeno, metodo de preparacion del mismo y uso medico del mismo. |
| CN118176198A (zh) * | 2021-11-01 | 2024-06-11 | 江苏恒瑞医药股份有限公司 | 含氮的四环化合物、其制备方法及其在医药上的应用 |
| WO2023103906A1 (zh) * | 2021-12-07 | 2023-06-15 | 贝达药业股份有限公司 | Kras g12d抑制剂及其在医药上的应用 |
| JP2025521737A (ja) * | 2022-06-27 | 2025-07-10 | 石▲薬▼集▲團▼中奇制▲薬▼技▲術▼（石家庄）有限公司 | 三環式化合物およびその使用 |
| IL318647A (en) | 2022-08-05 | 2025-03-01 | Kumquat Biosciences Inc | Heterocyclic compounds and their uses |
| JP2025528126A (ja) * | 2022-08-11 | 2025-08-26 | ベイジン スウィッツアランド ゲゼルシャフト ミット ベシュレンクテル ハフツング | 複素環式化合物、その組成物、及びそれらによる処置方法 |
| WO2024081674A1 (en) | 2022-10-11 | 2024-04-18 | Aadi Bioscience, Inc. | Combination therapies for the treatment of cancer |
| WO2024197503A1 (en) * | 2023-03-27 | 2024-10-03 | Nikang Therapeutics , Inc. | Tricyclic derivatives as kras inhibitors |
| CN120957997A (zh) * | 2023-04-21 | 2025-11-14 | 江苏恒瑞医药股份有限公司 | 一种含氮四环化合物的结晶形式及其制备方法 |
| US20250109147A1 (en) | 2023-09-08 | 2025-04-03 | Gilead Sciences, Inc. | Kras g12d modulating compounds |
| TW202529768A (zh) | 2023-09-29 | 2025-08-01 | 大陸商德昇濟醫藥（無錫）有限公司 | 癌症治療的療法 |
| AU2024361909A1 (en) | 2023-10-20 | 2026-03-26 | Merck Sharp & Dohme Llc | Small molecule inhibitors of kras proteins |
| US20250304556A1 (en) * | 2024-04-02 | 2025-10-02 | Mirati Therapeutics, Inc. | Processes for preparation of prmt5 inhibitors and intermediates for making the same |
| WO2026064527A1 (en) * | 2024-09-19 | 2026-03-26 | Tesseract Medicines Us, Llc | Kras-targeting covalent-induced drug conjugates comprising a tubulin inhibitor payload |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3053926B1 (en) * | 2013-09-30 | 2018-08-08 | Shanghai Yingli Pharmaceutical Co. Ltd. | Fused pyrimidine compound, intermediate, preparation method therefor, and composition and application thereof |
| CN110366550A (zh) * | 2016-12-22 | 2019-10-22 | 美国安进公司 | 作为用于治疗肺癌、胰腺癌或结直肠癌的KRAS G12C抑制剂的苯并异噻唑、异噻唑并[3,4-b]吡啶、喹唑啉、酞嗪、吡啶并[2,3-d]哒嗪和吡啶并[2,3-d]嘧啶衍生物 |
| EP3621968A1 (en) | 2017-05-11 | 2020-03-18 | Astrazeneca AB | Heteroaryl compounds that inhibit g12c mutant ras proteins |
| AU2018273356B2 (en) * | 2017-05-22 | 2021-09-16 | Amgen Inc. | KRAS G12C inhibitors and methods of using the same |
| AU2018329920B2 (en) * | 2017-09-08 | 2022-12-01 | Amgen Inc. | Inhibitors of KRAS G12C and methods of using the same |
| LT3710439T (lt) * | 2017-11-15 | 2023-05-10 | Mirati Therapeutics, Inc. | Kras g12c inhibitoriai |
| KR20220012255A (ko) * | 2019-04-28 | 2022-02-03 | 젠플리트 테라퓨틱스 (상하이) 아이엔씨. | 옥사아자퀴나졸린-7(8h)-케톤 화합물, 이의 제조 방법 및 이의 약학적 응용 |
| CN112390818B (zh) * | 2019-08-12 | 2023-08-22 | 劲方医药科技(上海)有限公司 | 取代的杂芳环并二氢嘧啶酮衍生物，其制法与医药上的用途 |
-
2020
- 2020-08-03 JP JP2022506075A patent/JP7756069B6/ja active Active
- 2020-08-03 KR KR1020227006959A patent/KR20220079521A/ko not_active Ceased
- 2020-08-03 US US17/632,167 patent/US20220298174A1/en active Pending
- 2020-08-03 CN CN202010769535.0A patent/CN112300195B/zh active Active
- 2020-08-03 CA CA3149403A patent/CA3149403A1/en active Pending
- 2020-08-03 MX MX2022001421A patent/MX2022001421A/es unknown
- 2020-08-03 AU AU2020325477A patent/AU2020325477A1/en active Pending
- 2020-08-03 EP EP20850862.2A patent/EP4011886A4/en active Pending
- 2020-08-03 WO PCT/CN2020/106573 patent/WO2021023154A1/zh not_active Ceased
-
2022
- 2022-02-01 IL IL290276A patent/IL290276B1/en unknown
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