JP2022532706A5 - - Google Patents
Info
- Publication number
- JP2022532706A5 JP2022532706A5 JP2021566558A JP2021566558A JP2022532706A5 JP 2022532706 A5 JP2022532706 A5 JP 2022532706A5 JP 2021566558 A JP2021566558 A JP 2021566558A JP 2021566558 A JP2021566558 A JP 2021566558A JP 2022532706 A5 JP2022532706 A5 JP 2022532706A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- group
- pharmaceutically acceptable
- tautomer
- stereoisomer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024180616A JP7844578B2 (ja) | 2019-05-08 | 2024-10-16 | THR-βの調節物質およびその使用方法 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962845252P | 2019-05-08 | 2019-05-08 | |
| US62/845,252 | 2019-05-08 | ||
| US201962944052P | 2019-12-05 | 2019-12-05 | |
| US62/944,052 | 2019-12-05 | ||
| US202063005661P | 2020-04-06 | 2020-04-06 | |
| US63/005,661 | 2020-04-06 | ||
| PCT/US2020/031904 WO2020227549A1 (en) | 2019-05-08 | 2020-05-07 | MODULATORS OF THR-β AND METHODS OF USE THEREOF |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024180616A Division JP7844578B2 (ja) | 2019-05-08 | 2024-10-16 | THR-βの調節物質およびその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022532706A JP2022532706A (ja) | 2022-07-19 |
| JP2022532706A5 true JP2022532706A5 (https=) | 2023-05-12 |
| JP7574223B2 JP7574223B2 (ja) | 2024-10-28 |
Family
ID=70919081
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021566558A Active JP7574223B2 (ja) | 2019-05-08 | 2020-05-07 | THR-βの調節物質およびその使用方法 |
| JP2024180616A Active JP7844578B2 (ja) | 2019-05-08 | 2024-10-16 | THR-βの調節物質およびその使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024180616A Active JP7844578B2 (ja) | 2019-05-08 | 2024-10-16 | THR-βの調節物質およびその使用方法 |
Country Status (32)
| Country | Link |
|---|---|
| US (3) | US11091467B2 (https=) |
| EP (2) | EP3965884B1 (https=) |
| JP (2) | JP7574223B2 (https=) |
| KR (1) | KR20220017917A (https=) |
| CN (1) | CN114096531B (https=) |
| AU (1) | AU2020267576B2 (https=) |
| BR (1) | BR112021021718A2 (https=) |
| CA (1) | CA3139101A1 (https=) |
| CL (1) | CL2021002883A1 (https=) |
| CO (1) | CO2021015698A2 (https=) |
| DK (1) | DK3965884T3 (https=) |
| ES (1) | ES3020290T3 (https=) |
| FI (1) | FI3965884T3 (https=) |
| GE (2) | GEP20247637B (https=) |
| HR (1) | HRP20250384T1 (https=) |
| HU (1) | HUE070650T2 (https=) |
| IL (1) | IL287720A (https=) |
| LT (1) | LT3965884T (https=) |
| MA (1) | MA55890B1 (https=) |
| MD (1) | MD3965884T2 (https=) |
| MX (1) | MX2021013472A (https=) |
| MY (1) | MY210357A (https=) |
| PE (1) | PE20220255A1 (https=) |
| PH (1) | PH12021552782A1 (https=) |
| PL (1) | PL3965884T3 (https=) |
| PT (1) | PT3965884T (https=) |
| RS (1) | RS66686B1 (https=) |
| SG (1) | SG11202111552YA (https=) |
| SI (1) | SI3965884T1 (https=) |
| TW (1) | TWI855068B (https=) |
| WO (1) | WO2020227549A1 (https=) |
| ZA (1) | ZA202409114B (https=) |
Families Citing this family (42)
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| CN111320609A (zh) | 2018-12-13 | 2020-06-23 | 拓臻股份有限公司 | 一种THRβ受体激动剂化合物及其制备方法和用途 |
| KR20220017917A (ko) * | 2019-05-08 | 2022-02-14 | 알리고스 테라퓨틱스 인코포레이티드 | Thr-베타의 조절제 및 이의 사용 방법 |
| AU2020336272A1 (en) * | 2019-08-23 | 2022-04-14 | Terns Pharmaceuticals, Inc. | Thyroid hormone receptor beta agonist compounds |
| WO2021050945A1 (en) | 2019-09-12 | 2021-03-18 | Terns, Inc. | Thyroid hormone receptor beta agonist compounds |
| WO2021104288A1 (zh) * | 2019-11-26 | 2021-06-03 | 昆药集团股份有限公司 | 1,2,4-三嗪-3,5-二酮类化合物及其制备方法和应用 |
| WO2021129465A1 (zh) * | 2019-12-26 | 2021-07-01 | 苏州科睿思制药有限公司 | 一种Resmetirom晶型及其制备方法和用途 |
| CN113278013B (zh) * | 2020-02-20 | 2022-09-23 | 昆药集团股份有限公司 | 2,6-二取代的1,2,4-三嗪-3,5-二酮化合物及其制备方法和应用 |
| US20230257367A1 (en) * | 2020-06-02 | 2023-08-17 | Chengdu Kanghong Pharmaceutical Co., Ltd. | Novel thyroid hormone beta receptor agonist |
| WO2021257851A1 (en) | 2020-06-17 | 2021-12-23 | Autobahn Therapeutics, Inc. | Thyromimetics |
| US12590072B2 (en) | 2020-06-17 | 2026-03-31 | Autobahn Therapeutics, Inc. | Thyromimetics |
| WO2022053028A1 (zh) * | 2020-09-10 | 2022-03-17 | 南京明德新药研发有限公司 | 1,2,4-三嗪-3,5(2h,4h)-二酮类化合物及其应用 |
| WO2022052822A1 (zh) * | 2020-09-10 | 2022-03-17 | 苏州科睿思制药有限公司 | Resmetirom的晶型及其制备方法和用途 |
| CA3192169A1 (en) * | 2020-09-17 | 2022-03-24 | Sunshine Lake Pharma Co., Ltd. | A compound as a thyroid hormone beta receptor agonist and use thereof |
| AU2021373043A1 (en) * | 2020-11-06 | 2023-06-15 | Aligos Therapeutics, Inc. | Oxindoles and methods of use thereof |
| JP2023551782A (ja) * | 2020-11-06 | 2023-12-13 | アリゴス セラピューティクス,インコーポレーテッド | 甲状腺受容体アゴニストとしてのピリダジノン誘導体、及びその使用 |
| CN114591300A (zh) * | 2020-12-04 | 2022-06-07 | 南京圣和药业股份有限公司 | 作为THRβ激动剂的杂环化合物及其应用 |
| CN112645936B (zh) * | 2020-12-17 | 2022-03-01 | 山东第一医科大学(山东省医学科学院) | 取代的哒嗪酮类化合物及其用途 |
| CN114685450A (zh) * | 2020-12-30 | 2022-07-01 | 昆药集团股份有限公司 | 2-吡啶酮类衍生物及其制备方法和在医药上的应用 |
| CN114907327A (zh) * | 2021-02-10 | 2022-08-16 | 杭州领业医药科技有限公司 | Resmetirom的晶型及其制备方法和用途 |
| PE20240097A1 (es) * | 2021-03-03 | 2024-01-18 | Terns Pharmaceuticals Inc | Compuestos agonistas beta del receptor de la hormona tiroidea |
| CA3210814A1 (en) * | 2021-03-04 | 2022-09-09 | Xiaokun SHEN | Aromatic compound, preparation method therefor, and application thereof |
| CN115073429A (zh) * | 2021-03-15 | 2022-09-20 | 昆药集团股份有限公司 | 一种1,2,4-三嗪-3,5-二酮类化合物的盐型、晶型及其制备方法 |
| CN117279911B (zh) * | 2021-05-21 | 2025-07-08 | 深圳微芯生物科技股份有限公司 | 一种杂环化合物及其应用 |
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| US20250243491A1 (en) | 2021-09-01 | 2025-07-31 | Aligos Therapeutics, Inc. | Pnpla3-targeting short interfering rna (sirna) molecules and uses thereof |
| CN118234862A (zh) | 2021-09-08 | 2024-06-21 | 阿利戈斯治疗公司 | 经修饰的短干扰核酸分子(siNA)及其用途 |
| TWI910297B (zh) * | 2021-12-24 | 2026-01-01 | 大陸商廣東東陽光藥業股份有限公司 | 一種作為甲狀腺激素β受體激動劑的化合物及其用途 |
| CN116354934A (zh) * | 2021-12-28 | 2023-06-30 | 中国科学院上海药物研究所 | 一类喹啉类化合物及其制备方法、药物组合物和用途 |
| CN115650928B (zh) * | 2022-12-28 | 2023-03-31 | 凯思凯旭(上海)医药科技有限公司 | 一种多环类甲状腺激素β受体激动剂及其用途 |
| WO2024182446A2 (en) | 2023-02-28 | 2024-09-06 | Aligos Therapeutics, Inc. | Pnpla3-targeting short interfering rna (sirna) molecules and uses thereof |
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| EP4568664B1 (en) | 2023-04-07 | 2026-04-01 | Terns Pharmaceuticals, Inc. | Combination comprising a thr-beta agonist and a glp-1r agonist for use in treating obesity |
| CN121358734A (zh) * | 2023-06-19 | 2026-01-16 | 西威埃医药技术(上海)有限公司 | THR-β受体激动剂、其制备方法和其使用方法 |
| WO2025011259A1 (zh) * | 2023-07-07 | 2025-01-16 | 苏州科睿思制药有限公司 | 瑞司美替罗的晶型及其制备方法和用途 |
| CN117327057B (zh) * | 2023-08-30 | 2026-03-03 | 南京雷正医药科技有限公司 | 一类作为甲状腺激素受体激动剂的三嗪二酮类化合物及其合成、用途 |
| US20250206725A1 (en) * | 2023-12-21 | 2025-06-26 | Aligos Therapeutics, Inc. | Modulators of thr-beta and methods of use thereof |
| WO2025230749A1 (en) | 2024-05-03 | 2025-11-06 | Aligos Therapeutics, Inc. | Methods of preparing 6-amino-2-[3,5-dichloro-4-[(5-isopropyl-6-oxo-1 h-pyridazin-3-yl)oxy]phenyl]-4h- 1, 2, 4-tri-azine-3, 5-dione |
| WO2025252147A1 (zh) * | 2024-06-07 | 2025-12-11 | 珠海联邦制药股份有限公司 | 一种甲状腺激素β受体激动剂的化合物及其应用 |
| WO2026050911A1 (zh) * | 2024-09-04 | 2026-03-12 | 西威埃医药技术(上海)有限公司 | 一种TR-β选择性激动剂的晶型、制备方法和应用 |
| WO2026067791A1 (en) | 2024-09-30 | 2026-04-02 | Ascletis Pharma (China) Co., Limited | 2-phenyl-1,2,4-triazine-3,5(2h,4h)-dione derivatives as thr-beta agonist or modulators for the treatment of obesity |
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| CN120923503A (zh) * | 2025-10-10 | 2025-11-11 | 吉斯凯(苏州)制药有限公司 | 具有杂环结构的化合物、THRβ受体激动剂及用途 |
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-
2020
- 2020-05-07 KR KR1020217039735A patent/KR20220017917A/ko active Pending
- 2020-05-07 LT LTEPPCT/US2020/031904T patent/LT3965884T/lt unknown
- 2020-05-07 JP JP2021566558A patent/JP7574223B2/ja active Active
- 2020-05-07 MY MYPI2021006587A patent/MY210357A/en unknown
- 2020-05-07 BR BR112021021718A patent/BR112021021718A2/pt unknown
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