JP2022512401A5 - - Google Patents
Info
- Publication number
- JP2022512401A5 JP2022512401A5 JP2021533540A JP2021533540A JP2022512401A5 JP 2022512401 A5 JP2022512401 A5 JP 2022512401A5 JP 2021533540 A JP2021533540 A JP 2021533540A JP 2021533540 A JP2021533540 A JP 2021533540A JP 2022512401 A5 JP2022512401 A5 JP 2022512401A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- seq
- linker
- cancer
- antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024176340A JP2025020131A (ja) | 2018-12-13 | 2024-10-08 | ハーボキシジエンスプライシング調節薬抗体－薬物コンジュゲート及びその使用方法 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862779400P | 2018-12-13 | 2018-12-13 | |
| US201862779406P | 2018-12-13 | 2018-12-13 | |
| US62/779,400 | 2018-12-13 | ||
| US62/779,406 | 2018-12-13 | ||
| US201962941220P | 2019-11-27 | 2019-11-27 | |
| US62/941,220 | 2019-11-27 | ||
| PCT/US2019/066029 WO2020123836A2 (en) | 2018-12-13 | 2019-12-12 | Herboxidiene splicing modulator antibody-drug conjugates and methods of use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024176340A Division JP2025020131A (ja) | 2018-12-13 | 2024-10-08 | ハーボキシジエンスプライシング調節薬抗体－薬物コンジュゲート及びその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022512401A JP2022512401A (ja) | 2022-02-03 |
| JP2022512401A5 true JP2022512401A5 (enExample) | 2022-12-19 |
| JP7570329B2 JP7570329B2 (ja) | 2024-10-21 |
Family
ID=69160369
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021533540A Active JP7570329B2 (ja) | 2018-12-13 | 2019-12-12 | ハーボキシジエンスプライシング調節薬抗体－薬物コンジュゲート及びその使用方法 |
| JP2024176340A Pending JP2025020131A (ja) | 2018-12-13 | 2024-10-08 | ハーボキシジエンスプライシング調節薬抗体－薬物コンジュゲート及びその使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024176340A Pending JP2025020131A (ja) | 2018-12-13 | 2024-10-08 | ハーボキシジエンスプライシング調節薬抗体－薬物コンジュゲート及びその使用方法 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US12514928B2 (enExample) |
| EP (1) | EP3893937A2 (enExample) |
| JP (2) | JP7570329B2 (enExample) |
| KR (1) | KR20210102274A (enExample) |
| CN (2) | CN120189526A (enExample) |
| AU (1) | AU2019397062A1 (enExample) |
| BR (1) | BR112021010936A2 (enExample) |
| CA (1) | CA3114931A1 (enExample) |
| CL (4) | CL2021001534A1 (enExample) |
| CO (1) | CO2021006503A2 (enExample) |
| IL (1) | IL283787A (enExample) |
| JO (1) | JOP20210045A1 (enExample) |
| MX (3) | MX2021005878A (enExample) |
| PE (1) | PE20211473A1 (enExample) |
| PH (1) | PH12021551389A1 (enExample) |
| SG (1) | SG11202102419VA (enExample) |
| TW (1) | TWI853863B (enExample) |
| WO (1) | WO2020123836A2 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN119405833A (zh) | 2018-06-01 | 2025-02-11 | 卫材R&D管理有限公司 | 剪接调节抗体-药物缀合物及其使用方法 |
| IL278740B2 (en) | 2018-06-01 | 2024-01-01 | Eisai R&D Man Co Ltd | Methods for using splicing modulators |
| CN120189526A (zh) | 2018-12-13 | 2025-06-24 | 卫材R&D管理有限公司 | 荷伯希二烯抗体-药物缀合物及使用方法 |
| WO2021090062A1 (en) | 2019-11-07 | 2021-05-14 | Eisai R&D Management Co., Ltd. | Anti-mesothelin eribulin antibody-drug conjugates and methods of use |
| EP4161966A1 (en) | 2020-06-05 | 2023-04-12 | Eisai R&D Management Co., Ltd. | Anti-bcma antibody-drug conjugates and methods of use |
| US20240043928A1 (en) | 2020-11-04 | 2024-02-08 | Eisai R&D Management Co., Ltd. | Biomarkers for myelodysplastic syndrome (mds) and methods of using the same |
| WO2023131866A1 (en) | 2022-01-05 | 2023-07-13 | Eisai R&D Management Co., Ltd. | Biomarkers for myelodysplastic syndrome (mds) and methods of using the same |
| EP4525925A1 (en) * | 2022-05-20 | 2025-03-26 | Novartis AG | Epha2 bcl-xl inhibitor antibody-drug conjugates and methods of use thereof |
Family Cites Families (55)
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| US4880078A (en) | 1987-06-29 | 1989-11-14 | Honda Giken Kogyo Kabushiki Kaisha | Exhaust muffler |
| IL89220A (en) | 1988-02-11 | 1994-02-27 | Bristol Myers Squibb Co | Anthracycline immunoconjugates, their production and pharmaceutical compositions containing them |
| FI903489A7 (fi) | 1988-11-11 | 1990-07-10 | Medical Res Council | Yhden osan sisältävät ligandit, näitä ligandeja sisältävät reseptorit, menetelmiä niiden valmistamiseksi sekä ligandien ja reseptorien käytt ö |
| WO1990014837A1 (en) | 1989-05-25 | 1990-12-13 | Chiron Corporation | Adjuvant formulation comprising a submicron oil droplet emulsion |
| JPH06507404A (ja) | 1991-05-01 | 1994-08-25 | ヘンリー エム．ジャクソン ファウンデイション フォー ザ アドバンスメント オブ ミリタリー メディスン | 感染性の呼吸性疾患の治療方法 |
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| US5622929A (en) | 1992-01-23 | 1997-04-22 | Bristol-Myers Squibb Company | Thioether conjugates |
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| US6214345B1 (en) | 1993-05-14 | 2001-04-10 | Bristol-Myers Squibb Co. | Lysosomal enzyme-cleavable antitumor drug conjugates |
| US6019968A (en) | 1995-04-14 | 2000-02-01 | Inhale Therapeutic Systems, Inc. | Dispersible antibody compositions and methods for their preparation and use |
| NZ322175A (en) | 1995-11-10 | 1999-02-25 | Elan Corp Plc | Peptides which enhance transport across tissues and methods of identifying the same |
| EP0871490B1 (en) | 1995-12-22 | 2003-03-19 | Bristol-Myers Squibb Company | Branched hydrazone linkers |
| US5719179A (en) | 1995-12-28 | 1998-02-17 | Kyowa Hakko Kogyo Co., Ltd. | Compound GEX1 |
| JP3795604B2 (ja) * | 1995-12-28 | 2006-07-12 | 協和醗酵工業株式会社 | Ｇｅｘ１化合物 |
| US5985320A (en) | 1996-03-04 | 1999-11-16 | The Penn State Research Foundation | Materials and methods for enhancing cellular internalization |
| US5874064A (en) | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
| US5855913A (en) | 1997-01-16 | 1999-01-05 | Massachusetts Instite Of Technology | Particles incorporating surfactants for pulmonary drug delivery |
| US5985309A (en) | 1996-05-24 | 1999-11-16 | Massachusetts Institute Of Technology | Preparation of particles for inhalation |
| DE69732306T2 (de) | 1997-01-16 | 2006-01-12 | Massachusetts Institute Of Technology, Cambridge | Zubereitung von partikelhaltigen arzneimitteln zur inhalation |
| ES2198922T3 (es) | 1998-06-24 | 2004-02-01 | Advanced Inhalation Research, Inc. | Particulas porosas grandes emitadas por un inhalador. |
| NZ517202A (en) | 1999-08-24 | 2004-05-28 | Medarex Inc | Human CTLA-4 antibodies and their uses |
| CZ20033208A3 (en) | 2001-04-26 | 2004-03-17 | Biogen, Inc. | Cripto blocking antibodies and uses thereof |
| JP4452787B2 (ja) * | 2003-03-11 | 2010-04-21 | アステラス製薬株式会社 | 新規発酵生産物 |
| CA2556027C (en) | 2004-02-12 | 2015-11-24 | Morphotek, Inc. | Monoclonal antibodies that specifically block biological activity of a tumor antigen |
| TR201808537T4 (tr) | 2004-09-23 | 2018-07-23 | Genentech Inc | Sistein değiştirilmiş antikorlar ve konjugatlar. |
| KR20080080482A (ko) | 2005-09-07 | 2008-09-04 | 메디뮨 엘엘씨 | 독소가 컨쥬게이트된 ｅｐｈ 수용체 항체 |
| PT2845866T (pt) | 2006-10-27 | 2017-08-09 | Genentech Inc | Anticorpos e imunoconjugados e utilizações dos mesmos |
| JP5524053B2 (ja) | 2008-06-04 | 2014-06-18 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ハーボキシジエンの生合成に関与するポリペプチドをコードするｄｎａ |
| JPWO2011074621A1 (ja) | 2009-12-18 | 2013-04-25 | 株式会社医学生物学研究所 | メソセリン（ｍｓｌｎ）に対する抗体及びその用途 |
| US9856320B2 (en) | 2012-05-15 | 2018-01-02 | Bristol-Myers Squibb Company | Cancer immunotherapy by disrupting PD-1/PD-L1 signaling |
| CN104640572B (zh) | 2012-05-15 | 2018-04-27 | 索伦托医疗有限公司 | 药物偶联物，偶联方法，及其用途 |
| US20140069822A1 (en) | 2012-09-10 | 2014-03-13 | Antec Leyden B.V. | Electrochemical reduction of disulfide bonds in proteinaceous substances and electrochemical cell for carrying out such reduction |
| MX340090B (es) * | 2012-11-05 | 2016-06-23 | Pfizer | Analogos de spliceostatina. |
| WO2014078749A1 (en) | 2012-11-15 | 2014-05-22 | The Regents Of The University Of California | Splice modulating oligonucleotides that inhibit cancer |
| GB201312318D0 (en) | 2013-07-09 | 2013-08-21 | Isomerase Therapeutics Ltd | Novel methods and compounds |
| EP3066470A4 (en) | 2013-11-05 | 2017-05-31 | Immunomedics, Inc. | Humanized anti-ceacam5 antibody and uses thereof |
| US10000505B2 (en) | 2013-11-19 | 2018-06-19 | Purdue Research Foundation | Anti-cancer agents and preparation thereof |
| CN106604933B (zh) | 2014-07-11 | 2021-08-10 | 文塔纳医疗系统公司 | 抗pd-l1抗体及其诊断用途 |
| MY199595A (en) | 2016-03-02 | 2023-11-08 | Eisai R&D Man Co Ltd | Eribulin-based antibody-drug conjugates and methods of use |
| WO2017156454A1 (en) * | 2016-03-10 | 2017-09-14 | The Regents Of The University Of California | Anti-cancer and splce modulating compounds and methods |
| CN117534764A (zh) | 2016-06-06 | 2024-02-09 | 阿布泽纳(英国)有限公司 | 抗体、其用途及其缀合物 |
| EP3468976A4 (en) | 2016-06-08 | 2019-11-27 | William Marsh Rice University | DERIVATIVES OF THAILANSTATIN A, METHOD FOR THE TREATMENT AND METHOD FOR SYNTHESIS THEREOF |
| WO2018152095A1 (en) | 2017-02-14 | 2018-08-23 | Celgene Corporation | Treatment of cancer with smg1-inhibitors |
| JP2020514348A (ja) | 2017-03-15 | 2020-05-21 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | スプライセオソーム変異及びその使用 |
| WO2018185618A1 (en) | 2017-04-03 | 2018-10-11 | Novartis Ag | Anti-cdh6 antibody drug conjugates and anti-gitr antibody combinations and methods of treatment |
| GB201711068D0 (en) | 2017-07-10 | 2017-08-23 | Crescendo Biologics Ltd | Therapeutic molecules binding PSMA |
| WO2019023450A1 (en) * | 2017-07-26 | 2019-01-31 | Ghosh Arun K | HERBOXIDIENE DERIVATIVES AND USES THEREOF |
| IL278740B2 (en) | 2018-06-01 | 2024-01-01 | Eisai R&D Man Co Ltd | Methods for using splicing modulators |
| CN119405833A (zh) * | 2018-06-01 | 2025-02-11 | 卫材R&D管理有限公司 | 剪接调节抗体-药物缀合物及其使用方法 |
| CN120189526A (zh) | 2018-12-13 | 2025-06-24 | 卫材R&D管理有限公司 | 荷伯希二烯抗体-药物缀合物及使用方法 |
| WO2021090062A1 (en) | 2019-11-07 | 2021-05-14 | Eisai R&D Management Co., Ltd. | Anti-mesothelin eribulin antibody-drug conjugates and methods of use |
| JP7821733B2 (ja) | 2020-01-22 | 2026-02-27 | 上海森輝医薬有限公司 | エリブリン誘導体の薬物複合体、その調製方法及びその医薬的応用 |
| EP4161966A1 (en) | 2020-06-05 | 2023-04-12 | Eisai R&D Management Co., Ltd. | Anti-bcma antibody-drug conjugates and methods of use |
-
2019
- 2019-12-12 CN CN202510341677.XA patent/CN120189526A/zh active Pending
- 2019-12-12 SG SG11202102419VA patent/SG11202102419VA/en unknown
- 2019-12-12 PH PH1/2021/551389A patent/PH12021551389A1/en unknown
- 2019-12-12 CN CN201980081875.XA patent/CN113271981B/zh active Active
- 2019-12-12 EP EP19836349.1A patent/EP3893937A2/en active Pending
- 2019-12-12 JP JP2021533540A patent/JP7570329B2/ja active Active
- 2019-12-12 PE PE2021000860A patent/PE20211473A1/es unknown
- 2019-12-12 TW TW108145609A patent/TWI853863B/zh active
- 2019-12-12 US US17/312,320 patent/US12514928B2/en active Active
- 2019-12-12 KR KR1020217018846A patent/KR20210102274A/ko active Pending
- 2019-12-12 WO PCT/US2019/066029 patent/WO2020123836A2/en not_active Ceased
- 2019-12-12 BR BR112021010936-6A patent/BR112021010936A2/pt unknown
- 2019-12-12 MX MX2021005878A patent/MX2021005878A/es unknown
- 2019-12-12 CA CA3114931A patent/CA3114931A1/en active Pending
- 2019-12-12 AU AU2019397062A patent/AU2019397062A1/en active Pending
-
2020
- 2020-06-13 JO JOP/2021/0045A patent/JOP20210045A1/ar unknown
-
2021
- 2021-05-19 MX MX2025013916A patent/MX2025013916A/es unknown
- 2021-05-19 MX MX2025013917A patent/MX2025013917A/es unknown
- 2021-05-20 CO CONC2021/0006503A patent/CO2021006503A2/es unknown
- 2021-06-07 IL IL283787A patent/IL283787A/en unknown
- 2021-06-10 CL CL2021001534A patent/CL2021001534A1/es unknown
-
2024
- 2024-01-30 CL CL2024000282A patent/CL2024000282A1/es unknown
- 2024-01-30 CL CL2024000286A patent/CL2024000286A1/es unknown
- 2024-01-30 CL CL2024000285A patent/CL2024000285A1/es unknown
- 2024-10-08 JP JP2024176340A patent/JP2025020131A/ja active Pending
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