MX2021005878A - Modulador de empalme de herboxidieno de conjugados de anticuerpo-farmaco y metodos de uso. - Google Patents

Modulador de empalme de herboxidieno de conjugados de anticuerpo-farmaco y metodos de uso.

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Publication number
MX2021005878A
MX2021005878A MX2021005878A MX2021005878A MX2021005878A MX 2021005878 A MX2021005878 A MX 2021005878A MX 2021005878 A MX2021005878 A MX 2021005878A MX 2021005878 A MX2021005878 A MX 2021005878A MX 2021005878 A MX2021005878 A MX 2021005878A
Authority
MX
Mexico
Prior art keywords
herboxidiene
drug conjugates
antibody
methods
drug
Prior art date
Application number
MX2021005878A
Other languages
English (en)
Inventor
Nathan Fishkin
Thiwanka Samarakoon
Yoshihiko Kotake
Masayuki Miyano
Norio Murai
Kenzo Arai
James Palacino
Shinya Okubo
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of MX2021005878A publication Critical patent/MX2021005878A/es

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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
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    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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Abstract

Se describen compuestos de ligador-fármaco y conjugados de anticuerpo-fármaco que se unen a objetivos oncológicos humanos. Los compuestos de ligador-fármaco y los conjugados de anticuerpo-fármaco comprenden un resto de fármaco de modulador de empalme de herboxidieno. La descripción se refiere además a métodos y composiciones para su uso en el tratamiento de trastornos neoplásicos mediante la administración de los conjugados de anticuerpo-fármaco proporcionados en el presente documento.
MX2021005878A 2018-12-13 2019-12-12 Modulador de empalme de herboxidieno de conjugados de anticuerpo-farmaco y metodos de uso. MX2021005878A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201862779406P 2018-12-13 2018-12-13
US201862779400P 2018-12-13 2018-12-13
US201962941220P 2019-11-27 2019-11-27
PCT/US2019/066029 WO2020123836A2 (en) 2018-12-13 2019-12-12 Herboxidiene splicing modulator antibody-drug conjugates and methods of use

Publications (1)

Publication Number Publication Date
MX2021005878A true MX2021005878A (es) 2021-07-16

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MX2021005878A MX2021005878A (es) 2018-12-13 2019-12-12 Modulador de empalme de herboxidieno de conjugados de anticuerpo-farmaco y metodos de uso.

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US (1) US20220031859A1 (es)
EP (1) EP3893937A2 (es)
KR (1) KR20210102274A (es)
CN (1) CN113271981A (es)
AU (1) AU2019397062A1 (es)
BR (1) BR112021010936A2 (es)
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