JP2022500388A - 組み合わせ療法 - Google Patents

組み合わせ療法 Download PDF

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Publication number
JP2022500388A
JP2022500388A JP2021513334A JP2021513334A JP2022500388A JP 2022500388 A JP2022500388 A JP 2022500388A JP 2021513334 A JP2021513334 A JP 2021513334A JP 2021513334 A JP2021513334 A JP 2021513334A JP 2022500388 A JP2022500388 A JP 2022500388A
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JP
Japan
Prior art keywords
inhibitor
kras
alkyl
formula
cdk4
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2021513334A
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English (en)
Japanese (ja)
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JP2022500388A5 (enExample
Inventor
エングストローム，ラーズ・ダニエル
アランダ，ルース・ウェイ
オルソン，ピーター
クリステンセン，ジェームズ・ゲイル
ハリン，ジル
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Mirati Therapeutics Inc
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Mirati Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Mirati Therapeutics Inc filed Critical Mirati Therapeutics Inc
Publication of JP2022500388A publication Critical patent/JP2022500388A/ja
Publication of JP2022500388A5 publication Critical patent/JP2022500388A5/ja
Priority to JP2024151993A priority Critical patent/JP2025000629A/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2021513334A 2018-09-10 2019-09-09 組み合わせ療法 Pending JP2022500388A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024151993A JP2025000629A (ja) 2018-09-10 2024-09-04 組み合わせ療法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862729205P 2018-09-10 2018-09-10
US62/729,205 2018-09-10
PCT/US2019/050233 WO2020055758A1 (en) 2018-09-10 2019-09-09 Combination therapies

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2024151993A Division JP2025000629A (ja) 2018-09-10 2024-09-04 組み合わせ療法

Publications (2)

Publication Number Publication Date
JP2022500388A true JP2022500388A (ja) 2022-01-04
JP2022500388A5 JP2022500388A5 (enExample) 2022-09-16

Family

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JP2024151993A Pending JP2025000629A (ja) 2018-09-10 2024-09-04 組み合わせ療法

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Country Status (17)

Country Link
US (1) US12485122B2 (enExample)
EP (1) EP3849537B1 (enExample)
JP (2) JP2022500388A (enExample)
AU (1) AU2019340436B2 (enExample)
CA (1) CA3111977A1 (enExample)
DK (1) DK3849537T3 (enExample)
ES (1) ES3004338T3 (enExample)
FI (1) FI3849537T3 (enExample)
HR (1) HRP20250059T1 (enExample)
HU (1) HUE070338T2 (enExample)
LT (1) LT3849537T (enExample)
PL (1) PL3849537T3 (enExample)
PT (1) PT3849537T (enExample)
RS (1) RS66424B1 (enExample)
SI (1) SI3849537T1 (enExample)
SM (1) SMT202500028T1 (enExample)
WO (1) WO2020055758A1 (enExample)

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JP2022500385A (ja) * 2018-09-10 2022-01-04 ミラティ セラピューティクス， インコーポレイテッド 組み合わせ療法
EA202190749A1 (ru) * 2018-09-10 2021-07-09 Мирати Терапьютикс, Инк. Способы комбинированной терапии
WO2021043322A1 (zh) * 2019-09-06 2021-03-11 正大天晴药业集团南京顺欣制药有限公司 氮杂环庚烷并嘧啶类衍生物及其医药用途
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CN114555586B (zh) * 2019-10-10 2023-06-23 信达生物制药(苏州)有限公司 Krasg12c蛋白抑制剂及其制备方法和用途
EP4067343A4 (en) 2019-11-29 2024-01-03 Taiho Pharmaceutical Co., Ltd. NEW PHENOLIC COMPOUND OR SALT THEREOF
WO2021219072A1 (zh) * 2020-04-30 2021-11-04 上海科州药物研发有限公司 作为kras抑制剂的杂环化合物的制备及其应用方法
KR20230028798A (ko) * 2020-06-25 2023-03-02 톨레모 테라퓨틱스 아게 암 치료를 위한 CBP/p300 브로모도메인 억제제 및 KRAS 억제제의 조합물
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WO2025145207A1 (en) 2023-12-29 2025-07-03 Bristol-Myers Squibb Company Combination therapy of kras inhibitor and treg-depleting agent

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