DE69736351D1 - Methoden und mittel zur hemmung der cdk4-aktivität - Google Patents
Methoden und mittel zur hemmung der cdk4-aktivitätInfo
- Publication number
- DE69736351D1 DE69736351D1 DE69736351A DE69736351A DE69736351D1 DE 69736351 D1 DE69736351 D1 DE 69736351D1 DE 69736351 A DE69736351 A DE 69736351A DE 69736351 A DE69736351 A DE 69736351A DE 69736351 D1 DE69736351 D1 DE 69736351D1
- Authority
- DE
- Germany
- Prior art keywords
- cdk4
- activity
- methods
- sup
- cdk4 activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9609521.1A GB9609521D0 (en) | 1996-05-08 | 1996-05-08 | Substances and their therapeutic use |
GBGB9621314.5A GB9621314D0 (en) | 1996-10-09 | 1996-10-09 | Substances and their therapeutic use |
PCT/GB1997/001250 WO1997042222A1 (en) | 1996-05-08 | 1997-05-08 | Methods and means for inhibition of cdk4 activity |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69736351D1 true DE69736351D1 (de) | 2006-08-31 |
Family
ID=26309279
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69736351A Expired - Fee Related DE69736351D1 (de) | 1996-05-08 | 1997-05-08 | Methoden und mittel zur hemmung der cdk4-aktivität |
DE69736351T Expired - Lifetime DE69736351T4 (de) | 1996-05-08 | 1997-05-08 | Methoden und mittel zur hemmung der cdk4-aktivität |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69736351T Expired - Lifetime DE69736351T4 (de) | 1996-05-08 | 1997-05-08 | Methoden und mittel zur hemmung der cdk4-aktivität |
Country Status (7)
Country | Link |
---|---|
US (3) | US6962792B1 (de) |
EP (1) | EP0898580B9 (de) |
JP (1) | JP4205165B2 (de) |
AT (1) | ATE333465T1 (de) |
AU (1) | AU2707797A (de) |
DE (2) | DE69736351D1 (de) |
WO (1) | WO1997042222A1 (de) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69736351D1 (de) | 1996-05-08 | 2006-08-31 | Cyclacel Ltd | Methoden und mittel zur hemmung der cdk4-aktivität |
GB9727277D0 (en) * | 1997-12-23 | 1998-02-25 | Medical Res Council | Assay |
ATE238554T1 (de) * | 1998-02-18 | 2003-05-15 | Theryte Ltd | Krebsbehandlung |
AU3103599A (en) * | 1998-03-23 | 1999-10-18 | E.I. Du Pont De Nemours And Company | Plant cell cyclin genes |
EP1338652A3 (de) * | 1998-03-23 | 2004-05-19 | E.I.Du pont de nemours and company | Pflanzenzelle Cyclin Gene |
EP1165793A2 (de) * | 1999-04-07 | 2002-01-02 | E.I. Du Pont De Nemours And Company | Cyclin-abhängige kinasehemmer gene aus pflanzen |
US7449544B2 (en) | 1999-11-30 | 2008-11-11 | Cyclacel Limited | p21 peptides |
GB2369823B (en) * | 1999-11-30 | 2003-06-04 | Cyclacel Ltd | Assays for cyclin-interacting compounds |
GB9928323D0 (en) * | 1999-11-30 | 2000-01-26 | Cyclacel Ltd | Peptides |
US20050153894A1 (en) * | 1999-11-30 | 2005-07-14 | Cyclacel Limited | p21 peptides |
GB0012528D0 (en) * | 2000-05-23 | 2000-07-12 | Univ Palackeho | Triterpenoid derivatives |
GB0030378D0 (en) | 2000-12-13 | 2001-01-24 | Cyclacel Ltd | Compound |
WO2004015071A2 (en) * | 2002-08-07 | 2004-02-19 | Exelixis, Inc. | CSNK1GS AS MODIFIERS OF THE p21 PATHWAY AND METHODS OF USE |
GB0229151D0 (en) | 2002-12-13 | 2003-01-15 | St Georges Entpr Ltd | Product and method |
WO2005040207A1 (en) * | 2003-10-20 | 2005-05-06 | F. Hoffmann-La Roche Ag | Tyrosine phosphorylation of cdk inhibitor proteins of the cip/kip family |
CA2542880A1 (en) * | 2003-10-21 | 2005-05-12 | Cyclacel Limited | Pyrimidin-4-yl-3, 4-thione compounds and their use in therapy |
GB0402653D0 (en) * | 2004-02-06 | 2004-03-10 | Cyclacel Ltd | Compounds |
GB0411791D0 (en) * | 2004-05-26 | 2004-06-30 | Cyclacel Ltd | Compounds |
AU2005276231A1 (en) | 2004-08-27 | 2006-03-02 | Cyclacel Limited | Purine and pyrimidine CDK inhibitors and their use for the treatment of autoimmune diseases |
ATE543504T1 (de) * | 2005-06-29 | 2012-02-15 | St Georges Entpr Ltd | Hox peptide als pbx-modulatoren zur behandlung von krebs |
EP2224961A1 (de) * | 2007-11-26 | 2010-09-08 | The Research Foundation of the State University of New York | Kleinmolekülige krebsbehandlungen, die nekrose in krebszellen verursachen, aber normale zellen nicht angreifen |
US9040046B2 (en) | 2011-01-31 | 2015-05-26 | Kai Xu | Sodium pump antibody agonists and methods of treating heart disease using the same |
JP2022500388A (ja) | 2018-09-10 | 2022-01-04 | ミラティ セラピューティクス, インコーポレイテッド | 組み合わせ療法 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2759164A1 (de) | 1977-12-31 | 1979-07-12 | Basf Ag | Photopolymerisierbare ueberzugs- und aufzeichnungsmaterialien, enthaltend einen photoinitiator und eine organische halogenverbindung |
US5229018A (en) | 1986-02-24 | 1993-07-20 | Forrest Gabriel T | Completion and workover fluid for oil and gas wells comprising ground peanut hulls |
FR2662698A1 (fr) * | 1990-06-05 | 1991-12-06 | Centre Nat Rech Scient | Nouveaux facteurs de croissance neurotropes comprenant un peptide homeoboite. |
US5596079A (en) | 1991-12-16 | 1997-01-21 | Smith; James R. | Mimetics of senescent cell derived inhibitors of DNA synthesis |
US5302706A (en) | 1991-12-16 | 1994-04-12 | Baylor College Of Medicine | Senescent cell derived inhibitors of DNA synthesis |
EP0665886B1 (de) | 1992-10-16 | 2003-06-11 | Cold Spring Harbor Laboratory | Umlagerung des cyclin komlexes und seine darauf bezogenen anwendungen |
GB9305448D0 (en) | 1993-03-17 | 1993-05-05 | British Tech Group | Semiconductor structure and method of manufacturing same |
CA2170641C (en) | 1993-08-30 | 2011-11-15 | James R. Smith | Senescent cell-derived inhibitors of dna synthesis |
WO1995013375A1 (en) | 1993-11-10 | 1995-05-18 | The Johns Hopkins University | Tumor suppressor waf1 |
ES2233943T3 (es) | 1994-05-24 | 2005-06-16 | Baylor College Of Medicine | Mimeticos de inhibidores de la sintesis de dna derivados de celulas senescentes. |
GB9422175D0 (en) | 1994-11-03 | 1994-12-21 | Univ Dundee | Indentification of the p21 waf1-pcna interaction site and therapeutic applications thereof |
GB9509557D0 (en) | 1995-05-11 | 1995-07-05 | Univ Dundee | PCNA binding substance |
AU6548396A (en) | 1995-07-20 | 1997-02-18 | Worcester Foundation For Biomedical Research, Inc. | Methods for selectively killing or inhibiting the growth of cells expressing the waf1 gene |
US5672508A (en) | 1996-01-23 | 1997-09-30 | Mitotix, Inc. | Inhibitors of cell-cycle progression, and uses related thereto |
DE69736351D1 (de) | 1996-05-08 | 2006-08-31 | Cyclacel Ltd | Methoden und mittel zur hemmung der cdk4-aktivität |
-
1997
- 1997-05-08 DE DE69736351A patent/DE69736351D1/de not_active Expired - Fee Related
- 1997-05-08 US US09/180,269 patent/US6962792B1/en not_active Expired - Fee Related
- 1997-05-08 DE DE69736351T patent/DE69736351T4/de not_active Expired - Lifetime
- 1997-05-08 EP EP97920857A patent/EP0898580B9/de not_active Expired - Lifetime
- 1997-05-08 AU AU27077/97A patent/AU2707797A/en not_active Abandoned
- 1997-05-08 AT AT97920857T patent/ATE333465T1/de not_active IP Right Cessation
- 1997-05-08 WO PCT/GB1997/001250 patent/WO1997042222A1/en active IP Right Grant
- 1997-05-08 JP JP52963597A patent/JP4205165B2/ja not_active Expired - Fee Related
-
2003
- 2003-08-22 US US10/646,267 patent/US20040214765A1/en not_active Abandoned
-
2008
- 2008-06-04 US US12/133,242 patent/US20080249025A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20040214765A1 (en) | 2004-10-28 |
EP0898580B9 (de) | 2009-08-12 |
EP0898580B3 (de) | 2008-10-29 |
US20080249025A1 (en) | 2008-10-09 |
JP4205165B2 (ja) | 2009-01-07 |
EP0898580B1 (de) | 2006-07-19 |
DE69736351T4 (de) | 2009-07-23 |
EP0898580A1 (de) | 1999-03-03 |
AU2707797A (en) | 1997-11-26 |
JP2000513805A (ja) | 2000-10-17 |
US6962792B1 (en) | 2005-11-08 |
WO1997042222A1 (en) | 1997-11-13 |
ATE333465T1 (de) | 2006-08-15 |
DE69736351T2 (de) | 2007-07-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |