ATE333465T1 - Methoden und mittel zur hemmung der cdk4- aktivität - Google Patents

Methoden und mittel zur hemmung der cdk4- aktivität

Info

Publication number
ATE333465T1
ATE333465T1 AT97920857T AT97920857T ATE333465T1 AT E333465 T1 ATE333465 T1 AT E333465T1 AT 97920857 T AT97920857 T AT 97920857T AT 97920857 T AT97920857 T AT 97920857T AT E333465 T1 ATE333465 T1 AT E333465T1
Authority
AT
Austria
Prior art keywords
cdk4
activity
methods
sup
cdk4 activity
Prior art date
Application number
AT97920857T
Other languages
English (en)
Inventor
Kathryn L Ball
David P Lane
Original Assignee
Cyclacel Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9609521.1A external-priority patent/GB9609521D0/en
Priority claimed from GBGB9621314.5A external-priority patent/GB9621314D0/en
Application filed by Cyclacel Ltd filed Critical Cyclacel Ltd
Application granted granted Critical
Publication of ATE333465T1 publication Critical patent/ATE333465T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT97920857T 1996-05-08 1997-05-08 Methoden und mittel zur hemmung der cdk4- aktivität ATE333465T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9609521.1A GB9609521D0 (en) 1996-05-08 1996-05-08 Substances and their therapeutic use
GBGB9621314.5A GB9621314D0 (en) 1996-10-09 1996-10-09 Substances and their therapeutic use

Publications (1)

Publication Number Publication Date
ATE333465T1 true ATE333465T1 (de) 2006-08-15

Family

ID=26309279

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97920857T ATE333465T1 (de) 1996-05-08 1997-05-08 Methoden und mittel zur hemmung der cdk4- aktivität

Country Status (7)

Country Link
US (3) US6962792B1 (de)
EP (1) EP0898580B9 (de)
JP (1) JP4205165B2 (de)
AT (1) ATE333465T1 (de)
AU (1) AU2707797A (de)
DE (2) DE69736351T4 (de)
WO (1) WO1997042222A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4205165B2 (ja) 1996-05-08 2009-01-07 サイクラセル リミテッド Ｃｄｋ４活性の阻害のための方法と手段
GB9727277D0 (en) * 1997-12-23 1998-02-25 Medical Res Council Assay
ATE238555T1 (de) * 1998-02-18 2003-05-15 Theryte Ltd Krebsbehandlung
EP1063979A2 (de) * 1998-03-23 2001-01-03 E.I. Du Pont De Nemours And Company Pflanzenzell cyclin gene
EP1338652A3 (de) * 1998-03-23 2004-05-19 E.I.Du pont de nemours and company Pflanzenzelle Cyclin Gene
CA2367385A1 (en) * 1999-04-07 2000-10-12 E.I. Du Pont De Nemours And Company Cell cycle in plants
US20050153894A1 (en) * 1999-11-30 2005-07-14 Cyclacel Limited p21 peptides
US7449544B2 (en) 1999-11-30 2008-11-11 Cyclacel Limited p21 peptides
GB2369823B (en) * 1999-11-30 2003-06-04 Cyclacel Ltd Assays for cyclin-interacting compounds
GB9928323D0 (en) * 1999-11-30 2000-01-26 Cyclacel Ltd Peptides
GB0012528D0 (en) * 2000-05-23 2000-07-12 Univ Palackeho Triterpenoid derivatives
GB0030378D0 (en) 2000-12-13 2001-01-24 Cyclacel Ltd Compound
CA2494236A1 (en) * 2002-08-07 2004-02-19 Exelixis, Inc. Csnk1gs as modifiers of the p21 pathway and methods of use
GB0229151D0 (en) 2002-12-13 2003-01-15 St Georges Entpr Ltd Product and method
US20080026992A1 (en) * 2003-10-20 2008-01-31 Ludger Hengst Tyrosine Phosphorylation of Cdk Inhibitor Proteins of the Cip/Kip Family
AU2004285745A1 (en) * 2003-10-21 2005-05-12 Cyclacel Limited Pyrimidin-4-YL-3, 4-thione compounds and their use in therapy
GB0402653D0 (en) * 2004-02-06 2004-03-10 Cyclacel Ltd Compounds
GB0411791D0 (en) * 2004-05-26 2004-06-30 Cyclacel Ltd Compounds
MX2007002169A (es) 2004-08-27 2007-08-14 Cyclacel Ltd Inhibidores de cdk de purina y pirimidina y su uso para el tratamiento de enfermedades inmunes.
JP2009500314A (ja) * 2005-06-29 2009-01-08 セント ジョージス エンタープライシス リミテッド 遺伝子調節
WO2009070650A1 (en) * 2007-11-26 2009-06-04 The Research Foundation Of State University Of New York Small molecule cancer treatments that cause necrosis in cancer cells but do not affect normal cells
US9040046B2 (en) 2011-01-31 2015-05-26 Kai Xu Sodium pump antibody agonists and methods of treating heart disease using the same
EP3849537A4 (de) 2018-09-10 2022-06-29 Mirati Therapeutics, Inc. Kombinationstherapien

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2759164A1 (de) 1977-12-31 1979-07-12 Basf Ag Photopolymerisierbare ueberzugs- und aufzeichnungsmaterialien, enthaltend einen photoinitiator und eine organische halogenverbindung
US5229018A (en) 1986-02-24 1993-07-20 Forrest Gabriel T Completion and workover fluid for oil and gas wells comprising ground peanut hulls
FR2662698A1 (fr) * 1990-06-05 1991-12-06 Centre Nat Rech Scient Nouveaux facteurs de croissance neurotropes comprenant un peptide homeoboite.
US5596079A (en) 1991-12-16 1997-01-21 Smith; James R. Mimetics of senescent cell derived inhibitors of DNA synthesis
US5302706A (en) 1991-12-16 1994-04-12 Baylor College Of Medicine Senescent cell derived inhibitors of DNA synthesis
JP3485186B2 (ja) 1992-10-16 2004-01-13 コールド・スプリング・ハーバー・ラボラトリー サイクリン複合体の転位およびそれに関連する使用
GB9305448D0 (en) 1993-03-17 1993-05-05 British Tech Group Semiconductor structure and method of manufacturing same
JP3822232B2 (ja) 1993-08-30 2006-09-13 ベイラー・カレッジ・オブ・メディシン 老化細胞由来ｄｎａ合成阻害因子
WO1995013375A1 (en) 1993-11-10 1995-05-18 The Johns Hopkins University Tumor suppressor waf1
ATE283355T1 (de) 1994-05-24 2004-12-15 Baylor College Medicine Mimetika von aus alternden zellen abgeleitete hemmer der dna synthese
GB9422175D0 (en) 1994-11-03 1994-12-21 Univ Dundee Indentification of the p21 waf1-pcna interaction site and therapeutic applications thereof
GB9509557D0 (en) 1995-05-11 1995-07-05 Univ Dundee PCNA binding substance
EP0850066A1 (de) 1995-07-20 1998-07-01 Worcester Foundation For Biomedical Research, Inc. Verfahren zur selektiven abtötung oder hemmung des wachstums von zellen, welche das waf1-gen exprimieren
US5672508A (en) 1996-01-23 1997-09-30 Mitotix, Inc. Inhibitors of cell-cycle progression, and uses related thereto
JP4205165B2 (ja) 1996-05-08 2009-01-07 サイクラセル リミテッド Ｃｄｋ４活性の阻害のための方法と手段

Also Published As

Publication number Publication date
DE69736351T4 (de) 2009-07-23
JP2000513805A (ja) 2000-10-17
EP0898580A1 (de) 1999-03-03
JP4205165B2 (ja) 2009-01-07
EP0898580B9 (de) 2009-08-12
EP0898580B1 (de) 2006-07-19
US6962792B1 (en) 2005-11-08
AU2707797A (en) 1997-11-26
US20080249025A1 (en) 2008-10-09
WO1997042222A1 (en) 1997-11-13
US20040214765A1 (en) 2004-10-28
EP0898580B3 (de) 2008-10-29
DE69736351T2 (de) 2007-07-12
DE69736351D1 (de) 2006-08-31

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