JP2022106952A5 - - Google Patents
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- JP2022106952A5 JP2022106952A5 JP2022077865A JP2022077865A JP2022106952A5 JP 2022106952 A5 JP2022106952 A5 JP 2022106952A5 JP 2022077865 A JP2022077865 A JP 2022077865A JP 2022077865 A JP2022077865 A JP 2022077865A JP 2022106952 A5 JP2022106952 A5 JP 2022106952A5
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- nucleotide sequence
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- 239000002773 nucleotide Substances 0.000 claims 20
- 125000003729 nucleotide group Chemical group 0.000 claims 20
- 125000003275 alpha amino acid group Chemical group 0.000 claims 14
- 210000004027 cell Anatomy 0.000 claims 10
- 238000000034 method Methods 0.000 claims 10
- 239000002157 polynucleotide Substances 0.000 claims 10
- 102000040430 polynucleotide Human genes 0.000 claims 10
- 108091033319 polynucleotide Proteins 0.000 claims 10
- 239000000427 antigen Substances 0.000 claims 8
- 102000036639 antigens Human genes 0.000 claims 8
- 108091007433 antigens Proteins 0.000 claims 8
- 239000012634 fragment Substances 0.000 claims 8
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000000295 complement effect Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023146751A JP7682964B2 (ja) | 2016-06-14 | 2023-09-11 | 抗ｃ５抗体及びそれらの使用 |
| JP2025080407A JP2025134088A (ja) | 2016-06-14 | 2025-05-13 | 抗ｃ５抗体及びそれらの使用 |
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662349705P | 2016-06-14 | 2016-06-14 | |
| US62/349,705 | 2016-06-14 | ||
| US201662405561P | 2016-10-07 | 2016-10-07 | |
| US62/405,561 | 2016-10-07 | ||
| US201662422107P | 2016-11-15 | 2016-11-15 | |
| US62/422,107 | 2016-11-15 | ||
| JP2018565286A JP7102353B2 (ja) | 2016-06-14 | 2017-06-13 | 抗ｃ５抗体及びそれらの使用 |
| PCT/US2017/037226 WO2017218515A1 (en) | 2016-06-14 | 2017-06-13 | Anti-c5 antibodies and uses thereof |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018565286A Division JP7102353B2 (ja) | 2016-06-14 | 2017-06-13 | 抗ｃ５抗体及びそれらの使用 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023146751A Division JP7682964B2 (ja) | 2016-06-14 | 2023-09-11 | 抗ｃ５抗体及びそれらの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022106952A JP2022106952A (ja) | 2022-07-20 |
| JP2022106952A5 true JP2022106952A5 (enExample) | 2022-12-09 |
| JP7368543B2 JP7368543B2 (ja) | 2023-10-24 |
Family
ID=59091673
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018565286A Active JP7102353B2 (ja) | 2016-06-14 | 2017-06-13 | 抗ｃ５抗体及びそれらの使用 |
| JP2022077865A Active JP7368543B2 (ja) | 2016-06-14 | 2022-05-11 | 抗ｃ５抗体及びそれらの使用 |
| JP2023146751A Active JP7682964B2 (ja) | 2016-06-14 | 2023-09-11 | 抗ｃ５抗体及びそれらの使用 |
| JP2025080407A Pending JP2025134088A (ja) | 2016-06-14 | 2025-05-13 | 抗ｃ５抗体及びそれらの使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018565286A Active JP7102353B2 (ja) | 2016-06-14 | 2017-06-13 | 抗ｃ５抗体及びそれらの使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023146751A Active JP7682964B2 (ja) | 2016-06-14 | 2023-09-11 | 抗ｃ５抗体及びそれらの使用 |
| JP2025080407A Pending JP2025134088A (ja) | 2016-06-14 | 2025-05-13 | 抗ｃ５抗体及びそれらの使用 |
Country Status (29)
| Country | Link |
|---|---|
| US (4) | US10633434B2 (enExample) |
| EP (2) | EP3468990B1 (enExample) |
| JP (4) | JP7102353B2 (enExample) |
| KR (3) | KR102667023B1 (enExample) |
| CN (3) | CN116751293A (enExample) |
| AU (2) | AU2017283470B2 (enExample) |
| CA (1) | CA3027487A1 (enExample) |
| CL (1) | CL2018003563A1 (enExample) |
| CO (1) | CO2018014413A2 (enExample) |
| DK (1) | DK3468990T3 (enExample) |
| ES (1) | ES2984352T3 (enExample) |
| FI (1) | FI3468990T3 (enExample) |
| HR (1) | HRP20240815T1 (enExample) |
| HU (1) | HUE067224T2 (enExample) |
| IL (2) | IL263481B2 (enExample) |
| LT (1) | LT3468990T (enExample) |
| MA (1) | MA45235B1 (enExample) |
| MD (1) | MD3468990T2 (enExample) |
| MX (3) | MX2018015149A (enExample) |
| MY (3) | MY191668A (enExample) |
| PH (2) | PH12018502560B1 (enExample) |
| PL (1) | PL3468990T3 (enExample) |
| PT (1) | PT3468990T (enExample) |
| RS (1) | RS65633B1 (enExample) |
| SG (2) | SG10202012243VA (enExample) |
| SI (1) | SI3468990T1 (enExample) |
| SM (1) | SMT202400269T1 (enExample) |
| UA (1) | UA124734C2 (enExample) |
| WO (1) | WO2017218515A1 (enExample) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2006381T3 (en) | 2006-03-31 | 2016-02-22 | Chugai Pharmaceutical Co Ltd | PROCEDURE FOR REGULATING ANTIBODIES BLOOD PHARMACOKINETICS |
| DK2202245T3 (en) | 2007-09-26 | 2016-11-21 | Chugai Pharmaceutical Co Ltd | A method of modifying an antibody isoelectric point VIA amino acid substitution in CDR |
| PT2708559T (pt) | 2008-04-11 | 2018-05-16 | Chugai Pharmaceutical Co Ltd | Molécula de ligação ao antigénio capaz de se ligar repetidamente a duas ou mais moléculas de antigénio |
| WO2010015608A1 (en) * | 2008-08-05 | 2010-02-11 | Novartis Ag | Compositions and methods for antibodies targeting complement protein c5 |
| MX365235B (es) | 2010-11-30 | 2019-05-28 | Chugai Pharmaceutical Co Ltd | Molécula de unión a antígeno capaz de unir repetidamente a la pluralidad de moléculas de antígeno. |
| NZ631007A (en) | 2014-03-07 | 2015-10-30 | Alexion Pharma Inc | Anti-c5 antibodies having improved pharmacokinetics |
| MX2017005774A (es) | 2014-12-19 | 2017-07-28 | Chugai Pharmaceutical Co Ltd | Anticuerpos antimiostatina, polipeptidos que contienen regiones fc variantes, y metodos de uso. |
| HUE056489T2 (hu) | 2014-12-19 | 2022-02-28 | Chugai Pharmaceutical Co Ltd | Anti-C5 antitestek és alkalmazási eljárások |
| JP2019517473A (ja) | 2016-05-27 | 2019-06-24 | アレクシオン ファーマシューティカルズ インコーポレイテッドＡｌｅｘｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 難治性全身型重症筋無力症の処置のための方法 |
| MY191668A (en) * | 2016-06-14 | 2022-07-06 | Regeneron Pharma | Anti-c5 antibodies and uses thereof |
| KR102538749B1 (ko) | 2016-08-05 | 2023-06-01 | 추가이 세이야쿠 가부시키가이샤 | Il-8 관련 질환의 치료용 또는 예방용 조성물 |
| BR112019018429A2 (pt) * | 2017-03-06 | 2020-04-14 | Univ Pennsylvania | anticorpo, métodos para tratar uma doença ou distúrbio mediado pela via do complemento em um indíviduo e para reduzir a atividade de um sistema complemento de um indivíduo, e, célula |
| ES2965486T3 (es) | 2017-07-27 | 2024-04-15 | Alexion Pharma Inc | Formulaciones de anticuerpos anti-C5 de alta concentración |
| US11525002B2 (en) | 2017-10-11 | 2022-12-13 | Board Of Regents, The University Of Texas System | Human PD-L1 antibodies and methods of use therefor |
| KR20200070355A (ko) | 2017-10-26 | 2020-06-17 | 알렉시온 파마슈티칼스, 인코포레이티드 | 발작성 야간 혈색소뇨 (pnh) 및 비정형 용혈성 요독 증후군 (ahus)의 치료를 위한 항-c5 항체의 투여량 및 투여 |
| JP2021506241A (ja) | 2017-12-13 | 2021-02-22 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 抗ｃ５抗体組み合わせ物およびその使用 |
| US20190247560A1 (en) * | 2018-02-13 | 2019-08-15 | Gambro Lundia Ab | Extracorporeal devices and methods of treating complement factor related diseases |
| EP4501355A3 (en) | 2018-03-23 | 2025-04-30 | Board Of Regents, The University Of Texas System | Dual specificity antibodies to pd-l1 and pd-l2 and methods of use therefor |
| CN119101158A (zh) | 2018-03-23 | 2024-12-10 | 得克萨斯州大学系统董事会 | 人pd-l2抗体及其使用方法 |
| CN117586412A (zh) * | 2018-03-23 | 2024-02-23 | 得克萨斯州大学系统董事会 | 针对人pd-l1和pd-l2的双重特异性抗体及其使用方法 |
| WO2019210155A1 (en) * | 2018-04-26 | 2019-10-31 | The Trustees Of The University Of Pennsylvania | Compositions and methods for retrieving tumor-related antibodies and antigens |
| ES2996257T3 (en) | 2018-05-31 | 2025-02-12 | Alexion Pharma Inc | Dosage and administration of anti-c5 antibodies for treatment of paroxysmal nocturnal hemoglobinuria (pnh) in pediatric patients |
| EP3802603A1 (en) | 2018-06-04 | 2021-04-14 | Alexion Pharmaceuticals, Inc. | Dosage and administration of anti-c5 antibodies for treatment of atypical hemolytic uremic syndrome (ahus) in pediatric patients |
| WO2020006266A1 (en) | 2018-06-28 | 2020-01-02 | Alexion Pharmaceuticals, Inc. | Methods of producing anti-c5 antibodies |
| JP7653909B2 (ja) * | 2018-09-06 | 2025-03-31 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | ヒト化抗ｃ５抗体とその利用 |
| JP2022500427A (ja) * | 2018-09-17 | 2022-01-04 | 国立大学法人京都大学 | 肝傷害又は肝不全の処置のための抗ｃ５剤の投与 |
| US20200095307A1 (en) | 2018-09-21 | 2020-03-26 | Alexion Pharmaceuticals, Inc. | Compositions and methods for the treatment of neuromyelitis optica |
| US12240893B2 (en) | 2018-10-30 | 2025-03-04 | Alexion Pharmaceuticals, Inc. | Subcutaneous dosage and administration of anti-C5 antibodies for treatment of paroxysmal nocturnal hemoglobinuria (PNH) |
| WO2020092546A1 (en) | 2018-10-30 | 2020-05-07 | Alexion Pharmaceuticals, Inc. | Co-administration of a hyaluronidase and anti-c5 antibody for treatment of complement-associated conditions |
| EP3914617B1 (en) | 2019-01-25 | 2024-03-13 | Alexion Pharmaceuticals, Inc. | Dosage and administration of anti-c5 antibodies for treatment of atypical hemolytic uremic syndrome (ahus) |
| WO2020168079A1 (en) | 2019-02-14 | 2020-08-20 | Alexion Pharmaceuticals, Inc. | Dosage and administration of anti-c5 antibodies for treatment of generalized myasthenia gravis |
| US20220227851A1 (en) * | 2019-05-24 | 2022-07-21 | Alexion Pharmaceuticals, Inc. | Methods of treating vitiligo using an anti-c5 antibody |
| US20220259305A1 (en) | 2019-08-05 | 2022-08-18 | Alexion Pharmaceuticals, Inc. | Methods for treatment of refractory generalized myasthenia gravis with eculizumab |
| BR112022002831A2 (pt) * | 2019-08-16 | 2022-06-28 | Regeneron Pharma | Formulações anti-c5 de alta concentração |
| WO2021067526A1 (en) | 2019-10-02 | 2021-04-08 | Alexion Pharmaceuticals, Inc. | Complement inhibitors for treating drug-induced complement-mediated response |
| WO2021081277A1 (en) | 2019-10-25 | 2021-04-29 | Regeneron Pharmaceuticals, Inc. | Dosing regimens for treating or preventing c5-associated diseases |
| CN114867747A (zh) | 2019-12-09 | 2022-08-05 | 阿雷克森制药公司 | 用于治疗视神经脊髓炎谱系障碍的抗c5抗体 |
| WO2021133660A1 (en) | 2019-12-23 | 2021-07-01 | Alexion Pharmaceuticals, Inc. | Methods of treating pregnancy-associated atypical hemolytic uremic syndrome using an anti-c5 antibody |
| KR20210095781A (ko) | 2020-01-24 | 2021-08-03 | 주식회사 에이프릴바이오 | 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물 |
| CN111234016B (zh) * | 2020-02-23 | 2021-09-07 | 北京康普美特创新医药科技有限责任公司 | 一种抗补体c5分子的全人源单克隆抗体及应用 |
| KR20230017789A (ko) | 2020-04-30 | 2023-02-06 | 알닐람 파마슈티칼스 인코포레이티드 | 보체 인자 B (CFB) iRNA 조성물 및 이의 사용 방법 |
| BR112022022980A2 (pt) | 2020-05-12 | 2022-12-20 | Alexion Pharma Inc | Uso de inibidores de fator d de complemento sozinhos ou em combinação com anticorpos anti-c5 para tratamento de hemoglobinúria paroxística noturna |
| WO2021231720A1 (en) | 2020-05-15 | 2021-11-18 | Alexion Pharmaceuticals, Inc. | Method of using extracellular vesicles to detect complement activation, and uses thereof to assess and/or monitor treatment of a complement-mediated disease |
| CN113754763B (zh) * | 2020-06-05 | 2024-03-08 | 天辰生物医药(苏州)有限公司 | 分离的抗原结合蛋白及其用途 |
| US20230303670A1 (en) | 2020-06-24 | 2023-09-28 | Alexion Pharmaceuticals, Inc. | Subcutaneous (sc) administration of anti-c5 antibodies for treatment of complement-associated conditions |
| EP4295905A1 (en) | 2020-07-09 | 2023-12-27 | Alexion Pharmaceuticals, Inc. | Dosage and administration of anti-c5 antibodies for treating paroxysmal nocturnal hemoglobinuria (pnh) in pediatric patients |
| EP4196161A1 (en) | 2020-08-13 | 2023-06-21 | Alexion Pharmaceuticals, Inc. | Dosage and administration of anti-c5 antibodies for treating hematopoietic stem cell transplant-associated thrombotic microangiopathy (hsct-tma) |
| US20230348579A1 (en) | 2020-09-21 | 2023-11-02 | Alexion Pharmaceuticals, Inc. | Dosage and administration of anti-c5 antibodies for treating c5-mediated glomerular nephritis (gn), including lupus nephritis (ln) and/or iga nephropathy (igan) |
| CA3196434A1 (en) | 2020-10-23 | 2022-04-28 | Krista K. JOHNSON | Methods of treating patients having complement disorders using anti-c5 antibodies |
| CA3173016A1 (en) | 2021-01-22 | 2022-07-28 | Gin-Fu CHEN | Methods of treating complement mediated thrombotic microangiopathy using an anti-c5 antibody |
| JP2024520497A (ja) | 2021-05-28 | 2024-05-24 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | Ｃｍ－ｔｍａバイオマーカーを検出するための方法 |
| WO2022265915A1 (en) | 2021-06-14 | 2022-12-22 | Alexion Pharmaceuticals, Inc. | Dosage and administration of anti-c5 antibodies for treating dermatomyositis (dm) |
| WO2023287991A1 (en) | 2021-07-14 | 2023-01-19 | Alexion Pharmaceuticals, Inc. | Dosage and administration of anti-c5 antibodies for treatment of myasthenia gravis |
| WO2023023220A1 (en) | 2021-08-20 | 2023-02-23 | Alexion Pharmaceuticals, Inc. | Methods for treating sickle cell disease or beta thalassemia using a complement alternative pathway inhibitor |
| WO2023050233A1 (en) * | 2021-09-29 | 2023-04-06 | The Trustees Of The University Of Pennsylvania | Humanized anti-c5a antibodies and uses thereof |
| CN118251491A (zh) | 2021-10-28 | 2024-06-25 | 瑞泽恩制药公司 | 用于敲除C5的CRISPR/Cas相关方法及组合物 |
| EP4423273A1 (en) | 2021-10-29 | 2024-09-04 | Alnylam Pharmaceuticals, Inc. | Complement factor b (cfb) irna compositions and methods of use thereof |
| JP2025529954A (ja) * | 2022-08-30 | 2025-09-09 | ロングバイオ ファーマ （スーチョウ） カンパニー、リミテッド | 抗ヒト補体ｃ５抗体およびその融合タンパク質 |
| TW202426048A (zh) | 2022-09-06 | 2024-07-01 | 美商阿雷希昂製藥公司 | 用於治療造血幹細胞移植相關血栓性（ｈｓｃｔ－ｔｍａ）的抗ｃ５抗體的補充劑量和投與 |
| CA3266977A1 (en) | 2022-09-06 | 2024-03-14 | Alexion Pharma Inc | DIAGNOSTIC AND PROGNOSIS BIOMARKER PROFILES IN PATIENTS WITH HEMATOPOIETIC STEM CELL TRANSPLANT-ASSOCIATED THROMBOTIC MICROANGIOPATHY (HSCT-TMA) |
| TW202423479A (zh) | 2022-09-28 | 2024-06-16 | 美商阿雷希昂製藥公司 | 用於預防或最小化患有慢性腎病的患者中的心臟手術相關急性腎損傷（csa-aki）和/或隨後的主要不良腎事件（make）的抗c5抗體之劑量及投與 |
| WO2024238422A1 (en) | 2023-05-12 | 2024-11-21 | Alexion Pharmaceuticals, Inc. | Use of a panel of lectins for detection of complement biomarkers in urine extracellular vesicles |
| WO2024238421A1 (en) | 2023-05-12 | 2024-11-21 | Alexion Pharmaceuticals, Inc. | Use of biomarkers for the identification and treatment of complement-mediated disorders |
| US12180274B2 (en) | 2023-05-26 | 2024-12-31 | Inflarx Gmbh | Treatment of pneumonia and ARDS with inhibitors of C5a and IL-6 activity |
| WO2025166118A1 (en) | 2024-02-02 | 2025-08-07 | Alexion Pharmaceuticals, Inc. | Dosage and administration of anti-c5 antibodies for treating iga nephropathy (igan) |
| WO2025221479A1 (en) | 2024-04-16 | 2025-10-23 | Alexion Pharmaceuticals, Inc. | Biomarkers for monitoring effective treatment of neuromyelitis optica spectrum disorder (nmosd) with complement component c5 inhibitors |
| CN119409815B (zh) * | 2025-01-07 | 2025-04-08 | 天辰生物医药(苏州)有限公司 | 抗人补体c5 vhh抗体及其应用 |
Family Cites Families (116)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4686100A (en) | 1985-04-02 | 1987-08-11 | The Board Of Trustees Of The Leland Stanford Junior University | Method for the treatment of adult respiratory distress syndrome |
| EP0591462B1 (en) | 1991-07-15 | 2003-04-16 | Oklahoma Medical Research Foundation | Universal donor cells |
| WO1994000560A1 (en) | 1992-06-29 | 1994-01-06 | Alexion Pharmaceuticals, Inc. | Matrix for universal donor microvascular endothelial cells |
| DE69533921T2 (de) | 1994-03-23 | 2005-12-01 | Alexion Pharmaceuticals, Inc., New Haven | Verfahren zur reduktion von fehlfunktionen des immunsystems und der hämostase während des extrakorporalen kreislaufs |
| US6074642A (en) | 1994-05-02 | 2000-06-13 | Alexion Pharmaceuticals, Inc. | Use of antibodies specific to human complement component C5 for the treatment of glomerulonephritis |
| US5562904A (en) | 1994-07-21 | 1996-10-08 | Alexion Pharmaceuticals, Inc. | Retroviral transduction of cells using soluble complement inhibitors |
| EP0777474B1 (en) | 1994-09-23 | 2005-12-21 | Alexion Pharmaceuticals, Inc. | Methods for the treatment of inflammatory joint disease |
| US6673346B1 (en) | 1999-08-31 | 2004-01-06 | The Regents Of The University Of Michigan | Compositions and methods for the treatment of sepsis |
| AU2001296594A1 (en) | 2000-10-10 | 2002-04-22 | Tanox, Inc. | Inhibition of complement c5 activation for the treatment and prevention of delayed xenograft or acute vascular rejection |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US7432356B2 (en) | 2001-08-17 | 2008-10-07 | Genentech, Inc. | Complement pathway inhibitors binding to C5 and C5a without preventing formation of C5b |
| EP3372243A1 (en) | 2001-08-17 | 2018-09-12 | Genentech, Inc. | Complement pathway inhibitors binding to c5 and c5a without preventing formation of c5b |
| ITMI20021527A1 (it) | 2002-07-11 | 2004-01-12 | Consiglio Nazionale Ricerche | Anticorpi anti componente c5 del complemento e loro uso |
| EP1545611B1 (en) | 2002-09-06 | 2016-11-09 | Alexion Pharmaceuticals, Inc. | Method of treatment of asthma using antibodies to complement component c5 |
| US9415102B2 (en) | 2002-09-06 | 2016-08-16 | Alexion Pharmaceuticals, Inc. | High concentration formulations of anti-C5 antibodies |
| US20050271660A1 (en) | 2002-09-06 | 2005-12-08 | Alexion Pharmaceuticals, Inc. | Nebulization of monoclonal antibodies for treating pulmonary diseases |
| WO2004035607A2 (en) | 2002-10-17 | 2004-04-29 | Genmab A/S | Human monoclonal antibodies against cd20 |
| US20040101920A1 (en) | 2002-11-01 | 2004-05-27 | Czeslaw Radziejewski | Modification assisted profiling (MAP) methodology |
| US7361339B2 (en) | 2003-01-09 | 2008-04-22 | Alexion Pharmaceuticals, Inc. | Methods for reducing morality associated with acute myocardial infarction |
| ES2702942T3 (es) | 2003-04-17 | 2019-03-06 | Alnylam Pharmaceuticals Inc | Agentes de ARNi modificados |
| JP4772667B2 (ja) | 2003-06-02 | 2011-09-14 | エヴォルーテック・リミテッド | 補体阻害剤 |
| US7199064B2 (en) | 2003-09-08 | 2007-04-03 | Matsushita Electric Industrial Co., Ltd. | Plasma processing method and apparatus |
| US20050169921A1 (en) | 2004-02-03 | 2005-08-04 | Leonard Bell | Method of treating hemolytic disease |
| US20070116710A1 (en) | 2004-02-03 | 2007-05-24 | Leonard Bell | Methods of treating hemolytic anemia |
| EP1740946B1 (en) | 2004-04-20 | 2013-11-06 | Genmab A/S | Human monoclonal antibodies against cd20 |
| EP3056218A1 (en) | 2004-05-14 | 2016-08-17 | Alexion Pharmaceuticals, Inc. | Prolongation of survival of an allograft by inhibiting complement activity |
| US7763708B2 (en) | 2004-08-12 | 2010-07-27 | Institute For Protein Science Co., Ltd. | Methods and compositions for modulating C5-a-mediated inflammatory responses |
| US8257740B1 (en) | 2011-08-15 | 2012-09-04 | Gp Medical, Inc. | Pharmaceutical composition of nanoparticles |
| US8246995B2 (en) | 2005-05-10 | 2012-08-21 | The Board Of Trustees Of The Leland Stanford Junior University | Hydrophobic nanotubes and nanoparticles as transporters for the delivery of drugs into cells |
| GB0518443D0 (en) | 2005-09-09 | 2005-10-19 | Evolutec Ltd | Method of treating myasthenia gravis |
| AU2013200223B2 (en) | 2005-11-04 | 2015-08-20 | Genentech, Inc. | Use of Complement Pathway Inhibitors to Treat Ocular Diseases |
| ES2551202T5 (es) | 2005-11-04 | 2018-11-30 | Genentech, Inc. | Uso de inhibidores de la vía del complemento para tratar enfermedades oculares |
| EP1988882B1 (en) | 2006-03-02 | 2014-12-17 | Alexion Pharmaceuticals, Inc. | Prolongation of survival of an allograft by inhibiting complement activity |
| DK2359834T5 (en) | 2006-03-15 | 2017-02-06 | Alexion Pharma Inc | Treatment of paroxysmal nocturnal hemoglobinuria patients with a complement inhibitor |
| CA2652976C (en) | 2006-06-02 | 2015-08-11 | Regeneron Pharmaceuticals, Inc. | High affinity antibodies to human il-6 receptor |
| EP2380907B1 (en) | 2006-09-05 | 2016-11-30 | Alexion Pharmaceuticals, Inc. | Methods and compositions for the treatment of antibody mediated neuropathies |
| EP2061501B1 (en) | 2006-09-08 | 2015-04-08 | Volution Immuno Pharmaceuticals SA | Method of treating respiratory disorders |
| GB0617734D0 (en) | 2006-09-08 | 2006-10-18 | Evolutec Ltd | Method of treating peripheral nerve disorders |
| EP3028716B1 (en) | 2006-10-10 | 2020-09-16 | Regenesance B.V. | Complement inhibition for improved nerve regeneration |
| EP2148691B1 (en) | 2007-02-05 | 2015-05-20 | Apellis Pharmaceuticals, Inc. | Compstatin analogues for use in the treatment of inflammatory conditions of the respiratory system |
| PE20091388A1 (es) | 2007-11-02 | 2009-09-24 | Novartis Ag | Moleculas y metodos para modular el componente de complemento |
| PT2708559T (pt) | 2008-04-11 | 2018-05-16 | Chugai Pharmaceutical Co Ltd | Molécula de ligação ao antigénio capaz de se ligar repetidamente a duas ou mais moléculas de antigénio |
| US9137739B2 (en) | 2009-01-28 | 2015-09-15 | Headwater Partners I Llc | Network based service policy implementation with network neutrality and user privacy |
| AU2014201433B2 (en) | 2008-08-05 | 2016-05-26 | Novartis Ag | Compositions and methods for antibodies targeting complement protein C5 |
| WO2010015608A1 (en) | 2008-08-05 | 2010-02-11 | Novartis Ag | Compositions and methods for antibodies targeting complement protein c5 |
| CA2738930C (en) | 2008-09-30 | 2021-08-17 | The Trustees Of The University Of Pennsylvania | Method of inhibiting biomaterial-induced procoagulant activity using complement inhibitors |
| US9891219B2 (en) | 2008-10-10 | 2018-02-13 | Mayo Foundation For Medical Education And Research | Methods for treating neuromyelitis optica (NMO) by administration of eculizumab to an individual that is aquaporin-4 (AQP4)-IgG autoantibody positive |
| RS64039B1 (sr) | 2008-11-10 | 2023-04-28 | Alexion Pharma Inc | Metode i kompozicije za lečenje poremećaja povezanih sa komplementom |
| NZ597259A (en) | 2009-06-23 | 2014-04-30 | Alexion Pharma Inc | Bispecific antibodies that bind to complement proteins |
| MX368932B (es) | 2009-06-26 | 2019-10-22 | Regeneron Pharma | Anticuerpos biespecificos facilmente aislados con formato de inmunoglobulina original. |
| CN102483501A (zh) | 2009-07-17 | 2012-05-30 | 康宁光缆系统有限责任公司 | 光纤带和具有低含量齐聚物的带基质材料 |
| EP2327725A1 (en) | 2009-11-26 | 2011-06-01 | InflaRx GmbH | Anti-C5a binding moieties with high blocking activity |
| JP5840623B2 (ja) | 2010-01-08 | 2016-01-06 | ヴォリューション イミュノ ファーマシューティカルズ エスエイ | 気道のウイルス感染症の治療に用いるｅｖ５７６ |
| SMT201900372T1 (it) | 2010-02-08 | 2019-09-09 | Regeneron Pharma | Topo con catena leggera comune |
| WO2011109338A1 (en) | 2010-03-01 | 2011-09-09 | Alexion Pharmaceuticals Inc. | Methods and compositions for treating degos' disease |
| TWI667346B (zh) | 2010-03-30 | 2019-08-01 | 中外製藥股份有限公司 | 促進抗原消失之具有經修飾的FcRn親和力之抗體 |
| KR101800913B1 (ko) | 2010-04-30 | 2017-12-20 | 알렉시온 파마슈티칼스, 인코포레이티드 | 항-c5a 항체들과 이 항체들을 이용하는 방법 |
| AU2015201676B2 (en) | 2010-04-30 | 2016-10-13 | Alexion Pharmaceuticals, Inc. | Anti-C5a antibodies and methods for using the antibodies |
| EP2585110A4 (en) * | 2010-06-22 | 2014-01-22 | Univ Colorado Regents | ANTIBODIES AGAINST THE C3D FRAGMENT OF THE COMPLEMENT COMPONENT 3 |
| KR20140059168A (ko) | 2011-04-21 | 2014-05-15 | 더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코포레이트 | 시신경 척수염 치료용 조성물 및 치료 방법 |
| CA2859493A1 (en) | 2011-12-21 | 2013-06-27 | Novartis Ag | Compositions and methods for antibodies targeting factor p |
| AU2013265255B2 (en) | 2012-05-25 | 2018-03-29 | Novartis Ag | Aqueous pharmaceutical composition containing a biologic therapeutic agent and guanidine or a guanidine derivative and an injection including the composition |
| US9133269B2 (en) | 2012-08-24 | 2015-09-15 | Anaptysbio, Inc. | Humanized antibodies directed against complement protein C5 |
| TW201418707A (zh) * | 2012-09-21 | 2014-05-16 | Alexion Pharma Inc | 補體組分ｃ５拮抗劑之篩選分析 |
| AU2014213147B2 (en) | 2013-01-31 | 2019-01-17 | lmmunAbs Inc. | C5 antibody and method for preventing and treating complement-related diseases |
| TWI635098B (zh) | 2013-02-01 | 2018-09-11 | 再生元醫藥公司 | 含嵌合恆定區之抗體 |
| WO2014160958A1 (en) | 2013-03-29 | 2014-10-02 | Alexion Pharmaceuticals, Inc. | Compositions and methods for increasing the serum half-life of a therapeutic agent targeting complement c5 |
| AU2014306002B2 (en) | 2013-08-07 | 2017-05-25 | Alexion Pharmaceuticals, Inc. | Atypical hemolytic uremic syndrome (aHUS) biomarker proteins |
| US10815296B2 (en) | 2013-09-16 | 2020-10-27 | Children's Hospital Medical Center | Methods of treatment of HSCT-associated thrombotic microangiopathy with eculizumab |
| EP3054965B1 (en) | 2013-10-07 | 2021-04-14 | Massachusetts Eye & Ear Infirmary | Anti-factor d antibody for use in preventing or reducing retinal detachment |
| US10238700B2 (en) | 2014-01-02 | 2019-03-26 | Genelux Corporation | Oncolytic virus adjunct therapy with agents that increase virus infectivity |
| EP3102701A1 (en) | 2014-02-07 | 2016-12-14 | Novartis AG | Impact of genetic factors on disease progression and response to anti-c5 antibody in geographic atrophy |
| WO2015127134A2 (en) | 2014-02-20 | 2015-08-27 | Allergan, Inc. | Complement component c5 antibodies |
| WO2015127273A1 (en) | 2014-02-21 | 2015-08-27 | Medimmune, Llc | Anti-pcsk9~glp-1 fusions and methods for use |
| NZ631007A (en) | 2014-03-07 | 2015-10-30 | Alexion Pharma Inc | Anti-c5 antibodies having improved pharmacokinetics |
| EP3119802B1 (en) | 2014-03-20 | 2019-12-04 | InflaRx GmbH | Inhibitors of c5a for the treatment of viral pneumonia |
| US9795121B2 (en) | 2014-05-05 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Humanized C3 animals |
| US20170290876A1 (en) | 2014-06-25 | 2017-10-12 | Novartis Ag | Compositions and methods for long acting proteins |
| US10177705B2 (en) | 2014-07-12 | 2019-01-08 | Kaneka Corporation | Composite solar cell, solar cell module, and concentrating solar cell |
| WO2016094834A2 (en) | 2014-12-12 | 2016-06-16 | Alexion Pharmaceuticals, Inc. | A method for treating a complement mediated disorder caused by an infectious agent in a patient |
| HUE056489T2 (hu) | 2014-12-19 | 2022-02-28 | Chugai Pharmaceutical Co Ltd | Anti-C5 antitestek és alkalmazási eljárások |
| JP2018511557A (ja) | 2015-01-22 | 2018-04-26 | 中外製薬株式会社 | ２種以上の抗ｃ５抗体の組み合わせおよび使用方法 |
| US20190135903A1 (en) | 2015-03-31 | 2019-05-09 | Alexion Pharmaceuticals, Inc. | Identifying and treating subpopulations of paroxysmal nocturnal hemoglobinuria (pnh) patients |
| US20180311299A1 (en) | 2015-05-01 | 2018-11-01 | Alexion Pharmaceuticals, Inc. | Efficacy of an anti-c5 antibody in the prevention of antibody mediated rejection in sensitized recipients of a kidney transplant |
| US11840564B2 (en) | 2015-06-09 | 2023-12-12 | Children's Hospital Medical Center | Dosing algorithm for complement inhibitor |
| US20160362482A1 (en) | 2015-06-10 | 2016-12-15 | Case Western Reserve University | Compositions and methods of modulating b cell response |
| EP4365291A3 (en) | 2015-06-12 | 2024-08-14 | Alnylam Pharmaceuticals, Inc. | Complement component c5 irna compositions and methods of use thereof |
| WO2017035362A1 (en) | 2015-08-26 | 2017-03-02 | Achillion Pharmaceuticals, Inc. | Use of complement pathway inhibitor compounds to mitigate adoptive t-cell therapy associated adverse immune responses |
| JP2018528218A (ja) | 2015-09-11 | 2018-09-27 | アンドリアン、ブルース | 組換えグリコシル化エクリズマブおよびエクリズマブ変異体 |
| US20180237509A1 (en) | 2015-09-28 | 2018-08-23 | Alexion Pharmaceuticals, Inc. | Methods of treating adamts13 deficiencies and congenital thrombotic thrombocytopenia in pediatric patients |
| JP2018530574A (ja) | 2015-10-07 | 2018-10-18 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 患者の加齢黄斑変性を治療する方法 |
| TW201718014A (zh) | 2015-10-12 | 2017-06-01 | 諾華公司 | C5抑制劑於移植相關微血管病之用途 |
| ES2986888T3 (es) | 2015-10-30 | 2024-11-13 | Alexion Pharma Inc | Un método para inhibir las exacerbaciones de la vasculopatía del aloinjerto mediada por células T |
| DK3390442T5 (da) | 2015-12-18 | 2024-09-23 | Chugai Pharmaceutical Co Ltd | Anti-C5 antistoffer og fremgangsmåde til anvendelse deraf |
| US20190023775A1 (en) | 2016-01-11 | 2019-01-24 | Alexion Pharmaceuticals, Inc. | Dosage and administration of anti-c5 antibodies for treatment |
| WO2017132259A1 (en) | 2016-01-25 | 2017-08-03 | Shire Human Genetic Therapies, Inc. | Anti-c5 antibodies with enhanced ph switch |
| GB201602802D0 (en) | 2016-02-17 | 2016-03-30 | Volution Immuno Pharmaceuticals Sa | Method of treatment |
| JP2019517473A (ja) | 2016-05-27 | 2019-06-24 | アレクシオン ファーマシューティカルズ インコーポレイテッドＡｌｅｘｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 難治性全身型重症筋無力症の処置のための方法 |
| EP3463460A1 (en) | 2016-06-07 | 2019-04-10 | Novartis AG | An anti-c5 antibody dosing regimen |
| CN109328197A (zh) | 2016-06-07 | 2019-02-12 | 诺华股份有限公司 | 用于治疗具有补体c5多态性的患者的抗c5抗体 |
| JP2019518028A (ja) | 2016-06-10 | 2019-06-27 | アルナイラム ファーマシューティカルズ， インコーポレイテッドＡｌｎｙｌａｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 補体成分Ｃ５ｉＲＮＡ組成物及び発作性夜間血色素尿症（ＰＮＨ）を処置するためのその使用方法 |
| MY191668A (en) | 2016-06-14 | 2022-07-06 | Regeneron Pharma | Anti-c5 antibodies and uses thereof |
| PE20240825A1 (es) | 2016-06-17 | 2024-04-18 | Chugai Pharmaceutical Co Ltd | Anticuerpos anti-c5 y metodos de uso |
| US11303992B2 (en) | 2016-07-06 | 2022-04-12 | Macho Daisy, Llc. | Wearable device and system for personal audio messaging |
| EP3512964B1 (en) | 2016-09-14 | 2021-12-15 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Methods of diagnosing and treating cd55 deficiency, hyperactivation of complement, angiopathic thrombosis and protein losing enteropathy (chaple), a newly identified orphan disease |
| US20190276524A1 (en) | 2016-10-12 | 2019-09-12 | Alexion Pharmaceuticals, Inc. | Efficacy of an anti-c5 antibody in the prevention of antibody mediated rejection in sensitized recipients of a kidney transplant |
| US10802945B2 (en) | 2016-12-07 | 2020-10-13 | Ab Initio Technology Llc | Differencing of executable dataflow graphs |
| EP3554543A4 (en) | 2016-12-16 | 2020-09-02 | Samsung Bioepis Co., Ltd. | STABLE Aqueous ANTI-C5 ANTIBODY COMPOSITION |
| CN110167961A (zh) | 2017-01-31 | 2019-08-23 | 中外制药株式会社 | 用于治疗或预防c5相关疾病的药物组合物和治疗或预防c5相关疾病的方法 |
| BR112019018429A2 (pt) | 2017-03-06 | 2020-04-14 | Univ Pennsylvania | anticorpo, métodos para tratar uma doença ou distúrbio mediado pela via do complemento em um indíviduo e para reduzir a atividade de um sistema complemento de um indivíduo, e, célula |
| EP3600421A4 (en) | 2017-03-23 | 2021-01-06 | The Trustees of The University of Pennsylvania | ANTI-C5A ANTIBODIES AND USES OF THEM |
| WO2018195034A1 (en) | 2017-04-19 | 2018-10-25 | Alexion Pharmaceuticals, Inc. | Efficacy of an anti-c5 antibody in the prevention of antibody mediated rejection in sensitized recipients of a kidney transplant |
| JP7502865B2 (ja) | 2017-06-23 | 2024-06-19 | インフラルクス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Ｃ５ａ活性のインヒビターでの炎症性疾患の処置 |
| JP2021506241A (ja) | 2017-12-13 | 2021-02-22 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 抗ｃ５抗体組み合わせ物およびその使用 |
| BR112022002831A2 (pt) | 2019-08-16 | 2022-06-28 | Regeneron Pharma | Formulações anti-c5 de alta concentração |
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