MX2023001726A - Anticuerpos anti-c5 y usos de los mismos. - Google Patents

Anticuerpos anti-c5 y usos de los mismos.

Info

Publication number
MX2023001726A
MX2023001726A MX2023001726A MX2023001726A MX2023001726A MX 2023001726 A MX2023001726 A MX 2023001726A MX 2023001726 A MX2023001726 A MX 2023001726A MX 2023001726 A MX2023001726 A MX 2023001726A MX 2023001726 A MX2023001726 A MX 2023001726A
Authority
MX
Mexico
Prior art keywords
antibodies
bind
protein
provides
neutralizing
Prior art date
Application number
MX2023001726A
Other languages
English (en)
Inventor
Adrianna Latuszek
Ying Hu
Carmelo Romano
William Olson
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of MX2023001726A publication Critical patent/MX2023001726A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
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  • Immunology (AREA)
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  • Biomedical Technology (AREA)
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  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
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  • Pain & Pain Management (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
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Abstract

La presente invención proporciona anticuerpos monoclonales que se unen a la proteína del factor de complemento 5 (C5), y métodos de uso de los mismos. En diversas realizaciones de la invención, los anticuerpos son anticuerpos completamente humanos que se unen a la proteína C5. En algunas realizaciones, los anticuerpos de la invención son útiles para inhibir o neutralizar la actividad de C5, proporcionando así un medio para tratar o prevenir una enfermedad o trastorno relacionado con C5 en humanos. En algunas realizaciones, la invención proporciona un anticuerpo anti-C5 que tiene propiedades farmacocinéticas y farmacodinámicas mejoradas, por ejemplo, una vida media de más de 10 días.
MX2023001726A 2016-06-14 2018-12-06 Anticuerpos anti-c5 y usos de los mismos. MX2023001726A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662349705P 2016-06-14 2016-06-14
US201662405561P 2016-10-07 2016-10-07
US201662422107P 2016-11-15 2016-11-15

Publications (1)

Publication Number Publication Date
MX2023001726A true MX2023001726A (es) 2023-02-22

Family

ID=59091673

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2018015149A MX2018015149A (es) 2016-06-14 2017-06-13 Anticuerpos anti-c5 y usos de los mismos.
MX2023001727A MX2023001727A (es) 2016-06-14 2018-12-06 Anticuerpos anti-c5 y usos de los mismos.
MX2023001726A MX2023001726A (es) 2016-06-14 2018-12-06 Anticuerpos anti-c5 y usos de los mismos.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
MX2018015149A MX2018015149A (es) 2016-06-14 2017-06-13 Anticuerpos anti-c5 y usos de los mismos.
MX2023001727A MX2023001727A (es) 2016-06-14 2018-12-06 Anticuerpos anti-c5 y usos de los mismos.

Country Status (24)

Country Link
US (4) US10633434B2 (es)
EP (2) EP4374922A3 (es)
JP (3) JP7102353B2 (es)
KR (3) KR102534895B1 (es)
CN (3) CN116751293A (es)
AU (2) AU2017283470B2 (es)
CA (1) CA3027487A1 (es)
CL (1) CL2018003563A1 (es)
CO (1) CO2018014413A2 (es)
DK (1) DK3468990T3 (es)
FI (1) FI3468990T3 (es)
IL (2) IL309975A (es)
LT (1) LT3468990T (es)
MA (1) MA45235A (es)
MX (3) MX2018015149A (es)
MY (3) MY196220A (es)
PH (1) PH12018502560A1 (es)
PL (1) PL3468990T3 (es)
PT (1) PT3468990T (es)
RS (1) RS65633B1 (es)
SG (2) SG10202012243VA (es)
SI (1) SI3468990T1 (es)
UA (1) UA124734C2 (es)
WO (1) WO2017218515A1 (es)

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EA201791366A1 (ru) 2014-12-19 2018-02-28 Чугаи Сейяку Кабусики Кайся Антитела к c5 и способы их применения
MA45235A (fr) 2016-06-14 2019-04-17 Regeneron Pharma Anticorps anti-c5 et leurs utilisations
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MA45235A (fr) 2019-04-17
SG11201810933QA (en) 2019-01-30
US20200262901A1 (en) 2020-08-20
IL309975A (en) 2024-03-01
IL263481B2 (en) 2024-06-01
PT3468990T (pt) 2024-06-25
PH12018502560A1 (en) 2019-10-14
SG10202012243VA (en) 2021-01-28
MY196006A (en) 2023-03-06
UA124734C2 (uk) 2021-11-10
AU2024204175A1 (en) 2024-07-11
LT3468990T (lt) 2024-06-25
JP2019528039A (ja) 2019-10-10
KR20230074831A (ko) 2023-05-31
JP7368543B2 (ja) 2023-10-24
KR102667023B1 (ko) 2024-05-21
MY196220A (en) 2023-03-23
EP4374922A2 (en) 2024-05-29
IL263481B1 (en) 2024-02-01
JP7102353B2 (ja) 2022-07-19
US20200262900A1 (en) 2020-08-20
BR112018075875A2 (pt) 2019-03-19
US11492392B2 (en) 2022-11-08
KR20190018166A (ko) 2019-02-21
US10633434B2 (en) 2020-04-28
KR102534895B1 (ko) 2023-05-24
DK3468990T3 (da) 2024-06-24
JP2023175765A (ja) 2023-12-12
MX2018015149A (es) 2019-08-21
IL263481A (en) 2019-01-31
US20230174631A1 (en) 2023-06-08

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