|
US319A
(en)
|
|
1837-07-31 |
|
Improvement in machines for breaking and dressing hemp and flax |
|
US8236A
(en)
|
|
1851-07-22 |
|
Hanging cakriage-body |
|
FR901464A
(fr)
|
1943-01-23 |
1945-07-27 |
Boehringer & Soehne Gmbh |
Procédé d'obtention de vanilline
|
|
US4434150A
(en)
|
1981-10-19 |
1984-02-28 |
Ortho Diagnostic Systems, Inc. |
Immunological reagents employing polymeric backbone possessing reactive functional groups
|
|
DE3307869A1
(de)
|
1983-03-05 |
1984-09-06 |
Dragoco Gerberding & Co Gmbh, 3450 Holzminden |
Methylsubstituierte 1-((3-methylthio)-1-oxo-butyl)-cyclohex-2-ene, verfahren zu deren herstellung und deren verwendung als riech- und aromastoffe
|
|
US4486414A
(en)
|
1983-03-21 |
1984-12-04 |
Arizona Board Of Reagents |
Dolastatins A and B cell growth inhibitory substances
|
|
US4545985A
(en)
|
1984-01-26 |
1985-10-08 |
The United States Of America As Represented By The Secretary, Dept. Of Health And Human Services |
Pseudomonas exotoxin conjugate immunotoxins
|
|
ATE68703T1
(de)
|
1984-02-08 |
1991-11-15 |
Cetus Corp |
Toxinkonjugate.
|
|
US4676980A
(en)
|
1985-09-23 |
1987-06-30 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Target specific cross-linked heteroantibodies
|
|
US4880935A
(en)
|
1986-07-11 |
1989-11-14 |
Icrf (Patents) Limited |
Heterobifunctional linking agents derived from N-succinimido-dithio-alpha methyl-methylene-benzoates
|
|
US4892827A
(en)
|
1986-09-24 |
1990-01-09 |
The United States Of America As Represented By The Department Of Health And Human Services |
Recombinant pseudomonas exotoxins: construction of an active immunotoxin with low side effects
|
|
WO1988007089A1
(en)
|
1987-03-18 |
1988-09-22 |
Medical Research Council |
Altered antibodies
|
|
US4880078A
(en)
|
1987-06-29 |
1989-11-14 |
Honda Giken Kogyo Kabushiki Kaisha |
Exhaust muffler
|
|
US4816444A
(en)
|
1987-07-10 |
1989-03-28 |
Arizona Board Of Regents, Arizona State University |
Cell growth inhibitory substance
|
|
IL106992A
(en)
|
1988-02-11 |
1994-06-24 |
Bristol Myers Squibb Co |
Acylhydrazone derivatives of anthracycline and methods for their preparation
|
|
US5076973A
(en)
|
1988-10-24 |
1991-12-31 |
Arizona Board Of Regents |
Synthesis of dolastatin 3
|
|
EP0368684B2
(en)
|
1988-11-11 |
2004-09-29 |
Medical Research Council |
Cloning immunoglobulin variable domain sequences.
|
|
US4978744A
(en)
|
1989-01-27 |
1990-12-18 |
Arizona Board Of Regents |
Synthesis of dolastatin 10
|
|
US4879278A
(en)
|
1989-05-16 |
1989-11-07 |
Arizona Board Of Regents |
Isolation and structural elucidation of the cytostatic linear depsipeptide dolastatin 15
|
|
US4986988A
(en)
|
1989-05-18 |
1991-01-22 |
Arizona Board Of Regents |
Isolation and structural elucidation of the cytostatic linear depsipeptides dolastatin 13 and dehydrodolastatin 13
|
|
US5208020A
(en)
|
1989-10-25 |
1993-05-04 |
Immunogen Inc. |
Cytotoxic agents comprising maytansinoids and their therapeutic use
|
|
US5138036A
(en)
|
1989-11-13 |
1992-08-11 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Isolation and structural elucidation of the cytostatic cyclodepsipeptide dolastatin 14
|
|
US5458878A
(en)
|
1990-01-02 |
1995-10-17 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
P. exotoxin fusio proteins have COOHG220101al alterations which increase cytotoxicity
|
|
US5124471A
(en)
|
1990-03-26 |
1992-06-23 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Bifunctional dtpa-type ligand
|
|
WO1992019244A2
(en)
|
1991-05-01 |
1992-11-12 |
Henry M. Jackson Foundation For The Advancement Of Military Medicine |
A method for treating infectious respiratory diseases
|
|
US6287792B1
(en)
|
1991-06-17 |
2001-09-11 |
The Regents Of The University Of California |
Drug delivery of antisense oligonucleotides and peptides to tissues in vivo and to cells using avidin-biotin technology
|
|
US5622929A
(en)
|
1992-01-23 |
1997-04-22 |
Bristol-Myers Squibb Company |
Thioether conjugates
|
|
US5714350A
(en)
|
1992-03-09 |
1998-02-03 |
Protein Design Labs, Inc. |
Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region
|
|
ES2149768T3
(es)
|
1992-03-25 |
2000-11-16 |
Immunogen Inc |
Conjugados de agentes enlazantes de celulas derivados de cc-1065.
|
|
ZA932522B
(en)
|
1992-04-10 |
1993-12-20 |
Res Dev Foundation |
Immunotoxins directed against c-erbB-2(HER/neu) related surface antigens
|
|
EP0643559B1
(en)
|
1992-05-06 |
1999-04-14 |
The President And Fellows Of Harvard College |
Diphtheria toxin receptor-binding region
|
|
US5635483A
(en)
|
1992-12-03 |
1997-06-03 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Tumor inhibiting tetrapeptide bearing modified phenethyl amides
|
|
US6034065A
(en)
|
1992-12-03 |
2000-03-07 |
Arizona Board Of Regents |
Elucidation and synthesis of antineoplastic tetrapeptide phenethylamides of dolastatin 10
|
|
US5410024A
(en)
|
1993-01-21 |
1995-04-25 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Human cancer inhibitory pentapeptide amides
|
|
US5780588A
(en)
|
1993-01-26 |
1998-07-14 |
Arizona Board Of Regents |
Elucidation and synthesis of selected pentapeptides
|
|
WO1994016729A1
(en)
|
1993-01-28 |
1994-08-04 |
Neorx Corporation |
Targeted nitric oxide pathway or nitric oxide synthase modulation
|
|
US5934272A
(en)
|
1993-01-29 |
1999-08-10 |
Aradigm Corporation |
Device and method of creating aerosolized mist of respiratory drug
|
|
US6214345B1
(en)
|
1993-05-14 |
2001-04-10 |
Bristol-Myers Squibb Co. |
Lysosomal enzyme-cleavable antitumor drug conjugates
|
|
WO1995015770A1
(en)
|
1993-12-09 |
1995-06-15 |
Neorx Corporation |
Pretargeting methods and compounds
|
|
US5530097A
(en)
|
1994-08-01 |
1996-06-25 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Human cancer inhibitory peptide amides
|
|
US5521284A
(en)
|
1994-08-01 |
1996-05-28 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Human cancer inhibitory pentapeptide amides and esters
|
|
US5504191A
(en)
|
1994-08-01 |
1996-04-02 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Human cancer inhibitory pentapeptide methyl esters
|
|
US5554725A
(en)
|
1994-09-14 |
1996-09-10 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Synthesis of dolastatin 15
|
|
US5599902A
(en)
|
1994-11-10 |
1997-02-04 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Cancer inhibitory peptides
|
|
US5663149A
(en)
|
1994-12-13 |
1997-09-02 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Human cancer inhibitory pentapeptide heterocyclic and halophenyl amides
|
|
US6019968A
(en)
|
1995-04-14 |
2000-02-01 |
Inhale Therapeutic Systems, Inc. |
Dispersible antibody compositions and methods for their preparation and use
|
|
US7696338B2
(en)
|
1995-10-30 |
2010-04-13 |
The United States Of America As Represented By The Department Of Health And Human Services |
Immunotoxin fusion proteins and means for expression thereof
|
|
ATE234635T1
(de)
|
1995-12-22 |
2003-04-15 |
Bristol Myers Squibb Co |
Verzweigte hydrazongruppen enthaltende kuppler
|
|
DK0929578T3
(da)
*
|
1996-02-09 |
2003-08-25 |
Abbott Lab Bermuda Ltd |
Humane antistoffer, der binder human TNFalfa
|
|
IT1282692B1
(it)
|
1996-02-27 |
1998-03-31 |
San Raffaele Centro Fond |
Citochine modificate per l'uso in terapia
|
|
DK0885002T3
(da)
|
1996-03-04 |
2011-08-22 |
Penn State Res Found |
Materialer og fremgangsmåder til forøgelse af cellulær internalisering
|
|
US5985309A
(en)
|
1996-05-24 |
1999-11-16 |
Massachusetts Institute Of Technology |
Preparation of particles for inhalation
|
|
US5874064A
(en)
|
1996-05-24 |
1999-02-23 |
Massachusetts Institute Of Technology |
Aerodynamically light particles for pulmonary drug delivery
|
|
US5855913A
(en)
|
1997-01-16 |
1999-01-05 |
Massachusetts Instite Of Technology |
Particles incorporating surfactants for pulmonary drug delivery
|
|
DE69708139D1
(de)
|
1996-10-28 |
2001-12-13 |
Abb Power Systems Ab Vaesteras |
Bodenelektrode für hgü system
|
|
DE69732306T2
(de)
|
1997-01-16 |
2006-01-12 |
Massachusetts Institute Of Technology, Cambridge |
Zubereitung von partikelhaltigen arzneimitteln zur inhalation
|
|
JP2001511811A
(ja)
|
1997-02-13 |
2001-08-14 |
ボーン ケア インターナショナル インコーポレイテッド |
ビタミンｄ化合物の標的治療放出
|
|
DE69832158T2
(de)
|
1997-02-25 |
2006-08-10 |
Arizona Board Of Regents, Tempe |
Isolierung und strukturelle aufklärung der kryostatischen linearen und cyclo-depsipeptide dolastatin 16, dolastatin 17, und dolastatin 18
|
|
US7314632B1
(en)
|
1997-07-11 |
2008-01-01 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Pseudomonas exotoxin A-like chimeric immunogens
|
|
AU9692498A
(en)
|
1997-10-10 |
1999-05-03 |
Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The |
Complex of biotinylated viral vector and ligand for targeted gene delivery
|
|
WO1999066027A1
(en)
|
1998-06-15 |
1999-12-23 |
The Research Foundation Of State University Of New York |
Monoclonal antibodies that recognize antigens associated with tumor metastasis
|
|
CA2336139C
(en)
|
1998-06-24 |
2008-10-14 |
Advanced Inhalation Research, Inc. |
Large porous particles emitted from an inhaler
|
|
EP1176195B1
(en)
|
1999-04-09 |
2013-05-22 |
Kyowa Hakko Kirin Co., Ltd. |
Method for controlling the activity of immunologically functional molecule
|
|
AU6186900A
(en)
|
1999-07-31 |
2001-02-19 |
Kyu Jin Park |
Study method and apparatus using digital audio and caption data
|
|
US6323315B1
(en)
|
1999-09-10 |
2001-11-27 |
Basf Aktiengesellschaft |
Dolastatin peptides
|
|
AU775373B2
(en)
|
1999-10-01 |
2004-07-29 |
Immunogen, Inc. |
Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
|
|
AU2001271273A1
(en)
|
2000-05-24 |
2001-12-03 |
Ludwig Institute For Cancer Research |
Multicomponent conjugates which bind to target molecules and stimulate cell lysis
|
|
EP2322644A1
(en)
|
2000-06-28 |
2011-05-18 |
GlycoFi, Inc. |
Methods for producing modified glycoproteins
|
|
US7449308B2
(en)
|
2000-06-28 |
2008-11-11 |
Glycofi, Inc. |
Combinatorial DNA library for producing modified N-glycans in lower eukaryotes
|
|
US6884869B2
(en)
|
2001-04-30 |
2005-04-26 |
Seattle Genetics, Inc. |
Pentapeptide compounds and uses related thereto
|
|
US20030083263A1
(en)
|
2001-04-30 |
2003-05-01 |
Svetlana Doronina |
Pentapeptide compounds and uses related thereto
|
|
US6441163B1
(en)
|
2001-05-31 |
2002-08-27 |
Immunogen, Inc. |
Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents
|
|
JP2005503789A
(ja)
|
2001-08-17 |
2005-02-10 |
イーライ・リリー・アンド・カンパニー |
抗Ａβ抗体
|
|
WO2003026577A2
(en)
|
2001-09-24 |
2003-04-03 |
Seattle Genetics, Inc. |
P-amidobenzylethers in drug delivery agents
|
|
US7091186B2
(en)
|
2001-09-24 |
2006-08-15 |
Seattle Genetics, Inc. |
p-Amidobenzylethers in drug delivery agents
|
|
HUP0600342A3
(en)
|
2001-10-25 |
2011-03-28 |
Genentech Inc |
Glycoprotein compositions
|
|
WO2003093793A2
(en)
|
2002-05-01 |
2003-11-13 |
Trellis Bioscience, Inc. |
Binary or polynary targeting and uses thereof
|
|
SI1545613T1
(sl)
|
2002-07-31 |
2011-11-30 |
Seattle Genetics Inc |
Avristatinski konjugati in njihova uporaba za zdravljenje raka avtoimunske bolezni ali infekcijskebolezni
|
|
CN100522955C
(zh)
|
2002-08-02 |
2009-08-05 |
伊缪诺金公司 |
含有新型强效紫杉烷的细胞毒性剂及其治疗用途
|
|
JP2006500364A
(ja)
|
2002-08-16 |
2006-01-05 |
イムノージェン インコーポレーテッド |
高い反応性と溶解度を有する架橋剤および小分子薬物の標的化送達用コンジュゲートの調製におけるそれらの使用
|
|
DE10242146A1
(de)
|
2002-09-04 |
2004-03-18 |
Eberhard-Karls-Universität Tübingen Universitätsklinikum |
Antikörper zur Identifizierung und/oder Isolierung von hämatopoetischen Stammzellen
|
|
US7388079B2
(en)
|
2002-11-27 |
2008-06-17 |
The Regents Of The University Of California |
Delivery of pharmaceutical agents via the human insulin receptor
|
|
CA2787820A1
(en)
|
2003-02-19 |
2004-09-02 |
Novartis Ag |
Glycoprotein antigen sima135 expressed in metastatic human tumor cells
|
|
AU2004213053C1
(en)
|
2003-02-20 |
2009-07-16 |
Seagen Inc. |
Anti-CD70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders
|
|
US20080166375A1
(en)
|
2003-05-06 |
2008-07-10 |
The Government Of The United States Of America, As Rep. By The Secretary Of Health And Human Service |
Activation of Recombinant Diphtheria Toxin Fusion Proteins by Specific Proteases Highly Expressed on the Surface of Tumor Cells
|
|
WO2005020883A2
(en)
|
2003-05-08 |
2005-03-10 |
Immunogen, Inc. |
Methods for the production of ansamitocins
|
|
US7432088B2
(en)
|
2003-05-08 |
2008-10-07 |
Immunogen Inc. |
Methods for the production of ansamitocins
|
|
US8088387B2
(en)
|
2003-10-10 |
2012-01-03 |
Immunogen Inc. |
Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
|
|
KR101424624B1
(ko)
|
2003-05-14 |
2014-07-31 |
이뮤노젠 아이엔씨 |
약물 콘쥬게이트 조성물
|
|
PL3524611T3
(pl)
|
2003-05-20 |
2021-06-14 |
Immunogen, Inc. |
Udoskonalone czynniki cytotoksyczne zawierające nowe maitansynoidy
|
|
US7276497B2
(en)
|
2003-05-20 |
2007-10-02 |
Immunogen Inc. |
Cytotoxic agents comprising new maytansinoids
|
|
GB0324656D0
(en)
|
2003-10-22 |
2003-11-26 |
Celltech R&D Ltd |
A protein involved in ovarian cancer
|
|
US7498298B2
(en)
|
2003-11-06 |
2009-03-03 |
Seattle Genetics, Inc. |
Monomethylvaline compounds capable of conjugation to ligands
|
|
EP1687016A4
(en)
|
2003-11-25 |
2009-07-29 |
Anjin Corp |
GENETIC VARIANT OF DIPHTHERIC TOXIN
|
|
WO2005070457A1
(en)
|
2004-01-23 |
2005-08-04 |
Seattle Genetics, Inc. |
Melphalan prodrugs
|
|
US20050175619A1
(en)
|
2004-02-05 |
2005-08-11 |
Robert Duffy |
Methods of producing antibody conjugates
|
|
WO2005081898A2
(en)
|
2004-02-20 |
2005-09-09 |
The Trustees Of The University Of Pennsylvania |
Binding peptidomimetics and uses of the same
|
|
EP1718667B1
(en)
|
2004-02-23 |
2013-01-09 |
Genentech, Inc. |
Heterocyclic self-immolative linkers and conjugates
|
|
AU2005218642B2
(en)
|
2004-03-02 |
2011-04-28 |
Seagen Inc. |
Partially loaded antibodies and methods of their conjugation
|
|
US20050226882A1
(en)
|
2004-04-08 |
2005-10-13 |
Awdalla Essam T |
Method and multicomponent conjugates for treating cancer
|
|
EP1737969B2
(en)
|
2004-04-15 |
2018-09-12 |
GlycoFi, Inc. |
Production of galactosylated glycoproteins in lower eukaryotes
|
|
RU2402548C2
(ru)
|
2004-05-19 |
2010-10-27 |
Медарекс, Инк. |
Химические линкеры и их конъюгаты
|
|
KR20120064120A
(ko)
|
2004-06-01 |
2012-06-18 |
제넨테크, 인크. |
항체 약물 접합체 및 방법
|
|
US20080008719A1
(en)
|
2004-07-10 |
2008-01-10 |
Bowdish Katherine S |
Methods and compositions for the treatment of prostate cancer
|
|
JP4193771B2
(ja)
|
2004-07-27 |
2008-12-10 |
セイコーエプソン株式会社 |
階調電圧発生回路及び駆動回路
|
|
WO2006132670A2
(en)
|
2004-11-12 |
2006-12-14 |
Seattle Genetics, Inc. |
Auristatins having an aminobenzoic acid unit at the n terminus
|
|
EP1817341A2
(en)
|
2004-11-29 |
2007-08-15 |
Seattle Genetics, Inc. |
Engineered antibodies and immunoconjugates
|
|
US7301019B2
(en)
|
2005-01-21 |
2007-11-27 |
Immunogen, Inc. |
Method for the preparation of maytansinoid esters
|
|
CA2597407C
(en)
|
2005-02-11 |
2013-09-10 |
Immunogen, Inc. |
Process for preparing stable drug conjugates
|
|
EP1695717A1
(en)
|
2005-02-23 |
2006-08-30 |
Ludwig-Maximilians-Universität |
Transport of nano-and macromolecular structures into cytoplasm and nucleus of cells
|
|
CN101203241B
(zh)
|
2005-04-19 |
2012-02-22 |
西雅图基因公司 |
人源化抗-cd70结合物和其应用
|
|
JP5171621B2
(ja)
|
2005-07-07 |
2013-03-27 |
シアトル ジェネティックス， インコーポレイテッド |
フェニルアラニン側鎖修飾をｃ末端に有するモノメチルバリン化合物
|
|
US8871720B2
(en)
|
2005-07-07 |
2014-10-28 |
Seattle Genetics, Inc. |
Monomethylvaline compounds having phenylalanine carboxy modifications at the C-terminus
|
|
HUE035853T2
(en)
|
2005-07-18 |
2018-05-28 |
Seattle Genetics Inc |
Beta-glucuronide-linker-drug conjugates
|
|
EP3539572A1
(en)
|
2005-08-24 |
2019-09-18 |
ImmunoGen, Inc. |
Process for preparing maytansinoid antibody conjugates
|
|
JP2007112734A
(ja)
|
2005-10-19 |
2007-05-10 |
Chugai Pharmaceut Co Ltd |
抗ｃｄｃｐ１抗体を含有する癌細胞増殖抑制剤
|
|
WO2007056550A2
(en)
|
2005-11-08 |
2007-05-18 |
Immunogen, Inc. |
Processes for preparation of maytansinol
|
|
WO2007103288A2
(en)
|
2006-03-02 |
2007-09-13 |
Seattle Genetics, Inc. |
Engineered antibody drug conjugates
|
|
WO2007150020A1
(en)
|
2006-06-23 |
2007-12-27 |
Simon Paul M |
Targeted immune conjugates
|
|
US7825267B2
(en)
|
2006-09-08 |
2010-11-02 |
University Of Pittsburgh-Of The Commonwealth System Of Higher Education |
Synthesis of FR901464 and analogs with antitumor activity
|
|
CN101522716B
(zh)
|
2006-10-02 |
2013-03-20 |
瑞泽恩制药公司 |
抗人il-4受体的高亲和力人抗体
|
|
US7598028B2
(en)
|
2006-11-28 |
2009-10-06 |
The Regents Of The University Of Michigan |
Compositions and methods for detecting and treating prostate disorders
|
|
WO2008070593A2
(en)
|
2006-12-01 |
2008-06-12 |
Seattle Genetics, Inc. |
Variant target binding agents and uses thereof
|
|
KR20090114430A
(ko)
|
2007-02-02 |
2009-11-03 |
베일러 리서치 인스티튜트 |
항원-제시 세포 상에서 발현된 ｄｃｉｒ에 대한 항원 표적화에 기초한 백신
|
|
TWI422594B
(zh)
|
2007-02-02 |
2014-01-11 |
Baylor Res Inst |
經由樹狀細胞去唾液酸糖蛋白受體（ｄｃ-ａｓｇｐｒ）接合抗原呈現細胞之藥劑
|
|
SG178789A1
(en)
|
2007-02-16 |
2012-03-29 |
Merrimack Pharmaceuticals Inc |
Antibodies against erbb3 and uses thereof
|
|
US20080254047A1
(en)
|
2007-02-23 |
2008-10-16 |
Baylor Research Institute |
Activation of Human Antigen-Presenting Cells Through CLEC-6
|
|
NZ579257A
(en)
|
2007-02-23 |
2011-05-27 |
Baylor Res Inst |
Activation of human antigen-presenting cells through dendritic cell lectin-like oxidized ldl receptor-1 (lox-1)
|
|
EP2447719B1
(en)
|
2007-02-26 |
2016-08-24 |
Oxford BioTherapeutics Ltd |
Proteins
|
|
EP2208737B1
(en)
|
2007-05-03 |
2017-07-05 |
Lysomab GmbH |
Complement factor H-derived short consensus repeat-antibody constructs
|
|
JP2010530895A
(ja)
|
2007-06-21 |
2010-09-16 |
アンジェリカ セラピューティックス，インク． |
修飾毒素
|
|
JP2011507933A
(ja)
|
2007-12-26 |
2011-03-10 |
バイオテスト・アクチエンゲゼルシヤフト |
免疫複合体の細胞傷害性副作用の低減及び有効性の改善方法
|
|
EP2265283B1
(en)
|
2008-03-18 |
2014-09-03 |
Seattle Genetics, Inc. |
Auristatin drug linker conjugates
|
|
WO2009134870A1
(en)
|
2008-04-30 |
2009-11-05 |
Immunogen, Inc. |
Potent cell-binding agent drug conjugates
|
|
KR20200058590A
(ko)
|
2008-04-30 |
2020-05-27 |
이뮤노젠 아이엔씨 |
가교제 및 그 용도
|
|
EP2276506A4
(en)
|
2008-04-30 |
2014-05-07 |
Immunogen Inc |
EFFICIENT CONJUGATES AND HYDROPHILIC BINDER
|
|
US20100233154A1
(en)
*
|
2008-10-08 |
2010-09-16 |
Medimmune Limited |
Targeted binding agents directed to heparanase and uses thereof 463
|
|
CN102256966B
(zh)
|
2008-10-17 |
2016-02-10 |
白头生物医学研究所 |
可溶性mTOR复合物和其调节剂
|
|
CN102365021B
(zh)
|
2009-02-05 |
2015-07-15 |
伊缪诺金公司 |
新型苯并二氮杂*衍生物
|
|
CN102378766A
(zh)
|
2009-03-23 |
2012-03-14 |
夸克医药公司 |
治疗癌症和纤维化疾病的化合物组合物和方法
|
|
WO2010126552A1
(en)
|
2009-04-30 |
2010-11-04 |
Immunogen, Inc. |
Potent cell-binding agent drug conjugates
|
|
NZ613647A
(en)
|
2009-05-06 |
2015-02-27 |
Biotest Ag |
Uses of immunoconjugates targeting cd138
|
|
BRPI1010620B8
(pt)
|
2009-06-03 |
2021-05-25 |
Immunogen Inc |
métodos de conjugação
|
|
DE102009026075A1
(de)
|
2009-06-30 |
2011-01-05 |
Röhm Gmbh |
Bohrvorrichtung
|
|
TWI412375B
(zh)
|
2009-08-28 |
2013-10-21 |
Roche Glycart Ag |
人類化抗ｃｄｃｐ１抗體
|
|
TW201113037A
(en)
*
|
2009-08-28 |
2011-04-16 |
Hoffmann La Roche |
Antibodies against CDCP1 for the treatment of cancer
|
|
US20110076232A1
(en)
|
2009-09-29 |
2011-03-31 |
Ludwig Institute For Cancer Research |
Specific binding proteins and uses thereof
|
|
EP2486023A4
(en)
|
2009-10-06 |
2014-05-07 |
Immunogen Inc |
EFFICIENT CONJUGATES AND HYDROPHILIC BINDER
|
|
US9149544B2
(en)
|
2009-11-06 |
2015-10-06 |
The Penn State Research Foundation |
Bioconjugation of calcium phosphosilicate nanoparticles for selective targeting of cells in vivo
|
|
GB0919751D0
(en)
|
2009-11-11 |
2009-12-30 |
King S College Hospital Nhs Fo |
Conjugate molecule
|
|
GB201001791D0
(en)
|
2010-02-03 |
2010-03-24 |
Ucb Pharma Sa |
Process for obtaining antibodies
|
|
CN103037900B
(zh)
|
2010-02-24 |
2016-04-06 |
伊缪诺金公司 |
叶酸受体1抗体与免疫缀合物以及其用途
|
|
US20110214205A1
(en)
|
2010-02-26 |
2011-09-01 |
Monsanto Technology Llc. |
Isolated Novel Nucleic Acid and Protein Molecules from Foxtail Millet and Methods of Using Those Molecules to Generate Transgenic Plants with Enhanced Agronomic Traits
|
|
MX391454B
(es)
|
2010-04-15 |
2025-03-05 |
Seagen Inc |
Compuesto de engarce-fármaco para conjugación a una unidad de ligando.
|
|
US8697688B2
(en)
|
2010-04-15 |
2014-04-15 |
Seattle Genetics Inc. |
Pyrrolobenzodiazepines used to treat proliferative diseases
|
|
WO2012027494A1
(en)
|
2010-08-24 |
2012-03-01 |
Regents Of The University Of Minnesota |
Bispecific targeting reagents
|
|
US8987209B2
(en)
|
2010-09-29 |
2015-03-24 |
Seattle Genetics, Inc. |
N-carboxyalkyl-auristatin and the use thereof
|
|
EP3409287B9
(en)
|
2010-09-29 |
2021-07-21 |
Agensys, Inc. |
Antibody drug conjugates (adc) that bind to 191p4d12 proteins
|
|
AU2011316917B2
(en)
|
2010-10-22 |
2016-02-25 |
Seagen Inc. |
Synergistic effects between auristatin-based antibody drug conjugates and inhibitors of the PI3K-AKT mTOR pathway
|
|
CN103298489A
(zh)
|
2010-10-29 |
2013-09-11 |
伊缪诺金公司 |
新型egfr结合分子及其免疫偶联物
|
|
CN103269712B
(zh)
|
2010-11-03 |
2016-09-21 |
伊缪诺金公司 |
包含新型安丝菌素衍生物的细胞毒性剂
|
|
LT3153504T
(lt)
|
2010-12-09 |
2019-02-11 |
Immunogen, Inc. |
Įkrautų skersinių jungčių agentų gavimo būdas
|
|
JP6049642B2
(ja)
|
2011-02-15 |
2016-12-21 |
イミュノジェン・インコーポレーテッド |
複合体の調製方法
|
|
US9029406B2
(en)
|
2011-03-16 |
2015-05-12 |
Seattle Genetics, Inc |
N-carboxyalkylauristatins and use thereof
|
|
WO2012135517A2
(en)
|
2011-03-29 |
2012-10-04 |
Immunogen, Inc. |
Preparation of maytansinoid antibody conjugates by a one-step process
|
|
US20120282282A1
(en)
|
2011-04-04 |
2012-11-08 |
Immunogen, Inc. |
Methods for Decreasing Ocular Toxicity of Antibody Drug Conjugates
|
|
KR102023496B1
(ko)
|
2011-04-21 |
2019-09-20 |
시애틀 지네틱스, 인크. |
신규 결합제-약물 콘주게이트 (adc) 및 그의 용도
|
|
US9574002B2
(en)
|
2011-06-06 |
2017-02-21 |
Amgen Inc. |
Human antigen binding proteins that bind to a complex comprising β-Klotho and an FGF receptor
|
|
JP2014524902A
(ja)
|
2011-06-14 |
2014-09-25 |
アメリカ合衆国 |
Ｔｅｍ８抗体、そのコンジュゲートおよびそれらの使用
|
|
CN103648532A
(zh)
|
2011-06-21 |
2014-03-19 |
伊缪诺金公司 |
具有肽连接子的新型美登木素生物碱衍生物及其偶联物
|
|
ES2945932T3
(es)
|
2011-10-14 |
2023-07-10 |
Seagen Inc |
Pirrolobenzodiazepinas y conjugados dirigidos
|
|
WO2013055993A1
(en)
|
2011-10-14 |
2013-04-18 |
Seattle Genetics, Inc. |
Pyrrolobenzodiazepines and targeted conjugates
|
|
LT2794658T
(lt)
|
2011-12-19 |
2017-05-10 |
Synimmune Gmbh |
Bispecifinė antikūno molekulė
|
|
WO2013102825A1
(en)
|
2012-01-02 |
2013-07-11 |
Novartis Ag |
Cdcp1 and breast cancer
|
|
US8975398B2
(en)
|
2012-05-11 |
2015-03-10 |
Abbvie Inc. |
NAMPT inhibitors
|
|
US9504756B2
(en)
|
2012-05-15 |
2016-11-29 |
Seattle Genetics, Inc. |
Self-stabilizing linker conjugates
|
|
LT2900676T
(lt)
|
2012-09-26 |
2019-03-25 |
Immunogen, Inc. |
Maitanzinolio acilinimo patobulintas būdas
|
|
ES2898620T3
(es)
*
|
2013-03-14 |
2022-03-08 |
Regeneron Pharma |
Anticuerpos humanos contra GREM 1
|
|
WO2015082446A1
(en)
*
|
2013-12-02 |
2015-06-11 |
F. Hoffmann-La Roche Ag |
Treatment of cancer using an anti-cdcp1 antibody and a taxane
|
|
TWI541022B
(zh)
|
2013-12-18 |
2016-07-11 |
應克隆公司 |
針對纖維母細胞生長因子受體－３（ｆｇｆｒ３）之化合物及治療方法
|
|
ES2919749T3
(es)
|
2014-06-11 |
2022-07-28 |
Molecular Templates Inc |
Moléculas dirigidas a células citotóxicas resistentes a la escisión por proteasa
|
|
US10969391B2
(en)
|
2014-07-11 |
2021-04-06 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for diagnosing hematological cancers
|
|
TW201609152A
(zh)
|
2014-09-03 |
2016-03-16 |
免疫原公司 |
包含細胞結合劑及細胞毒性劑之偶聯物
|
|
EP3029067A1
(en)
|
2014-12-01 |
2016-06-08 |
Deutsches Krebsforschungszentrum |
Use of blocking-reagents for reducing unspecific T cell-activation
|
|
EP3283520B1
(en)
*
|
2015-04-13 |
2020-05-06 |
Pfizer Inc |
Chimeric antigen receptors targeting b-cell maturation antigen
|
|
EP3554544A4
(en)
|
2016-12-16 |
2020-07-29 |
Bluefin Biomedicine, Inc. |
ANTI-PROTEIN 1 ANTIBODY CONTAINING AN ANTI-CUB DOMAIN (CDCP1), ANTIBODY-DRUG CONJUGATES AND THEIR METHODS OF USE
|