JP2025507817A5 - - Google Patents
Info
- Publication number
- JP2025507817A5 JP2025507817A5 JP2024551663A JP2024551663A JP2025507817A5 JP 2025507817 A5 JP2025507817 A5 JP 2025507817A5 JP 2024551663 A JP2024551663 A JP 2024551663A JP 2024551663 A JP2024551663 A JP 2024551663A JP 2025507817 A5 JP2025507817 A5 JP 2025507817A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- amino acid
- acid sequence
- seq
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202263314490P | 2022-02-28 | 2022-02-28 | |
| US63/314,490 | 2022-02-28 | ||
| PCT/IL2023/050203 WO2023161943A1 (en) | 2022-02-28 | 2023-02-27 | Humanized antibodies against nectin-2 and drug conjugates thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2025507817A JP2025507817A (ja) | 2025-03-21 |
| JP2025507817A5 true JP2025507817A5 (https=) | 2026-02-25 |
Family
ID=85641023
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024551663A Pending JP2025507817A (ja) | 2022-02-28 | 2023-02-27 | ネクチン－２に対するヒト化抗体及びその薬物コンジュゲート |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20240409632A1 (https=) |
| EP (1) | EP4486776A1 (https=) |
| JP (1) | JP2025507817A (https=) |
| KR (1) | KR20240152879A (https=) |
| CN (1) | CN119451983A (https=) |
| AU (1) | AU2023226094A1 (https=) |
| CA (1) | CA3243763A1 (https=) |
| IL (1) | IL314622A (https=) |
| WO (1) | WO2023161943A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3908372A1 (en) | 2019-01-13 | 2021-11-17 | Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd. | Antibodies specific to human nectin-2 |
| KR20240152879A (ko) | 2022-02-28 | 2024-10-22 | 넥틴 테라퓨틱스 리미티드 | 넥틴-2에 대한 인간화 항체 및 이의 약물 접합체 |
| EP4716696A1 (en) * | 2023-05-23 | 2026-04-01 | Fondazione Per L'Istituto Oncologico Di Ricerca (IOR) | Monospecific and bispecific antibodies and antibody-drug conjugates targeting nectin2 (cd112) and psma |
| KR20250161706A9 (ko) * | 2024-05-08 | 2026-02-03 | 아주대학교산학협력단 | Nectin-2에 특이적으로 결합하는 항체 및 이의 용도 |
| KR20250161707A (ko) * | 2024-05-08 | 2025-11-18 | 아주대학교산학협력단 | Nectin-2에 결합하는 항체 약물 접합체 및 이의 용도 |
| KR20250175021A (ko) * | 2024-06-05 | 2025-12-16 | 아주대학교산학협력단 | Nectin-2에 특이적으로 결합하는 인간화 항체 및 이의 용도 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| EP1400536A1 (en) | 1991-06-14 | 2004-03-24 | Genentech Inc. | Method for making humanized antibodies |
| ATE207080T1 (de) | 1991-11-25 | 2001-11-15 | Enzon Inc | Multivalente antigen-bindende proteine |
| DE69309472T2 (de) | 1992-01-23 | 1997-10-23 | Merck Patent Gmbh, 64293 Darmstadt | Fusionsproteine von monomeren und dimeren von antikörperfragmenten |
| EP0787185A2 (en) | 1994-10-20 | 1997-08-06 | MorphoSys AG | Targeted hetero-association of recombinant proteins to multi-functional complexes |
| US5641870A (en) | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
| CA2222055A1 (en) | 1995-05-23 | 1996-11-28 | Morphosys Gesellschaft Fur Proteinoptimierung Mbh | Multimeric proteins |
| AU2003210060B2 (en) | 2002-03-22 | 2010-02-25 | Aprogen, Inc. | Humanized antibody and process for preparing same |
| US20090142346A1 (en) | 2005-10-07 | 2009-06-04 | Takeda Pharmaceutical Company Limited | Preventive/Remedy for Cancer |
| JPWO2008044754A1 (ja) * | 2006-10-06 | 2010-02-18 | 武田薬品工業株式会社 | 癌の予防・治療剤 |
| WO2008126847A1 (ja) * | 2007-04-11 | 2008-10-23 | Takeda Pharmaceutical Company Limited | 癌の予防・治療剤 |
| JO3620B1 (ar) | 2015-08-05 | 2020-08-27 | Amgen Res Munich Gmbh | مثبطات نقطة فحص مناعية للاستخدام في علاج سرطانات محمولة عبر الدم |
| US10407484B2 (en) | 2015-09-02 | 2019-09-10 | The Regents Of The University Of Colorado, A Body Corporate | Compositions and methods for modulating T-cell mediated immune response |
| EP3344658B1 (en) | 2015-09-02 | 2022-05-11 | Yissum Research Development Company of The Hebrew University of Jerusalem Ltd. | Antibodies specific to human t-cell immunoglobulin and itim domain (tigit) |
| CN108513576A (zh) | 2015-09-14 | 2018-09-07 | 高山免疫科学股份有限公司 | 可调变体免疫球蛋白超家族结构域和工程改造的细胞治疗 |
| CA3015619A1 (en) | 2016-03-01 | 2017-09-08 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Antibodies specific to human poliovirus receptor (pvr) |
| US20190224339A1 (en) | 2016-04-29 | 2019-07-25 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
| EP3908372A1 (en) | 2019-01-13 | 2021-11-17 | Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd. | Antibodies specific to human nectin-2 |
| KR20240152879A (ko) | 2022-02-28 | 2024-10-22 | 넥틴 테라퓨틱스 리미티드 | 넥틴-2에 대한 인간화 항체 및 이의 약물 접합체 |
-
2023
- 2023-02-27 KR KR1020247030827A patent/KR20240152879A/ko active Pending
- 2023-02-27 CA CA3243763A patent/CA3243763A1/en active Pending
- 2023-02-27 JP JP2024551663A patent/JP2025507817A/ja active Pending
- 2023-02-27 EP EP23711192.7A patent/EP4486776A1/en active Pending
- 2023-02-27 AU AU2023226094A patent/AU2023226094A1/en active Pending
- 2023-02-27 CN CN202380036403.9A patent/CN119451983A/zh active Pending
- 2023-02-27 IL IL314622A patent/IL314622A/en unknown
- 2023-02-27 WO PCT/IL2023/050203 patent/WO2023161943A1/en not_active Ceased
-
2024
- 2024-08-28 US US18/818,418 patent/US20240409632A1/en active Pending
- 2024-08-28 US US18/818,412 patent/US12612457B2/en active Active
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