JP2021535104A5 - - Google Patents
Info
- Publication number
- JP2021535104A5 JP2021535104A5 JP2021509151A JP2021509151A JP2021535104A5 JP 2021535104 A5 JP2021535104 A5 JP 2021535104A5 JP 2021509151 A JP2021509151 A JP 2021509151A JP 2021509151 A JP2021509151 A JP 2021509151A JP 2021535104 A5 JP2021535104 A5 JP 2021535104A5
- Authority
- JP
- Japan
- Prior art keywords
- piperazine
- pyrrolidine
- pharmaceutically acceptable
- imidazo
- fluorophenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2018/101715 | 2018-08-22 | ||
| CN2018101715 | 2018-08-22 | ||
| CN2019086894 | 2019-05-14 | ||
| CNPCT/CN2019/086894 | 2019-05-14 | ||
| PCT/CN2019/101850 WO2020038415A1 (en) | 2018-08-22 | 2019-08-21 | Tropomyosin receptor kinase (trk) degradation compounds and methods of use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021535104A JP2021535104A (ja) | 2021-12-16 |
| JP2021535104A5 true JP2021535104A5 (enExample) | 2022-08-29 |
| JP7472103B2 JP7472103B2 (ja) | 2024-04-22 |
Family
ID=69592803
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021509151A Active JP7472103B2 (ja) | 2018-08-22 | 2019-08-21 | トロポミオシン受容体キナーゼ（ｔｒｋ）分解化合物とその使用方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US12065442B2 (enExample) |
| EP (2) | EP3841098B1 (enExample) |
| JP (1) | JP7472103B2 (enExample) |
| KR (1) | KR102850550B1 (enExample) |
| CN (3) | CN112888681B (enExample) |
| AU (2) | AU2019323446B2 (enExample) |
| BR (1) | BR112021003098A2 (enExample) |
| CA (1) | CA3110267A1 (enExample) |
| DK (1) | DK3841098T3 (enExample) |
| IL (1) | IL280984B2 (enExample) |
| MX (1) | MX2021001957A (enExample) |
| WO (1) | WO2020038415A1 (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7472103B2 (ja) | 2018-08-22 | 2024-04-22 | クルゲン（シャンハイ），インク． | トロポミオシン受容体キナーゼ（ｔｒｋ）分解化合物とその使用方法 |
| US11969472B2 (en) | 2018-08-22 | 2024-04-30 | Cullgen (Shanghai), Inc. | Tropomyosin receptor kinase (TRK) degradation compounds and methods of use |
| CA3119773A1 (en) | 2018-11-30 | 2020-06-04 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
| GB201820165D0 (en) * | 2018-12-11 | 2019-01-23 | Ucb Biopharma Sprl | Therapeutic agents |
| PH12022500002A1 (en) | 2019-06-28 | 2023-04-03 | Kymera Therapeutics Inc | Irak degraders and uses thereof |
| WO2021011868A1 (en) | 2019-07-17 | 2021-01-21 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
| WO2021119159A1 (en) | 2019-12-10 | 2021-06-17 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
| WO2021126973A1 (en) * | 2019-12-17 | 2021-06-24 | Orionis Biosciences, Inc. | Compounds modulating protein recruitment and/or degradation |
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| US20230219945A1 (en) * | 2019-12-17 | 2023-07-13 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
| US20230099031A1 (en) * | 2019-12-17 | 2023-03-30 | Orionis Biosciences, Inc. | Bifunctional agents for protein recruitment and/or degradation |
| EP4110772A4 (en) * | 2020-02-26 | 2024-04-03 | Cullgen (Shanghai), Inc. | TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE |
| KR20230005160A (ko) * | 2020-03-19 | 2023-01-09 | 카이메라 쎄라퓨틱스 인코포레이티드 | Mdm2 분해제 및 이의 용도 |
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| AU2022207648A1 (en) | 2021-01-13 | 2023-07-27 | Monte Rosa Therapeutics Ag | Isoindolinone compounds |
| CN116867494A (zh) | 2021-02-15 | 2023-10-10 | 凯麦拉医疗公司 | Irak4降解剂和其用途 |
| US12171768B2 (en) | 2021-02-15 | 2024-12-24 | Kymera Therapeutics, Inc. | IRAK4 degraders and uses thereof |
| WO2022218289A1 (en) * | 2021-04-12 | 2022-10-20 | Cullgen (Shanghai), Inc. | Tropomyosin receptor kinase (trk) degradation compounds and methods of use |
| CN113402467B (zh) * | 2021-06-18 | 2022-05-13 | 山东汇海医药化工有限公司 | 一种氟班色林的合成方法 |
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| CN113278023B (zh) * | 2021-07-22 | 2021-10-15 | 上海睿跃生物科技有限公司 | 含氮杂环化合物及其制备方法和应用 |
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| CA3236265A1 (en) | 2021-10-29 | 2023-05-04 | William Leong | Irak4 degraders and synthesis thereof |
| AR127625A1 (es) | 2021-11-10 | 2024-02-14 | Nurix Therapeutics Inc | Degradadores bifuncionales inhibidores de la quinasa del progenitor hematopoyético y usos terapeuticos de los mismos |
| EP4180428A1 (en) | 2021-11-12 | 2023-05-17 | Genzyme Corporation | Crystalline imidazo[4,5-b]pyridine compound, pharmaceutical compositions, and their use in treating medical conditions |
| CN114230518A (zh) * | 2021-12-13 | 2022-03-25 | 海南梵圣生物科技有限公司 | 一种5-苄基-1h-吲唑-3-胺类化合物的制备方法 |
| WO2023116835A1 (zh) * | 2021-12-24 | 2023-06-29 | 苏州开拓药业股份有限公司 | 一种具有酰亚胺骨架的多蛋白降解剂 |
| CN116217578B (zh) * | 2021-12-30 | 2026-02-24 | 清华大学 | 一类抑制mTOR同时降解GSPT1蛋白的双功能化合物 |
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| KR20250173033A (ko) * | 2024-05-31 | 2025-12-10 | 국민대학교산학협력단 | 알티라티닙을 유효성분으로 포함하는 관절염 예방 또는 치료용 조성물 |
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-
2019
- 2019-08-21 JP JP2021509151A patent/JP7472103B2/ja active Active
- 2019-08-21 DK DK19852808.5T patent/DK3841098T3/da active
- 2019-08-21 EP EP19852808.5A patent/EP3841098B1/en active Active
- 2019-08-21 CN CN201980067402.4A patent/CN112888681B/zh active Active
- 2019-08-21 AU AU2019323446A patent/AU2019323446B2/en active Active
- 2019-08-21 CN CN202311721460.9A patent/CN118530239A/zh active Pending
- 2019-08-21 US US17/269,670 patent/US12065442B2/en active Active
- 2019-08-21 CA CA3110267A patent/CA3110267A1/en active Pending
- 2019-08-21 CN CN202210693243.2A patent/CN115626927B/zh active Active
- 2019-08-21 EP EP26151494.7A patent/EP4736882A2/en active Pending
- 2019-08-21 BR BR112021003098-0A patent/BR112021003098A2/pt unknown
- 2019-08-21 MX MX2021001957A patent/MX2021001957A/es unknown
- 2019-08-21 KR KR1020217008232A patent/KR102850550B1/ko active Active
- 2019-08-21 IL IL280984A patent/IL280984B2/en unknown
- 2019-08-21 WO PCT/CN2019/101850 patent/WO2020038415A1/en not_active Ceased
-
2024
- 2024-05-03 US US18/654,554 patent/US20240400570A1/en not_active Abandoned
-
2025
- 2025-04-11 AU AU2025202596A patent/AU2025202596A1/en active Pending
- 2025-08-19 US US19/304,433 patent/US20250388587A1/en active Pending
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