JP2021535104A5 - - Google Patents
Info
- Publication number
- JP2021535104A5 JP2021535104A5 JP2021509151A JP2021509151A JP2021535104A5 JP 2021535104 A5 JP2021535104 A5 JP 2021535104A5 JP 2021509151 A JP2021509151 A JP 2021509151A JP 2021509151 A JP2021509151 A JP 2021509151A JP 2021535104 A5 JP2021535104 A5 JP 2021535104A5
- Authority
- JP
- Japan
- Prior art keywords
- piperazine
- pyrrolidine
- pharmaceutically acceptable
- imidazo
- fluorophenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2018/101715 | 2018-08-22 | ||
| CN2018101715 | 2018-08-22 | ||
| CN2019086894 | 2019-05-14 | ||
| CNPCT/CN2019/086894 | 2019-05-14 | ||
| PCT/CN2019/101850 WO2020038415A1 (en) | 2018-08-22 | 2019-08-21 | Tropomyosin receptor kinase (trk) degradation compounds and methods of use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021535104A JP2021535104A (ja) | 2021-12-16 |
| JP2021535104A5 true JP2021535104A5 (enExample) | 2022-08-29 |
| JP7472103B2 JP7472103B2 (ja) | 2024-04-22 |
Family
ID=69592803
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021509151A Active JP7472103B2 (ja) | 2018-08-22 | 2019-08-21 | トロポミオシン受容体キナーゼ（ｔｒｋ）分解化合物とその使用方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US12065442B2 (enExample) |
| EP (2) | EP4736882A2 (enExample) |
| JP (1) | JP7472103B2 (enExample) |
| KR (1) | KR102850550B1 (enExample) |
| CN (3) | CN115626927B (enExample) |
| AU (2) | AU2019323446B2 (enExample) |
| BR (1) | BR112021003098A2 (enExample) |
| CA (1) | CA3110267A1 (enExample) |
| DK (1) | DK3841098T3 (enExample) |
| IL (1) | IL280984B2 (enExample) |
| MX (1) | MX2021001957A (enExample) |
| WO (1) | WO2020038415A1 (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2019323446B2 (en) | 2018-08-22 | 2025-01-30 | Cullgen (Shanghai), Inc. | Tropomyosin receptor kinase (TRK) degradation compounds and methods of use |
| US11969472B2 (en) | 2018-08-22 | 2024-04-30 | Cullgen (Shanghai), Inc. | Tropomyosin receptor kinase (TRK) degradation compounds and methods of use |
| JP7623943B2 (ja) | 2018-11-30 | 2025-01-29 | カイメラ セラピューティクス， インコーポレイテッド | Ｉｒａｋ分解剤およびそれらの使用 |
| GB201820165D0 (en) * | 2018-12-11 | 2019-01-23 | Ucb Biopharma Sprl | Therapeutic agents |
| BR112021026517A2 (pt) | 2019-06-28 | 2022-05-10 | Kymera Therapeutics Inc | Degradadores de irak e usos dos mesmos |
| WO2021011868A1 (en) | 2019-07-17 | 2021-01-21 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
| EP4072591A4 (en) | 2019-12-10 | 2024-06-05 | Kymera Therapeutics, Inc. | IRAQ DEGRADER AND USES THEREOF |
| WO2021127278A1 (en) * | 2019-12-17 | 2021-06-24 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
| WO2021126974A1 (en) * | 2019-12-17 | 2021-06-24 | Orionis Biosciences, Inc. | Bifunctional agents for protein recruitment and/or degradation |
| JP2023509366A (ja) | 2019-12-17 | 2023-03-08 | カイメラ セラピューティクス， インコーポレイテッド | Ｉｒａｋ分解剤およびそれらの使用 |
| US20230111853A1 (en) * | 2019-12-17 | 2023-04-13 | Orionis Biosciences, Inc. | Compounds modulating protein recruitment and/or degradation |
| JP7692924B2 (ja) * | 2020-02-26 | 2025-06-16 | クルゲン（シャンハイ），インク． | トロポミオシン受容体キナーゼ（ｔｒｋ）分解化合物とその使用方法 |
| IL296451B2 (en) * | 2020-03-19 | 2026-05-01 | Kymera Therapeutics Inc | MDM2 joints and their uses |
| US11858940B2 (en) * | 2020-03-21 | 2024-01-02 | Arvinas Operations, Inc. | Selective modulators of mutant LRRK2 proteolysis and associated methods of use |
| WO2021222542A1 (en) * | 2020-04-30 | 2021-11-04 | President And Fellows Of Harvard College | 5-amino-2-piperidinon-3-yl-1-oxoisoindoline derivatives for degradation of ikzf2 degraders |
| JP7857232B2 (ja) * | 2020-05-06 | 2026-05-12 | ニューリックス セラピューティクス，インコーポレイテッド | 造血前駆体キナーゼの二官能性分解物質およびその治療的使用 |
| CN115768768A (zh) * | 2020-05-28 | 2023-03-07 | 百时美施贵宝公司 | 半乳凝素-3抑制剂 |
| CN113801062B (zh) * | 2020-06-15 | 2023-05-26 | 沈阳药科大学 | 3-氨基-5-(3,5-二氟苄基)-1h-吲唑的制备方法 |
| CN116507333B (zh) * | 2020-08-27 | 2025-05-09 | 上海睿跃生物科技有限公司 | 环amp反应元件结合蛋白(cbp)和/或300kda腺病毒e1a结合蛋白(p300)降解化合物和使用方法 |
| CN112125977B (zh) * | 2020-09-29 | 2022-03-08 | 西安交通大学 | 一种tweak-mv1偶联蛋白及其抗银屑病的应用 |
| EP4225749A4 (en) * | 2020-10-07 | 2025-05-14 | Cullgen (Shanghai), Inc. | Compounds and methods of treating cancers |
| JP2024504932A (ja) | 2021-01-13 | 2024-02-02 | モンテ ローザ セラピューティクス， インコーポレイテッド | イソインドリノン化合物 |
| CN116867494A (zh) | 2021-02-15 | 2023-10-10 | 凯麦拉医疗公司 | Irak4降解剂和其用途 |
| TW202245788A (zh) | 2021-02-15 | 2022-12-01 | 美商凱麥拉醫療公司 | Irak4降解劑及其用途 |
| EP4323353A4 (en) * | 2021-04-12 | 2025-04-02 | Cullgen (Shanghai), Inc. | TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE |
| CN113402467B (zh) * | 2021-06-18 | 2022-05-13 | 山东汇海医药化工有限公司 | 一种氟班色林的合成方法 |
| WO2022270994A1 (ko) | 2021-06-25 | 2022-12-29 | 한국화학연구원 | 유비퀴틴 프로테오좀 경로를 통해 비티케이 분해작용을 가지는 신규한 이작용성 헤테로사이클릭 화합물과 이의 용도 |
| CN113278023B (zh) * | 2021-07-22 | 2021-10-15 | 上海睿跃生物科技有限公司 | 含氮杂环化合物及其制备方法和应用 |
| KR20240110576A (ko) * | 2021-10-22 | 2024-07-15 | 글루탁스 테라퓨틱스 (상하이) 씨오., 엘티디. | Crbn e3 리가제 리간드 화합물, 리간드 화합물에 기초하여 개발된 단백질 분해제 및 이들의 응용 |
| EP4422635A4 (en) | 2021-10-29 | 2025-11-26 | Kymera Therapeutics Inc | IRAQ4 DEGRADATION AGENTS AND THEIR SYNTHESIS |
| AU2022388571A1 (en) | 2021-11-10 | 2024-05-09 | Gilead Sciences, Inc. | Bifunctional degraders of hematopoietic progenitor kinase and therapeutic uses thereof |
| EP4180428A1 (en) * | 2021-11-12 | 2023-05-17 | Genzyme Corporation | Crystalline imidazo[4,5-b]pyridine compound, pharmaceutical compositions, and their use in treating medical conditions |
| CN114230518A (zh) * | 2021-12-13 | 2022-03-25 | 海南梵圣生物科技有限公司 | 一种5-苄基-1h-吲唑-3-胺类化合物的制备方法 |
| EP4455133A4 (en) * | 2021-12-24 | 2026-04-15 | Suzhou Kintor Pharmaceuticals Inc | MULTI-PROTEIN DEGRADING AGENT WITH AN IMIDE SKELETON |
| CN116217578B (zh) * | 2021-12-30 | 2026-02-24 | 清华大学 | 一类抑制mTOR同时降解GSPT1蛋白的双功能化合物 |
| WO2023239629A1 (en) | 2022-06-06 | 2023-12-14 | Plexium, Inc. | Compounds and pharmaceutical compositions that degrade cdk2 |
| WO2023249994A1 (en) * | 2022-06-22 | 2023-12-28 | Mayo Foundation For Medical Education And Research | Methods and materials for treating cancer |
| WO2024027792A1 (en) * | 2022-08-05 | 2024-02-08 | Shenzhen Newdel Biotech Co., Ltd. | Protein kinase degrading agent, medicament and use |
| KR20250130412A (ko) * | 2023-01-13 | 2025-09-01 | 선전 뉴델 바이오텍 씨오., 엘티디. | 화합물 a의 염과 결정형, 및 그 제조 방법과 용도 |
| KR20250173033A (ko) * | 2024-05-31 | 2025-12-10 | 국민대학교산학협력단 | 알티라티닙을 유효성분으로 포함하는 관절염 예방 또는 치료용 조성물 |
Family Cites Families (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6306663B1 (en) | 1999-02-12 | 2001-10-23 | Proteinex, Inc. | Controlling protein levels in eucaryotic organisms |
| US8299057B2 (en) | 2007-07-20 | 2012-10-30 | Nerviano Medical Sciences S.R.L. | Substituted indazole derivatives active as kinase inhibitors |
| EP2300469B1 (en) | 2008-05-13 | 2015-06-24 | Novartis AG | Fused nitrogen containing heterocycles and compositions thereof as kinase inhibitors |
| AR077468A1 (es) | 2009-07-09 | 2011-08-31 | Array Biopharma Inc | Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa |
| TWI619713B (zh) | 2010-04-21 | 2018-04-01 | 普雷辛肯公司 | 用於激酶調節的化合物和方法及其適應症 |
| EP2588129A4 (en) | 2010-06-30 | 2014-07-09 | Univ Brandeis | ON SMALL MOLECULES TARGETED PROTEIN REMOVAL |
| WO2012037155A2 (en) | 2010-09-13 | 2012-03-22 | Gtx, Inc. | Tyrosine kinase inhibitors |
| AU2011338615B2 (en) | 2010-12-07 | 2017-07-27 | Yale University | Small-molecule hydrophobic tagging of fusion proteins and induced degradation of same |
| JP2015508414A (ja) | 2012-01-12 | 2015-03-19 | イエール ユニバーシティ | Ｅ３ユビキチンリガーゼによる標的タンパク質および他のポリペプチドの分解増強のための化合物および方法 |
| US20150119435A1 (en) | 2012-05-11 | 2015-04-30 | Yale University | Compounds useful for promoting protein degradation and methods using same |
| US9758522B2 (en) | 2012-10-19 | 2017-09-12 | Dana-Farber Cancer Institute, Inc. | Hydrophobically tagged small molecules as inducers of protein degradation |
| EP3097091A1 (en) * | 2014-01-24 | 2016-11-30 | AbbVie Inc. | 6-phenyl- or 6-(pyridin-3-yl)indazole derivatives and methods of use |
| WO2015143652A1 (en) * | 2014-03-26 | 2015-10-01 | Merck Sharp & Dohme Corp. | TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF |
| CN119591582A (zh) | 2014-04-14 | 2025-03-11 | 阿尔维纳斯运营股份有限公司 | 基于酰亚胺的蛋白水解调节剂和相关使用方法 |
| US20180228907A1 (en) | 2014-04-14 | 2018-08-16 | Arvinas, Inc. | Cereblon ligands and bifunctional compounds comprising the same |
| US20160058872A1 (en) | 2014-04-14 | 2016-03-03 | Arvinas, Inc. | Imide-based modulators of proteolysis and associated methods of use |
| WO2016096709A1 (en) | 2014-12-16 | 2016-06-23 | Eudendron S.R.L. | Heterocyclic derivatives modulating activity of certain protein kinases |
| US9694084B2 (en) | 2014-12-23 | 2017-07-04 | Dana-Farber Cancer Institute, Inc. | Methods to induce targeted protein degradation through bifunctional molecules |
| GB201504314D0 (en) | 2015-03-13 | 2015-04-29 | Univ Dundee | Small molecules |
| JP7269731B2 (ja) | 2015-03-18 | 2023-05-09 | アルビナス・オペレーションズ・インコーポレイテッド | 標的タンパク質の分解向上のための化合物および方法 |
| GB201506871D0 (en) | 2015-04-22 | 2015-06-03 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| AU2016275051A1 (en) | 2015-06-10 | 2017-12-07 | Epizyme, Inc. | EZH2 inhibitors for treating lymphoma |
| CN105085620B (zh) | 2015-06-25 | 2018-05-08 | 中山大学附属第一医院 | 一种靶向泛素化降解Smad3的化合物 |
| CN108137507A (zh) | 2015-07-10 | 2018-06-08 | 阿尔维纳斯股份有限公司 | 基于mdm2的蛋白水解调节剂和相关的使用方法 |
| CA2988436A1 (en) | 2015-07-13 | 2017-01-19 | Arvinas, Inc. | Alanine-based modulators of proteolysis and associated methods of use |
| EP3337476A4 (en) | 2015-08-19 | 2019-09-04 | Arvinas, Inc. | Compounds and methods for the targeted degradation of bromodomain-containing proteins |
| AU2016349781A1 (en) | 2015-11-02 | 2018-05-10 | Yale University | Proteolysis targeting chimera compounds and methods of preparing and using same |
| JP7037500B2 (ja) | 2016-04-06 | 2022-03-16 | ザ リージェンツ オブ ザ ユニヴァシティ オブ ミシガン | Ｍｄｍ２タンパク質分解剤 |
| AU2017246453A1 (en) | 2016-04-06 | 2018-11-08 | The Regents Of The University Of Michigan | Monofunctional intermediates for ligand-dependent target protein degradation |
| AU2017250076B2 (en) | 2016-04-12 | 2021-07-22 | The Regents Of The University Of Michigan | Bet protein degraders |
| CN109562107A (zh) * | 2016-05-10 | 2019-04-02 | C4医药公司 | 用于靶蛋白降解的杂环降解决定子体 |
| CN109641874A (zh) * | 2016-05-10 | 2019-04-16 | C4医药公司 | 用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体 |
| EP3455219A4 (en) * | 2016-05-10 | 2019-12-18 | C4 Therapeutics, Inc. | AMINE-RELATED C3-GLUTARIMIDE DEGRONIMERS FOR TARGET PROTEIN REDUCTION |
| WO2017201069A1 (en) | 2016-05-18 | 2017-11-23 | Biotheryx, Inc. | Oxoindoline derivatives as protein function modulators |
| KR101825065B1 (ko) | 2016-05-24 | 2018-02-05 | 한국화학연구원 | Alk 단백질의 분해를 유도하는 약학적 조성물 및 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물 |
| GB201610156D0 (en) | 2016-06-10 | 2016-07-27 | Otsuka Pharma Co Ltd | Cliptac compositions |
| CA3025806C (en) | 2016-06-23 | 2023-04-04 | Dana-Farber Cancer Institute, Inc. | Degradation of bromodomain-containing protein 9 (brd9) by conjugation of brd9 inhibitors with e3 ligase ligand and methods of use |
| ES2857743T3 (es) | 2016-09-13 | 2021-09-29 | Univ Michigan Regents | 1,4-diazepinas fusionadas como degradadores de proteína BET |
| LT3660004T (lt) | 2016-10-11 | 2023-06-12 | Arvinas Operations, Inc. | Junginiai ir metodai, skirti tikslinei androgeno receptoriaus degradacijai |
| EP3535265A4 (en) | 2016-11-01 | 2020-07-08 | Arvinas, Inc. | PROTACS TARGETING ON TAU PROTEIN AND RELATED METHODS FOR USE |
| CN106543185B (zh) | 2016-11-10 | 2017-12-15 | 吉林大学 | 一种靶向泛素化降解plk1和brd4蛋白的化合物及其应用 |
| WO2018089736A1 (en) | 2016-11-10 | 2018-05-17 | Dana-Farber Cancer Institute, Inc. | Degradation of protein kinases by conjugation of protein kinase inhibitors with e3 ligase ligand and methods of use |
| AU2017382176A1 (en) | 2016-12-21 | 2019-05-30 | Biotheryx, Inc. | Thienopyrrole derivatives for use in targeting proteins, compositions, methods, and uses thereof |
| EP3559006A4 (en) | 2016-12-23 | 2021-03-03 | Arvinas Operations, Inc. | COMPOUNDS AND METHODS FOR TARGETED DEGRADATION OF F TAL LIVER KINASE POLYPEPTIDES |
| EP3558994A4 (en) | 2016-12-23 | 2021-05-12 | Arvinas Operations, Inc. | COMPOUNDS AND METHODS FOR TARGETED DEGRADATION OF FAST ACCELERATED FIBROSARCOMA POLYPEPTIDES |
| RU2019121527A (ru) | 2016-12-23 | 2021-01-15 | Эрвинэс Оперейшнс, Инк. | Химерные молекулы, нацеливающиеся на протеолиз egfr, и связанные с ними способы применения |
| US11191741B2 (en) | 2016-12-24 | 2021-12-07 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of enhancer of zeste homolog 2 polypeptide |
| MX2019008934A (es) | 2017-01-26 | 2019-11-05 | Arvinas Operations Inc | Moduladores de la proteolisis del receptor de estrogeno y métodos asociados de uso,. |
| EP3577109A4 (en) | 2017-01-31 | 2020-11-18 | Arvinas Operations, Inc. | CEREMONY LIGANDS AND BIFUNCTIONAL COMPOUNDS CONTAINING THEM |
| US11261179B2 (en) | 2017-04-14 | 2022-03-01 | University Of Dundee | Small molecules |
| CN108976278B (zh) | 2017-06-05 | 2021-04-06 | 海创药业股份有限公司 | 一种嵌合分子及其制备和应用 |
| US20180353501A1 (en) | 2017-06-09 | 2018-12-13 | Arvinas, Inc. | Modulators of proteolysis and associated methods of use |
| EP3725771B1 (en) * | 2017-12-13 | 2026-02-04 | Shanghaitech University | Alk protein degradation agent and anti-tumor application thereof |
| WO2020023549A1 (en) | 2018-07-24 | 2020-01-30 | January Therapeutics, Inc. | Nanoparticle compositions |
| US11969472B2 (en) * | 2018-08-22 | 2024-04-30 | Cullgen (Shanghai), Inc. | Tropomyosin receptor kinase (TRK) degradation compounds and methods of use |
| AU2019323446B2 (en) | 2018-08-22 | 2025-01-30 | Cullgen (Shanghai), Inc. | Tropomyosin receptor kinase (TRK) degradation compounds and methods of use |
| JP7692924B2 (ja) * | 2020-02-26 | 2025-06-16 | クルゲン（シャンハイ），インク． | トロポミオシン受容体キナーゼ（ｔｒｋ）分解化合物とその使用方法 |
| WO2023055952A1 (en) | 2021-09-29 | 2023-04-06 | C4 Therapeutics, Inc. | Neurotrophic tyrosine receptor kinase (ntrk) degrading compounds |
-
2019
- 2019-08-21 AU AU2019323446A patent/AU2019323446B2/en active Active
- 2019-08-21 CA CA3110267A patent/CA3110267A1/en active Pending
- 2019-08-21 CN CN202210693243.2A patent/CN115626927B/zh active Active
- 2019-08-21 WO PCT/CN2019/101850 patent/WO2020038415A1/en not_active Ceased
- 2019-08-21 US US17/269,670 patent/US12065442B2/en active Active
- 2019-08-21 DK DK19852808.5T patent/DK3841098T3/da active
- 2019-08-21 MX MX2021001957A patent/MX2021001957A/es unknown
- 2019-08-21 CN CN202311721460.9A patent/CN118530239A/zh active Pending
- 2019-08-21 BR BR112021003098-0A patent/BR112021003098A2/pt unknown
- 2019-08-21 JP JP2021509151A patent/JP7472103B2/ja active Active
- 2019-08-21 EP EP26151494.7A patent/EP4736882A2/en active Pending
- 2019-08-21 CN CN201980067402.4A patent/CN112888681B/zh active Active
- 2019-08-21 KR KR1020217008232A patent/KR102850550B1/ko active Active
- 2019-08-21 IL IL280984A patent/IL280984B2/en unknown
- 2019-08-21 EP EP19852808.5A patent/EP3841098B1/en active Active
-
2024
- 2024-05-03 US US18/654,554 patent/US20240400570A1/en not_active Abandoned
-
2025
- 2025-04-11 AU AU2025202596A patent/AU2025202596A1/en active Pending
- 2025-08-19 US US19/304,433 patent/US20250388587A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2023514872A5 (enExample) | ||
| US7629374B2 (en) | Use of aminoindazole derivatives for the inhibition of tau phosphorylation | |
| RU2378259C2 (ru) | Новые производные аминоиндазолов в качестве лекарственных средств и содержащие их фармацевтические композиции | |
| JP2022191517A5 (enExample) | ||
| RU2218337C2 (ru) | Производные тиазола, способ их получения и фармацевтическая композиция на их основе | |
| JP2024537824A5 (enExample) | ||
| JP2021500345A5 (enExample) | ||
| JP2021535134A5 (enExample) | ||
| JP2021535159A5 (enExample) | ||
| JP2002030084A5 (enExample) | ||
| RU2003129502A (ru) | Соединение, фармацевтическая композиция, применение, способ предупреждения или лечения заболеваний | |
| JP2012503018A5 (enExample) | ||
| JP2006513202A5 (enExample) | ||
| IL295799A (en) | Trophomyosin receptor kinase (trk) degradation compounds and methods of use | |
| JP2006510716A5 (enExample) | ||
| JP2010520893A5 (enExample) | ||
| HRP20180199T1 (hr) | Urea derivati ili njihove farmakološki prihvatljive soli korisni kao agonisti formil peptidnom receptoru-sličnom i (fprl-1) | |
| JP2005508923A5 (enExample) | ||
| JP2007520440A5 (enExample) | ||
| JP2024505558A5 (enExample) | ||
| JP2004502674A5 (enExample) | ||
| JP2024542248A5 (enExample) | ||
| RU2003131970A (ru) | Производные 4-(фенил-пиперидин-4-илиден-метил)-бензамида и их применение для лечения боли, тревоги или желудочно-кишечных расстройств | |
| RU2007127864A (ru) | Производные n-[(4, 5-дифенил-3-алкил-2-тиенил)метил]амина (амид, сульфонамид, карбамат и карбамид) в качестве антагонистов рецепторов св1 каннабиноидов | |
| JP2021523109A5 (enExample) |