JP2021519079A5 - - Google Patents

Info

Publication number
JP2021519079A5
JP2021519079A5 JP2020551828A JP2020551828A JP2021519079A5 JP 2021519079 A5 JP2021519079 A5 JP 2021519079A5 JP 2020551828 A JP2020551828 A JP 2020551828A JP 2020551828 A JP2020551828 A JP 2020551828A JP 2021519079 A5 JP2021519079 A5 JP 2021519079A5
Authority
JP
Japan
Prior art keywords
cancer
state
methylation
hydroxymethylation
disease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2020551828A
Other languages
English (en)
Japanese (ja)
Other versions
JP7474702B2 (ja
JP2021519079A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2019/024584 external-priority patent/WO2019191429A2/en
Publication of JP2021519079A publication Critical patent/JP2021519079A/ja
Publication of JP2021519079A5 publication Critical patent/JP2021519079A5/ja
Application granted granted Critical
Publication of JP7474702B2 publication Critical patent/JP7474702B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2020551828A 2018-03-28 2019-03-28 エキソソームから単離されたdnaにおけるエピジェネティック変化の同定法 Active JP7474702B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862649042P 2018-03-28 2018-03-28
US62/649,042 2018-03-28
PCT/US2019/024584 WO2019191429A2 (en) 2018-03-28 2019-03-28 Identification of epigenetic alterations in dna isolated from exosomes

Publications (3)

Publication Number Publication Date
JP2021519079A JP2021519079A (ja) 2021-08-10
JP2021519079A5 true JP2021519079A5 (https=) 2022-04-01
JP7474702B2 JP7474702B2 (ja) 2024-04-25

Family

ID=68060497

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020551828A Active JP7474702B2 (ja) 2018-03-28 2019-03-28 エキソソームから単離されたdnaにおけるエピジェネティック変化の同定法

Country Status (8)

Country Link
US (1) US12473598B2 (https=)
EP (1) EP3775258A4 (https=)
JP (1) JP7474702B2 (https=)
KR (1) KR20200136977A (https=)
CN (1) CN112513297B (https=)
AU (1) AU2019242912B2 (https=)
CA (1) CA3095134A1 (https=)
WO (1) WO2019191429A2 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3775258A4 (en) 2018-03-28 2022-01-26 Board of Regents, The University of Texas System IDENTIFICATION OF EPIGENETIC ALTERATIONS IN DNA ISOLATED FROM EXOSOMES
WO2021158966A1 (en) 2020-02-05 2021-08-12 Board Of Regents, The University Of Texas System Diagnostic and prognostic utility of exosomes in immunotherapy
WO2022086218A1 (ko) 2020-10-21 2022-04-28 주식회사 강스템바이오텍 만능성 줄기세포 유래 피부 오가노이드를 이용한 아토피 피부염 모델 제작 방법
KR102499154B1 (ko) 2022-07-06 2023-02-14 주식회사 클리셀 역분화 줄기세포에서 분화된 세포를 이용한 인공피부의 제조방법
KR102543340B1 (ko) 2022-07-06 2023-06-16 주식회사 클리셀 역분화 줄기세포에서 분화된 세포를 이용한 인공피부의 제조장치
WO2024014580A1 (ko) * 2022-07-13 2024-01-18 이왕재바이오연구소 주식회사 엑소좀에서 발현되는 바이오 마커를 이용하는 인공지능 기반 암 진단용 정보제공 방법
WO2024112893A1 (en) * 2022-11-23 2024-05-30 Foundation Medicine, Inc. Systems and methods for tracking personalized methylation biomarkers for the detection of disease

Family Cites Families (212)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3687808A (en) 1969-08-14 1972-08-29 Univ Leland Stanford Junior Synthetic polynucleotides
US4162282A (en) 1976-04-22 1979-07-24 Coulter Electronics, Inc. Method for producing uniform particles
US4310505A (en) 1979-11-08 1982-01-12 California Institute Of Technology Lipid vesicles bearing carbohydrate surfaces as lymphatic directed vehicles for therapeutic and diagnostic substances
US4533254A (en) 1981-04-17 1985-08-06 Biotechnology Development Corporation Apparatus for forming emulsions
US5030453A (en) 1983-03-24 1991-07-09 The Liposome Company, Inc. Stable plurilamellar vesicles
US5118800A (en) 1983-12-20 1992-06-02 California Institute Of Technology Oligonucleotides possessing a primary amino group in the terminal nucleotide
US4728575A (en) 1984-04-27 1988-03-01 Vestar, Inc. Contrast agents for NMR imaging
CA1264668A (en) 1984-06-20 1990-01-23 Pieter R. Cullis Extrusion techniques for producing liposomes
FR2567892B1 (fr) 1984-07-19 1989-02-17 Centre Nat Rech Scient Nouveaux oligonucleotides, leur procede de preparation et leurs applications comme mediateurs dans le developpement des effets des interferons
US5367066A (en) 1984-10-16 1994-11-22 Chiron Corporation Oligonucleotides with selectably cleavable and/or abasic sites
US4921706A (en) 1984-11-20 1990-05-01 Massachusetts Institute Of Technology Unilamellar lipid vesicles and method for their formation
FR2575751B1 (fr) 1985-01-08 1987-04-03 Pasteur Institut Nouveaux nucleosides de derives de l'adenosine, leur preparation et leurs applications biologiques
US4737323A (en) 1986-02-13 1988-04-12 Liposome Technology, Inc. Liposome extrusion method
US4728578A (en) 1986-08-13 1988-03-01 The Lubrizol Corporation Compositions containing basic metal salts and/or non-Newtonian colloidal disperse systems and vinyl aromatic containing polymers
EP0366685B1 (en) 1987-06-24 1994-10-19 Howard Florey Institute Of Experimental Physiology And Medicine Nucleoside derivatives
US5824311A (en) 1987-11-30 1998-10-20 Trustees Of The University Of Pennsylvania Treatment of tumors with monoclonal antibodies against oncogene antigens
US4870287A (en) 1988-03-03 1989-09-26 Loma Linda University Medical Center Multi-station proton beam therapy system
US5175273A (en) 1988-07-01 1992-12-29 Genentech, Inc. Nucleic acid intercalating agents
DE68912139T2 (de) 1988-11-09 1994-04-28 Colin Tilcock Liposomale radiologische kontrastmittel.
US5134066A (en) 1989-08-29 1992-07-28 Monsanto Company Improved probes using nucleosides containing 3-dezauracil analogs
US5591722A (en) 1989-09-15 1997-01-07 Southern Research Institute 2'-deoxy-4'-thioribonucleosides and their antiviral activity
DE69034150T2 (de) 1989-10-24 2005-08-25 Isis Pharmaceuticals, Inc., Carlsbad 2'-Modifizierte Oligonukleotide
US5130302A (en) 1989-12-20 1992-07-14 Boron Bilogicals, Inc. Boronated nucleoside, nucleotide and oligonucleotide compounds, compositions and methods for using same
US6005087A (en) 1995-06-06 1999-12-21 Isis Pharmaceuticals, Inc. 2'-modified oligonucleotides
US5681941A (en) 1990-01-11 1997-10-28 Isis Pharmaceuticals, Inc. Substituted purines and oligonucleotide cross-linking
US5646265A (en) 1990-01-11 1997-07-08 Isis Pharmceuticals, Inc. Process for the preparation of 2'-O-alkyl purine phosphoramidites
US5670633A (en) 1990-01-11 1997-09-23 Isis Pharmaceuticals, Inc. Sugar modified oligonucleotides that detect and modulate gene expression
US5459255A (en) 1990-01-11 1995-10-17 Isis Pharmaceuticals, Inc. N-2 substituted purines
GB9009980D0 (en) 1990-05-03 1990-06-27 Amersham Int Plc Phosphoramidite derivatives,their preparation and the use thereof in the incorporation of reporter groups on synthetic oligonucleotides
ES2116977T3 (es) 1990-05-11 1998-08-01 Microprobe Corp Soportes solidos para ensayos de hibridacion de acidos nucleicos y metodos para inmovilizar oligonucleotidos de modo covalente.
JPH0874B2 (ja) 1990-07-27 1996-01-10 アイシス・ファーマシューティカルス・インコーポレーテッド 遺伝子発現を検出および変調するヌクレアーゼ耐性、ピリミジン修飾オリゴヌクレオチド
US5432272A (en) 1990-10-09 1995-07-11 Benner; Steven A. Method for incorporating into a DNA or RNA oligonucleotide using nucleotides bearing heterocyclic bases
DE4126983A1 (de) 1991-08-15 1993-02-18 Boehringer Mannheim Gmbh Verfahren zur herstellung von humanprotein-enthaltenden, konservierten arzneimitteln fuer infusions- oder injektionszwecke
EP0538194B1 (de) 1991-10-17 1997-06-04 Novartis AG Bicyclische Nukleoside, Oligonukleotide, Verfahren zu deren Herstellung und Zwischenprodukte
US5594121A (en) 1991-11-07 1997-01-14 Gilead Sciences, Inc. Enhanced triple-helix and double-helix formation with oligomers containing modified purines
AU3222793A (en) 1991-11-26 1993-06-28 Gilead Sciences, Inc. Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines
TW393513B (en) 1991-11-26 2000-06-11 Isis Pharmaceuticals Inc Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines
US5484908A (en) 1991-11-26 1996-01-16 Gilead Sciences, Inc. Oligonucleotides containing 5-propynyl pyrimidines
US5359044A (en) 1991-12-13 1994-10-25 Isis Pharmaceuticals Cyclobutyl oligonucleotide surrogates
EP0577558A2 (de) 1992-07-01 1994-01-05 Ciba-Geigy Ag Carbocyclische Nukleoside mit bicyclischen Ringen, Oligonukleotide daraus, Verfahren zu deren Herstellung, deren Verwendung und Zwischenproduckte
US5801029A (en) 1993-02-16 1998-09-01 Onyx Pharmaceuticals, Inc. Cytopathic viruses for therapy and prophylaxis of neoplasia
US5801005A (en) 1993-03-17 1998-09-01 University Of Washington Immune reactivity to HER-2/neu protein for diagnosis of malignancies in which the HER-2/neu oncogene is associated
CA2159631A1 (en) 1993-03-30 1994-10-13 Sanofi Acyclic nucleoside analogs and oligonucleotide sequences containing them
DE4311944A1 (de) 1993-04-10 1994-10-13 Degussa Umhüllte Natriumpercarbonatpartikel, Verfahren zu deren Herstellung und sie enthaltende Wasch-, Reinigungs- und Bleichmittelzusammensetzungen
US5502177A (en) 1993-09-17 1996-03-26 Gilead Sciences, Inc. Pyrimidine derivatives for labeled binding partners
US5457187A (en) 1993-12-08 1995-10-10 Board Of Regents University Of Nebraska Oligonucleotides containing 5-fluorouracil
US5446137B1 (en) 1993-12-09 1998-10-06 Behringwerke Ag Oligonucleotides containing 4'-substituted nucleotides
US5595756A (en) 1993-12-22 1997-01-21 Inex Pharmaceuticals Corporation Liposomal compositions for enhanced retention of bioactive agents
US5519134A (en) 1994-01-11 1996-05-21 Isis Pharmaceuticals, Inc. Pyrrolidine-containing monomers and oligomers
US5596091A (en) 1994-03-18 1997-01-21 The Regents Of The University Of California Antisense oligonucleotides comprising 5-aminoalkyl pyrimidine nucleotides
US5627053A (en) 1994-03-29 1997-05-06 Ribozyme Pharmaceuticals, Inc. 2'deoxy-2'-alkylnucleotide containing nucleic acid
US5525711A (en) 1994-05-18 1996-06-11 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Pteridine nucleotide analogs as fluorescent DNA probes
US5597909A (en) 1994-08-25 1997-01-28 Chiron Corporation Polynucleotide reagents containing modified deoxyribose moieties, and associated methods of synthesis and use
GB9506466D0 (en) 1994-08-26 1995-05-17 Prolifix Ltd Cell cycle regulated repressor and dna element
US6366682B1 (en) 1994-11-28 2002-04-02 Indivos Corporation Tokenless electronic transaction system
CN1178470A (zh) 1995-01-10 1998-04-08 菲布洛根有限公司 用于治疗免疫性疾病的基于胶原的方法和制剂
US5792747A (en) 1995-01-24 1998-08-11 The Administrators Of The Tulane Educational Fund Highly potent agonists of growth hormone releasing hormone
GB9507985D0 (en) 1995-04-19 1995-06-07 Orion Yhtymae Oy Antibody to aminoterminal propeptide to type 1 procollagen and assay method using it
US5760395A (en) 1996-04-18 1998-06-02 Universities Research Assoc., Inc. Method and apparatus for laser-controlled proton beam radiology
US5739169A (en) 1996-05-31 1998-04-14 Procept, Incorporated Aromatic compounds for inhibiting immune response
US20080119427A1 (en) 1996-06-06 2008-05-22 Isis Pharmaceuticals, Inc. Double Strand Compositions Comprising Differentially Modified Strands for Use in Gene Modulation
US5898031A (en) 1996-06-06 1999-04-27 Isis Pharmaceuticals, Inc. Oligoribonucleotides for cleaving RNA
US5891467A (en) 1997-01-31 1999-04-06 Depotech Corporation Method for utilizing neutral lipids to modify in vivo release from multivesicular liposomes
US6506559B1 (en) 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
AUPP249298A0 (en) 1998-03-20 1998-04-23 Ag-Gene Australia Limited Synthetic genes and genetic constructs comprising same I
CN101818145A (zh) 1998-03-20 2010-09-01 联邦科学和工业研究组织 控制基因表达
EP1071753A2 (en) 1998-04-20 2001-01-31 Ribozyme Pharmaceuticals, Inc. Nucleic acid molecules with novel chemical compositions capable of modulating gene expression
US6043352A (en) 1998-08-07 2000-03-28 Isis Pharmaceuticals, Inc. 2'-O-Dimethylaminoethyloxyethyl-modified oligonucleotides
WO2000026342A1 (en) 1998-10-30 2000-05-11 Northwestern University Method of interfering with cell proliferation
US7098192B2 (en) 1999-04-08 2006-08-29 Isis Pharmaceuticals, Inc. Antisense oligonucleotide modulation of STAT3 expression
DK1218504T3 (da) 1999-09-21 2007-11-12 Genetics Inst Llc GL50 molekyler og anvendelser deraf
HK1047109A1 (zh) 1999-10-15 2003-02-07 University Of Massachusetts 作为指定基因干预工具的rna干预轨迹基因
RU2002112751A (ru) 1999-11-12 2004-02-27 Файброджен, Инк. (Us) Рекомбинантные желатины
US6680068B2 (en) 2000-07-06 2004-01-20 The General Hospital Corporation Drug delivery formulations and targeting
DE10122140A1 (de) 2001-05-08 2002-11-28 Apotech Res & Dev Ltd Rekombinante Fusionsproteine und deren Trimere
WO2002097114A2 (en) 2001-05-29 2002-12-05 Sirna Therapeutics, Inc. Nucleic acid treatment of diseases or conditions related to levels of ras, her2 and hiv
US20040019001A1 (en) 2002-02-20 2004-01-29 Mcswiggen James A. RNA interference mediated inhibition of protein typrosine phosphatase-1B (PTP-1B) gene expression using short interfering RNA
EP1399189A1 (en) 2001-06-11 2004-03-24 Universite De Montreal Compositions and methods for enhancing nucleic acid transfer into cells
JP5170934B2 (ja) 2001-08-16 2013-03-27 ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア 改良dnaリポフェクションならびに/または徐放性プロドラッグおよび薬物療法のための試薬の合成と使用
US7390885B2 (en) 2001-11-26 2008-06-24 Cell Matrix, Inc. Humanized collagen antibodies and related methods
US20050008617A1 (en) 2002-09-28 2005-01-13 Massachusetts Institute Of Technology Compositions and methods for delivery of short interfering RNA and short hairpin RNA
US20040208921A1 (en) 2003-01-14 2004-10-21 Ho Rodney J. Y. Lipid-drug formulations and methods for targeted delivery of lipid-drug complexes to lymphoid tissues
JP4939926B2 (ja) 2003-02-14 2012-05-30 アノシス・インコーポレーテッド 抗体を生成し抗体レパートリーをスクリーニングするための方法とコンパウンド
MXPA06011526A (es) 2004-04-06 2007-03-21 Novimmune Sa Metodos de tratamiento de enfermedades autoinmunes e inflamatorias.
US7473678B2 (en) 2004-10-14 2009-01-06 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods of use thereof
US20070014788A1 (en) 2004-12-13 2007-01-18 Novo Nordisk A/S Laminin-5 modulators and uses thereof
CA2504279A1 (en) 2005-04-15 2006-10-15 University Of Saskatchewan Materials and method of modulating the immune response using t helper-antigen presenting cells
US20070292866A1 (en) * 2005-12-08 2007-12-20 Ambergen, Inc. Diagnosing human diseases by detecting DNA methylation changes
US9085778B2 (en) 2006-05-03 2015-07-21 VL27, Inc. Exosome transfer of nucleic acids to cells
JP2009536222A (ja) 2006-05-05 2009-10-08 アイシス ファーマシューティカルズ, インコーポレーテッド Pcsk9の発現を調節するための化合物および方法
CN101437485A (zh) 2006-05-09 2009-05-20 高露洁-棕榄公司 口腔护理方案
KR101560844B1 (ko) 2007-06-04 2015-10-15 벤-구리온 유니버시티 오브 더 네게브 리서치 앤드 디벨럽먼트 어쏘러티 트라이-아릴계 화합물 및 이를 포함하는 조성물
GB0711858D0 (en) 2007-06-19 2007-07-25 Glaxosmithkline Biolog Sa Vaccine
US20100298409A1 (en) 2007-09-17 2010-11-25 Intradigm Corporation Compositions comprising stat3 sirna and methods of use thereof
KR101810799B1 (ko) 2008-02-01 2017-12-19 더 제너럴 하스피탈 코포레이션 의학적 질환 및 병태의 진단, 예후, 및 치료에 있어서 미세소포체의 용도
WO2009100446A1 (en) 2008-02-07 2009-08-13 Terapio, Llc Compositions for delivery of cargo such as drugs proteins and/or genetic materials
FR2928926B1 (fr) 2008-03-18 2015-08-21 Centre Nat Rech Scient Polynucleotides et polypeptides chimeriques permettant la secretion d'un polypeptide d'interet en association avec des exosomes et leur utilisation pour la production de compositions immunogenes
EP2313435A4 (en) 2008-07-01 2012-08-08 Aveo Pharmaceuticals Inc FIBROBLAST GROWTH FACTOR RECEPTOR 3 (FGFR3) BINDING PROTEINS
WO2010056337A2 (en) 2008-11-12 2010-05-20 Caris Mpi, Inc. Methods and systems of using exosomes for determining phenotypes
US20130053426A1 (en) 2009-04-17 2013-02-28 Yiqi Seow Composition For Delivery Of Genetic Material
KR20120081972A (ko) 2009-07-02 2012-07-20 아이티에이치 임뮨 세라피 홀딩스 에이비 엑소좀에 기초한 암의 치료
PT2769737T (pt) 2009-07-20 2017-06-29 Bristol Myers Squibb Co Combinação de um anticorpo anti-ctla4 com etopósido para o tratamento sinérgico de doenças proliferativas
US8889394B2 (en) 2009-09-07 2014-11-18 Empire Technology Development Llc Multiple domain proteins
US20130029339A1 (en) 2009-09-09 2013-01-31 The General Hospital Corporation Use of microvesicles in analyzing kras mutations
US8518405B2 (en) 2009-10-08 2013-08-27 The University Of North Carolina At Charlotte Tumor specific antibodies and uses therefor
WO2011127136A1 (en) * 2010-04-06 2011-10-13 University Of Chicago Composition and methods related to modification of 5-hydroxymethylcytosine (5-hmc)
WO2011149046A1 (ja) 2010-05-28 2011-12-01 独立行政法人国立がん研究センター 膵癌治療剤
AU2011278931A1 (en) 2010-07-16 2013-03-07 Epeius Biotechnologies Corporation Targeted nanoparticles for cancer and other disorders
CN102372773B (zh) 2010-08-11 2013-06-05 中国科学院生物物理研究所 人膀胱癌肿瘤标志物及其抗体和应用
US20120107317A1 (en) 2010-10-27 2012-05-03 The University Of Hong Kong Use of cytoplasmic c-myc for regulating immune responses
WO2012087241A1 (en) 2010-12-20 2012-06-28 Agency For Science, Technology And Research Method of purifying exosomes
WO2012112315A2 (en) 2011-02-20 2012-08-23 The Board Of Trustees Of The Leland Stanford Junior University Methods for diagnosis of kawasaki disease
ITRM20110403A1 (it) 2011-07-28 2013-01-29 Ospedale Pediatrico Bambino Gesu Microvescicole isolate da cellule mesenchimali come agenti immunosoppressori.
GB201121069D0 (en) 2011-12-07 2012-01-18 Isis Innovation Delivery system
RU2664698C2 (ru) 2011-12-13 2018-08-21 Энджинеик Молекьюлар Деливери Пти Лтд Полученные из бактерий интактные мини-клетки для доставки лекарственных средств к опухолям мозга
AU2013229764A1 (en) 2012-03-09 2014-09-25 Massachusetts Institute Of Technology Adhesion signatures
US20130247924A1 (en) 2012-03-23 2013-09-26 Mark Scatterday Electronic cigarette having a flexible and soft configuration
ES3039913T3 (en) 2012-05-09 2025-10-27 Gradalis Inc Bi-functional short-hairpin rna (bi-shrna) specific for single-nucleotide kras mutations
US20150125950A1 (en) 2012-05-18 2015-05-07 Agency For Science, Technology And Research (A*Sta (A*Star) Umbilical cord mesenchymal stem cell exosomes
EP2687219A1 (en) 2012-07-18 2014-01-22 Universität Duisburg-Essen Use of preparations comprising exosomes derived from mesenchymal stem cells (MSCs) in the prevention and therapy of inflammatory conditions
US20150176073A1 (en) 2012-07-18 2015-06-25 Exosome Diagnostics, Inc. Use of microvesicles in diagnosis, prognosis, and treatment of medical diseases and conditions
AU2013315543A1 (en) 2012-09-14 2015-04-09 Dicerna Pharmaceuticals, Inc. Methods and compostions for the specific inhibition of MYC by double-stranded RNA
CN105051192B (zh) 2012-11-13 2020-04-17 科迪艾克生物科学公司 治疗剂的递送
CA2877847A1 (en) 2012-11-29 2014-06-05 Yeda Research And Development Co. Ltd. Methods of preventing tumor metastasis, treating and prognosing cancer and identifying agents which are putative metastasis inhibitors
AU2014218667A1 (en) 2013-02-22 2015-10-08 The Board Of Trustees Of The Leland Stanford Junior University Compounds, compositions, methods, and kits relating to telomere extension
US10150800B2 (en) 2013-03-15 2018-12-11 Zyngenia, Inc. EGFR-binding modular recognition domains
BR112015023275B1 (pt) 2013-03-15 2022-06-21 Board Of Regents, The University Of Texas System Método in vitro de detecção de biomarcador de câncer
EP2801370A1 (en) 2013-05-07 2014-11-12 Fundació Privada Institut d'Investigació Oncològica de Vall Hebron Methods and compositions for the treatment of cancer
US10545133B2 (en) 2013-05-13 2020-01-28 The Johns Hopkins University Molecular signatures of invasive cancer subpopulations
JP2015001694A (ja) 2013-06-18 2015-01-05 株式会社リコー 現像装置、プロセスカートリッジ、及び画像形成装置
WO2015002956A1 (en) 2013-07-01 2015-01-08 Ohio State Innovation Foundation Exosome delivery system
AU2014296887A1 (en) 2013-08-02 2016-01-28 Aduro Biotech Holdings, Europe B.V. Combining CD27 agonists and immune checkpoint inhibition for immune stimulation
GB201317887D0 (en) 2013-10-09 2013-11-20 Reneuron Ltd Product
US9458169B2 (en) 2013-11-01 2016-10-04 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
CN106459995B (zh) 2013-11-07 2020-02-21 爱迪塔斯医药有限公司 使用统治型gRNA的CRISPR相关方法和组合物
CA2930665A1 (en) 2013-11-18 2015-05-21 Rubius Therapeutics, Inc. Synthetic membrane-receiver complexes
US9921223B2 (en) * 2013-12-04 2018-03-20 Board Of Regents, The University Of Texas System Analysis of genomic DNA, RNA, and proteins in exosomes for diagnosis and theranosis
EP3470089A1 (en) 2013-12-12 2019-04-17 The Broad Institute Inc. Delivery, use and therapeutic applications of the crispr-cas systems and compositions for targeting disorders and diseases using particle delivery components
US20160324986A1 (en) 2013-12-27 2016-11-10 Teloregen, Inc. Compositions and methods for providing active telomerase to cells in vivo
US9745614B2 (en) 2014-02-28 2017-08-29 Nugen Technologies, Inc. Reduced representation bisulfite sequencing with diversity adaptors
EP3125907A4 (en) * 2014-04-01 2017-11-29 Cornell University Use of double-stranded dna in exosomes: a novel biomarker in cancer detection
US9895312B2 (en) 2014-04-08 2018-02-20 Pablo E. Vivas-Mejia Nanoliposomal c-MYC-siRNA inhibits in vivo tumor growth of cisplatin-resistant ovarian cancer
US10513710B2 (en) 2014-04-18 2019-12-24 University Of Massachusetts Exosomal loading using hydrophobically modified oligonucleotides
EP3134546A4 (en) 2014-04-24 2017-12-06 Dana-Farber Cancer Institute, Inc. Tumor suppressor and oncogene biomarkers predictive of anti-immune checkpoint inhibitor response
DK3145493T3 (da) 2014-05-18 2022-10-31 Childrens Medical Center Fremgangsmåder og sammensætninger vedrørende exosomer
EP3158056B1 (en) 2014-06-20 2021-10-06 Rutgers, the State University of New Jersey Single cell-derived organoids
GB201413357D0 (en) 2014-07-28 2014-09-10 Philogen Spa Antibodies for treatment and diagnosis
KR20230128139A (ko) 2014-10-24 2023-09-01 아스트라제네카 아베 조합물
BR112017008959A2 (pt) 2014-10-29 2018-01-16 Seattle Genetics, Inc. método para tratamento de uma doença.
GB201421094D0 (en) 2014-11-27 2015-01-14 Koninklijke Nederlandse Akademie Van Wetenschappen Culture medium
US10697965B2 (en) * 2015-03-02 2020-06-30 INSERM (INSITUT NATIONAL de la SANTE ET de la RECHERCHE MEDICALE) Method for treating and prognosing cancer
WO2016145030A1 (en) 2015-03-11 2016-09-15 Providence Health & Services-Oregon Compositions and methods for enhancing the efficacy of cancer therapy
EP3736287A1 (en) 2015-05-11 2020-11-11 The Johns Hopkins University Autoimmune antibodies for use in inhibiting cancer cell growth
US20180135012A1 (en) 2015-05-13 2018-05-17 Rubius Therapeutics, Inc. Membrane-receiver complex therapeutics
WO2016185481A2 (en) 2015-05-20 2016-11-24 Yeda Research And Development Co. Ltd. Method of targeting senescent cells
WO2016187717A1 (en) 2015-05-26 2016-12-01 Exerkine Corporation Exosomes useful for genome editing
EP3307890A1 (en) 2015-06-10 2018-04-18 Board of Regents, The University of Texas System Use of exosomes for the treatment of disease
WO2016208673A1 (ja) 2015-06-25 2016-12-29 学校法人早稲田大学 コラーゲン様構造を有する重合ペプチド及びゲル
HRP20230865T1 (hr) 2015-07-31 2023-11-10 Exotropin, Llc Kompozicije egzosoma i postupci za njihovu pripremu i primjenu za reguliranje i kondicioniranje kože i kose
RU2018105118A (ru) 2015-08-21 2019-09-23 Пфайзер Инк. Терапевтические наночастицы, содержащие терапевтический агент, и способы их получения и применения
WO2017040686A1 (en) 2015-09-01 2017-03-09 University Of Miami Identification of circulating cancer associated fibroblasts
US10508143B1 (en) 2015-10-30 2019-12-17 Aleta Biotherapeutics Inc. Compositions and methods for treatment of cancer
US20170119682A1 (en) 2015-11-02 2017-05-04 Tigenix, S.A.U. Mesenchymal stem cell-derived exosomes and their uses
US20170121685A1 (en) 2015-11-02 2017-05-04 Tigenix S.A.U. Mesenchymal stem cell-derived exosomes and their uses
EP3371211B1 (en) 2015-11-04 2025-01-01 Icahn School of Medicine at Mount Sinai Rho-associated protein kinase ("rock") inhibitor for treating tumors and cancer, and identifying candidate subjects for such treatment
BR112018008971A2 (pt) 2015-11-06 2018-11-27 Crispr Therapeutics Ag materiais e métodos para tratamento de doença de armazenamento de glicogênio tipo 1a
WO2017087560A1 (en) * 2015-11-16 2017-05-26 Progenity, Inc. Nucleic acids and methods for detecting methylation status
WO2017091702A1 (en) 2015-11-25 2017-06-01 The Methodist Hospital System Telomere extension and anti-inflammatory agents for cell regeneration
EP4212166A1 (en) 2015-12-03 2023-07-19 Juno Therapeutics, Inc. Compositions and methods for reducing immune responses against cell therapies
JP2017120263A (ja) 2015-12-25 2017-07-06 株式会社特殊免疫研究所 腫瘍由来の微小胞マーカーによる薬物感受性予測方法
EP3397264A4 (en) 2015-12-30 2019-06-05 The Regents of The University of California METHOD FOR IMPROVED PREPARATION AND INSULATION OF CELL-DERIVED VESICLES
WO2017139694A1 (en) 2016-02-12 2017-08-17 Nantomics, Llc High-throughput identification of patient-specific neoepitopes as therapeutic targets for cancer immunotherapies
KR20180118175A (ko) 2016-03-04 2018-10-30 노파르티스 아게 다중 키메라 항원 수용체 (car) 분자를 발현하는 세포 및 그에 따른 용도
CA3017586A1 (en) 2016-03-15 2017-09-21 Codiak Biosciences, Inc. Therapeutic membrane vesicles
EP3440090B1 (en) 2016-04-06 2022-09-28 Ohio State Innovation Foundation Rna ligand-displaying exosomes for specific delivery of therapeutics to cell by rna nanotechnology
ES3002715T3 (en) * 2016-04-14 2025-03-07 Guardant Health Inc Methods for early detection of cancer
TWI910495B (zh) 2016-05-13 2026-01-01 美商再生元醫藥公司 藉由投予pd-1抑制劑治療皮膚癌之方法
JP2019519516A (ja) 2016-05-18 2019-07-11 モデルナティーエックス, インコーポレイテッド がんの治療のためのmRNA併用療法
EP3439666A4 (en) 2016-05-20 2019-12-11 The University of Chicago NANOPARTICLES FOR CHEMOTHERAPY, TARGETED THERAPY, PHOTODYNAMIC THERAPY, IMMUNOTHERAPY AND ALL COMBINATIONS THEREOF
GB201609216D0 (en) 2016-05-25 2016-07-06 Evox Therapeutics And Isis Innovation Ltd Exosomes comprising therapeutic polypeptides
KR20190039115A (ko) 2016-07-05 2019-04-10 더 존스 홉킨스 유니버시티 암을 치료하기 위한 crispr/cas9-기반 조성물 및 방법
TWI601741B (zh) 2016-07-11 2017-10-11 財團法人國家衛生研究院 利用前列腺素受體ep4-拮抗劑誘導幹細胞製造含有高囊泡含物之外泌體囊泡的方法及其應用
SG11201900344YA (en) 2016-07-15 2019-02-27 Novartis Ag Treatment and prevention of cytokine release syndrome using a chimeric antigen receptor in combination with a kinase inhibitor
US20190226031A1 (en) * 2016-09-02 2019-07-25 Fujifilm Wako Pure Chemical Corporation Method for amplifying methylated dna, method for determining methylation of dna, and method for determining cancer
JP2019534041A (ja) 2016-10-06 2019-11-28 トランスジェネックス ナノバイオテック、インコーポレイテッド がん幹細胞(csc)増大のための方法
JP2018059865A (ja) 2016-10-07 2018-04-12 株式会社特殊免疫研究所 微小胞マーカーによる抗cd20抗体医薬品に対する薬物感受性の予測方法
AU2018239339A1 (en) 2017-03-23 2019-10-03 Penn State Research Foundation Method for diagnosing or monitoring conditions characterized by abnormal temporal variations method of normalizing epigenetic data to compensate for temporal variations
CN107034188B (zh) 2017-05-24 2018-07-24 中山大学附属口腔医院 一种靶向骨的外泌体载体、CRISPR/Cas9基因编辑系统及应用
GB202209539D0 (en) 2017-06-13 2022-08-10 Bostongene Corp Systems and methods for identifying cancer treatments from normalized biomarker scores
JP2020527340A (ja) 2017-06-30 2020-09-10 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア セルフリーdna中のdnaメチル化を評価するための方法およびシステム
US20210369858A1 (en) 2017-08-16 2021-12-02 Board Of Regents, The University Of Texas System Use of exosomes for targeted delivery of therapeutic agents
JP2021503077A (ja) 2017-11-09 2021-02-04 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 細胞外小胞タンパク質、ならびに癌診断、療法に対する応答予測、および治療をするためのそれらの使用
CN111527199A (zh) 2017-11-16 2020-08-11 得克萨斯大学体系董事会 用于制备来源于msc的外泌体的方法
AU2018386215B2 (en) 2017-12-15 2024-11-28 Board Of Regents, The University Of Texas System Methods and compositions for treating cancer using exosomes-associated gene editing
CN111655271B (zh) 2017-12-28 2025-09-23 隆萨销售股份公司 用于免疫肿瘤学和抗炎疗法的外来体
US11512315B2 (en) 2018-02-12 2022-11-29 Codiak Biosciences, Inc. Methods and compositions for macrophage polarization
CA3093856A1 (en) 2018-03-12 2019-09-19 Board Of Regents, The University Of Texas System Immuno-exosomes and methods of use thereof
AU2019243179B2 (en) 2018-03-28 2025-09-18 Board Of Regents, The University Of Texas System Use of exosomes for targeted delivery of therapeutic agents
EP3775258A4 (en) 2018-03-28 2022-01-26 Board of Regents, The University of Texas System IDENTIFICATION OF EPIGENETIC ALTERATIONS IN DNA ISOLATED FROM EXOSOMES
WO2019199803A1 (en) 2018-04-09 2019-10-17 Board Of Regents, The University Of Texas System Therapeutic targeting of oncogenes using exosomes
US20210115449A1 (en) 2018-04-19 2021-04-22 Board Of Regents, The University Of Texas System Therapeutic modulation of tumor suppressors using exosomes
JP2022505032A (ja) 2018-10-16 2022-01-14 ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム 腫瘍オルガノイドを産生するための組成物および腫瘍オルガノイドを産生する方法
CN113507935A (zh) 2018-10-16 2021-10-15 得克萨斯州大学系统董事会 用于诊断和治疗癌症及其他疾病的对致病性胞外基质的鉴定和靶向
US20200123258A1 (en) 2018-10-23 2020-04-23 Board Of Regents, The University Of Texas System Targeting b cells to enhance response to immune checkpoint blockade
EP3890802A4 (en) 2018-12-08 2023-03-22 Board of Regents, The University of Texas System IDENTIFICATION AND TARGETING OF TUMOR-FOMOTING CARCINOMA ASSOCIATED WITH FIBROBLAST FOR DIAGNOSIS AND TREATMENT OF CANCER AND OTHER DISEASES
US20220136011A1 (en) 2019-02-08 2022-05-05 Board Of Regents, The University Of Texas System Telomerase-containing exosomes for treatment of diseases associated with aging and age-related organ dysfunction
EP3921325A4 (en) 2019-02-08 2022-11-23 Board of Regents, The University of Texas System ISOLATION AND DETECTION OF AN EXOSOME-ASSOCIATED MICROBIOME FOR DIAGNOSTIC AND THERAPEUTIC PURPOSES
CN114641310A (zh) 2019-06-21 2022-06-17 德克萨斯大学系统董事会 治疗癌症和其他疾病的靶向α3β1整合素
KR20220124170A (ko) 2019-12-05 2022-09-13 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 간 섬유증 및 섬유증 관련 기타 질환에 대한 엑소좀 기반 치료요법
WO2021158966A1 (en) 2020-02-05 2021-08-12 Board Of Regents, The University Of Texas System Diagnostic and prognostic utility of exosomes in immunotherapy
US20230372468A1 (en) 2020-03-23 2023-11-23 Board Of Regents, The University Of Texas System Compositions and methods for targeting coronavirus using lipid vesicles including exosomes
WO2022032238A1 (en) 2020-08-07 2022-02-10 Board Of Regents, The University Of Texas System Methods and compositions for pancreatic cancer evaluation and treatment

Similar Documents

Publication Publication Date Title
JP2021519079A5 (https=)
ES2650610T3 (es) Perfiles de expresión génica para predecir desenlaces en cáncer de mama
Rekker et al. Circulating miR-200–family micro-RNAs have altered plasma levels in patients with endometriosis and vary with blood collection time
EP3208614B1 (en) Composition for diagnosing pancreatic cancer and method for diagnosing pancreatic cancer by using same
EP3967767A1 (en) Microrna marker combination for diagnosing gastric cancer and diagnostic kit
WO2017215230A1 (zh) 一组胃癌基因的应用
Yun et al. Exosomal miR-181b-5p downregulation in ascites serves as a potential diagnostic biomarker for gastric cancer-associated malignant ascites
JP7182317B2 (ja) 婦人科新生物の診断方法
US20120178093A1 (en) Methods of assessing a risk of cancer progression
WO2017073862A1 (ko) 두경부암 예후 예측용 바이오마커 마이크로 rna
CN115820860B (zh) 基于增强子甲基化差异的非小细胞肺癌标志物筛选方法及其标志物和应用
JP2022519326A5 (https=)
Wang et al. The joint detection of CEA and ctDNA in cerebrospinal fluid: an auxiliary tool for the diagnosis of leptomeningeal metastases in cancer
Ke et al. Identification of core genes shared by endometrial cancer and ovarian cancer using an integrated approach
Khailany et al. Genetic biomarkers: Potential roles in cancer diagnosis
KR102327080B1 (ko) 암 진단용 바이오마커 및 이의 용도
US20230212688A1 (en) Methods for identifying a medical condition in a human subject
JP7392224B2 (ja) びまん性肺胞傷害型薬剤性間質性肺炎のmiRNA診断バイオマーカー
ITMI20091538A1 (it) Profili di espressione di micro-rna nel sangue periferico di pazienti affetti da epatocarcinoma o cirrosi epatica e loro usi
Porcel-Pastrana et al. miR-191–5p: A tumour suppressor miRNA and a personalized biomarker and potential therapeutic tool connecting prostate cancer and obesity
Rokhzadi et al. Advancements in Emerging Molecular Approaches: Promising Diagnostic and Therapies Methods for Triple-Negative Breast Cancer (TNBC) Treatment
CN111662985B (zh) 一种microRNA联合CEA用于制备宫颈癌早期诊断试剂盒的用途
CN110331207A (zh) 肺腺癌生物标志物及相关应用
RU2851793C1 (ru) Способы идентификации медицинского состояния у субъекта-человека
CN111733236A (zh) 胆管癌和胆囊癌的piRNA标记物及其应用