JP2021513330A5 - - Google Patents

Info

Publication number
JP2021513330A5
JP2021513330A5 JP2020541883A JP2020541883A JP2021513330A5 JP 2021513330 A5 JP2021513330 A5 JP 2021513330A5 JP 2020541883 A JP2020541883 A JP 2020541883A JP 2020541883 A JP2020541883 A JP 2020541883A JP 2021513330 A5 JP2021513330 A5 JP 2021513330A5
Authority
JP
Japan
Prior art keywords
nucleic acid
acid molecule
seq
human insulin
insulin analog
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2020541883A
Other languages
English (en)
Japanese (ja)
Other versions
JP2021513330A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/CN2019/074384 external-priority patent/WO2019154311A1/zh
Publication of JP2021513330A publication Critical patent/JP2021513330A/ja
Publication of JP2021513330A5 publication Critical patent/JP2021513330A5/ja
Withdrawn legal-status Critical Current

Links

JP2020541883A 2018-02-09 2019-02-01 ヒトインスリンアナログのコドン最適化前駆体遺伝子およびシグナルペプチド遺伝子 Withdrawn JP2021513330A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201810131794 2018-02-09
CN201810131794.3 2018-02-09
PCT/CN2019/074384 WO2019154311A1 (zh) 2018-02-09 2019-02-01 一种密码子优化的人胰岛素类似物前体基因和信号肽基因

Publications (2)

Publication Number Publication Date
JP2021513330A JP2021513330A (ja) 2021-05-27
JP2021513330A5 true JP2021513330A5 (https=) 2022-02-07

Family

ID=67548783

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020541883A Withdrawn JP2021513330A (ja) 2018-02-09 2019-02-01 ヒトインスリンアナログのコドン最適化前駆体遺伝子およびシグナルペプチド遺伝子

Country Status (12)

Country Link
US (1) US20210032307A1 (https=)
EP (1) EP3750998A4 (https=)
JP (1) JP2021513330A (https=)
KR (1) KR20200119237A (https=)
CN (1) CN111094572B (https=)
AU (1) AU2019218315A1 (https=)
BR (1) BR112020015238A2 (https=)
CA (1) CA3086618A1 (https=)
MX (1) MX2020007929A (https=)
RU (1) RU2020128190A (https=)
TW (1) TW201934752A (https=)
WO (1) WO2019154311A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111560379B (zh) * 2020-05-26 2022-09-13 北京惠之衡生物科技有限公司 密码子优化的门冬胰岛素前体基因、重组载体、基因工程菌及其应用
CN116751817B (zh) * 2023-05-29 2024-07-09 广东东阳光药业股份有限公司 检测胰岛素或其类似物的生物学活性的方法及试剂盒
CN117384275B (zh) * 2023-12-13 2024-03-15 北京科为博生物科技有限公司 胰岛素样生长因子突变体igf1m及其应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1340772C (en) * 1987-12-30 1999-09-28 Patricia Tekamp-Olson Expression and secretion of heterologous protiens in yeast employing truncated alpha-factor leader sequences
EP1132404A3 (en) 1993-09-17 2002-03-27 Novo Nordisk A/S Acylated insulin
US5639642A (en) * 1994-06-16 1997-06-17 Novo Nordisk A/S Synthetic leader peptide sequences
ES2258797T3 (es) * 1996-12-20 2006-09-01 Novo Nordisk A/S Proteinas con extension n-terminal expresadas en la levadura.
CN1302333A (zh) * 1998-01-23 2001-07-04 诺沃挪第克公司 在酵母中制备目的多肽的方法
AR025646A1 (es) * 2000-09-13 2002-12-04 Beta Lab Sa Cepa de levaduras metilotroficas recombinantes productoras de un precursor de insulina, construcciones de adn y metodo para obtener la cepa.
PL1633876T3 (pl) * 2003-06-17 2009-01-30 Sembiosys Genetics Inc Sposoby wytwarzania insuliny w roślinach
CA2531988C (en) 2003-08-05 2016-06-28 Novo Nordisk A/S Novel insulin derivatives
CN1873006A (zh) * 2005-05-30 2006-12-06 上海新生源医药研究有限公司 一种重组人胰岛素原的生产方法
MY161552A (en) * 2009-03-12 2017-04-28 Bigtec Private Ltd A polynucleotide and polypeptide sequence and methods thereof
AR087433A1 (es) * 2011-08-08 2014-03-26 Merck Sharp & Dohme Analogos de insulina n-glicosilados
KR20140104994A (ko) * 2011-12-15 2014-08-29 샹하이 헨그루이 파마수티컬 컴퍼니 리미티드 인간 인슐린 유사체 및 이의 아실화 유도체
WO2018024186A1 (zh) 2016-08-02 2018-02-08 江苏恒瑞医药股份有限公司 一种人胰岛素或其类似物的酰化衍生物

Similar Documents

Publication Publication Date Title
CN103122027B (zh) 一种重组人源胶原蛋白及其生产方法
JP2019047804A5 (https=)
JP2021513330A5 (https=)
CN101809145B (zh) 具有nadh依赖性hmf还原酶活性的多肽
CN105112313B (zh) 马克思克鲁维酵母营养缺陷型菌株及无痕基因组改造方法
JP2010512160A5 (https=)
Lu et al. A jacalin-related lectin regulated the formation of aerial mycelium and fruiting body in Flammulina velutipes
CN102373230A (zh) 某种梭菌d-塔格糖3-差向异构酶的核苷酸序列及其应用
WO2016119756A1 (zh) 糖基转移酶突变蛋白及其应用
CN110590920A (zh) 一种l-丝氨酸转运蛋白及其应用
CN101845439A (zh) 家蚕培养细胞表达抗菌肽Cecropin B的方法
CN108884120A (zh) 用于通过使用微生物纯化3,6-脱水-l-半乳糖的新颖方法
CN101302517B (zh) 人白细胞介素7在真核宿主中表达的方法
CN103773746A (zh) 一种脂肪酶及其突变体
RU2020128190A (ru) Кодон-оптимизированный ген предшественника и ген сигнального пептида аналога человеческого инсулина
CN113249240A (zh) 一种高产羟基酪醇的酿酒酵母及其构建方法
CN109295067A (zh) 一种密码子优化的德谷胰岛素前体基因及其表达方法
CN112899177A (zh) 表达黑芥子酶tgg4的重组解脂耶氏酵母菌及其应用
JP2020513843A (ja) シトクロムp450の突然変異タンパク質およびその使用
CN108239632A (zh) 一种热稳定性得到改善的d-阿洛酮糖-3-差向异构酶的突变体及其应用
CN104419688B (zh) 一种果糖基转移酶及其基因、其分泌型表达载体和应用
CN110257347A (zh) 硫氧还蛋白突变体、其制备方法及其在重组融合蛋白生产中的应用
CN100460515C (zh) 一种改进的重叠延伸pcr方法及其所获得的突变基因
WO2002098455A3 (en) Production of recombinant human arylsulfatase a
CN114277024B (zh) 一种新型三萜合酶及其应用