RU2020128190A - Кодон-оптимизированный ген предшественника и ген сигнального пептида аналога человеческого инсулина - Google Patents
Кодон-оптимизированный ген предшественника и ген сигнального пептида аналога человеческого инсулина Download PDFInfo
- Publication number
- RU2020128190A RU2020128190A RU2020128190A RU2020128190A RU2020128190A RU 2020128190 A RU2020128190 A RU 2020128190A RU 2020128190 A RU2020128190 A RU 2020128190A RU 2020128190 A RU2020128190 A RU 2020128190A RU 2020128190 A RU2020128190 A RU 2020128190A
- Authority
- RU
- Russia
- Prior art keywords
- nucleic acid
- acid molecule
- seq
- molecule encoding
- human insulin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
- C12R2001/84—Pichia
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810131794 | 2018-02-09 | ||
| CN201810131794.3 | 2018-02-09 | ||
| PCT/CN2019/074384 WO2019154311A1 (zh) | 2018-02-09 | 2019-02-01 | 一种密码子优化的人胰岛素类似物前体基因和信号肽基因 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2020128190A3 RU2020128190A3 (https=) | 2022-03-09 |
| RU2020128190A true RU2020128190A (ru) | 2022-03-09 |
Family
ID=67548783
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2020128190A RU2020128190A (ru) | 2018-02-09 | 2019-02-01 | Кодон-оптимизированный ген предшественника и ген сигнального пептида аналога человеческого инсулина |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20210032307A1 (https=) |
| EP (1) | EP3750998A4 (https=) |
| JP (1) | JP2021513330A (https=) |
| KR (1) | KR20200119237A (https=) |
| CN (1) | CN111094572B (https=) |
| AU (1) | AU2019218315A1 (https=) |
| BR (1) | BR112020015238A2 (https=) |
| CA (1) | CA3086618A1 (https=) |
| MX (1) | MX2020007929A (https=) |
| RU (1) | RU2020128190A (https=) |
| TW (1) | TW201934752A (https=) |
| WO (1) | WO2019154311A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111560379B (zh) * | 2020-05-26 | 2022-09-13 | 北京惠之衡生物科技有限公司 | 密码子优化的门冬胰岛素前体基因、重组载体、基因工程菌及其应用 |
| CN116751817B (zh) * | 2023-05-29 | 2024-07-09 | 广东东阳光药业股份有限公司 | 检测胰岛素或其类似物的生物学活性的方法及试剂盒 |
| CN117384275B (zh) * | 2023-12-13 | 2024-03-15 | 北京科为博生物科技有限公司 | 胰岛素样生长因子突变体igf1m及其应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1340772C (en) * | 1987-12-30 | 1999-09-28 | Patricia Tekamp-Olson | Expression and secretion of heterologous protiens in yeast employing truncated alpha-factor leader sequences |
| EP1132404A3 (en) | 1993-09-17 | 2002-03-27 | Novo Nordisk A/S | Acylated insulin |
| US5639642A (en) * | 1994-06-16 | 1997-06-17 | Novo Nordisk A/S | Synthetic leader peptide sequences |
| ES2258797T3 (es) * | 1996-12-20 | 2006-09-01 | Novo Nordisk A/S | Proteinas con extension n-terminal expresadas en la levadura. |
| CN1302333A (zh) * | 1998-01-23 | 2001-07-04 | 诺沃挪第克公司 | 在酵母中制备目的多肽的方法 |
| AR025646A1 (es) * | 2000-09-13 | 2002-12-04 | Beta Lab Sa | Cepa de levaduras metilotroficas recombinantes productoras de un precursor de insulina, construcciones de adn y metodo para obtener la cepa. |
| PL1633876T3 (pl) * | 2003-06-17 | 2009-01-30 | Sembiosys Genetics Inc | Sposoby wytwarzania insuliny w roślinach |
| CA2531988C (en) | 2003-08-05 | 2016-06-28 | Novo Nordisk A/S | Novel insulin derivatives |
| CN1873006A (zh) * | 2005-05-30 | 2006-12-06 | 上海新生源医药研究有限公司 | 一种重组人胰岛素原的生产方法 |
| MY161552A (en) * | 2009-03-12 | 2017-04-28 | Bigtec Private Ltd | A polynucleotide and polypeptide sequence and methods thereof |
| AR087433A1 (es) * | 2011-08-08 | 2014-03-26 | Merck Sharp & Dohme | Analogos de insulina n-glicosilados |
| KR20140104994A (ko) * | 2011-12-15 | 2014-08-29 | 샹하이 헨그루이 파마수티컬 컴퍼니 리미티드 | 인간 인슐린 유사체 및 이의 아실화 유도체 |
| WO2018024186A1 (zh) | 2016-08-02 | 2018-02-08 | 江苏恒瑞医药股份有限公司 | 一种人胰岛素或其类似物的酰化衍生物 |
-
2019
- 2019-02-01 CN CN201980004477.8A patent/CN111094572B/zh active Active
- 2019-02-01 JP JP2020541883A patent/JP2021513330A/ja not_active Withdrawn
- 2019-02-01 KR KR1020207020915A patent/KR20200119237A/ko not_active Withdrawn
- 2019-02-01 WO PCT/CN2019/074384 patent/WO2019154311A1/zh not_active Ceased
- 2019-02-01 MX MX2020007929A patent/MX2020007929A/es unknown
- 2019-02-01 CA CA3086618A patent/CA3086618A1/en active Pending
- 2019-02-01 TW TW108104187A patent/TW201934752A/zh unknown
- 2019-02-01 US US16/967,117 patent/US20210032307A1/en not_active Abandoned
- 2019-02-01 EP EP19751736.0A patent/EP3750998A4/en not_active Withdrawn
- 2019-02-01 RU RU2020128190A patent/RU2020128190A/ru unknown
- 2019-02-01 AU AU2019218315A patent/AU2019218315A1/en not_active Abandoned
- 2019-02-01 BR BR112020015238-2A patent/BR112020015238A2/pt not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2021513330A (ja) | 2021-05-27 |
| EP3750998A4 (en) | 2022-02-23 |
| RU2020128190A3 (https=) | 2022-03-09 |
| MX2020007929A (es) | 2020-10-01 |
| BR112020015238A2 (pt) | 2020-12-29 |
| CA3086618A1 (en) | 2019-08-15 |
| KR20200119237A (ko) | 2020-10-19 |
| TW201934752A (zh) | 2019-09-01 |
| AU2019218315A1 (en) | 2020-07-09 |
| CN111094572B (zh) | 2023-04-04 |
| US20210032307A1 (en) | 2021-02-04 |
| CN111094572A (zh) | 2020-05-01 |
| WO2019154311A1 (zh) | 2019-08-15 |
| EP3750998A1 (en) | 2020-12-16 |
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