JP2021510682A5 - - Google Patents

Info

Publication number

JP2021510682A5

JP2021510682A5 JP2020536519A JP2020536519A JP2021510682A5 JP 2021510682 A5 JP2021510682 A5 JP 2021510682A5 JP 2020536519 A JP2020536519 A JP 2020536519A JP 2020536519 A JP2020536519 A JP 2020536519A JP 2021510682 A5 JP2021510682 A5 JP 2021510682A5

Authority

JP

Japan

Prior art keywords

ketamine

composition

use according

dose

puffs

Prior art date

2018-09-28

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 239000000203 mixture Substances 0.000 claims 38
• YQEZLKZALYSWHR-UHFFFAOYSA-N Ketamine Chemical compound C=1C=CC=C(Cl)C=1C1(NC)CCCCC1=O YQEZLKZALYSWHR-UHFFFAOYSA-N 0.000 claims 33
• 229960003299 ketamine Drugs 0.000 claims 33
• 239000012458 free base Substances 0.000 claims 8
• 230000002685 pulmonary effect Effects 0.000 claims 8
• 239000000843 powder Substances 0.000 claims 7
• 150000003839 salts Chemical class 0.000 claims 6
• 238000009472 formulation Methods 0.000 claims 4
• 210000004072 lung Anatomy 0.000 claims 4
• 238000000034 method Methods 0.000 claims 4
• 239000008194 pharmaceutical composition Substances 0.000 claims 4
• 239000003795 chemical substances by application Substances 0.000 claims 3
• YQEZLKZALYSWHR-ZDUSSCGKSA-N (S)-ketamine Chemical compound C=1C=CC=C(Cl)C=1[C@@]1(NC)CCCCC1=O YQEZLKZALYSWHR-ZDUSSCGKSA-N 0.000 claims 2
• UPXRTVAIJMUAQR-UHFFFAOYSA-N 4-(9h-fluoren-9-ylmethoxycarbonylamino)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid Chemical compound C1C(C(O)=O)N(C(=O)OC(C)(C)C)CC1NC(=O)OCC1C2=CC=CC=C2C2=CC=CC=C21 UPXRTVAIJMUAQR-UHFFFAOYSA-N 0.000 claims 2
• QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical group N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims 2
• VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
• 239000000654 additive Substances 0.000 claims 2
• 239000002775 capsule Substances 0.000 claims 2
• 150000001720 carbohydrates Chemical class 0.000 claims 2
• 229960000450 esketamine Drugs 0.000 claims 2
• 229960004184 ketamine hydrochloride Drugs 0.000 claims 2
• 239000002245 particle Substances 0.000 claims 2
• 239000003381 stabilizer Substances 0.000 claims 2
• 208000020401 Depressive disease Diseases 0.000 claims 1
• 229940079593 drug Drugs 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1