JP2021510376A5 - - Google Patents
Info
- Publication number
- JP2021510376A5 JP2021510376A5 JP2020538691A JP2020538691A JP2021510376A5 JP 2021510376 A5 JP2021510376 A5 JP 2021510376A5 JP 2020538691 A JP2020538691 A JP 2020538691A JP 2020538691 A JP2020538691 A JP 2020538691A JP 2021510376 A5 JP2021510376 A5 JP 2021510376A5
- Authority
- JP
- Japan
- Prior art keywords
- unsubstituted
- cancer
- substituted
- pharmaceutically acceptable
- acceptable salt
- Prior art date
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023156385A JP2024001052A (ja) | 2018-01-10 | 2023-09-21 | ベンズアミド化合物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862615857P | 2018-01-10 | 2018-01-10 | |
| US62/615,857 | 2018-01-10 | ||
| PCT/US2019/012695 WO2019139899A1 (en) | 2018-01-10 | 2019-01-08 | Benzamide compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023156385A Division JP2024001052A (ja) | 2018-01-10 | 2023-09-21 | ベンズアミド化合物 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021510376A JP2021510376A (ja) | 2021-04-22 |
| JPWO2019139899A5 JPWO2019139899A5 (https=) | 2022-01-17 |
| JP2021510376A5 true JP2021510376A5 (https=) | 2022-01-17 |
| JP7355741B2 JP7355741B2 (ja) | 2023-10-03 |
Family
ID=67218673
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020538692A Pending JP2021510165A (ja) | 2018-01-10 | 2019-01-08 | ベンズアミド化合物 |
| JP2020538644A Pending JP2021510163A (ja) | 2018-01-10 | 2019-01-08 | ベンズアミド化合物 |
| JP2020538691A Active JP7355741B2 (ja) | 2018-01-10 | 2019-01-08 | ベンズアミド化合物 |
| JP2023156385A Pending JP2024001052A (ja) | 2018-01-10 | 2023-09-21 | ベンズアミド化合物 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020538692A Pending JP2021510165A (ja) | 2018-01-10 | 2019-01-08 | ベンズアミド化合物 |
| JP2020538644A Pending JP2021510163A (ja) | 2018-01-10 | 2019-01-08 | ベンズアミド化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023156385A Pending JP2024001052A (ja) | 2018-01-10 | 2023-09-21 | ベンズアミド化合物 |
Country Status (16)
| Country | Link |
|---|---|
| US (7) | USRE50643E1 (https=) |
| EP (4) | EP3737681A4 (https=) |
| JP (4) | JP2021510165A (https=) |
| KR (4) | KR20200108301A (https=) |
| CN (5) | CN111801320A (https=) |
| AR (4) | AR114998A1 (https=) |
| AU (4) | AU2019207608B2 (https=) |
| BR (3) | BR112020014151A2 (https=) |
| CA (3) | CA3087262A1 (https=) |
| ES (1) | ES3013457T3 (https=) |
| IL (4) | IL316472A (https=) |
| MX (4) | MX2020007392A (https=) |
| RU (2) | RU2020120928A (https=) |
| SG (3) | SG11202005784YA (https=) |
| TW (5) | TW201934550A (https=) |
| WO (4) | WO2019139899A1 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3565815B1 (en) | 2017-01-07 | 2024-03-13 | Fochon Pharmaceuticals, Ltd. | Compounds as bcl-2-selective apoptosis-inducing agents |
| HUE060310T2 (hu) | 2017-04-18 | 2023-02-28 | Shanghai Fochon Pharmaceutical Co Ltd | Apoptosis-indukáló szerek |
| EP3737681A4 (en) | 2018-01-10 | 2022-01-12 | Recurium IP Holdings, LLC | BENZAMIDE COMPOUNDS |
| WO2021007307A1 (en) * | 2019-07-10 | 2021-01-14 | Recurium Ip Holdings, Llc | Bcl-2 protein inhibitors |
| US20220273666A1 (en) * | 2019-07-10 | 2022-09-01 | Recurium Ip Holdings, Llc | Nanoparticle formulation of bcl-2 inhibitor |
| KR20220100992A (ko) | 2019-12-06 | 2022-07-18 | 록쏘 온콜로지, 인코포레이티드 | 브루톤 티로신 키나제 억제제의 투여 |
| AU2020407070A1 (en) * | 2019-12-20 | 2022-07-14 | Recurium Ip Holdings, Llc | Combinations |
| JP2023508324A (ja) * | 2019-12-20 | 2023-03-02 | リキュリウム アイピー ホールディングス リミテッド ライアビリティー カンパニー | 組み合わせ |
| MX2022007623A (es) * | 2019-12-20 | 2022-09-23 | Recurium Ip Holdings Llc | Combinaciones. |
| AU2020404995A1 (en) * | 2019-12-20 | 2022-07-14 | Recurium Ip Holdings, Llc | Combinations |
| KR20220143909A (ko) | 2020-02-21 | 2022-10-25 | 리커리엄 아이피 홀딩스, 엘엘씨 | 디플루오로메틸 요오도 화합물 및 방법 |
| MX2022010512A (es) * | 2020-04-28 | 2022-11-16 | Recurium Ip Holdings Llc | Inhibidores de proteína bcl-2. |
| CN115666574A (zh) * | 2020-05-07 | 2023-01-31 | 里科瑞尔姆Ip控股有限责任公司 | 组合 |
| CN116133661A (zh) * | 2020-05-19 | 2023-05-16 | 里科瑞尔姆Ip控股有限责任公司 | 淀粉样变性的治疗 |
| US20230250077A1 (en) * | 2020-07-10 | 2023-08-10 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Sulfonylbenzamide derivative and conjugate thereof, preparation method therefor and use thereof |
| JP2023545498A (ja) * | 2020-10-16 | 2023-10-30 | リキュリウム アイピー ホールディングス リミテッド ライアビリティー カンパニー | Bcl-2阻害剤と化学療法剤との組み合わせ |
| WO2022133446A1 (en) * | 2020-12-16 | 2022-06-23 | Recurium Ip Holdings, Llc | Combinations |
| CN113143930B (zh) * | 2021-04-08 | 2023-05-30 | 深圳湾实验室 | 化合物在制备SARS-Cov-2 E蛋白抑制剂中的用途 |
| CN113816889B (zh) * | 2021-10-11 | 2023-08-22 | 中国药科大学 | 一类4-磺酰亚胺-1H-吡咯类Mcl-1抑制剂及其抗肿瘤医药用途 |
Family Cites Families (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UY26942A1 (es) | 2000-09-20 | 2002-04-26 | Abbott Lab | N-acilsulfonamidas promotoras de la apoptosis |
| JP2003096461A (ja) | 2001-09-25 | 2003-04-03 | Fuji Photo Film Co Ltd | 液晶組成物およびそれを用いた液晶素子 |
| DE10217814A1 (de) | 2002-04-22 | 2003-11-13 | Ibfb Pharma Gmbh | Neue tricyclische Mercaptane, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| WO2005049593A2 (en) | 2003-11-13 | 2005-06-02 | Abbott Laboratories | N-acylsulfonamide apoptosis promoters |
| US7642260B2 (en) | 2003-11-13 | 2010-01-05 | Abbott Laboratories, Inc. | Apoptosis promoters |
| US7767684B2 (en) * | 2003-11-13 | 2010-08-03 | Abbott Laboratories | Apoptosis promoters |
| US8614318B2 (en) | 2003-11-13 | 2013-12-24 | Abbvie Inc. | Apoptosis promoters |
| WO2005079803A1 (en) | 2004-02-13 | 2005-09-01 | Pfizer Products, Inc. | Compounds for treatment of cardiovascular diseases |
| JP4628140B2 (ja) | 2005-03-03 | 2011-02-09 | 富士フイルム株式会社 | セルロースアシレートフィルム、偏光板および液晶表示装置 |
| US8624027B2 (en) | 2005-05-12 | 2014-01-07 | Abbvie Inc. | Combination therapy for treating cancer and diagnostic assays for use therein |
| EP1888550B1 (en) | 2005-05-12 | 2014-06-25 | AbbVie Bahamas Ltd. | Apoptosis promoters |
| US20100234364A1 (en) | 2006-07-14 | 2010-09-16 | Arindrajit Basak | Ccr2 inhibitors and methods of use thereof |
| CA2662320C (en) | 2006-09-05 | 2014-07-22 | Abbott Laboratories | Bcl inhibitors treating platelet excess |
| EP2061772A4 (en) | 2006-09-11 | 2011-06-29 | Curis Inc | MULTIFUNCTIONAL SMALL MOLECULES AS PROLIFERATION-ACTIVE ACTIVE SUBSTANCES |
| EP2094672B1 (en) | 2006-11-15 | 2013-05-29 | Genentech, Inc. | Arylsulfonamide compounds |
| WO2008064116A2 (en) | 2006-11-16 | 2008-05-29 | Abbott Laboratories | Method of preventing or treating organ, hematopoietic stem cell or bone marrow transplant rejection |
| RU2009125575A (ru) * | 2006-12-04 | 2011-01-20 | Эбботт Лэборетриз (Us) | Комплексные диагностические анализы для терапии рака |
| WO2009036051A1 (en) | 2007-09-10 | 2009-03-19 | Curis, Inc. | Bcl-2 inhibitors containing a zinc binding moiety |
| US20100160322A1 (en) | 2008-12-04 | 2010-06-24 | Abbott Laboratories | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| UA108193C2 (uk) | 2008-12-04 | 2015-04-10 | Апоптозіндукуючий засіб для лікування раку і імунних і аутоімунних захворювань | |
| US8557983B2 (en) | 2008-12-04 | 2013-10-15 | Abbvie Inc. | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| HUE029289T2 (en) | 2008-12-05 | 2017-02-28 | Abbvie Inc | Sulfonamide derivatives as Bcl-2 selective apoptosis inducers for the treatment of cancer and immune diseases |
| US8563735B2 (en) | 2008-12-05 | 2013-10-22 | Abbvie Inc. | Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases |
| CN102282128B (zh) | 2009-01-19 | 2015-06-17 | Abbvie公司 | 用于治疗癌症和免疫和自身免疫疾病的细胞程序死亡诱导药剂 |
| US9034875B2 (en) | 2009-05-26 | 2015-05-19 | Abbvie Inc. | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| US8546399B2 (en) | 2009-05-26 | 2013-10-01 | Abbvie Inc. | Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases |
| NZ595708A (en) | 2009-05-26 | 2014-03-28 | Abbvie Bahamas Ltd | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| TWI532484B (zh) | 2009-06-08 | 2016-05-11 | 艾伯維有限公司 | 包含凋亡促進劑之固態分散劑 |
| MX2011013797A (es) | 2009-06-18 | 2012-01-30 | Abbott Lab | Suspension de farmaco estable de nanoparticula. |
| WO2010148422A1 (en) | 2009-06-25 | 2010-12-29 | Walter And Eliza Hall Institute Of Medical Research | Compounds and methods for treating parasitic infestations |
| IN2012DN01325A (https=) | 2009-08-20 | 2015-06-05 | Karus Therapeutics Ltd | |
| CN101798292A (zh) | 2010-03-29 | 2010-08-11 | 无锡好芳德药业有限公司 | ABT-263衍生的新型Bcl-2蛋白抑制剂的制备 |
| TWI520960B (zh) | 2010-05-26 | 2016-02-11 | 艾伯維有限公司 | 用於治療癌症及免疫及自體免疫疾病之細胞凋亡誘導劑 |
| TWI535712B (zh) | 2010-08-06 | 2016-06-01 | 阿斯特捷利康公司 | 化合物 |
| CA3152557A1 (en) | 2010-10-29 | 2012-05-03 | Abbvie Inc. | Solid dispersions containing an apoptosis-inducing agent |
| UA113500C2 (xx) | 2010-10-29 | 2017-02-10 | Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб | |
| PH12013500954A1 (en) | 2010-11-11 | 2017-05-19 | Redx Pharma Plc | Drug derivatives |
| TWI620736B (zh) | 2010-11-23 | 2018-04-11 | 艾伯維巴哈馬有限公司 | 使用選擇性bcl-2抑制劑之治療方法 |
| SG192126A1 (en) | 2011-01-25 | 2013-09-30 | Univ Michigan | Bcl-2/bcl-xl inhibitors and therapeutic methods using the same |
| FR2986002B1 (fr) | 2012-01-24 | 2014-02-21 | Servier Lab | Nouveaux derives d'indolizine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| WO2013185202A1 (en) | 2012-06-14 | 2013-12-19 | Beta Pharma Canada Inc | Apoptosis inducers |
| KR102318204B1 (ko) | 2013-01-16 | 2021-10-26 | 더 리젠츠 오브 더 유니버시티 오브 미시간 | Bcl-2bcl-xl 억제제 및 그를 사용하는 치료 방법 |
| UY39848A (es) | 2013-03-13 | 2022-09-30 | Abbvie Ireland Unlimited Co | Procesos para la preparación de un agente inductor de la apoptosis |
| US20140275082A1 (en) | 2013-03-14 | 2014-09-18 | Abbvie Inc. | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| CA2907960C (en) | 2013-05-22 | 2021-10-19 | Children's Hospital Medical Center | Combination therapy for mds |
| US10364250B2 (en) | 2013-05-24 | 2019-07-30 | Mark Barry HAMPTON | Bioactive compounds |
| JP6730183B2 (ja) | 2013-07-12 | 2020-07-29 | ヘルムホルツ−ツェントルム フュア インフェクツィオンスフォルシュンク ゲーエムベーハー | シストバクトアミド(Cystobactamides) |
| WO2015085238A1 (en) | 2013-12-05 | 2015-06-11 | The Regents Of The University Of California, A California Corporation | Inhibitors of lpxc |
| CN105012318B (zh) | 2014-04-17 | 2020-02-11 | 沈华浩 | 磺酰胺类化合物在气道慢性炎症性疾病中的应用 |
| CN104131034B (zh) | 2014-06-19 | 2017-04-05 | 中山大学 | 一种嵌合载体及其制备方法和应用 |
| WO2016025652A1 (en) | 2014-08-13 | 2016-02-18 | Celgene Avilomics Research, Inc. | Combinations of an erk inhibitor and a bcl-2 pathway modulator and related methods |
| CN106999451B (zh) * | 2014-09-17 | 2021-04-02 | 里科瑞尔姆Ip控股有限责任公司 | 双环化合物 |
| UY36391A (es) * | 2014-11-05 | 2016-06-01 | Flexus Biosciences Inc | Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido1), sus métodos de síntesis y composiciones farmacèuticas que las contienen |
| US9694084B2 (en) | 2014-12-23 | 2017-07-04 | Dana-Farber Cancer Institute, Inc. | Methods to induce targeted protein degradation through bifunctional molecules |
| TW201639573A (zh) | 2015-02-03 | 2016-11-16 | 吉李德科學股份有限公司 | 有關治療癌症之合併治療 |
| CA2981753A1 (en) | 2015-02-06 | 2016-08-11 | Unity Biotechnology, Inc. | Compounds and uses in treatment of senescence-associated conditions |
| WO2016131100A1 (en) | 2015-02-18 | 2016-08-25 | The Walter And Eliza Hall Institute Of Medical Research | Methods of treating infectious diseases |
| EP3285775B1 (en) * | 2015-04-20 | 2020-04-15 | Mayo Foundation for Medical Education and Research | Methods and materials for killing hiv infected cells |
| PT3302549T (pt) | 2015-05-26 | 2019-09-09 | H Hoffnabb La Roche Ag | Terapêutica combinada de um anticorpo anti-cd20 com um inibidor de bcl-2 e um inibidor de mdm2 |
| GB201513481D0 (en) | 2015-07-30 | 2015-09-16 | Univ Manchester | Inhibitor compounds |
| US10683308B2 (en) | 2015-09-11 | 2020-06-16 | Navitor Pharmaceuticals, Inc. | Rapamycin analogs and uses thereof |
| CN106608895A (zh) | 2015-10-21 | 2017-05-03 | 苏州国匡医药科技有限公司 | 一类具有糖环结构的bcl-2选择性抑制剂及其用途 |
| US11111259B2 (en) | 2015-12-18 | 2021-09-07 | Unity Biotechnology, Inc. | Acylsulfonamide derivatives for treating senescence-associated diseases and disorders |
| CN106957315B (zh) | 2016-01-08 | 2019-08-13 | 中国人民解放军第二军医大学 | N-取代苯磺酰基-氮杂吲哚氧基苯甲酰胺类化合物及其制备药物的用途 |
| WO2017123616A1 (en) | 2016-01-11 | 2017-07-20 | Merrimack Pharmaceuticals, Inc. | Inhibiting b-cell lymphoma 2 (bcl-2) and related proteins |
| WO2017132474A1 (en) | 2016-01-30 | 2017-08-03 | Newave Pharmaceutical Inc. | Bcl-2 inhibitors |
| JP6936498B2 (ja) | 2016-04-21 | 2021-09-15 | バイオベンチャーズ・リミテッド・ライアビリティ・カンパニーBioVentures, LLC | 抗アポトーシス性Bcl−2ファミリータンパク質の分解を誘導する化合物及びその使用 |
| CA3026651A1 (en) | 2016-06-09 | 2017-12-14 | Blinkbio, Inc. | Silanol based therapeutic payloads |
| EP3318276A1 (en) * | 2016-11-04 | 2018-05-09 | Janssen Biotech, Inc. | Combinations of a telomerase inhibitor and a bcl-2 inhibitor for the treatment of hematological cancers |
| CN106565607B (zh) | 2016-10-11 | 2019-03-26 | 湖北泓肽生物科技有限公司 | 一种l-肌肽的合成方法 |
| CN106565706B (zh) | 2016-10-27 | 2018-05-01 | 广东东阳光药业有限公司 | 一种磺酰胺衍生物及其在药学中的应用 |
| CN106749233B (zh) | 2016-11-24 | 2020-04-21 | 中山大学 | 一类磺酰胺衍生物及其应用 |
| EP3565815B1 (en) | 2017-01-07 | 2024-03-13 | Fochon Pharmaceuticals, Ltd. | Compounds as bcl-2-selective apoptosis-inducing agents |
| WO2018146506A1 (en) | 2017-02-10 | 2018-08-16 | Universitat Politècnica De València | Therapeutic derivatives |
| CN107089981A (zh) | 2017-04-24 | 2017-08-25 | 杭州科耀医药科技有限公司 | 一种BCL‑2抑制剂Venetoclax的合成方法 |
| EP3737681A4 (en) | 2018-01-10 | 2022-01-12 | Recurium IP Holdings, LLC | BENZAMIDE COMPOUNDS |
| SI3788042T1 (sl) | 2018-04-29 | 2025-06-30 | Beigene Switzerland Gmbh | Zaviralci BCL-2 |
| US12097194B2 (en) | 2018-09-18 | 2024-09-24 | Signalchem Lifesciences Corporation | Combination therapy for treating blood cancer |
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2019
- 2019-01-08 EP EP19738858.0A patent/EP3737681A4/en not_active Withdrawn
- 2019-01-08 JP JP2020538692A patent/JP2021510165A/ja active Pending
- 2019-01-08 IL IL316472A patent/IL316472A/en unknown
- 2019-01-08 JP JP2020538644A patent/JP2021510163A/ja active Pending
- 2019-01-08 US US18/212,692 patent/USRE50643E1/en active Active
- 2019-01-08 KR KR1020207022537A patent/KR20200108301A/ko not_active Withdrawn
- 2019-01-08 CN CN201980015896.1A patent/CN111801320A/zh active Pending
- 2019-01-08 CN CN201980015882.XA patent/CN111801327B/zh active Active
- 2019-01-08 JP JP2020538691A patent/JP7355741B2/ja active Active
- 2019-01-08 US US16/957,861 patent/US11318134B2/en not_active Ceased
- 2019-01-08 CA CA3087262A patent/CA3087262A1/en active Pending
- 2019-01-08 US US16/957,862 patent/US11344546B2/en active Active
- 2019-01-08 WO PCT/US2019/012695 patent/WO2019139899A1/en not_active Ceased
- 2019-01-08 MX MX2020007392A patent/MX2020007392A/es unknown
- 2019-01-08 SG SG11202005784YA patent/SG11202005784YA/en unknown
- 2019-01-08 KR KR1020247043033A patent/KR20250008139A/ko active Pending
- 2019-01-08 RU RU2020120928A patent/RU2020120928A/ru unknown
- 2019-01-08 EP EP25150549.1A patent/EP4556469A1/en not_active Withdrawn
- 2019-01-08 ES ES19738996T patent/ES3013457T3/es active Active
- 2019-01-08 US US16/957,865 patent/US11590126B2/en active Active
- 2019-01-08 RU RU2020120929A patent/RU2020120929A/ru unknown
- 2019-01-08 CN CN202410225032.5A patent/CN118084905A/zh active Pending
- 2019-01-08 EP EP19738922.4A patent/EP3737672A4/en not_active Withdrawn
- 2019-01-08 WO PCT/US2019/012719 patent/WO2019139907A1/en not_active Ceased
- 2019-01-08 MX MX2020007388A patent/MX2020007388A/es unknown
- 2019-01-08 WO PCT/US2019/012699 patent/WO2019139900A1/en not_active Ceased
- 2019-01-08 SG SG11202005785XA patent/SG11202005785XA/en unknown
- 2019-01-08 CN CN201980015923.5A patent/CN111788203A/zh active Pending
- 2019-01-08 BR BR112020014151-8A patent/BR112020014151A2/pt not_active Application Discontinuation
- 2019-01-08 BR BR112020014160-7A patent/BR112020014160A2/pt not_active Application Discontinuation
- 2019-01-08 AU AU2019207608A patent/AU2019207608B2/en active Active
- 2019-01-08 MX MX2020007014A patent/MX2020007014A/es unknown
- 2019-01-08 CN CN202410225030.6A patent/CN118084904A/zh active Pending
- 2019-01-08 BR BR112020014169-0A patent/BR112020014169A2/pt active IP Right Grant
- 2019-01-08 WO PCT/US2019/012704 patent/WO2019139902A1/en not_active Ceased
- 2019-01-08 AU AU2019207616A patent/AU2019207616A1/en not_active Abandoned
- 2019-01-08 IL IL275762A patent/IL275762B2/en unknown
- 2019-01-08 CA CA3087261A patent/CA3087261A1/en active Pending
- 2019-01-08 KR KR1020207022538A patent/KR102751751B1/ko active Active
- 2019-01-08 AU AU2019207611A patent/AU2019207611A1/en not_active Abandoned
- 2019-01-08 KR KR1020207022443A patent/KR20200108298A/ko not_active Withdrawn
- 2019-01-08 EP EP19738996.8A patent/EP3740487B1/en active Active
- 2019-01-08 CA CA3087263A patent/CA3087263A1/en active Pending
- 2019-01-08 SG SG11202005985PA patent/SG11202005985PA/en unknown
- 2019-01-10 AR ARP190100053A patent/AR114998A1/es unknown
- 2019-01-10 TW TW108101045A patent/TW201934550A/zh unknown
- 2019-01-10 AR ARP190100051A patent/AR114949A1/es not_active Application Discontinuation
- 2019-01-10 TW TW108101047A patent/TW201930317A/zh unknown
- 2019-01-10 TW TW113101066A patent/TW202417442A/zh unknown
- 2019-01-10 AR ARP190100050A patent/AR114948A1/es unknown
- 2019-01-10 TW TW108101046A patent/TW201934538A/zh unknown
- 2019-01-10 AR ARP190100052A patent/AR114950A1/es not_active Application Discontinuation
- 2019-01-10 TW TW108101048A patent/TWI829664B/zh active
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2020
- 2020-06-30 IL IL275761A patent/IL275761A/en unknown
- 2020-06-30 IL IL275763A patent/IL275763A/en unknown
- 2020-07-13 MX MX2023009185A patent/MX2023009185A/es unknown
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2022
- 2022-03-28 US US17/656,726 patent/US11813259B2/en active Active
-
2023
- 2023-05-26 US US18/202,622 patent/US11813260B1/en active Active
- 2023-09-20 US US18/471,017 patent/US20240180899A1/en not_active Abandoned
- 2023-09-21 JP JP2023156385A patent/JP2024001052A/ja active Pending
-
2024
- 2024-06-06 AU AU2024203833A patent/AU2024203833A1/en active Pending
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