JP2021500551A5 - - Google Patents
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- Publication number
- JP2021500551A5 JP2021500551A5 JP2020521964A JP2020521964A JP2021500551A5 JP 2021500551 A5 JP2021500551 A5 JP 2021500551A5 JP 2020521964 A JP2020521964 A JP 2020521964A JP 2020521964 A JP2020521964 A JP 2020521964A JP 2021500551 A5 JP2021500551 A5 JP 2021500551A5
- Authority
- JP
- Japan
- Prior art keywords
- sdma
- antibody
- solid matrix
- affinity
- capture reagent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- HVPFXCBJHIIJGS-LURJTMIESA-N N(omega),N'(omega)-dimethyl-L-arginine Chemical compound CN\C(=N/C)NCCC[C@H](N)C(O)=O HVPFXCBJHIIJGS-LURJTMIESA-N 0.000 claims 25
- 239000011159 matrix material Substances 0.000 claims 25
- 239000007787 solid Substances 0.000 claims 20
- 239000003153 chemical reaction reagent Substances 0.000 claims 17
- 239000000203 mixture Substances 0.000 claims 15
- 102000004169 proteins and genes Human genes 0.000 claims 13
- 108090000623 proteins and genes Proteins 0.000 claims 13
- 239000002245 particle Substances 0.000 claims 12
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims 11
- 150000001483 arginine derivatives Chemical class 0.000 claims 9
- 102100031126 6-phosphogluconolactonase Human genes 0.000 claims 8
- 108010029731 6-phosphogluconolactonase Proteins 0.000 claims 8
- 108010018962 Glucosephosphate Dehydrogenase Proteins 0.000 claims 8
- YDGMGEXADBMOMJ-LURJTMIESA-N N(g)-dimethylarginine Chemical compound CN(C)C(\N)=N\CCC[C@H](N)C(O)=O YDGMGEXADBMOMJ-LURJTMIESA-N 0.000 claims 8
- 238000000034 method Methods 0.000 claims 8
- 239000007790 solid phase Substances 0.000 claims 8
- 108091003079 Bovine Serum Albumin Proteins 0.000 claims 6
- NTWVQPHTOUKMDI-YFKPBYRVSA-N N-Methyl-arginine Chemical compound CN[C@H](C(O)=O)CCCN=C(N)N NTWVQPHTOUKMDI-YFKPBYRVSA-N 0.000 claims 6
- 229940098773 bovine serum albumin Drugs 0.000 claims 6
- 108010045069 keyhole-limpet hemocyanin Proteins 0.000 claims 6
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 claims 4
- 108010058846 Ovalbumin Proteins 0.000 claims 3
- 239000012491 analyte Substances 0.000 claims 3
- 229940092253 ovalbumin Drugs 0.000 claims 3
- 238000005406 washing Methods 0.000 claims 3
- 230000010933 acylation Effects 0.000 claims 2
- 238000005917 acylation reaction Methods 0.000 claims 2
- YDGMGEXADBMOMJ-UHFFFAOYSA-N asymmetrical dimethylarginine Natural products CN(C)C(N)=NCCCC(N)C(O)=O YDGMGEXADBMOMJ-UHFFFAOYSA-N 0.000 claims 2
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762574592P | 2017-10-19 | 2017-10-19 | |
| US62/574,592 | 2017-10-19 | ||
| US201762599117P | 2017-12-15 | 2017-12-15 | |
| US62/599,117 | 2017-12-15 | ||
| PCT/US2018/056687 WO2019079707A1 (en) | 2017-10-19 | 2018-10-19 | SYMMETRIC DIMETHYLARGININE DETECTION |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021500551A JP2021500551A (ja) | 2021-01-07 |
| JP2021500551A5 true JP2021500551A5 (https=) | 2021-11-25 |
| JP7398366B2 JP7398366B2 (ja) | 2023-12-14 |
Family
ID=66170983
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020521964A Active JP7398366B2 (ja) | 2017-10-19 | 2018-10-19 | 対称性ジメチルアルギニンの検出 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US11422136B2 (https=) |
| EP (1) | EP3697499A4 (https=) |
| JP (1) | JP7398366B2 (https=) |
| KR (2) | KR20250034534A (https=) |
| CN (1) | CN111246918B (https=) |
| AU (1) | AU2018351349B2 (https=) |
| CA (1) | CA3079011A1 (https=) |
| MX (1) | MX2020003523A (https=) |
| TW (1) | TWI831753B (https=) |
| WO (1) | WO2019079707A1 (https=) |
| ZA (1) | ZA202002415B (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2313364B1 (en) * | 2008-08-07 | 2020-09-02 | Idexx Laboratories, Inc. | Methods for detecting symmetrical demethylarginine |
| EP3259593B1 (en) | 2015-02-20 | 2022-10-05 | IDEXX Laboratories, Inc. | Homogenous immunoassay with compensation for background signal |
| MX2020003523A (es) * | 2017-10-19 | 2020-07-22 | Idexx Lab Inc | Deteccion de dimetilarginina simetrica. |
| US10745492B1 (en) | 2019-04-03 | 2020-08-18 | Ark Diagnostics, Inc. | Antibodies to symmetrically dimethylated arginine analytes and use thereof |
| CA3152793A1 (en) | 2019-09-05 | 2021-03-11 | The Regents Of The University Of California | Noninvasive method to quantify kidney function and functional decline |
| CN113125697B (zh) * | 2019-12-31 | 2024-03-26 | 科美博阳诊断技术(上海)有限公司 | 一种睾酮均相化学发光检测试剂盒及其应用 |
| MX2022012840A (es) * | 2020-04-17 | 2022-11-07 | Idexx Lab Inc | Inmunoensayo de desactivacion de fluorescencia. |
| EP4263383A4 (en) | 2020-12-17 | 2024-10-23 | Nephrosant, Inc. | KITS FOR STABILIZATION OF URINE SAMPLES |
| WO2025070448A1 (ja) * | 2023-09-26 | 2025-04-03 | 富士フイルム株式会社 | 対称性ジメチルアルギニンを測定するためのキットおよび対称性ジメチルアルギニンの測定方法 |
| WO2025205769A1 (ja) * | 2024-03-26 | 2025-10-02 | 富士フイルム株式会社 | α－アミラーゼと対称性ジメチルアルギニンとのコンジュゲート、およびその応用 |
| KR102929013B1 (ko) | 2025-07-25 | 2026-02-25 | 주식회사 아리젠 | 대칭성 디메틸아르기닌에 특이적으로 결합하는 항체 및 이의 용도 |
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| DE3134787A1 (de) | 1981-09-02 | 1983-03-10 | Boehringer Mannheim Gmbh, 6800 Mannheim | Creatinin-antikoerper |
| IT1199088B (it) * | 1984-03-09 | 1988-12-30 | Miles Italiana | Saggio di legame specifico mediante impiego di anti-g6pdh come marcante |
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| US6699673B2 (en) | 1999-12-22 | 2004-03-02 | The Research Foundation Of State University Of New York | Protein methylarginine-specific antibodies |
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| JP2004279412A (ja) * | 2003-02-24 | 2004-10-07 | Sanwa Kagaku Kenkyusho Co Ltd | 低分子化合物の免疫学的測定・検出方法 |
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| CN1786713A (zh) * | 2004-12-09 | 2006-06-14 | 陈金华 | 酶标仪在胶乳增强免疫透射比浊法中的应用 |
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| JP2007176872A (ja) | 2005-12-28 | 2007-07-12 | Sentan Seimei Kagaku Kenkyusho:Kk | アシンメトリックジメチルアルギニンを認識する抗体及びその製造方法並びに翻訳後修飾アミノ酸含有タンパク質の検出方法 |
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| EP2313364B1 (en) * | 2008-08-07 | 2020-09-02 | Idexx Laboratories, Inc. | Methods for detecting symmetrical demethylarginine |
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| EP3259593B1 (en) | 2015-02-20 | 2022-10-05 | IDEXX Laboratories, Inc. | Homogenous immunoassay with compensation for background signal |
| MX2020003523A (es) | 2017-10-19 | 2020-07-22 | Idexx Lab Inc | Deteccion de dimetilarginina simetrica. |
| CN108469419A (zh) * | 2018-03-09 | 2018-08-31 | 山东泰邦生物制品有限公司 | 采用酶标仪免疫透射比浊法高通量检测IgG含量的方法 |
-
2018
- 2018-10-19 MX MX2020003523A patent/MX2020003523A/es unknown
- 2018-10-19 EP EP18868800.6A patent/EP3697499A4/en active Pending
- 2018-10-19 JP JP2020521964A patent/JP7398366B2/ja active Active
- 2018-10-19 KR KR1020257007101A patent/KR20250034534A/ko active Pending
- 2018-10-19 WO PCT/US2018/056687 patent/WO2019079707A1/en not_active Ceased
- 2018-10-19 US US16/165,337 patent/US11422136B2/en active Active
- 2018-10-19 TW TW107136895A patent/TWI831753B/zh active
- 2018-10-19 AU AU2018351349A patent/AU2018351349B2/en active Active
- 2018-10-19 KR KR1020207013888A patent/KR102902843B1/ko active Active
- 2018-10-19 CN CN201880068370.5A patent/CN111246918B/zh active Active
- 2018-10-19 CA CA3079011A patent/CA3079011A1/en active Pending
-
2020
- 2020-05-04 ZA ZA2020/02415A patent/ZA202002415B/en unknown
-
2022
- 2022-07-29 US US17/877,410 patent/US20230102277A1/en active Pending
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