JP2021500354A5 - - Google Patents
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- Publication number
- JP2021500354A5 JP2021500354A5 JP2020522054A JP2020522054A JP2021500354A5 JP 2021500354 A5 JP2021500354 A5 JP 2021500354A5 JP 2020522054 A JP2020522054 A JP 2020522054A JP 2020522054 A JP2020522054 A JP 2020522054A JP 2021500354 A5 JP2021500354 A5 JP 2021500354A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- solvate
- salt
- enantiomer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- QJTVUTGFAJUZFW-UHFFFAOYSA-N CC(C)(C)OC(NC1C(OC(C(CC(C2OC(C(C3NC)O)OCC3(C)O)N)NC(OC(C)(C)C)=O)C2O)OC(CNC(OCc(cc2)ccc2[N+]([O-])=O)=O)CC1)=O Chemical compound CC(C)(C)OC(NC1C(OC(C(CC(C2OC(C(C3NC)O)OCC3(C)O)N)NC(OC(C)(C)C)=O)C2O)OC(CNC(OCc(cc2)ccc2[N+]([O-])=O)=O)CC1)=O QJTVUTGFAJUZFW-UHFFFAOYSA-N 0.000 description 3
- DJOTZABNEKMOOP-UHFFFAOYSA-N CC(C)(C)OC(NCCC(C(NC(CC(C(C1O)OC2OC(CNCCO)CCC2NC(OC(C)(C)C)=O)NC(OC(C)(C)C)=O)C1OC(C(C1N(C)C(OC(C)(C)C)=O)O)OCC1(C)O)=O)O)=O Chemical compound CC(C)(C)OC(NCCC(C(NC(CC(C(C1O)OC2OC(CNCCO)CCC2NC(OC(C)(C)C)=O)NC(OC(C)(C)C)=O)C1OC(C(C1N(C)C(OC(C)(C)C)=O)O)OCC1(C)O)=O)O)=O DJOTZABNEKMOOP-UHFFFAOYSA-N 0.000 description 1
- 0 CC(COC(C1O)OC(C(CC(C2OC3OC(CN)(C4)[C@@]4CC3N*)N*)N*)C2O)(C1NC)O Chemical compound CC(COC(C1O)OC(C(CC(C2OC3OC(CN)(C4)[C@@]4CC3N*)N*)N*)C2O)(C1NC)O 0.000 description 1
- IABOUOACXBRYTJ-UHFFFAOYSA-N CC(COC(C1O)OC(C(CC(C2OC3OC(CNC(OCc(cc4)ccc4[N+]([O-])=O)=O)CCC3N)N)N)C2O)(C1NC)O Chemical compound CC(COC(C1O)OC(C(CC(C2OC3OC(CNC(OCc(cc4)ccc4[N+]([O-])=O)=O)CCC3N)N)N)C2O)(C1NC)O IABOUOACXBRYTJ-UHFFFAOYSA-N 0.000 description 1
- GLWXTGFUBZBMLC-UHFFFAOYSA-N CC(COC(C1O)OC(C(CC(C2OC3OC(CNCCO)CCC3N)N)NC(C(CCN)O)=O)C2O)(C1NC)O Chemical compound CC(COC(C1O)OC(C(CC(C2OC3OC(CNCCO)CCC3N)N)NC(C(CCN)O)=O)C2O)(C1NC)O GLWXTGFUBZBMLC-UHFFFAOYSA-N 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023027439A JP2023054316A (ja) | 2017-10-19 | 2023-02-24 | 抗菌性アミノグリコシド類似体の合成 |
| JP2025015211A JP2025062009A (ja) | 2017-10-19 | 2025-01-31 | 抗菌性アミノグリコシド類似体の合成 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762574544P | 2017-10-19 | 2017-10-19 | |
| US62/574,544 | 2017-10-19 | ||
| PCT/US2018/056536 WO2019079613A1 (en) | 2017-10-19 | 2018-10-18 | SYNTHESIS OF ANTIBACTERIAL AMINOGLYCOSIDE ANALOGUES |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023027439A Division JP2023054316A (ja) | 2017-10-19 | 2023-02-24 | 抗菌性アミノグリコシド類似体の合成 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021500354A JP2021500354A (ja) | 2021-01-07 |
| JP2021500354A5 true JP2021500354A5 (https=) | 2021-11-18 |
| JP7235741B2 JP7235741B2 (ja) | 2023-03-08 |
Family
ID=64110232
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020522054A Active JP7235741B2 (ja) | 2017-10-19 | 2018-10-18 | 抗菌性アミノグリコシド類似体の合成 |
| JP2023027439A Withdrawn JP2023054316A (ja) | 2017-10-19 | 2023-02-24 | 抗菌性アミノグリコシド類似体の合成 |
| JP2025015211A Pending JP2025062009A (ja) | 2017-10-19 | 2025-01-31 | 抗菌性アミノグリコシド類似体の合成 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023027439A Withdrawn JP2023054316A (ja) | 2017-10-19 | 2023-02-24 | 抗菌性アミノグリコシド類似体の合成 |
| JP2025015211A Pending JP2025062009A (ja) | 2017-10-19 | 2025-01-31 | 抗菌性アミノグリコシド類似体の合成 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US11453658B2 (https=) |
| EP (1) | EP3697797A1 (https=) |
| JP (3) | JP7235741B2 (https=) |
| CN (1) | CN111655709B (https=) |
| AR (1) | AR113780A1 (https=) |
| AU (2) | AU2023219819B2 (https=) |
| CA (1) | CA3079508A1 (https=) |
| EA (1) | EA202090980A1 (https=) |
| MX (1) | MX2020003701A (https=) |
| TW (1) | TWI801438B (https=) |
| WO (1) | WO2019079613A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019079613A1 (en) * | 2017-10-19 | 2019-04-25 | Achaogen, Inc. | SYNTHESIS OF ANTIBACTERIAL AMINOGLYCOSIDE ANALOGUES |
| CN110878108B (zh) * | 2019-06-17 | 2022-11-11 | 山东安信制药有限公司 | 一种普拉佐米星的合成方法 |
| CN110885350A (zh) * | 2019-08-28 | 2020-03-17 | 山东安信制药有限公司 | 一种普拉佐米星的制备方法 |
| CN110642907B (zh) * | 2019-10-12 | 2020-11-06 | 上海博璞诺科技发展有限公司 | 普拉唑米星或其盐的合成方法 |
| CN111116688B (zh) * | 2020-01-07 | 2021-07-27 | 杭州华东医药集团新药研究院有限公司 | 普拉佐米星的制备方法 |
| CN111205341A (zh) * | 2020-02-17 | 2020-05-29 | 山东安信制药有限公司 | 一种普拉佐米星关键中间体的制备方法 |
| CN112079882B (zh) * | 2020-10-10 | 2021-10-08 | 山东安信制药有限公司 | 一种Plazomicin的制备方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4388233A (en) * | 1981-05-15 | 1983-06-14 | The Regents Of The University Of California | Synthetic substrates for enzyme analysis |
| MX2009003909A (es) | 2006-10-12 | 2009-05-25 | Ptc Therapeutics Inc | Métodos para dosificar un compuesto 1,2,4, - oxadiazol oralmente activo para el tratamiento de supresión de la mutación finalizadora. |
| US8614233B2 (en) * | 2007-05-29 | 2013-12-24 | Universite De Montreal | Cinnamoyl inhibitors of transglutaminase |
| LT2217610T (lt) | 2007-11-21 | 2017-02-27 | Achaogen, Inc. | Antibakteriniai aminoglikozidų analogai |
| EP2103602A1 (en) * | 2008-03-17 | 2009-09-23 | AEterna Zentaris GmbH | Novel 1,2,4-triazole derivatives and process of manufacturing thereof |
| CA2761674C (en) * | 2009-05-14 | 2016-11-29 | Achaogen, Inc. | Treatment of klebsiella pneumoniae infections with antibacterial aminoglycoside compounds |
| CA2761756A1 (en) * | 2009-05-14 | 2010-11-18 | Achaogen, Inc. | Treatment of urinary tract infections with antibacterial aminoglycoside compounds |
| WO2010147836A1 (en) | 2009-06-17 | 2010-12-23 | Achaogen, Inc. | Combination therapies using antibacterial aminoglycoside compounds |
| WO2011143497A1 (en) * | 2010-05-12 | 2011-11-17 | Rempex Pharmaceuticals, Inc. | Aminoglycoside derivatives |
| US9238670B2 (en) * | 2013-03-15 | 2016-01-19 | The Board Of Trustees Of The Leland Stanford Junior University | Aminoglycoside antibiotics with reduced ototoxicity |
| WO2019079613A1 (en) * | 2017-10-19 | 2019-04-25 | Achaogen, Inc. | SYNTHESIS OF ANTIBACTERIAL AMINOGLYCOSIDE ANALOGUES |
-
2018
- 2018-10-18 WO PCT/US2018/056536 patent/WO2019079613A1/en not_active Ceased
- 2018-10-18 CA CA3079508A patent/CA3079508A1/en active Pending
- 2018-10-18 EA EA202090980A patent/EA202090980A1/ru unknown
- 2018-10-18 CN CN201880081473.5A patent/CN111655709B/zh active Active
- 2018-10-18 JP JP2020522054A patent/JP7235741B2/ja active Active
- 2018-10-18 AR ARP180103039A patent/AR113780A1/es unknown
- 2018-10-18 EP EP18797440.7A patent/EP3697797A1/en active Pending
- 2018-10-18 TW TW107136676A patent/TWI801438B/zh active
- 2018-10-18 MX MX2020003701A patent/MX2020003701A/es unknown
-
2020
- 2020-04-16 US US16/850,771 patent/US11453658B2/en active Active
-
2022
- 2022-08-04 US US17/881,462 patent/US12122769B2/en active Active
-
2023
- 2023-02-24 JP JP2023027439A patent/JP2023054316A/ja not_active Withdrawn
- 2023-08-22 AU AU2023219819A patent/AU2023219819B2/en active Active
-
2024
- 2024-09-20 US US18/892,191 patent/US20250122177A1/en active Pending
-
2025
- 2025-01-31 JP JP2025015211A patent/JP2025062009A/ja active Pending
- 2025-09-05 AU AU2025226793A patent/AU2025226793A1/en active Pending
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