JP2021105067A - 抗腫瘍t細胞応答増強剤 - Google Patents
抗腫瘍t細胞応答増強剤 Download PDFInfo
- Publication number
- JP2021105067A JP2021105067A JP2021074601A JP2021074601A JP2021105067A JP 2021105067 A JP2021105067 A JP 2021105067A JP 2021074601 A JP2021074601 A JP 2021074601A JP 2021074601 A JP2021074601 A JP 2021074601A JP 2021105067 A JP2021105067 A JP 2021105067A
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- receptor
- cells
- cancer
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2815—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD8
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Description
なお、本出願の発明に関連する先行技術文献情報を以下に示す。
〔1〕インターロイキン6(IL-6)阻害剤、および/または、ゲムシタビン若しくはその塩を含有する、担癌生体の抗腫瘍T細胞応答増強用組成物。
〔2〕IL-6阻害剤、および、ゲムシタビン若しくはその塩を併用して投与することを特徴とする、〔1〕に記載の抗腫瘍T細胞応答増強用組成物。
〔3〕前記IL-6阻害剤がIL-6受容体に結合する物質である、〔1〕または〔2〕に記載の組成物。
〔4〕前記IL-6受容体に結合する物質が抗IL-6受容体抗体である、〔3〕に記載の組成物。
〔5〕前記抗IL-6受容体抗体がキメラ抗体、ヒト化抗体またはヒト抗体である、〔4〕に記載の組成物。
〔6〕前記ゲムシタビン若しくはその塩がゲムシタビン塩酸塩である〔1〕〜〔5〕に記載の組成物。
〔7〕IL-6阻害剤、および/または、ゲムシタビン若しくはその塩を担癌生体に投与する工程を含む、抗腫瘍T細胞応答を増強する方法。
〔8〕前記IL-6阻害剤がIL-6受容体に結合する物質である〔7〕に記載の方法。
〔9〕前記IL-6受容体に結合する物質が抗IL-6受容体抗体である〔8〕に記載の方法。
〔10〕前記抗IL-6受容体抗体がキメラ抗体、ヒト化抗体またはヒト抗体である〔9〕に記載の方法。
〔11〕前記ゲムシタビン若しくはその塩がゲムシタビン塩酸塩である〔7〕〜〔10〕に記載の方法。
〔12〕担癌生体における抗腫瘍T細胞応答の増強に使用するための、IL-6阻害剤。
〔13〕IL-6阻害剤およびゲムシタビン若しくはその塩の併用により抗腫瘍T細胞応答を増強することを特徴とする、〔12〕に記載の阻害剤。
〔14〕前記IL-6阻害剤がIL-6受容体に結合する物質である〔13〕に記載の阻害剤。
〔15〕前記IL-6受容体に結合する物質が抗IL-6受容体抗体である〔14〕に記載の阻害剤。
〔16〕前記抗IL-6受容体抗体がキメラ抗体、ヒト化抗体またはヒト抗体である〔15〕に記載の阻害剤。
〔17〕前記ゲムシタビン若しくはその塩がゲムシタビン塩酸塩である〔13〕〜〔16〕に記載の阻害剤。
なお本明細書において引用された全ての先行技術文献は、参照として本明細書に組み入れられる。
メチルコラントレン誘発偏平上皮癌細胞株 CMC-1 (2x106)をBALB/cマウスに皮内接種し、5日後よりGEM (ジェムザール:塩酸ゲムシタビン)(120 mg/kg)を1週間毎に腹腔内投与した。腫瘍の増殖を2日毎に計測し、GEMによる抗腫瘍効果を評価した。その結果を図1に示した。
CMC-1接種後30日の担癌マウスにGEMを接種し、48時間後、脾臓内の各細胞群の絶対数をフローサイトメトリーにて解析した。その結果を図2に示した。CMC-1接種後30日の担癌マウスにサイクロフォスファミド (CY)(60 mg/kg)、フルオロ-5-ウラシル(5-FU) (120 mg/kg)、GEMを腹腔内投与した。48時間後、脾臓内CD8+細胞を単離し、固層化抗CD3抗体 (2 μg/ml)にて60時間刺激後の増殖能を3H取り込み試験にて評価した。その結果を図3に示した。
これらの結果から、GEMが免疫抑制細胞を排除し、担癌生体のCD8+T細胞に対して優れた増殖促進効果を有することが示された。当該効果は、CYや5-FUでは確認することができなかった。また、腫瘍増殖抑制効果を有することも確認することができた。
CMC-1(2x106)をBALB/cマウスに皮内接種後、5日後よりGEM (120 mg/kg)を1週間毎に腹腔内投与、抗CD8抗体 (250 μg)を3日毎に静脈内投与し、腫瘍径を2日毎に計測した。その結果を図4に示した。
マウス肺癌細胞株 LLCに卵白アルブミン (OVA)遺伝子を導入したLLC-OVA (2x106)をC57BL6マウスに皮内接種し、5日後にGEM (120 mg/kg)を腹腔内投与した。9日後に、所属リンパ節を採取し、OVA特異的CD8+細胞傷害性T細胞の割合をフローサイトメトリーにて評価した。その結果を図5に示した。
これらの結果から、GEMによるCD8+T細胞の活性増加を介して、抗腫瘍効果が認められていることを確認することができた。
メチルコラントレン誘発線維芽肉腫細胞株CMC-G4 (2x106)をBALB/cマウスに皮内接種し、1週間後および2週間後の血清中IL-6濃度をELISAにて測定した。その結果を図6に示した。CMC-G4を皮内接種後、3日毎に抗IL-6受容体抗体(MR16-1:Tamura, T. et al. Proc. Natl. Acad. Sci. USA (1993) 90, 11924-11928) (250 μg)を静脈内投与した。28日後に脾臓細胞を採取し、抗CD3抗体 (2 μg/ml)、あるいはコンカナバリンA (ConA:2.5μg/ml)存在下で36時間培養後の培養上清中IFN-γ濃度をELISAにて測定した。その結果を図7に示した。さらに、腫瘍径を2日毎に測定し、腫瘍増殖抑制効果を評価した。その結果を図8に示した。
これらの結果から、抗IL-6受容体抗体が担癌生体におけるIFN−γの産生を促進させる効果を有していることが明らかとなった。当該結果から、抗IL-6受容体抗体もGEM同様に免疫担当細胞に対して優れた活性化促進効果を有することが示された。また、腫瘍増殖抑制効果を有することも確認することができた。
CMC-G4 (2x106)をBALB/cマウスに皮内接種後、6日後からGEM (120 mg/kg)を1週間毎に腹腔内投与、抗IL-6受容体抗体 MR16-1 (200 μg)を3日毎に静脈内投与し、腫瘍径を2日毎に計測した。その結果を図9に示した。
当該結果から、ゲムシタビン(GEM)および抗IL-6受容体抗体(MR16-1)を併用することにより、それぞれ単独で投与したときよりも優れた抗腫瘍効果が得られることが明らかとなった。
Claims (6)
- インターロイキン6(IL-6)阻害剤を含有する、担癌生体の抗腫瘍T細胞応答増強用組成物であって、前記癌は線維芽肉腫および頭頚部癌からなる群より選択される、組成物。
- IL-6阻害剤、および、ゲムシタビン若しくはその塩を併用して投与することを特徴とする、請求項1に記載の抗腫瘍T細胞応答増強用組成物。
- 前記IL-6阻害剤がIL-6受容体に結合する物質である、請求項1または2に記載の組成物。
- 前記IL-6受容体に結合する物質が抗IL-6受容体抗体である、請求項3に記載の組成物。
- 前記抗IL-6受容体抗体がキメラ抗体、ヒト化抗体またはヒト抗体である、請求項4に記載の組成物。
- 前記ゲムシタビン若しくはその塩がゲムシタビン塩酸塩である、請求項2〜5のいずれかに記載の組成物。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2022172859A JP2022187002A (ja) | 2010-05-28 | 2022-10-28 | 抗腫瘍t細胞応答増強剤 |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2010122951 | 2010-05-28 | ||
JP2010122951 | 2010-05-28 | ||
JP2016229667A JP6952454B2 (ja) | 2010-05-28 | 2016-11-28 | 抗腫瘍t細胞応答増強剤 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2016229667A Division JP6952454B2 (ja) | 2010-05-28 | 2016-11-28 | 抗腫瘍t細胞応答増強剤 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2022172859A Division JP2022187002A (ja) | 2010-05-28 | 2022-10-28 | 抗腫瘍t細胞応答増強剤 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2021105067A true JP2021105067A (ja) | 2021-07-26 |
JP7174960B2 JP7174960B2 (ja) | 2022-11-18 |
Family
ID=45004034
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2012517328A Active JP6051049B2 (ja) | 2010-05-28 | 2011-05-27 | 抗腫瘍t細胞応答増強剤 |
JP2016229667A Active JP6952454B2 (ja) | 2010-05-28 | 2016-11-28 | 抗腫瘍t細胞応答増強剤 |
JP2021074601A Active JP7174960B2 (ja) | 2010-05-28 | 2021-04-27 | 抗腫瘍t細胞応答増強剤 |
JP2022172859A Pending JP2022187002A (ja) | 2010-05-28 | 2022-10-28 | 抗腫瘍t細胞応答増強剤 |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2012517328A Active JP6051049B2 (ja) | 2010-05-28 | 2011-05-27 | 抗腫瘍t細胞応答増強剤 |
JP2016229667A Active JP6952454B2 (ja) | 2010-05-28 | 2016-11-28 | 抗腫瘍t細胞応答増強剤 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2022172859A Pending JP2022187002A (ja) | 2010-05-28 | 2022-10-28 | 抗腫瘍t細胞応答増強剤 |
Country Status (12)
Country | Link |
---|---|
US (1) | US9539322B2 (ja) |
EP (2) | EP4115906A1 (ja) |
JP (4) | JP6051049B2 (ja) |
DK (1) | DK2578231T3 (ja) |
ES (1) | ES2932398T3 (ja) |
HR (1) | HRP20221490T1 (ja) |
HU (1) | HUE060454T2 (ja) |
PL (1) | PL2578231T3 (ja) |
PT (1) | PT2578231T (ja) |
RS (1) | RS63800B1 (ja) |
SI (1) | SI2578231T1 (ja) |
WO (1) | WO2011149051A1 (ja) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU736282B2 (en) | 1997-03-21 | 2001-07-26 | Chugai Seiyaku Kabushiki Kaisha | A preventive or therapeutic agent for sensitized T cell- mediated diseases comprising IL-6 antagonist as an active ingredient |
UA80091C2 (en) | 2001-04-02 | 2007-08-27 | Chugai Pharmaceutical Co Ltd | Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist |
DK1475101T3 (da) | 2002-02-14 | 2011-01-10 | Chugai Pharmaceutical Co Ltd | Antistof-holdige farmaceutiske opløsninger |
GB2401040A (en) | 2003-04-28 | 2004-11-03 | Chugai Pharmaceutical Co Ltd | Method for treating interleukin-6 related diseases |
EP3269738A1 (en) | 2004-03-24 | 2018-01-17 | Chugai Seiyaku Kabushiki Kaisha | Subtypes of humanized antibody against interleukin-6 receptor |
AU2006305119B2 (en) * | 2005-10-21 | 2012-12-20 | Chugai Seiyaku Kabushiki Kaisha | Agents for treating cardiopathy |
CN101370521A (zh) * | 2006-01-27 | 2009-02-18 | 学校法人庆应义塾 | 伴有脉络膜血管生成的疾病的治疗药 |
WO2007116962A1 (ja) * | 2006-04-07 | 2007-10-18 | Osaka University | 筋再生促進剤 |
RU2450829C2 (ru) * | 2007-01-23 | 2012-05-20 | Синсу Юниверсити | Ингибитор хронического отторжения |
GB0717337D0 (en) | 2007-09-06 | 2007-10-17 | Ucb Pharma Sa | Method of treatment |
PE20091174A1 (es) | 2007-12-27 | 2009-08-03 | Chugai Pharmaceutical Co Ltd | Formulacion liquida con contenido de alta concentracion de anticuerpo |
US10717781B2 (en) | 2008-06-05 | 2020-07-21 | National Cancer Center | Neuroinvasion inhibitor |
TWI440469B (zh) | 2008-09-26 | 2014-06-11 | Chugai Pharmaceutical Co Ltd | Improved antibody molecules |
KR20160084500A (ko) | 2009-10-26 | 2016-07-13 | 에프. 호프만-라 로슈 아게 | 글리코실화된 면역글로불린의 제조 방법 |
ES2932398T3 (es) | 2010-05-28 | 2023-01-18 | Chugai Pharmaceutical Co Ltd | Potenciador de la respuesta de las células T antitumorales |
KR102116202B1 (ko) | 2010-11-08 | 2020-05-28 | 제넨테크, 인크. | 피하 투여용 항―il―6 수용체 항체 |
WO2014200018A1 (ja) | 2013-06-11 | 2014-12-18 | 独立行政法人 国立精神・神経医療研究センター | 再発寛解型多発性硬化症(rrms)患者の治療予後予測方法、及び新規治療適応判断方法 |
RU2674996C2 (ru) | 2013-07-04 | 2018-12-14 | Ф. Хоффманн-Ля Рош Аг | Иммуноферментный анализ с подавлением интерференции для определения антител к лекарствам в образцах сыворотки |
KR101892883B1 (ko) | 2015-02-27 | 2018-10-05 | 추가이 세이야쿠 가부시키가이샤 | Il-6 관련 질환 치료용 조성물 |
JP6875683B2 (ja) | 2015-05-19 | 2021-05-26 | 国立研究開発法人国立精神・神経医療研究センター | 多発性硬化症(ms)患者の新規治療適用判断方法 |
WO2016195088A1 (ja) * | 2015-06-04 | 2016-12-08 | 国立研究開発法人 国立精神・神経医療研究センター | Il-6阻害剤を有効成分とする精神疾患治療剤 |
WO2018203545A1 (ja) | 2017-05-02 | 2018-11-08 | 国立研究開発法人国立精神・神経医療研究センター | Il-6及び好中球の関連する疾患の治療効果の予測及び判定方法 |
US11692037B2 (en) | 2017-10-20 | 2023-07-04 | Hyogo College Of Medicine | Anti-IL-6 receptor antibody-containing medicinal composition for preventing post-surgical adhesion |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006051049A (ja) * | 2004-08-09 | 2006-02-23 | Moriyama Kasei Kk | 固形石鹸用泡立てネット及びその製造方法 |
WO2007061029A1 (ja) * | 2005-11-25 | 2007-05-31 | Keio University | 前立腺癌治療剤 |
JP2008297315A (ja) * | 1994-10-21 | 2008-12-11 | Chuzo Kishimoto | Il−6産生に起因する疾患の治療剤 |
WO2009148148A1 (ja) * | 2008-06-05 | 2009-12-10 | 国立がんセンター総長が代表する日本国 | 神経浸潤抑制剤 |
WO2011013786A1 (ja) * | 2009-07-31 | 2011-02-03 | Maeda Shin | 癌の転移抑制剤 |
Family Cites Families (110)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
JPS58201994A (ja) | 1982-05-21 | 1983-11-25 | Hideaki Hagiwara | 抗原特異的ヒト免疫グロブリンの生産方法 |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
HUT35524A (en) | 1983-08-02 | 1985-07-29 | Hoechst Ag | Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
US5171840A (en) | 1988-01-22 | 1992-12-15 | Tadamitsu Kishimoto | Receptor protein for human B cell stimulatory factor-2 |
US5670373A (en) | 1988-01-22 | 1997-09-23 | Kishimoto; Tadamitsu | Antibody to human interleukin-6 receptor |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
US5216128A (en) | 1989-06-01 | 1993-06-01 | Yeda Research And Development Co., Ltd. | IFN-β2/IL-6 receptor its preparation and pharmaceutical compositions containing it |
JP2998976B2 (ja) | 1989-07-20 | 2000-01-17 | 忠三 岸本 | ヒトインタ―ロイキン―6レセプターに対する抗体 |
JP2898064B2 (ja) | 1989-08-03 | 1999-05-31 | 忠三 岸本 | ヒトgp130蛋白質 |
JPH03155795A (ja) | 1989-11-13 | 1991-07-03 | Chuzo Kishimoto | マウス・インターロイキン―6レセプター蛋白質 |
JP2898040B2 (ja) | 1990-01-26 | 1999-05-31 | 忠三 岸本 | gp130蛋白質に対する抗体 |
ES2139598T3 (es) | 1990-07-10 | 2000-02-16 | Medical Res Council | Procedimientos para la produccion de miembros de parejas de union especifica. |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
CA2089661C (en) | 1990-08-29 | 2007-04-03 | Nils Lonberg | Transgenic non-human animals capable of producing heterologous antibodies |
JP3370324B2 (ja) | 1991-04-25 | 2003-01-27 | 中外製薬株式会社 | ヒトインターロイキン−6受容体に対する再構成ヒト抗体 |
WO1993006213A1 (en) | 1991-09-23 | 1993-04-01 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
DK0661985T3 (da) | 1991-11-08 | 2000-01-31 | Univ Leland Stanford Junior | Peptider, der er i stand til at binde til CTL-prækursere |
US5885793A (en) | 1991-12-02 | 1999-03-23 | Medical Research Council | Production of anti-self antibodies from antibody segment repertoires and displayed on phage |
EP0746609A4 (en) | 1991-12-17 | 1997-12-17 | Genpharm Int | NON-HUMAN TRANSGENIC ANIMALS CAPABLE OF PRODUCING HETEROLOGOUS ANTIBODIES |
EP0656941B1 (en) | 1992-03-24 | 2005-06-01 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
SG48760A1 (en) | 1992-07-24 | 2003-03-18 | Abgenix Inc | Generation of xenogenetic antibodies |
FR2694767B1 (fr) | 1992-08-13 | 1994-10-21 | Innotherapie Lab Sa | Anticorps monoclonaux anti-IL6R, et leurs applications. |
US5648267A (en) | 1992-11-13 | 1997-07-15 | Idec Pharmaceuticals Corporation | Impaired dominant selectable marker sequence and intronic insertion strategies for enhancement of expression of gene product and expression vector systems comprising same |
JP3525221B2 (ja) | 1993-02-17 | 2004-05-10 | 味の素株式会社 | 免疫抑制剤 |
US5468772A (en) | 1993-03-10 | 1995-11-21 | Pharmagenesis, Inc. | Tripterinin compound and method |
AU6819494A (en) | 1993-04-26 | 1994-11-21 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
US5856135A (en) | 1993-05-31 | 1999-01-05 | Chugai Seiyaku Kabushiki Kaisha | Reshaped human antibody to human interleukin-6 |
JP3614183B2 (ja) | 1993-05-31 | 2005-01-26 | 中外製薬株式会社 | ヒトインターロイキン−6に対する再構成ヒト抗体 |
GB9313509D0 (en) | 1993-06-30 | 1993-08-11 | Medical Res Council | Chemisynthetic libraries |
US5888510A (en) | 1993-07-21 | 1999-03-30 | Chugai Seiyaku Kabushiki Kaisha | Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component |
US6074643A (en) | 1993-09-09 | 2000-06-13 | Cli Oncology, Inc. | Site-directed chemotherapy of metastases |
AU7967294A (en) | 1993-10-06 | 1995-05-01 | Board Of Regents, The University Of Texas System | A monoclonal anti-human il-6 receptor antibody |
EP0731842A1 (en) | 1993-12-03 | 1996-09-18 | Medical Research Council | Recombinant binding proteins and peptides |
CA2168963C (en) | 1994-06-07 | 2007-01-16 | Masayuki Miyata | Drug for prevention and therapy of diseases caused by fibrinoid formation or thrombus formation in the lung and model animals of the diseases |
US8017121B2 (en) | 1994-06-30 | 2011-09-13 | Chugai Seiyaku Kabushika Kaisha | Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component |
DK0783893T3 (da) | 1994-10-07 | 2012-05-29 | Chugai Pharmaceutical Co Ltd | Inhibering af unormal vækst af synovial-celler under anvendelse af il-6-antagonist som aktiv bestanddel |
IT1274350B (it) | 1994-12-06 | 1997-07-17 | Angeletti P Ist Richerche Bio | Antagonisti di interleuchina-6(il-6) che consistono di forme solubili del ricettore alfa di il-6, mutate nell'interfaccia che si lega a gp 130 |
IT1274782B (it) | 1994-12-14 | 1997-07-24 | Angeletti P Ist Richerche Bio | Metodo per selezionare superagonisti, antagonisti e superantagonisti di ormoni del cui complesso recettoriale fa parte gp 130 |
CA2209124C (en) | 1994-12-29 | 2010-03-23 | Chugai Seiyaku Kabushiki Kaisha | Antitumor agent effect enhancer containing il-6 antagonist |
CA2211578C (en) | 1995-02-13 | 2010-09-21 | Chugai Seiyaku Kabushiki Kaisha | Muscle protein proteolysis inhibiting agent containing il-6 receptor antibody |
AU5332196A (en) | 1995-03-31 | 1996-10-16 | Henrik Georg Bohr | Method for protein folding |
FR2733250B1 (fr) | 1995-04-21 | 1997-07-04 | Diaclone | Anticorps monoclonaux anti-gp130, et leurs utilisations |
ATE390933T1 (de) | 1995-04-27 | 2008-04-15 | Amgen Fremont Inc | Aus immunisierten xenomäusen stammende menschliche antikörper gegen il-8 |
CA2219486A1 (en) | 1995-04-28 | 1996-10-31 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
US5571513A (en) | 1995-05-31 | 1996-11-05 | The Board Of Regents Of The University Of Oklahoma | Anti-gp130 monoclonal antibodies |
RU2127117C1 (ru) | 1996-06-26 | 1999-03-10 | Филиппова Ольга Всеволодовна | Способ лечения ишемической болезни сердца |
GB9702944D0 (en) | 1997-02-13 | 1997-04-02 | Univ Manchester | Reducing fibrosis |
AU736282B2 (en) | 1997-03-21 | 2001-07-26 | Chugai Seiyaku Kabushiki Kaisha | A preventive or therapeutic agent for sensitized T cell- mediated diseases comprising IL-6 antagonist as an active ingredient |
PL192521B1 (pl) | 1997-05-17 | 2006-11-30 | Biogen Idec Inc | Zastosowanie przerywacza wiązania CD40:CD154 i kompozycja |
US20020187150A1 (en) | 1997-08-15 | 2002-12-12 | Chugai Seiyaku Kabushiki Kaisha | Preventive and/or therapeutic agent for systemic lupus erythematosus comprising anti-IL-6 receptor antibody as an active ingredient |
JPH11180873A (ja) | 1997-12-22 | 1999-07-06 | Kaken Shoyaku Kk | NF−κB活性阻害剤 |
CZ297083B6 (cs) | 1998-03-17 | 2006-09-13 | Chugai Seiyaku Kabushiki Kaisha | Cinidlo pro prevenci a lécbu zánetlivého onemocnení streva obsahující aktivní slozku antagonistu IL-6 |
JP4698652B2 (ja) | 1998-03-17 | 2011-06-08 | 中外製薬株式会社 | Il−6アンタゴニストを有効成分として含有する炎症性腸疾患の予防又は治療剤 |
EP0972780A1 (en) | 1998-05-18 | 2000-01-19 | Applied Research Systems ARS Holding N.V. | Il-6 antagonist peptides |
DE69934698T2 (de) | 1998-08-24 | 2007-10-04 | Chugai Seiyaku K.K. | Mittel zur vorbeugung oder behandlung von pankreatitis die anti-il-6 receptor antikörper als aktive komponente enthalten |
JP4799516B2 (ja) | 1998-08-24 | 2011-10-26 | 中外製薬株式会社 | Il−6アンタゴニストを有効成分として含有する膵炎の予防又は治療剤 |
US20030130212A1 (en) | 1999-01-14 | 2003-07-10 | Rossignol Daniel P. | Administration of an anti-endotoxin drug by intravenous infusion |
WO2001005394A1 (fr) | 1999-07-16 | 2001-01-25 | Kissei Pharmaceutical Co., Ltd. | Agents inhibant les reactions de rejet chronique faisant suite a une greffe d'organe |
AU3162001A (en) | 1999-12-21 | 2001-07-03 | Id-Pharma Gmbh | Medicament, a method for its production and the use thereof |
US6413663B1 (en) | 2000-06-29 | 2002-07-02 | Graftech Inc. | Fluid permeable flexible graphite fuel cell electrode |
ES2298273T3 (es) | 2000-10-25 | 2008-05-16 | Chugai Seiyaku Kabushiki Kaisha | Agentes preventivos o terapeuticos contra la psoriasis que contienen un antagonista de il-6 como su ingrediente activo. |
WO2002036165A1 (fr) | 2000-10-27 | 2002-05-10 | Chugai Seiyaku Kabushiki Kaisha | Agent à base d'antagoniste d'il-6, faisant baisser le niveau des mmp-3 dans le sang |
UA80091C2 (en) | 2001-04-02 | 2007-08-27 | Chugai Pharmaceutical Co Ltd | Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist |
US20050182007A1 (en) | 2001-05-18 | 2005-08-18 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of interleukin and interleukin receptor gene expression using short interfering nucleic acid (SINA) |
MXPA04004671A (es) | 2001-11-14 | 2005-08-25 | Johnson & Johnson | Anticuerpos anti-interleucina-6, composiciones, metodos y usos. |
FR2833011B1 (fr) | 2001-12-04 | 2004-10-29 | Univ Claude Bernard Lyon | Nouvelle proteine a activite inhibitrice de l'il-6 |
DE10231655A1 (de) | 2002-07-12 | 2004-02-26 | Blasticon Biotechnologische Forschung Gmbh | Transplantat-Akzeptanz induzierende Zellen monozytären Ursprungs, sowie deren Herstellung und Verwendung |
CN101124244B (zh) | 2002-11-15 | 2012-10-10 | 根马布股份公司 | 抗cd25的人单克隆抗体 |
EP1572103A4 (en) | 2002-11-15 | 2008-02-13 | Centocor Inc | ANTI-ANGIOGENIC USES OF IL-6 ANTAGONISTS |
US20040161426A1 (en) | 2003-02-04 | 2004-08-19 | Mohit Trikha | Use of IL-6 antagonists in combination with steroids to enhance apoptosis |
MXPA05008713A (es) | 2003-02-24 | 2005-09-20 | Chugai Pharmaceutical Co Ltd | Agente terapeutico para dano de medula espinal que comprende antagonista de interluceina-6. |
US20040208876A1 (en) | 2003-04-18 | 2004-10-21 | Kim Kyung Jin | Monoclonal antibodies to hepatocyte growth factor |
GB2401040A (en) | 2003-04-28 | 2004-11-03 | Chugai Pharmaceutical Co Ltd | Method for treating interleukin-6 related diseases |
CN1934255B (zh) | 2003-08-27 | 2012-07-11 | 奥普索特克公司 | 用于治疗眼新血管疾病的组合治疗 |
CN101407471A (zh) | 2003-08-29 | 2009-04-15 | 小野药品工业株式会社 | 能够结合s1p受体的化合物及其药物用途 |
JP4960096B2 (ja) | 2003-09-22 | 2012-06-27 | ペントラコール ゲゼルシャフト ミット ベシュレンクテル ハフツング | Il−6の生物学的効果を減じる化合物の使用 |
CA2540133A1 (en) | 2003-09-24 | 2005-03-31 | Kyowa Hakko Kogyo Co., Ltd. | Drugs for treating cancer |
ES2392824T3 (es) | 2003-10-17 | 2012-12-14 | Chugai Seiyaku Kabushiki Kaisha | Agente terapéutico contra el mesotelioma |
KR100556660B1 (ko) | 2003-11-11 | 2006-03-10 | 국립암센터 | Hgf의 중화가능 에피토프 및 이에 결합하는 중화 항체 |
AR048210A1 (es) | 2003-12-19 | 2006-04-12 | Chugai Pharmaceutical Co Ltd | Un agente preventivo para la vasculitis. |
JP4609877B2 (ja) | 2004-03-30 | 2011-01-12 | 塩野義製薬株式会社 | 慢性拒絶反応抑制剤 |
KR101178318B1 (ko) | 2004-07-16 | 2012-08-29 | 교린 세이야꾸 가부시키 가이샤 | 효과적인 의약의 사용법 및 부작용 발현의 방어에 관한방법 |
CA2574848A1 (en) | 2004-08-05 | 2006-12-21 | Wyeth | Antagonizing interleukin-21 receptor activity |
US7884196B2 (en) | 2004-10-06 | 2011-02-08 | Oliver Lawless | Vaccine composition comprising methylated DNA and immunomodulatory motifs |
US8993319B2 (en) | 2004-12-28 | 2015-03-31 | Innate Pharma S.A. | Monoclonal antibodies against NKG2A |
PE20061324A1 (es) | 2005-04-29 | 2007-01-15 | Centocor Inc | Anticuerpos anti-il-6, composiciones, metodos y usos |
AR061400A1 (es) | 2005-10-14 | 2008-08-27 | Chugai Kabushiki Kaisha | Agentes para suprimir el dano a los islotes transplantados despues del transplante de islotes |
AU2006305119B2 (en) | 2005-10-21 | 2012-12-20 | Chugai Seiyaku Kabushiki Kaisha | Agents for treating cardiopathy |
AR057582A1 (es) | 2005-11-15 | 2007-12-05 | Nat Hospital Organization | Agentes para suprimir la induccion de linfocitos t citotoxicos |
AR057227A1 (es) | 2005-12-09 | 2007-11-21 | Centocor Inc | Metodo para usar antagonistas de il6 con inhibidores del proteasoma |
BRPI0620797A2 (pt) | 2005-12-30 | 2011-11-22 | Merck Patent Ges Mit Beschonkter Haftung | anticorpos anti-il-6 que previnem a ligação de il-6 complexado com il-6ralfa a gp130 |
CN101370521A (zh) | 2006-01-27 | 2009-02-18 | 学校法人庆应义塾 | 伴有脉络膜血管生成的疾病的治疗药 |
WO2007116962A1 (ja) | 2006-04-07 | 2007-10-18 | Osaka University | 筋再生促進剤 |
CA2652976C (en) | 2006-06-02 | 2015-08-11 | Regeneron Pharmaceuticals, Inc. | High affinity antibodies to human il-6 receptor |
US8629244B2 (en) | 2006-08-18 | 2014-01-14 | Ablynx N.V. | Interleukin-6 receptor binding polypeptides |
US20080081041A1 (en) | 2006-09-29 | 2008-04-03 | Jeffrey Nemeth | Method of Using IL6 Antagonists with Mitoxantrone for Prostate Cancer |
RU2450829C2 (ru) | 2007-01-23 | 2012-05-20 | Синсу Юниверсити | Ингибитор хронического отторжения |
NZ581596A (en) * | 2007-05-21 | 2012-02-24 | Alderbio Holdings Llc | Antibodies to il-6 and use thereof |
WO2009010539A2 (en) | 2007-07-19 | 2009-01-22 | Ablynx. N.V. | Receptor for interleukin-6 (il-6) from macaca fascicularis |
MX2010003329A (es) | 2007-09-26 | 2010-04-27 | Chugai Pharmaceutical Co Ltd | Anticuerpo anti-receptor de il-6. |
TWI464262B (zh) | 2007-09-26 | 2014-12-11 | 中外製藥股份有限公司 | 抗體固定區的變異 |
CN102056946A (zh) | 2008-04-11 | 2011-05-11 | 中外制药株式会社 | 与多个分子的抗原反复结合的抗原结合分子 |
TWI440469B (zh) | 2008-09-26 | 2014-06-11 | Chugai Pharmaceutical Co Ltd | Improved antibody molecules |
US8323649B2 (en) | 2008-11-25 | 2012-12-04 | Alderbio Holdings Llc | Antibodies to IL-6 and use thereof |
RU2524152C2 (ru) | 2009-03-19 | 2014-07-27 | Чугаи Сейяку Кабусики Кайся | Средство для лечения ревматоидного артрита |
EP2578233B1 (en) * | 2010-05-28 | 2017-04-26 | National Cancer Center | Therapeutic agent for pancreatic cancer |
ES2932398T3 (es) | 2010-05-28 | 2023-01-18 | Chugai Pharmaceutical Co Ltd | Potenciador de la respuesta de las células T antitumorales |
-
2011
- 2011-05-27 ES ES11786748T patent/ES2932398T3/es active Active
- 2011-05-27 US US13/700,355 patent/US9539322B2/en active Active
- 2011-05-27 PT PT117867481T patent/PT2578231T/pt unknown
- 2011-05-27 JP JP2012517328A patent/JP6051049B2/ja active Active
- 2011-05-27 RS RS20221126A patent/RS63800B1/sr unknown
- 2011-05-27 HU HUE11786748A patent/HUE060454T2/hu unknown
- 2011-05-27 DK DK11786748.1T patent/DK2578231T3/da active
- 2011-05-27 EP EP22192455.8A patent/EP4115906A1/en active Pending
- 2011-05-27 SI SI201132068T patent/SI2578231T1/sl unknown
- 2011-05-27 HR HRP20221490TT patent/HRP20221490T1/hr unknown
- 2011-05-27 WO PCT/JP2011/062209 patent/WO2011149051A1/ja active Application Filing
- 2011-05-27 PL PL11786748.1T patent/PL2578231T3/pl unknown
- 2011-05-27 EP EP11786748.1A patent/EP2578231B1/en active Active
-
2016
- 2016-11-28 JP JP2016229667A patent/JP6952454B2/ja active Active
-
2021
- 2021-04-27 JP JP2021074601A patent/JP7174960B2/ja active Active
-
2022
- 2022-10-28 JP JP2022172859A patent/JP2022187002A/ja active Pending
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008297315A (ja) * | 1994-10-21 | 2008-12-11 | Chuzo Kishimoto | Il−6産生に起因する疾患の治療剤 |
JP2006051049A (ja) * | 2004-08-09 | 2006-02-23 | Moriyama Kasei Kk | 固形石鹸用泡立てネット及びその製造方法 |
WO2007061029A1 (ja) * | 2005-11-25 | 2007-05-31 | Keio University | 前立腺癌治療剤 |
WO2009148148A1 (ja) * | 2008-06-05 | 2009-12-10 | 国立がんセンター総長が代表する日本国 | 神経浸潤抑制剤 |
WO2011013786A1 (ja) * | 2009-07-31 | 2011-02-03 | Maeda Shin | 癌の転移抑制剤 |
Non-Patent Citations (7)
Title |
---|
ANNUAL REVIEW 免疫, vol. 1999, JPN6011034625, 1999, pages 257 - 269, ISSN: 0004789000 * |
CLIN. CANCER RES., vol. 15, no. 17, JPN6021001850, 1 September 2009 (2009-09-01), JP, pages 5426 - 5434, ISSN: 0004789005 * |
CLINICAL CANCER RESEARCH, vol. 11, JPN6015019208, 2005, pages 6713 - 6721, ISSN: 0004789002 * |
GASTROENTEROLOGY, vol. VOL.128, NO.4, SUPPL.2, JPN6015046901, April 2005 (2005-04-01), pages 30 - 165, ISSN: 0004789003 * |
JOURNAL OF HEPATOLOGY, vol. 44, JPN6015046904, 2006, pages 1055 - 1065, ISSN: 0004789004 * |
OTOLARYNGOL HEAD NECK SURG., vol. 131, JPN6021008032, 2004, US, pages 573 - 576, ISSN: 0004788999 * |
基盤的癌免疫研究会総会抄録, vol. 10, JPN6011034621, 2006, pages 49, ISSN: 0004789001 * |
Also Published As
Publication number | Publication date |
---|---|
EP2578231B1 (en) | 2022-10-26 |
EP4115906A1 (en) | 2023-01-11 |
HRP20221490T1 (hr) | 2023-02-03 |
PL2578231T3 (pl) | 2023-01-16 |
JP2022187002A (ja) | 2022-12-15 |
JP7174960B2 (ja) | 2022-11-18 |
RS63800B1 (sr) | 2022-12-30 |
EP2578231A1 (en) | 2013-04-10 |
EP2578231A4 (en) | 2013-10-30 |
ES2932398T3 (es) | 2023-01-18 |
SI2578231T1 (sl) | 2023-01-31 |
DK2578231T3 (da) | 2022-12-12 |
PT2578231T (pt) | 2022-12-02 |
JP6952454B2 (ja) | 2021-10-20 |
JPWO2011149051A1 (ja) | 2013-07-25 |
JP2017061541A (ja) | 2017-03-30 |
US20130202588A1 (en) | 2013-08-08 |
JP6051049B2 (ja) | 2016-12-21 |
WO2011149051A1 (ja) | 2011-12-01 |
HUE060454T2 (hu) | 2023-03-28 |
US9539322B2 (en) | 2017-01-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP7174960B2 (ja) | 抗腫瘍t細胞応答増強剤 | |
US20220175919A1 (en) | Therapeutic agents for pancreatic cancer | |
JP5264752B2 (ja) | インターロイキン6受容体阻害剤を有効成分とする移植片対宿主病治療剤 | |
JP5544290B2 (ja) | 神経浸潤抑制剤 | |
KR101239051B1 (ko) | 심장질환 치료제 | |
KR101343190B1 (ko) | 췌도 이식에 있어서의 이식 췌도 장애 억제제 | |
JP5424330B2 (ja) | インターロイキン6受容体阻害剤を有効成分とする眼炎症疾患治療剤 | |
US20090269335A1 (en) | Therapeutic agent for prostate cancer | |
JP2010095445A (ja) | Il−6アンタゴニストを有効成分とする炎症性筋疾患治療剤 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20210526 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20220601 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20220729 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20221003 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20221028 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 7174960 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |