JP2021098692A - 核内受容体に対して活性の化合物 - Google Patents

核内受容体に対して活性の化合物 Download PDF

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Publication number
JP2021098692A
JP2021098692A JP2020209927A JP2020209927A JP2021098692A JP 2021098692 A JP2021098692 A JP 2021098692A JP 2020209927 A JP2020209927 A JP 2020209927A JP 2020209927 A JP2020209927 A JP 2020209927A JP 2021098692 A JP2021098692 A JP 2021098692A
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Japan
Prior art keywords
fluoro
methyl
amino
trifluoromethyl
acetamide
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Pending
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JP2020209927A
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Japanese (ja)
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JP2021098692A5 (enExample
Inventor
シュレーダー グラド サネ
Schroeder Glad Sanne
シュレーダー グラド サネ
サルバリー イアン
Sarvary Ian
サルバリー イアン
ホー ゴリアエフ アレクス
Haahr Gouliaev Alex
ホー ゴリアエフ アレクス
フランク トマス
Franch Thomas
フランク トマス
イェンスビュー ニルスン セーレン
Jensby Nielsen Soren
イェンスビュー ニルスン セーレン
ピエロ スタシ ルイージ
Piero Stasi Luigi
ピエロ スタシ ルイージ
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Nuevolution AS
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Nuevolution AS
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Publication of JP2021098692A publication Critical patent/JP2021098692A/ja
Publication of JP2021098692A5 publication Critical patent/JP2021098692A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2020209927A 2019-12-20 2020-12-18 核内受容体に対して活性の化合物 Pending JP2021098692A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962951239P 2019-12-20 2019-12-20
US62/951,239 2019-12-20

Publications (2)

Publication Number Publication Date
JP2021098692A true JP2021098692A (ja) 2021-07-01
JP2021098692A5 JP2021098692A5 (enExample) 2023-12-18

Family

ID=74003833

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020209927A Pending JP2021098692A (ja) 2019-12-20 2020-12-18 核内受容体に対して活性の化合物

Country Status (7)

Country Link
US (1) US11447479B2 (enExample)
EP (1) EP4076657A1 (enExample)
JP (1) JP2021098692A (enExample)
AU (1) AU2020405446A1 (enExample)
CA (1) CA3160522A1 (enExample)
MX (1) MX2022007265A (enExample)
WO (1) WO2021124277A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4076661A1 (en) 2019-12-20 2022-10-26 Nuevolution A/S Compounds active towards nuclear receptors
WO2021198955A1 (en) 2020-03-31 2021-10-07 Nuevolution A/S Compounds active towards nuclear receptors
EP4126875A1 (en) 2020-03-31 2023-02-08 Nuevolution A/S Compounds active towards nuclear receptors
CN113461687B (zh) * 2021-08-10 2022-04-19 四川大学华西医院 2,8-氮杂-[4,5]十螺环酮衍生物及其制备方法和用途
CN119060034A (zh) * 2024-09-02 2024-12-03 上海信诺维生物医药有限公司 一种含吡喃取代的吗啉类化合物的制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010514676A (ja) * 2006-12-21 2010-05-06 バーテックス ファーマシューティカルズ インコーポレイテッド タンパク質キナーゼ阻害剤として有用な５−シアノ−４−（ピロロ［２，３ｂ］ピリジン−３−イル）−ピリミジン誘導体
WO2012020762A1 (ja) * 2010-08-10 2012-02-16 アステラス製薬株式会社 へテロ環化合物
JP2017523192A (ja) * 2014-08-04 2017-08-17 ヌエヴォリューション・アクティーゼルスカブＮｕｅｖｏｌｕｔｉｏｎ Ａ／Ｓ 炎症性、代謝性、腫瘍性および自己免疫疾患の処置に有用なピリミジンの任意選択により縮合されているヘテロシクリル置換誘導体

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