JP2020528430A5 - - Google Patents
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- JP2020528430A5 JP2020528430A5 JP2020503840A JP2020503840A JP2020528430A5 JP 2020528430 A5 JP2020528430 A5 JP 2020528430A5 JP 2020503840 A JP2020503840 A JP 2020503840A JP 2020503840 A JP2020503840 A JP 2020503840A JP 2020528430 A5 JP2020528430 A5 JP 2020528430A5
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- Prior art keywords
- disorder
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- obsessive
- compulsive
- dependence
- Prior art date
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 38
- 208000035475 disorder Diseases 0.000 claims description 37
- 150000001875 compounds Chemical class 0.000 claims description 34
- 150000003839 salts Chemical group 0.000 claims description 27
- 208000002193 Pain Diseases 0.000 claims description 20
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 claims description 19
- 208000020016 psychiatric disease Diseases 0.000 claims description 18
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims description 14
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims description 14
- 206010013663 drug dependence Diseases 0.000 claims description 14
- 239000008194 pharmaceutical composition Substances 0.000 claims description 14
- 201000000980 schizophrenia Diseases 0.000 claims description 12
- 208000011117 substance-related disease Diseases 0.000 claims description 12
- 208000015114 central nervous system disease Diseases 0.000 claims description 11
- 208000007848 Alcoholism Diseases 0.000 claims description 8
- 208000019901 Anxiety disease Diseases 0.000 claims description 8
- 206010012289 Dementia Diseases 0.000 claims description 8
- 208000026251 Opioid-Related disease Diseases 0.000 claims description 8
- 208000018737 Parkinson disease Diseases 0.000 claims description 8
- 201000007930 alcohol dependence Diseases 0.000 claims description 8
- 239000003814 drug Substances 0.000 claims description 8
- 208000030459 obsessive-compulsive personality disease Diseases 0.000 claims description 8
- 201000005040 opiate dependence Diseases 0.000 claims description 8
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 claims description 8
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims description 7
- 208000035231 inattentive type attention deficit hyperactivity disease Diseases 0.000 claims description 7
- 208000012902 Nervous system disease Diseases 0.000 claims description 6
- 206010041250 Social phobia Diseases 0.000 claims description 6
- 125000000217 alkyl group Chemical group 0.000 claims description 6
- 230000036506 anxiety Effects 0.000 claims description 6
- 229940079593 drug Drugs 0.000 claims description 6
- 229940127240 opiate Drugs 0.000 claims description 6
- 239000002245 particle Substances 0.000 claims description 6
- 208000019116 sleep disease Diseases 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 5
- 208000024827 Alzheimer disease Diseases 0.000 claims description 4
- 208000029197 Amphetamine-Related disease Diseases 0.000 claims description 4
- 208000000094 Chronic Pain Diseases 0.000 claims description 4
- 208000022497 Cocaine-Related disease Diseases 0.000 claims description 4
- 206010061619 Deformity Diseases 0.000 claims description 4
- 208000001640 Fibromyalgia Diseases 0.000 claims description 4
- 206010019233 Headaches Diseases 0.000 claims description 4
- 208000019022 Mood disease Diseases 0.000 claims description 4
- 208000012488 Opiate Overdose Diseases 0.000 claims description 4
- 206010034158 Pathological gambling Diseases 0.000 claims description 4
- 206010034912 Phobia Diseases 0.000 claims description 4
- 208000028552 Treatment-Resistant Depressive disease Diseases 0.000 claims description 4
- 208000029650 alcohol withdrawal Diseases 0.000 claims description 4
- 201000006145 cocaine dependence Diseases 0.000 claims description 4
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 claims description 4
- 206010016256 fatigue Diseases 0.000 claims description 4
- 230000003370 grooming effect Effects 0.000 claims description 4
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- 238000011282 treatment Methods 0.000 claims description 4
- 206010003805 Autism Diseases 0.000 claims description 3
- 208000020706 Autistic disease Diseases 0.000 claims description 3
- 239000000556 agonist Substances 0.000 claims description 3
- 230000002265 prevention Effects 0.000 claims description 3
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims description 2
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims description 2
- USSIQXCVUWKGNF-UHFFFAOYSA-N 6-(dimethylamino)-4,4-diphenylheptan-3-one Chemical compound C=1C=CC=CC=1C(CC(C)N(C)C)(C(=O)CC)C1=CC=CC=C1 USSIQXCVUWKGNF-UHFFFAOYSA-N 0.000 claims description 2
- 206010012239 Delusion Diseases 0.000 claims description 2
- 208000019454 Feeding and Eating disease Diseases 0.000 claims description 2
- 208000018460 Feeding disease Diseases 0.000 claims description 2
- 208000010235 Food Addiction Diseases 0.000 claims description 2
- 208000018522 Gastrointestinal disease Diseases 0.000 claims description 2
- 206010020710 Hyperphagia Diseases 0.000 claims description 2
- 208000030990 Impulse-control disease Diseases 0.000 claims description 2
- 208000019695 Migraine disease Diseases 0.000 claims description 2
- 208000025966 Neurological disease Diseases 0.000 claims description 2
- 102000048266 Nociceptin Human genes 0.000 claims description 2
- 108090000622 Nociceptin Proteins 0.000 claims description 2
- 208000028017 Psychotic disease Diseases 0.000 claims description 2
- 239000005557 antagonist Substances 0.000 claims description 2
- RMRJXGBAOAMLHD-IHFGGWKQSA-N buprenorphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]11CC[C@]3([C@H](C1)[C@](C)(O)C(C)(C)C)OC)CN2CC1CC1 RMRJXGBAOAMLHD-IHFGGWKQSA-N 0.000 claims description 2
- 229960001736 buprenorphine Drugs 0.000 claims description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 2
- 239000013078 crystal Substances 0.000 claims description 2
- 231100000868 delusion Toxicity 0.000 claims description 2
- 235000014632 disordered eating Nutrition 0.000 claims description 2
- 229960003638 dopamine Drugs 0.000 claims description 2
- 230000004064 dysfunction Effects 0.000 claims description 2
- 230000005176 gastrointestinal motility Effects 0.000 claims description 2
- 238000002347 injection Methods 0.000 claims description 2
- 239000007924 injection Substances 0.000 claims description 2
- 238000010255 intramuscular injection Methods 0.000 claims description 2
- 239000007927 intramuscular injection Substances 0.000 claims description 2
- 208000024714 major depressive disease Diseases 0.000 claims description 2
- 208000011736 mal de Debarquement Diseases 0.000 claims description 2
- 229960001797 methadone Drugs 0.000 claims description 2
- 206010027599 migraine Diseases 0.000 claims description 2
- 102000051367 mu Opioid Receptors Human genes 0.000 claims description 2
- UZHSEJADLWPNLE-GRGSLBFTSA-N naloxone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(O)C2=C5[C@@]13CCN4CC=C UZHSEJADLWPNLE-GRGSLBFTSA-N 0.000 claims description 2
- 229960004127 naloxone Drugs 0.000 claims description 2
- DQCKKXVULJGBQN-XFWGSAIBSA-N naltrexone Chemical compound N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=O)O)CC1)O)CC1CC1 DQCKKXVULJGBQN-XFWGSAIBSA-N 0.000 claims description 2
- 229960003086 naltrexone Drugs 0.000 claims description 2
- PULGYDLMFSFVBL-SMFNREODSA-N nociceptin Chemical compound C([C@@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(O)=O)[C@@H](C)O)NC(=O)CNC(=O)CNC(=O)[C@@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 PULGYDLMFSFVBL-SMFNREODSA-N 0.000 claims description 2
- 239000004031 partial agonist Substances 0.000 claims description 2
- 230000037361 pathway Effects 0.000 claims description 2
- 102000005962 receptors Human genes 0.000 claims description 2
- 108020003175 receptors Proteins 0.000 claims description 2
- 229940076279 serotonin Drugs 0.000 claims description 2
- 230000000697 serotonin reuptake Effects 0.000 claims description 2
- 208000012201 sexual and gender identity disease Diseases 0.000 claims description 2
- 208000015891 sexual disease Diseases 0.000 claims description 2
- 238000010254 subcutaneous injection Methods 0.000 claims description 2
- 239000007929 subcutaneous injection Substances 0.000 claims description 2
- 108020001612 μ-opioid receptors Proteins 0.000 claims description 2
- 208000012661 Dyskinesia Diseases 0.000 claims 1
- 230000007812 deficiency Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 230000000750 progressive effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 6
- 230000036470 plasma concentration Effects 0.000 description 4
- 230000007062 hydrolysis Effects 0.000 description 2
- 238000006460 hydrolysis reaction Methods 0.000 description 2
- WUZBOJXXYMKMMF-UHFFFAOYSA-N COC1=CC2=NC=3N(C(N(C(C=3N2C=C1)=O)CCC)=O)CCCCNC(=O)C1=CC=C(C=C1)S(=O)(=O)F Chemical compound COC1=CC2=NC=3N(C(N(C(C=3N2C=C1)=O)CCC)=O)CCCCNC(=O)C1=CC=C(C=C1)S(=O)(=O)F WUZBOJXXYMKMMF-UHFFFAOYSA-N 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 229940125425 inverse agonist Drugs 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 229940002612 prodrug Drugs 0.000 description 1
- 239000000651 prodrug Substances 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762537292P | 2017-07-26 | 2017-07-26 | |
| US62/537,292 | 2017-07-26 | ||
| US201862647492P | 2018-03-23 | 2018-03-23 | |
| US62/647,492 | 2018-03-23 | ||
| PCT/US2018/043102 WO2019023063A1 (en) | 2017-07-26 | 2018-07-20 | ORGANIC COMPOUNDS |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020528430A JP2020528430A (ja) | 2020-09-24 |
| JP2020528430A5 true JP2020528430A5 (enExample) | 2021-08-26 |
| JP7224333B2 JP7224333B2 (ja) | 2023-02-17 |
Family
ID=65041284
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020503840A Active JP7224333B2 (ja) | 2017-07-26 | 2018-07-20 | 有機化合物 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US11427587B2 (enExample) |
| EP (1) | EP3658144B1 (enExample) |
| JP (1) | JP7224333B2 (enExample) |
| KR (1) | KR102667268B1 (enExample) |
| CN (1) | CN111093664B (enExample) |
| AU (1) | AU2018307480B2 (enExample) |
| CA (1) | CA3071137A1 (enExample) |
| IL (1) | IL272252B2 (enExample) |
| MX (1) | MX2020000967A (enExample) |
| WO (1) | WO2019023063A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX377802B (es) * | 2008-05-27 | 2025-03-11 | Intra Cellular Therapies Inc | Metodos y composiciones para trastornos del sueño y otros trastornos. |
| RU2014145682A (ru) | 2012-04-14 | 2016-06-10 | Интра-Селлулар Терапиз, Инк | Органические соединения |
| PL3838274T3 (pl) | 2016-01-26 | 2024-04-02 | Intra-Cellular Therapies, Inc. | Pochodna pirydo[3',4':4,5]pirolo[1,2,3-DE]chinoksaliny do zastosowania w leczeniu zaburzeń OUN |
| CA3016353C (en) | 2016-03-25 | 2021-04-27 | Intra-Cellular Therapies, Inc. | Deuterated fused heterocycle gamma-carbolines and compositions thereof useful in the treatment of nervous system disorders |
| KR102398194B1 (ko) | 2017-03-24 | 2022-05-18 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 신규한 조성물 및 방법 |
| BR112020001666A2 (pt) * | 2017-07-26 | 2020-07-21 | Intra-Cellular Therapies, Inc. | compostos orgânicos |
| KR102667268B1 (ko) * | 2017-07-26 | 2024-05-17 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 유기 화합물 |
| MX2020007271A (es) | 2017-09-26 | 2020-08-17 | Intra Cellular Therapies Inc | Sales y cristales novedosos. |
| MX2020009668A (es) | 2018-03-16 | 2021-01-08 | Intra Cellular Therapies Inc | Métodos novedosos. |
| WO2019183341A1 (en) | 2018-03-23 | 2019-09-26 | Intra-Cellular Therapies, Inc. | Organic compounds |
| WO2019237037A1 (en) | 2018-06-08 | 2019-12-12 | Intra-Cellular Therapies, Inc. | Novel methods |
| ES3047409T3 (en) * | 2018-12-17 | 2025-12-03 | Intra Cellular Therapies Inc | Substituted heterocycle fused gamma-carbolines synthesis |
| EP3898221A4 (en) | 2018-12-17 | 2022-09-14 | Intra-Cellular Therapies, Inc. | ORGANIC COMPOUND |
| IL283959B2 (en) * | 2018-12-17 | 2025-01-01 | Intra Cellular Therapies Inc | Synthesis of condensed gamma-carbolines and converted heterocycles |
| JP7377871B2 (ja) | 2018-12-21 | 2023-11-10 | イントラ－セルラー・セラピーズ・インコーポレイテッド | 有機化合物 |
| US12331052B2 (en) | 2018-12-21 | 2025-06-17 | Intra-Cellular Therapies, Inc. | Organic compounds |
| CN118105390A (zh) * | 2019-01-23 | 2024-05-31 | 细胞内治疗公司 | 治疗成瘾的方法 |
| US20220184072A1 (en) * | 2019-04-04 | 2022-06-16 | Intra-Cellular Therapies, Inc. | Methods of treating neuropathic pain |
| AU2020311894B2 (en) | 2019-07-07 | 2025-06-26 | Intra-Cellular Therapies, Inc. | Novel methods |
| JP2022549335A (ja) * | 2019-09-25 | 2022-11-24 | イントラ－セルラー・セラピーズ・インコーポレイテッド | 新規方法 |
| US11753419B2 (en) | 2019-12-11 | 2023-09-12 | Intra-Cellular Therapies, Inc. | 4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl)-1-(4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3′4′:4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl)phenyl)butan-1-one for treating conditions of the central nervous system and cardiac disorders |
| US12414948B2 (en) | 2022-05-18 | 2025-09-16 | Intra-Cellular Therapies, Inc. | Methods |
| KR102689037B1 (ko) | 2022-07-12 | 2024-07-30 | 에스케이바이오사이언스 주식회사 | SARS-CoV-2 백신 부스터 조성물 |
| WO2024145659A1 (en) | 2022-12-30 | 2024-07-04 | Intra-Cellular Therapies, Inc. | Heterocycle fused gamma-carbolines acting on the serotonine 5-ht2a receptor |
| EP4665344A1 (en) | 2023-02-17 | 2025-12-24 | Intra-Cellular Therapies, Inc. | Lumateperone and derivatives thereof for modulating the nervous system |
| WO2025257090A1 (en) | 2024-06-10 | 2025-12-18 | Interquim, S.A. | Process for the preparation of synthesis intermediates of lumateperone and lumateperone analogues |
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2018
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- 2018-07-20 WO PCT/US2018/043102 patent/WO2019023063A1/en not_active Ceased
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- 2018-07-20 MX MX2020000967A patent/MX2020000967A/es unknown
- 2018-07-20 AU AU2018307480A patent/AU2018307480B2/en active Active
- 2018-07-20 JP JP2020503840A patent/JP7224333B2/ja active Active
- 2018-07-20 EP EP18837299.9A patent/EP3658144B1/en active Active
- 2018-07-20 CN CN201880057525.5A patent/CN111093664B/zh active Active
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