JP2020526484A5 - - Google Patents
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- Publication number
- JP2020526484A5 JP2020526484A5 JP2019570919A JP2019570919A JP2020526484A5 JP 2020526484 A5 JP2020526484 A5 JP 2020526484A5 JP 2019570919 A JP2019570919 A JP 2019570919A JP 2019570919 A JP2019570919 A JP 2019570919A JP 2020526484 A5 JP2020526484 A5 JP 2020526484A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- alkyl
- compound
- halo
- carboxyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims description 119
- 125000000217 alkyl group Chemical group 0.000 claims description 37
- 125000005843 halogen group Chemical group 0.000 claims description 27
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 19
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 16
- 125000003545 alkoxy group Chemical group 0.000 claims description 14
- 229910052739 hydrogen Inorganic materials 0.000 claims description 14
- 239000001257 hydrogen Substances 0.000 claims description 14
- 239000008194 pharmaceutical composition Substances 0.000 claims description 12
- 150000002148 esters Chemical group 0.000 claims description 10
- 230000003779 hair growth Effects 0.000 claims description 10
- 125000004423 acyloxy group Chemical group 0.000 claims description 9
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 9
- 150000002431 hydrogen Chemical class 0.000 claims description 8
- 150000003839 salts Chemical class 0.000 claims description 8
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 7
- 125000004429 atom Chemical group 0.000 claims description 7
- 125000000623 heterocyclic group Chemical group 0.000 claims description 7
- 239000003112 inhibitor Substances 0.000 claims description 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 7
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 6
- 150000001408 amides Chemical group 0.000 claims description 6
- 125000003118 aryl group Chemical group 0.000 claims description 6
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 6
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 5
- 230000001737 promoting effect Effects 0.000 claims description 5
- 201000004384 Alopecia Diseases 0.000 claims description 4
- 229940122159 Myeloperoxidase inhibitor Drugs 0.000 claims description 4
- -1 carboxyl compound Chemical class 0.000 claims description 4
- 125000001309 chloro group Chemical group Cl* 0.000 claims description 4
- 230000003676 hair loss Effects 0.000 claims description 4
- 208000002271 trichotillomania Diseases 0.000 claims description 4
- 125000003668 acetyloxy group Chemical group [H]C([H])([H])C(=O)O[*] 0.000 claims description 3
- 125000001188 haloalkyl group Chemical group 0.000 claims description 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 2
- 125000001153 fluoro group Chemical group F* 0.000 claims description 2
- 125000003709 fluoroalkyl group Chemical group 0.000 claims description 2
- 125000002757 morpholinyl group Chemical group 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 238000011200 topical administration Methods 0.000 claims description 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 2
- 230000001575 pathological effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 14
- 239000000203 mixture Substances 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 3
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 230000003834 intracellular effect Effects 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 2
- 0 CC(*)(C=CC=C1)C2=C1N(*)C[C@]2C=C(*)C(**)=O Chemical compound CC(*)(C=CC=C1)C2=C1N(*)C[C@]2C=C(*)C(**)=O 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
- 125000001246 bromo group Chemical group Br* 0.000 description 1
- 210000003780 hair follicle Anatomy 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023013832A JP2023061995A (ja) | 2017-06-30 | 2023-02-01 | 発毛を調節するための組成物及び方法 |
| JP2025043221A JP2025102814A (ja) | 2017-06-30 | 2025-03-18 | 発毛を調節するための組成物及び方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762527775P | 2017-06-30 | 2017-06-30 | |
| US62/527,775 | 2017-06-30 | ||
| US201862654095P | 2018-04-06 | 2018-04-06 | |
| US62/654,095 | 2018-04-06 | ||
| PCT/US2018/040385 WO2019006359A1 (en) | 2017-06-30 | 2018-06-29 | COMPOSITIONS AND METHODS FOR MODULATION OF HAIR GROWTH |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023013832A Division JP2023061995A (ja) | 2017-06-30 | 2023-02-01 | 発毛を調節するための組成物及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020526484A JP2020526484A (ja) | 2020-08-31 |
| JP2020526484A5 true JP2020526484A5 (enExample) | 2021-09-16 |
| JP7221227B2 JP7221227B2 (ja) | 2023-02-13 |
Family
ID=64742233
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019570919A Active JP7221227B2 (ja) | 2017-06-30 | 2018-06-29 | 発毛を調節するための組成物及び方法 |
| JP2023013832A Pending JP2023061995A (ja) | 2017-06-30 | 2023-02-01 | 発毛を調節するための組成物及び方法 |
| JP2025043221A Pending JP2025102814A (ja) | 2017-06-30 | 2025-03-18 | 発毛を調節するための組成物及び方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023013832A Pending JP2023061995A (ja) | 2017-06-30 | 2023-02-01 | 発毛を調節するための組成物及び方法 |
| JP2025043221A Pending JP2025102814A (ja) | 2017-06-30 | 2025-03-18 | 発毛を調節するための組成物及び方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (5) | US11312714B2 (enExample) |
| EP (1) | EP3644989A4 (enExample) |
| JP (3) | JP7221227B2 (enExample) |
| KR (3) | KR20250151619A (enExample) |
| CN (2) | CN110944634A (enExample) |
| AR (1) | AR114075A1 (enExample) |
| AU (3) | AU2018294351B2 (enExample) |
| CA (1) | CA3067746A1 (enExample) |
| CL (1) | CL2019003886A1 (enExample) |
| EA (1) | EA202090179A1 (enExample) |
| IL (3) | IL271443B2 (enExample) |
| MX (2) | MX2019015475A (enExample) |
| PE (1) | PE20200743A1 (enExample) |
| PH (1) | PH12019502776A1 (enExample) |
| WO (1) | WO2019006359A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110300583A (zh) | 2017-02-24 | 2019-10-01 | 加利福尼亚大学董事会 | 利用mpc1抑制剂促进毛发生长的组合物和方法 |
| JP7221227B2 (ja) | 2017-06-30 | 2023-02-13 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 発毛を調節するための組成物及び方法 |
| WO2019200063A1 (en) * | 2018-04-13 | 2019-10-17 | North Carolina State University | Use of microneedle patch to promote hair growth |
| CA3124820A1 (en) * | 2019-01-02 | 2020-07-09 | The Regents Of The University Of California | Compositions and methods for modulating hair growth |
| JP7728260B6 (ja) * | 2019-12-20 | 2025-09-18 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 発毛を促進する化合物の合成 |
| FR3105222B1 (fr) * | 2019-12-20 | 2022-06-03 | Nunii Laboratoire | Inhibiteur du transporteur MCT7/SLC16A6 pour son utilisation pour la régulation de la pigmentation cutanée et une composition comprenant ledit inhibiteur |
| US20230227406A1 (en) * | 2020-06-12 | 2023-07-20 | Rekindle Therapeutics Inc. | Modulators of e3 ligases |
| US20230322765A1 (en) * | 2020-06-30 | 2023-10-12 | The Regents Of The University Of California | Compositions and methods for modulating hair growth |
| WO2022006039A1 (en) * | 2020-06-30 | 2022-01-06 | The Regents Of The University Of California | Compositions and methods for modulating hair growth |
| KR20240130763A (ko) * | 2021-12-29 | 2024-08-29 | 펠라지 파마슈티컬스, 인크. | 탈모 치료용 화합물 |
| US20250163045A1 (en) | 2021-12-29 | 2025-05-22 | Pelage Pharmaceuticals, Inc. | Compounds for treatment of hair loss |
| WO2023191515A1 (ko) * | 2022-03-29 | 2023-10-05 | 연세대학교 산학협력단 | 인디루빈 유도체 및 대사활성화제를 포함하는 탈모 방지 또는 발모 촉진용 조성물 |
| KR20250123928A (ko) * | 2022-12-27 | 2025-08-18 | 펠라지 파마슈티컬스, 인크. | 탈모 치료용 화합물 |
| CN116251086A (zh) * | 2023-02-15 | 2023-06-13 | 江西中医药大学 | 乳酸及其衍生物在促毛发生长及缓解脱发中的应用 |
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| JPH0235746B2 (ja) | 1983-03-07 | 1990-08-13 | Sagami Chem Res | 33chikantetorafuruoroindoorujudotai |
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| GB9023585D0 (en) | 1990-10-30 | 1990-12-12 | Beecham Group Plc | Novel compounds |
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| FR2796274B1 (fr) | 1999-07-16 | 2001-09-21 | Oreal | Utilisation de l'acide 4,6-dimethoxy-indole 2-carboxylique ou de ses derives pour stimuler ou induire la pousse des cheveux et/ou stopper leur chute |
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| WO2018039612A1 (en) * | 2016-08-26 | 2018-03-01 | The Regents Of The University Of California | Compositions and methods for promoting hair growth with mpc1 inhibitors |
| KR20190126283A (ko) | 2016-12-22 | 2019-11-11 | 마브파마, 인크. | 포스포디에스테라아제 저해제 및 미생물 치료 방법 |
| CN110300583A (zh) * | 2017-02-24 | 2019-10-01 | 加利福尼亚大学董事会 | 利用mpc1抑制剂促进毛发生长的组合物和方法 |
| CN106880693A (zh) | 2017-03-22 | 2017-06-23 | 广州国草夏方生物科技有限公司 | 一种治疗脂溢性脱发的生发液组合物及其制备方法 |
| JP7221227B2 (ja) | 2017-06-30 | 2023-02-13 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 発毛を調節するための組成物及び方法 |
| WO2019067860A1 (en) | 2017-09-29 | 2019-04-04 | The Regents Of The University Of California | COMPOSITIONS AND METHODS FOR MODULATION OF HAIR GROWTH |
| CA3124820A1 (en) | 2019-01-02 | 2020-07-09 | The Regents Of The University Of California | Compositions and methods for modulating hair growth |
| US20220079900A1 (en) | 2019-01-14 | 2022-03-17 | The Regents Of The University Of California | Compositions and methods for treating cardiac injury |
| US20220079899A1 (en) | 2019-01-14 | 2022-03-17 | The Regents Of The University Of California | Compositions and methods for treating ocular conditions |
| JP7728260B6 (ja) | 2019-12-20 | 2025-09-18 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 発毛を促進する化合物の合成 |
| WO2022006039A1 (en) | 2020-06-30 | 2022-01-06 | The Regents Of The University Of California | Compositions and methods for modulating hair growth |
| US20230322765A1 (en) | 2020-06-30 | 2023-10-12 | The Regents Of The University Of California | Compositions and methods for modulating hair growth |
-
2018
- 2018-06-29 JP JP2019570919A patent/JP7221227B2/ja active Active
- 2018-06-29 CN CN201880043696.2A patent/CN110944634A/zh active Pending
- 2018-06-29 AU AU2018294351A patent/AU2018294351B2/en active Active
- 2018-06-29 EP EP18823621.0A patent/EP3644989A4/en active Pending
- 2018-06-29 CN CN202310059843.8A patent/CN116120314A/zh active Pending
- 2018-06-29 EA EA202090179A patent/EA202090179A1/ru unknown
- 2018-06-29 PH PH1/2019/502776A patent/PH12019502776A1/en unknown
- 2018-06-29 IL IL271443A patent/IL271443B2/en unknown
- 2018-06-29 KR KR1020257034172A patent/KR20250151619A/ko active Pending
- 2018-06-29 CA CA3067746A patent/CA3067746A1/en active Pending
- 2018-06-29 IL IL321754A patent/IL321754A/en unknown
- 2018-06-29 WO PCT/US2018/040385 patent/WO2019006359A1/en not_active Ceased
- 2018-06-29 KR KR1020247006533A patent/KR102872871B1/ko active Active
- 2018-06-29 KR KR1020207002665A patent/KR102642823B1/ko active Active
- 2018-06-29 US US16/627,630 patent/US11312714B2/en active Active
- 2018-06-29 MX MX2019015475A patent/MX2019015475A/es unknown
- 2018-06-29 PE PE2019002625A patent/PE20200743A1/es unknown
-
2019
- 2019-01-03 AR ARP190100011A patent/AR114075A1/es not_active Application Discontinuation
- 2019-12-18 MX MX2022007823A patent/MX2022007823A/es unknown
- 2019-12-27 CL CL2019003886A patent/CL2019003886A1/es unknown
-
2022
- 2022-01-25 US US17/584,091 patent/US11472804B2/en active Active
- 2022-06-23 US US17/847,980 patent/US11787804B2/en active Active
-
2023
- 2023-02-01 JP JP2023013832A patent/JP2023061995A/ja active Pending
- 2023-03-17 AU AU2023201669A patent/AU2023201669B2/en active Active
- 2023-08-17 IL IL305317A patent/IL305317B2/en unknown
- 2023-09-01 US US18/241,583 patent/US12227503B2/en active Active
-
2025
- 2025-02-14 US US19/053,911 patent/US20250304579A1/en active Pending
- 2025-03-18 JP JP2025043221A patent/JP2025102814A/ja active Pending
- 2025-04-28 AU AU2025202961A patent/AU2025202961A1/en active Pending
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