EA202090987A1 - Новые пролекарства на основе катехоламина для применения в лечении болезни паркинсона - Google Patents

Новые пролекарства на основе катехоламина для применения в лечении болезни паркинсона

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EA202090987A1
EA202090987A1 EA202090987A EA202090987A EA202090987A1 EA 202090987 A1 EA202090987 A1 EA 202090987A1 EA 202090987 A EA202090987 A EA 202090987A EA 202090987 A EA202090987 A EA 202090987A EA 202090987 A1 EA202090987 A1 EA 202090987A1
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substituent
present
compounds
disease
treatment
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EA202090987A
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English (en)
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EA202090987A8 (ru
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Клаус Гьервиг Йенсен
Лисбет Кваерно
Мартин Джухл
Йоргенсен Мортен
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Х. Лундбекк А/С
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Publication of EA202090987A1 publication Critical patent/EA202090987A1/ru
Publication of EA202090987A8 publication Critical patent/EA202090987A8/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

В настоящем изобретении предусмотрены соединения формулы (I), которые представляют собой пролекарства на основе катехоламина для применения в лечении нейродегенеративных заболеваний и нарушений. В настоящем изобретении также предусмотрены фармацевтические композиции, содержащие соединения по настоящему изобретению, и способы лечения нейродегенеративных или нейропсихиатрических заболеваний и нарушений с применением соединений по настоящему изобретению, в частности болезни Паркинсона. Соответственно, настоящее изобретение относится к соединениям формулы (Id)где R1 представляет собой H и R2 выбран из одного из заместителей (i) и (ii), указанных ниже; или R1 выбран из одного из заместителей (i) и (ii), указанных ниже, и R2 представляет собой H; или R1 и R2 одновременно представлены заместителем (i), указанным ниже; или R1 и R2 одновременно представлены заместителем (ii), указанным ниже; или R1 представляет собой заместитель (i) и R2 представляет собой заместитель (ii); или R1 представляет собой заместитель (ii) и R2 представляет собой заместитель (i)где * обозначает точку присоединения; и при этом атом углерода в точке присоединения при заместителе (i) находится в S-конфигурации; или их фармацевтически приемлемой соли.
EA202090987A 2017-11-24 2018-11-23 Новые пролекарства на основе катехоламина для применения в лечении болезни паркинсона EA202090987A8 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA201700674 2017-11-24
PCT/EP2018/082361 WO2019101917A1 (en) 2017-11-24 2018-11-23 New catecholamine prodrugs for use in the treatment of parkinson's disease

Publications (2)

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EA202090987A1 true EA202090987A1 (ru) 2020-08-07
EA202090987A8 EA202090987A8 (ru) 2020-09-29

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Country Status (25)

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US (4) US10729710B2 (ru)
EP (1) EP3713933A1 (ru)
JP (4) JP7320507B2 (ru)
KR (1) KR20200092955A (ru)
CN (3) CN117599073A (ru)
AR (1) AR113908A1 (ru)
AU (2) AU2018371193B2 (ru)
BR (1) BR112019014981A2 (ru)
CA (1) CA3082757A1 (ru)
CL (1) CL2020001343A1 (ru)
CO (1) CO2020006224A2 (ru)
CR (1) CR20200225A (ru)
EA (1) EA202090987A8 (ru)
EC (1) ECSP20030074A (ru)
GE (1) GEP20227446B (ru)
IL (1) IL274648A (ru)
JO (1) JOP20200114A1 (ru)
MA (1) MA50800A (ru)
MX (2) MX2020005366A (ru)
PE (1) PE20211290A1 (ru)
PH (1) PH12020550631A1 (ru)
SG (1) SG11202004461YA (ru)
TW (1) TWI816716B (ru)
UA (1) UA127575C2 (ru)
WO (1) WO2019101917A1 (ru)

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AR113908A1 (es) 2020-06-24
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ECSP20030074A (es) 2020-07-31
CN117599073A (zh) 2024-02-27
AU2023201741A1 (en) 2023-04-20
US20240156851A1 (en) 2024-05-16
GEP20227446B (en) 2022-12-12
CR20200225A (es) 2020-07-25
WO2019101917A1 (en) 2019-05-31
TWI816716B (zh) 2023-10-01
CN111386267A (zh) 2020-07-07
RU2020116419A (ru) 2021-12-27
US11110110B2 (en) 2021-09-07
US11707476B2 (en) 2023-07-25
MX2020005366A (es) 2020-08-13
UA127575C2 (uk) 2023-10-18
JP2021504345A (ja) 2021-02-15
US20190160083A1 (en) 2019-05-30
US20220257623A1 (en) 2022-08-18
EA202090987A8 (ru) 2020-09-29
IL274648A (en) 2020-06-30
EP3713933A1 (en) 2020-09-30
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CN117653649A (zh) 2024-03-08
CN111386267B (zh) 2023-12-12
TW201924693A (zh) 2019-07-01
SG11202004461YA (en) 2020-06-29
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CL2020001343A1 (es) 2020-09-25
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JP2023145580A (ja) 2023-10-11
JP2023055830A (ja) 2023-04-18
US20200338102A1 (en) 2020-10-29
JOP20200114A1 (ar) 2020-05-17
KR20200092955A (ko) 2020-08-04
AU2018371193B2 (en) 2022-12-22
BR112019014981A2 (pt) 2020-04-07
US10729710B2 (en) 2020-08-04
CO2020006224A2 (es) 2020-05-29
JP7320507B2 (ja) 2023-08-03
AU2018371193A1 (en) 2020-06-11

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