CY1124828T1 - Αλλοστερικοι διαμορφωτες των νικοτινικων υποδοχεων ακετυλχολινης - Google Patents

Αλλοστερικοι διαμορφωτες των νικοτινικων υποδοχεων ακετυλχολινης

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Publication number
CY1124828T1
CY1124828T1 CY20211101106T CY211101106T CY1124828T1 CY 1124828 T1 CY1124828 T1 CY 1124828T1 CY 20211101106 T CY20211101106 T CY 20211101106T CY 211101106 T CY211101106 T CY 211101106T CY 1124828 T1 CY1124828 T1 CY 1124828T1
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CY
Cyprus
Prior art keywords
disease
compounds
allosteric modulators
acetylcholine receptors
nicotine acetylcholine
Prior art date
Application number
CY20211101106T
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English (en)
Inventor
Brendan M. Crowley
Brian T. Campbell
Joseph L. Duffy
Thomas J. Greshock
Andrew John Harvey
Belinda C. Huff
Kenneth J. Leavitt
Vanessa L. Rada
John M. Sanders
William D. Shipe
Linda M. Suen
Ian M. Bell
Deodial G. GUIADEEN
Original Assignee
Merck Sharp & Dohme Corp.
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Publication date
Application filed by Merck Sharp & Dohme Corp. filed Critical Merck Sharp & Dohme Corp.
Publication of CY1124828T1 publication Critical patent/CY1124828T1/el

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    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
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    • A61K31/42—Oxazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/425—Thiazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
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    • C07D495/04—Ortho-condensed systems

Abstract

Η παρούσα αποκάλυψη σχετίζεται με ενώσεις του χημικού τύπου (Ι) που είναι χρήσιμες ως διαμορφωτές του α7 nAChR, συνθέσεις που περιλαμβάνουν τέτοιες ενώσεις, και τη χρήση τέτοιων ενώσεων για πρόληψη, αγωγή, ή βελτίωση πάθησης, ειδικότερα διαταραχών του κεντρικού νευρικού συστήματος όπως είναι οι γνωσιακές εξασθενίσεις σε νόσο του Αλτσχάιμερ, νόσο του Πάρκινσον, και σχιζοφρένεια, ως επίσης και για επαγόμενη από L-DOPA δυσκινησία και φλεγμονή.
CY20211101106T 2016-03-22 2021-12-16 Αλλοστερικοι διαμορφωτες των νικοτινικων υποδοχεων ακετυλχολινης CY1124828T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662311888P 2016-03-22 2016-03-22
US201662369778P 2016-08-02 2016-08-02
PCT/US2017/023127 WO2017165256A1 (en) 2016-03-22 2017-03-20 Allosteric modulators of nicotinic acetylcholine receptors

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CY1124828T1 true CY1124828T1 (el) 2022-11-25

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