JP2020517738A5 - - Google Patents
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- Publication number
- JP2020517738A5 JP2020517738A5 JP2020507515A JP2020507515A JP2020517738A5 JP 2020517738 A5 JP2020517738 A5 JP 2020517738A5 JP 2020507515 A JP2020507515 A JP 2020507515A JP 2020507515 A JP2020507515 A JP 2020507515A JP 2020517738 A5 JP2020517738 A5 JP 2020517738A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- cycloalkyl
- conhch
- cme
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 25
- 150000001875 compounds Chemical class 0.000 claims 17
- 150000003839 salts Chemical class 0.000 claims 16
- 125000003545 alkoxy group Chemical group 0.000 claims 10
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 5
- 125000000753 cycloalkyl group Chemical group 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- 125000004076 pyridyl group Chemical group 0.000 claims 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
- -1 C 2-6 Alkoxyyl Chemical group 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 239000003112 inhibitor Substances 0.000 claims 4
- 125000004458 methylaminocarbonyl group Chemical group [H]N(C(*)=O)C([H])([H])[H] 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 125000002541 furyl group Chemical group 0.000 claims 3
- 125000001188 haloalkyl group Chemical group 0.000 claims 3
- 125000002883 imidazolyl group Chemical group 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 102000004310 Ion Channels Human genes 0.000 claims 2
- 102000005348 Neuraminidase Human genes 0.000 claims 2
- 108010006232 Neuraminidase Proteins 0.000 claims 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 2
- 150000001408 amides Chemical group 0.000 claims 2
- 125000005098 aryl alkoxy carbonyl group Chemical group 0.000 claims 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
- 125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 206010022000 influenza Diseases 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 239000001301 oxygen Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000001544 thienyl group Chemical group 0.000 claims 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 1
- 125000006704 (C5-C6) cycloalkyl group Chemical group 0.000 claims 1
- 229940123424 Neuraminidase inhibitor Drugs 0.000 claims 1
- 239000012190 activator Substances 0.000 claims 1
- NLUNLVTVUDIHFE-UHFFFAOYSA-N cyclooctylcyclooctane Chemical group C1CCCCCCC1C1CCCCCCC1 NLUNLVTVUDIHFE-UHFFFAOYSA-N 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 125000004464 hydroxyphenyl group Chemical group 0.000 claims 1
- 125000003387 indolinyl group Chemical group N1(CCC2=CC=CC=C12)* 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 230000002685 pulmonary effect Effects 0.000 claims 1
- 239000002911 sialidase inhibitor Substances 0.000 claims 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 125000004001 thioalkyl group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762489167P | 2017-04-24 | 2017-04-24 | |
| US62/489,167 | 2017-04-24 | ||
| PCT/US2018/028986 WO2018200425A1 (en) | 2017-04-24 | 2018-04-24 | Pyrrolopyrimidine derivatives useful as inhibitors of influenza virus replication |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020517738A JP2020517738A (ja) | 2020-06-18 |
| JP2020517738A5 true JP2020517738A5 (https=) | 2021-06-10 |
| JP7165721B2 JP7165721B2 (ja) | 2022-11-04 |
Family
ID=62117141
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020507515A Active JP7165721B2 (ja) | 2017-04-24 | 2018-04-24 | インフルエンザウイルス複製の阻害剤として有用なピロロピリミジン誘導体 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US11014941B2 (https=) |
| EP (1) | EP3615545B1 (https=) |
| JP (1) | JP7165721B2 (https=) |
| KR (1) | KR102598466B1 (https=) |
| CN (1) | CN110637022B (https=) |
| AU (1) | AU2018257778B2 (https=) |
| CA (1) | CA3059449A1 (https=) |
| DK (1) | DK3615545T3 (https=) |
| EA (1) | EA039181B1 (https=) |
| ES (1) | ES2901875T3 (https=) |
| IL (1) | IL269900B (https=) |
| MX (1) | MX393113B (https=) |
| MY (1) | MY199746A (https=) |
| NZ (1) | NZ757442A (https=) |
| PH (1) | PH12019502376B1 (https=) |
| PL (1) | PL3615545T3 (https=) |
| SG (1) | SG11201909478UA (https=) |
| SM (1) | SMT202100684T1 (https=) |
| TW (1) | TWI778052B (https=) |
| WO (1) | WO2018200425A1 (https=) |
| ZA (1) | ZA201906327B (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2939148T3 (es) * | 2018-10-17 | 2023-04-19 | Cocrystal Pharma Inc | Combinaciones de inhibidores de la replicación del virus de la influenza |
| BR112021009254A2 (pt) * | 2018-11-13 | 2021-08-10 | Cocrystal Pharma, Inc. | formulações para produtos terapêuticos para influenza |
| KR102890026B1 (ko) * | 2019-04-26 | 2025-11-24 | 닛산 가가쿠 가부시키가이샤 | 아릴술폰산 에스테르 화합물의 제조 방법 |
| WO2022007966A1 (zh) * | 2020-07-10 | 2022-01-13 | 四川海思科制药有限公司 | Pb2抑制剂及其制备方法和用途 |
| WO2022109495A1 (en) * | 2020-11-23 | 2022-05-27 | The Regents Of The University Of California | Methods and compositions for linking rna stem loops |
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-
2018
- 2018-04-24 TW TW107113876A patent/TWI778052B/zh active
- 2018-04-24 JP JP2020507515A patent/JP7165721B2/ja active Active
- 2018-04-24 KR KR1020197033668A patent/KR102598466B1/ko active Active
- 2018-04-24 DK DK18723298.8T patent/DK3615545T3/da active
- 2018-04-24 PL PL18723298T patent/PL3615545T3/pl unknown
- 2018-04-24 PH PH1/2019/502376A patent/PH12019502376B1/en unknown
- 2018-04-24 US US16/603,951 patent/US11014941B2/en active Active
- 2018-04-24 SG SG11201909478U patent/SG11201909478UA/en unknown
- 2018-04-24 AU AU2018257778A patent/AU2018257778B2/en active Active
- 2018-04-24 CA CA3059449A patent/CA3059449A1/en active Pending
- 2018-04-24 CN CN201880030665.3A patent/CN110637022B/zh active Active
- 2018-04-24 SM SM20210684T patent/SMT202100684T1/it unknown
- 2018-04-24 NZ NZ757442A patent/NZ757442A/en unknown
- 2018-04-24 ES ES18723298T patent/ES2901875T3/es active Active
- 2018-04-24 MX MX2019012759A patent/MX393113B/es unknown
- 2018-04-24 EP EP18723298.8A patent/EP3615545B1/en active Active
- 2018-04-24 MY MYPI2019005805A patent/MY199746A/en unknown
- 2018-04-24 EA EA201992543A patent/EA039181B1/ru unknown
- 2018-04-24 WO PCT/US2018/028986 patent/WO2018200425A1/en not_active Ceased
-
2019
- 2019-09-25 ZA ZA2019/06327A patent/ZA201906327B/en unknown
- 2019-10-07 IL IL269900A patent/IL269900B/en unknown