EA039181B1 - Производные пирролопиримидина, пригодные в качестве ингибиторов репликации вируса гриппа - Google Patents

Info

Publication number

EA039181B1

EA039181B1 EA201992543A EA201992543A EA039181B1 EA 039181 B1 EA039181 B1 EA 039181B1 EA 201992543 A EA201992543 A EA 201992543A EA 201992543 A EA201992543 A EA 201992543A EA 039181 B1 EA039181 B1 EA 039181B1

Authority

EA

Eurasian Patent Office

Prior art keywords

compound

mmol

alkyl

salt according

ethoxy

Prior art date

2017-04-24

Links

• Espacenet
• Global Dossier
• Discuss

• 241000712461 unidentified influenza virus Species 0.000 title claims abstract description 42
• 239000003112 inhibitor Substances 0.000 title claims description 5
• 230000029812 viral genome replication Effects 0.000 title description 8
• 150000004944 pyrrolopyrimidines Chemical class 0.000 title 1
• 150000001875 compounds Chemical class 0.000 claims abstract description 252
• 150000003839 salts Chemical class 0.000 claims abstract description 97
• 206010022000 influenza Diseases 0.000 claims abstract description 70
• 239000003814 drug Substances 0.000 claims abstract description 37
• 238000002360 preparation method Methods 0.000 claims abstract description 16
• 239000000203 mixture Substances 0.000 claims description 115
• -1 CO2R Chemical group 0.000 claims description 70
• 239000002245 particle Substances 0.000 claims description 44
• 125000000217 alkyl group Chemical group 0.000 claims description 30
• 229940079593 drug Drugs 0.000 claims description 24
• 238000011282 treatment Methods 0.000 claims description 22
• 229910052799 carbon Inorganic materials 0.000 claims description 15
• 210000004072 lung Anatomy 0.000 claims description 15
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 15
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 14
• 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 claims description 13
• 125000004076 pyridyl group Chemical group 0.000 claims description 13
• 125000001424 substituent group Chemical group 0.000 claims description 11
• 125000003545 alkoxy group Chemical group 0.000 claims description 10
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 10
• 229910052739 hydrogen Inorganic materials 0.000 claims description 10
• 229910052757 nitrogen Inorganic materials 0.000 claims description 10
• 230000002685 pulmonary effect Effects 0.000 claims description 9
• 125000002541 furyl group Chemical group 0.000 claims description 8
• 125000002883 imidazolyl group Chemical group 0.000 claims description 8
• 125000004433 nitrogen atom Chemical group N* 0.000 claims description 8
• 125000001544 thienyl group Chemical group 0.000 claims description 8
• 125000004458 methylaminocarbonyl group Chemical group [H]N(C(*)=O)C([H])([H])[H] 0.000 claims description 5
• 230000002265 prevention Effects 0.000 claims description 5
• 239000002691 unilamellar liposome Substances 0.000 claims description 5
• 125000000304 alkynyl group Chemical group 0.000 claims description 4
• 125000003368 amide group Chemical group 0.000 claims description 4
• 229940042406 direct acting antivirals neuraminidase inhibitors Drugs 0.000 claims description 4
• 125000001188 haloalkyl group Chemical group 0.000 claims description 4
• 229910052736 halogen Inorganic materials 0.000 claims description 4
• 150000002367 halogens Chemical class 0.000 claims description 4
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 4
• CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 claims description 4
• 229910052760 oxygen Inorganic materials 0.000 claims description 4
• 239000002911 sialidase inhibitor Substances 0.000 claims description 4
• 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 4
• 239000013543 active substance Substances 0.000 claims description 3
• 229910052801 chlorine Inorganic materials 0.000 claims description 3
• 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 claims description 3
• 229910052731 fluorine Inorganic materials 0.000 claims description 3
• 125000001475 halogen functional group Chemical group 0.000 claims description 3
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 3
• 125000004001 thioalkyl group Chemical group 0.000 claims description 3
• 125000000520 N-substituted aminocarbonyl group Chemical group [*]NC(=O)* 0.000 claims description 2
• 125000002768 hydroxyalkyl group Chemical group 0.000 claims description 2
• 125000004464 hydroxyphenyl group Chemical group 0.000 claims description 2
• 238000001990 intravenous administration Methods 0.000 claims description 2
• 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
• 229940126181 ion channel inhibitor Drugs 0.000 claims 1
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
• XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 575
• OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 213
• YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 212
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 210
• 235000019439 ethyl acetate Nutrition 0.000 description 198
• 239000000243 solution Substances 0.000 description 197
• RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 183
• WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 169
• VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 164
• 235000002639 sodium chloride Nutrition 0.000 description 163
• HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 123
• ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 115
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 114
• 229920006395 saturated elastomer Polymers 0.000 description 107
• 239000011780 sodium chloride Substances 0.000 description 105
• 239000007788 liquid Substances 0.000 description 103
• 238000006243 chemical reaction Methods 0.000 description 89
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 86
• 239000012044 organic layer Substances 0.000 description 81
• 239000011541 reaction mixture Substances 0.000 description 79
• 239000011734 sodium Substances 0.000 description 70
• 230000002829 reductive effect Effects 0.000 description 67
• 239000003208 petroleum Substances 0.000 description 59
• IUELZZOCOJFXRF-UHFFFAOYSA-N 2-[2-[2-(oxan-2-yloxy)ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate Chemical compound C1=CC(C)=CC=C1S(=O)(=O)OCCOCCOCCOC1OCCCC1 IUELZZOCOJFXRF-UHFFFAOYSA-N 0.000 description 57
• 238000004895 liquid chromatography mass spectrometry Methods 0.000 description 54
• IICZBCNNFSBXDJ-FMPDERDJSA-N ethyl (2S,3S)-3-(2-chloro-5-fluoropyrrolo[2,3-d]pyrimidin-7-yl)bicyclo[2.2.2]octane-2-carboxylate Chemical compound ClC=1N=CC2=C(N=1)N(C=C2F)[C@@H]1[C@H](C2CCC1CC2)C(=O)OCC IICZBCNNFSBXDJ-FMPDERDJSA-N 0.000 description 52
• XNAVXXSQFXHDMT-UHFFFAOYSA-N 2-[2-[2-[2-[2-(oxan-2-yloxy)ethoxy]ethoxy]ethoxy]ethyl]isoindole-1,3-dione Chemical compound O1C(CCCC1)OCCOCCOCCOCCN1C(C2=CC=CC=C2C1=O)=O XNAVXXSQFXHDMT-UHFFFAOYSA-N 0.000 description 50
• PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 47
• 239000008194 pharmaceutical composition Substances 0.000 description 45
• 238000000034 method Methods 0.000 description 44
• 239000005457 ice water Substances 0.000 description 41
• 229910052938 sodium sulfate Inorganic materials 0.000 description 40
• 235000011152 sodium sulphate Nutrition 0.000 description 40
• 235000019441 ethanol Nutrition 0.000 description 37
• VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 35
• 239000007787 solid Substances 0.000 description 35
• RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 34
• 229910000104 sodium hydride Inorganic materials 0.000 description 34
• ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 31
• 239000003795 chemical substances by application Substances 0.000 description 31
• JQBPIXJAJYUTKK-UHFFFAOYSA-N phenyl N-[2-(5-ethoxypentoxy)ethyl]carbamate Chemical compound C(C)OCCCCCOCCNC(OC1=CC=CC=C1)=O JQBPIXJAJYUTKK-UHFFFAOYSA-N 0.000 description 30
• 239000007858 starting material Substances 0.000 description 30
• 239000000460 chlorine Substances 0.000 description 29
• 238000004440 column chromatography Methods 0.000 description 29
• 238000003786 synthesis reaction Methods 0.000 description 28
• 230000015572 biosynthetic process Effects 0.000 description 27
• 239000003960 organic solvent Substances 0.000 description 27
• 239000002502 liposome Substances 0.000 description 26
• 241000700605 Viruses Species 0.000 description 25
• VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 24
• 210000004027 cell Anatomy 0.000 description 24
• YYROPELSRYBVMQ-UHFFFAOYSA-N 4-toluenesulfonyl chloride Chemical compound CC1=CC=C(S(Cl)(=O)=O)C=C1 YYROPELSRYBVMQ-UHFFFAOYSA-N 0.000 description 23
• 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 description 23
• 239000000741 silica gel Substances 0.000 description 23
• 229910002027 silica gel Inorganic materials 0.000 description 23
• CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 21
• IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 21
• 229910000041 hydrogen chloride Inorganic materials 0.000 description 21
• 208000015181 infectious disease Diseases 0.000 description 21
• 239000000725 suspension Substances 0.000 description 21
• WMFOQBRAJBCJND-UHFFFAOYSA-M Lithium hydroxide Chemical compound [Li+].[OH-] WMFOQBRAJBCJND-UHFFFAOYSA-M 0.000 description 20
• JMDJTPCVJFJTSX-JFFVOTQRSA-N ethyl (2S,3S)-3-[2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrrolo[2,3-d]pyrimidin-7-yl]bicyclo[2.2.2]octane-2-carboxylate Chemical compound ClC=1C=C2C(=NC=1)NC=C2C=1N=CC2=C(N=1)N(C=C2F)[C@@H]1[C@H](C2CCC1CC2)C(=O)OCC JMDJTPCVJFJTSX-JFFVOTQRSA-N 0.000 description 20
• 239000000843 powder Substances 0.000 description 20
• 229960004132 diethyl ether Drugs 0.000 description 19
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 19
• 239000000546 pharmaceutical excipient Substances 0.000 description 18
• 239000012043 crude product Substances 0.000 description 16
• 238000003818 flash chromatography Methods 0.000 description 16
• 239000002904 solvent Substances 0.000 description 16
• 208000024891 symptom Diseases 0.000 description 16
• 238000010521 absorption reaction Methods 0.000 description 15
• 239000002253 acid Substances 0.000 description 15
• VHYFNPMBLIVWCW-UHFFFAOYSA-N 4-Dimethylaminopyridine Chemical compound CN(C)C1=CC=NC=C1 VHYFNPMBLIVWCW-UHFFFAOYSA-N 0.000 description 14
• XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 14
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 14
• 201000010099 disease Diseases 0.000 description 14
• 239000002552 dosage form Substances 0.000 description 14
• 239000003937 drug carrier Substances 0.000 description 14
• 230000000694 effects Effects 0.000 description 14
• 239000000706 filtrate Substances 0.000 description 14
• 230000001225 therapeutic effect Effects 0.000 description 14
• UYRQAWXASDWYFX-UHFFFAOYSA-N 2-(5-ethoxypentoxy)ethyl 4-methylbenzenesulfonate Chemical compound CC1=CC=C(C=C1)S(=O)(=O)OCCOCCCCCOCC UYRQAWXASDWYFX-UHFFFAOYSA-N 0.000 description 13
• QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Substances CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 13
• 239000000443 aerosol Substances 0.000 description 13
• 239000010410 layer Substances 0.000 description 13
• 150000003904 phospholipids Chemical class 0.000 description 13
• 125000006239 protecting group Chemical group 0.000 description 13
• 238000012384 transportation and delivery Methods 0.000 description 13
• 241000282412 Homo Species 0.000 description 12
• GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 12
• BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 description 12
• DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 12
• YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 12
• 239000007864 aqueous solution Substances 0.000 description 12
• WGQKYBSKWIADBV-UHFFFAOYSA-N benzylamine Chemical compound NCC1=CC=CC=C1 WGQKYBSKWIADBV-UHFFFAOYSA-N 0.000 description 12
• 125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 description 12
• 208000037798 influenza B Diseases 0.000 description 12
• 239000000463 material Substances 0.000 description 12
• 239000000126 substance Substances 0.000 description 12
• JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 12
• HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 11
• 239000003708 ampul Substances 0.000 description 11
• 239000003085 diluting agent Substances 0.000 description 11
• 239000003755 preservative agent Substances 0.000 description 11
• 239000004094 surface-active agent Substances 0.000 description 11
• 229960005486 vaccine Drugs 0.000 description 11
• 230000003612 virological effect Effects 0.000 description 11
• OFBQJSOFQDEBGM-UHFFFAOYSA-N Pentane Chemical compound CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 10
• 229940125904 compound 1 Drugs 0.000 description 10
• 229920001223 polyethylene glycol Polymers 0.000 description 10
• IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 9
• 241000282414 Homo sapiens Species 0.000 description 9
• 241000712431 Influenza A virus Species 0.000 description 9
• 239000004480 active ingredient Substances 0.000 description 9
• XMIIGOLPHOKFCH-UHFFFAOYSA-N beta-phenylpropanoic acid Natural products OC(=O)CCC1=CC=CC=C1 XMIIGOLPHOKFCH-UHFFFAOYSA-N 0.000 description 9
• 239000002775 capsule Substances 0.000 description 9
• 238000005859 coupling reaction Methods 0.000 description 9
• 235000014113 dietary fatty acids Nutrition 0.000 description 9
• 239000000194 fatty acid Substances 0.000 description 9
• 229930195729 fatty acid Natural products 0.000 description 9
• 238000009472 formulation Methods 0.000 description 9
• 239000003921 oil Substances 0.000 description 9
• 235000019198 oils Nutrition 0.000 description 9
• 241000894007 species Species 0.000 description 9
• GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 8
• JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 description 8
• 239000002585 base Substances 0.000 description 8
• 150000004665 fatty acids Chemical class 0.000 description 8
• 208000037797 influenza A Diseases 0.000 description 8
• 239000000543 intermediate Substances 0.000 description 8
• 239000008101 lactose Substances 0.000 description 8
• HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 8
• 239000004005 microsphere Substances 0.000 description 8
• 210000003928 nasal cavity Anatomy 0.000 description 8
• 230000000069 prophylactic effect Effects 0.000 description 8
• 238000000926 separation method Methods 0.000 description 8
• 239000003826 tablet Substances 0.000 description 8
• 229940124597 therapeutic agent Drugs 0.000 description 8
• GYSSYGOYECOPGB-UHFFFAOYSA-N 2-[2-(2-ethoxyethoxy)ethoxy]ethyl 4-methylbenzenesulfonate Chemical compound CCOCCOCCOCCOS(=O)(=O)C1=CC=C(C)C=C1 GYSSYGOYECOPGB-UHFFFAOYSA-N 0.000 description 7
• 229960000549 4-dimethylaminophenol Drugs 0.000 description 7
• VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 7
• 239000007832 Na2SO4 Substances 0.000 description 7
• MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 7
• 229920002472 Starch Polymers 0.000 description 7
• 229910052786 argon Inorganic materials 0.000 description 7
• 230000037396 body weight Effects 0.000 description 7
• KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 7
• 238000000576 coating method Methods 0.000 description 7
• 239000006185 dispersion Substances 0.000 description 7
• IMCWDOPSYUIRNW-UHFFFAOYSA-N ethyl 2-[2-[2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethoxy]ethoxy]ethoxy]acetate Chemical compound CC(C)(OC(NCCOCCOCCOCC(=O)OCC)=O)C IMCWDOPSYUIRNW-UHFFFAOYSA-N 0.000 description 7
• 239000000499 gel Substances 0.000 description 7
• HVTICUPFWKNHNG-UHFFFAOYSA-N iodoethane Chemical compound CCI HVTICUPFWKNHNG-UHFFFAOYSA-N 0.000 description 7
• 230000001404 mediated effect Effects 0.000 description 7
• 239000012528 membrane Substances 0.000 description 7
• 210000004379 membrane Anatomy 0.000 description 7
• 239000012299 nitrogen atmosphere Substances 0.000 description 7
• LCEFEIBEOBPPSJ-UHFFFAOYSA-N phenyl selenohypobromite Chemical compound Br[Se]C1=CC=CC=C1 LCEFEIBEOBPPSJ-UHFFFAOYSA-N 0.000 description 7
• 230000008569 process Effects 0.000 description 7
• 238000010898 silica gel chromatography Methods 0.000 description 7
• 235000019698 starch Nutrition 0.000 description 7
• 230000009385 viral infection Effects 0.000 description 7
• PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 6
• GQHTUMJGOHRCHB-UHFFFAOYSA-N 2,3,4,6,7,8,9,10-octahydropyrimido[1,2-a]azepine Chemical compound C1CCCCN2CCCN=C21 GQHTUMJGOHRCHB-UHFFFAOYSA-N 0.000 description 6
• WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 6
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
• WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 6
• 241001465754 Metazoa Species 0.000 description 6
• PCLIMKBDDGJMGD-UHFFFAOYSA-N N-bromosuccinimide Chemical compound BrN1C(=O)CCC1=O PCLIMKBDDGJMGD-UHFFFAOYSA-N 0.000 description 6
• 101710102873 Polymerase basic protein 2 Proteins 0.000 description 6
• UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 6
• 235000010443 alginic acid Nutrition 0.000 description 6
• 229920000615 alginic acid Polymers 0.000 description 6
• 239000007900 aqueous suspension Substances 0.000 description 6
• 230000008901 benefit Effects 0.000 description 6
• 239000012472 biological sample Substances 0.000 description 6
• 125000004432 carbon atom Chemical group C* 0.000 description 6
• HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 6
• MGNZXYYWBUKAII-UHFFFAOYSA-N cyclohexa-1,3-diene Chemical compound C1CC=CC=C1 MGNZXYYWBUKAII-UHFFFAOYSA-N 0.000 description 6
• 239000003995 emulsifying agent Substances 0.000 description 6
• 239000003623 enhancer Substances 0.000 description 6
• 239000000796 flavoring agent Substances 0.000 description 6
• 235000011187 glycerol Nutrition 0.000 description 6
• IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 6
• 239000002609 medium Substances 0.000 description 6
• 229910052751 metal Inorganic materials 0.000 description 6
• 239000002184 metal Substances 0.000 description 6
• 231100000252 nontoxic Toxicity 0.000 description 6
• 230000003000 nontoxic effect Effects 0.000 description 6
• KDLHZDBZIXYQEI-UHFFFAOYSA-N palladium Substances [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 6
• 229920000642 polymer Polymers 0.000 description 6
• SCVFZCLFOSHCOH-UHFFFAOYSA-M potassium acetate Chemical compound [K+].CC([O-])=O SCVFZCLFOSHCOH-UHFFFAOYSA-M 0.000 description 6
• BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 6
• FYRHIOVKTDQVFC-UHFFFAOYSA-M potassium phthalimide Chemical compound [K+].C1=CC=C2C(=O)[N-]C(=O)C2=C1 FYRHIOVKTDQVFC-UHFFFAOYSA-M 0.000 description 6
• 238000011321 prophylaxis Methods 0.000 description 6
• ZDYVRSLAEXCVBX-UHFFFAOYSA-N pyridinium p-toluenesulfonate Chemical compound C1=CC=[NH+]C=C1.CC1=CC=C(S([O-])(=O)=O)C=C1 ZDYVRSLAEXCVBX-UHFFFAOYSA-N 0.000 description 6
• YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 6
• 230000000699 topical effect Effects 0.000 description 6
• 238000002255 vaccination Methods 0.000 description 6
• 239000003039 volatile agent Substances 0.000 description 6
• 239000001993 wax Substances 0.000 description 6
• 125000006704 (C5-C6) cycloalkyl group Chemical group 0.000 description 5
• SXXLKZCNJHJYFL-UHFFFAOYSA-N 4,5,6,7-tetrahydro-[1,2]oxazolo[4,5-c]pyridin-5-ium-3-olate Chemical compound C1CNCC2=C1ONC2=O SXXLKZCNJHJYFL-UHFFFAOYSA-N 0.000 description 5
• OZZBSXNMZWVYQU-UHFFFAOYSA-N 5-ethoxypentan-1-ol Chemical compound CCOCCCCCO OZZBSXNMZWVYQU-UHFFFAOYSA-N 0.000 description 5
• 102000004190 Enzymes Human genes 0.000 description 5
• 108090000790 Enzymes Proteins 0.000 description 5
• 230000005526 G1 to G0 transition Effects 0.000 description 5
• 108010010803 Gelatin Proteins 0.000 description 5
• 101000799461 Homo sapiens Thrombopoietin Proteins 0.000 description 5
• 208000002193 Pain Diseases 0.000 description 5
• 239000002202 Polyethylene glycol Substances 0.000 description 5
• ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 5
• 101000906384 Rattus norvegicus Glutathione S-transferase Mu 7 Proteins 0.000 description 5
• 102100034195 Thrombopoietin Human genes 0.000 description 5
• 239000002671 adjuvant Substances 0.000 description 5
• 239000003443 antiviral agent Substances 0.000 description 5
• 238000003556 assay Methods 0.000 description 5
• 239000000969 carrier Substances 0.000 description 5
• 238000004587 chromatography analysis Methods 0.000 description 5
• 239000013078 crystal Substances 0.000 description 5
• 208000035475 disorder Diseases 0.000 description 5
• 239000002270 dispersing agent Substances 0.000 description 5
• 239000000839 emulsion Substances 0.000 description 5
• 150000002148 esters Chemical group 0.000 description 5
• 125000000524 functional group Chemical group 0.000 description 5
• 239000008273 gelatin Substances 0.000 description 5
• 229920000159 gelatin Polymers 0.000 description 5
• 235000019322 gelatine Nutrition 0.000 description 5
• 235000011852 gelatine desserts Nutrition 0.000 description 5
• 150000002632 lipids Chemical class 0.000 description 5
• 239000000314 lubricant Substances 0.000 description 5
• CXKWCBBOMKCUKX-UHFFFAOYSA-M methylene blue Chemical compound [Cl-].C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 CXKWCBBOMKCUKX-UHFFFAOYSA-M 0.000 description 5
• 229960000907 methylthioninium chloride Drugs 0.000 description 5
• 239000002674 ointment Substances 0.000 description 5
• 239000012071 phase Substances 0.000 description 5
• 239000006187 pill Substances 0.000 description 5
• 229910052700 potassium Inorganic materials 0.000 description 5
• 239000011591 potassium Substances 0.000 description 5
• 239000002243 precursor Substances 0.000 description 5
• 230000001932 seasonal effect Effects 0.000 description 5
• 239000007909 solid dosage form Substances 0.000 description 5
• 239000007921 spray Substances 0.000 description 5
• 239000008107 starch Substances 0.000 description 5
• BNWCETAHAJSBFG-UHFFFAOYSA-N tert-butyl 2-bromoacetate Chemical compound CC(C)(C)OC(=O)CBr BNWCETAHAJSBFG-UHFFFAOYSA-N 0.000 description 5
• 239000003981 vehicle Substances 0.000 description 5
• 108091032973 (ribonucleotides)n+m Proteins 0.000 description 4
• NRJAVPSFFCBXDT-HUESYALOSA-N 1,2-distearoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCCCC NRJAVPSFFCBXDT-HUESYALOSA-N 0.000 description 4
• LHGMBOUFOFHWRR-UHFFFAOYSA-N 2-(2-pentoxyethoxy)ethyl 4-methylbenzenesulfonate Chemical compound CCCCCOCCOCCOS(=O)(=O)C1=CC=C(C)C=C1 LHGMBOUFOFHWRR-UHFFFAOYSA-N 0.000 description 4
• KUBUREHZQPDYHT-UHFFFAOYSA-N 2-[2-[2-(oxan-2-yloxy)ethoxy]ethoxy]ethanol Chemical compound OCCOCCOCCOC1CCCCO1 KUBUREHZQPDYHT-UHFFFAOYSA-N 0.000 description 4
• FJDUTKICDGFBHX-UHFFFAOYSA-N 5-(2-ethoxyethoxy)pentyl 4-methylbenzenesulfonate Chemical compound CCOCCOCCCCCOS(=O)(=O)C1=CC=C(C)C=C1 FJDUTKICDGFBHX-UHFFFAOYSA-N 0.000 description 4
• FYARTQIITABLRT-UHFFFAOYSA-N 5-chloro-1-(4-methylphenyl)sulfonyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrrolo[2,3-b]pyridine Chemical compound C1=CC(C)=CC=C1S(=O)(=O)N1C2=NC=C(Cl)C=C2C(B2OC(C)(C)C(C)(C)O2)=C1 FYARTQIITABLRT-UHFFFAOYSA-N 0.000 description 4
• DNWQYGMQDCDMKY-UHFFFAOYSA-N 5-pentoxypentyl 4-methylbenzenesulfonate Chemical compound S(=O)(=O)(OCCCCCOCCCCC)C1=CC=C(C)C=C1 DNWQYGMQDCDMKY-UHFFFAOYSA-N 0.000 description 4
• CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
• 239000007821 HATU Substances 0.000 description 4
• 241000713297 Influenza C virus Species 0.000 description 4
• 241000124008 Mammalia Species 0.000 description 4
• 102000005348 Neuraminidase Human genes 0.000 description 4
• 108010006232 Neuraminidase Proteins 0.000 description 4
• 101100272976 Panax ginseng CYP716A53v2 gene Proteins 0.000 description 4
• ALQSHHUCVQOPAS-UHFFFAOYSA-N Pentane-1,5-diol Chemical compound OCCCCCO ALQSHHUCVQOPAS-UHFFFAOYSA-N 0.000 description 4
• 206010037660 Pyrexia Diseases 0.000 description 4
• CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 4
• 229930006000 Sucrose Natural products 0.000 description 4
• 108091034135 Vault RNA Proteins 0.000 description 4
• 150000001412 amines Chemical class 0.000 description 4
• 125000004429 atom Chemical group 0.000 description 4
• QRUDEWIWKLJBPS-UHFFFAOYSA-N benzotriazole Chemical group C1=CC=C2N[N][N]C2=C1 QRUDEWIWKLJBPS-UHFFFAOYSA-N 0.000 description 4
• UORVGPXVDQYIDP-UHFFFAOYSA-N borane Chemical compound B UORVGPXVDQYIDP-UHFFFAOYSA-N 0.000 description 4
• 239000006172 buffering agent Substances 0.000 description 4
• 239000001768 carboxy methyl cellulose Substances 0.000 description 4
• 239000003153 chemical reaction reagent Substances 0.000 description 4
• OSASVXMJTNOKOY-UHFFFAOYSA-N chlorobutanol Chemical compound CC(C)(O)C(Cl)(Cl)Cl OSASVXMJTNOKOY-UHFFFAOYSA-N 0.000 description 4
• 230000002255 enzymatic effect Effects 0.000 description 4
• INGCFUDUPJPKMI-ZDGBYWQASA-N ethyl (1R,4R)-bicyclo[2.2.2]oct-5-ene-2-carboxylate Chemical compound [C@H]12C(C[C@H](C=C1)CC2)C(=O)OCC INGCFUDUPJPKMI-ZDGBYWQASA-N 0.000 description 4
• QJTDHVGNMDZLLI-UHFFFAOYSA-N ethyl 3-[2-[2-[2-[(2-methylpropan-2-yl)oxy]-2-oxoethoxy]ethoxy]ethoxy]propanoate Chemical compound C(C)(C)(C)OC(COCCOCCOCCC(=O)OCC)=O QJTDHVGNMDZLLI-UHFFFAOYSA-N 0.000 description 4
• FMVJYQGSRWVMQV-UHFFFAOYSA-N ethyl propiolate Chemical compound CCOC(=O)C#C FMVJYQGSRWVMQV-UHFFFAOYSA-N 0.000 description 4
• 239000000284 extract Substances 0.000 description 4
• 235000013355 food flavoring agent Nutrition 0.000 description 4
• 239000012634 fragment Substances 0.000 description 4
• 239000003906 humectant Substances 0.000 description 4
• IKDUDTNKRLTJSI-UHFFFAOYSA-N hydrazine monohydrate Substances O.NN IKDUDTNKRLTJSI-UHFFFAOYSA-N 0.000 description 4
• 239000003701 inert diluent Substances 0.000 description 4
• 208000037799 influenza C Diseases 0.000 description 4
• 230000003993 interaction Effects 0.000 description 4
• 235000019359 magnesium stearate Nutrition 0.000 description 4
• 239000011159 matrix material Substances 0.000 description 4
• 108020004999 messenger RNA Proteins 0.000 description 4
• 229940071648 metered dose inhaler Drugs 0.000 description 4
• 239000004530 micro-emulsion Substances 0.000 description 4
• 210000004400 mucous membrane Anatomy 0.000 description 4
• QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 4
• 231100000344 non-irritating Toxicity 0.000 description 4
• 239000000346 nonvolatile oil Substances 0.000 description 4
• ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 4
• 230000002335 preservative effect Effects 0.000 description 4
• 230000009467 reduction Effects 0.000 description 4
• 230000010076 replication Effects 0.000 description 4
• 210000002345 respiratory system Anatomy 0.000 description 4
• 238000003756 stirring Methods 0.000 description 4
• 239000005720 sucrose Substances 0.000 description 4
• 239000000829 suppository Substances 0.000 description 4
• 239000000375 suspending agent Substances 0.000 description 4
• 210000001519 tissue Anatomy 0.000 description 4
• SYNVQASQYAMPQE-UHFFFAOYSA-N undecyl 4-methylbenzenesulfonate Chemical compound CCCCCCCCCCCOS(=O)(=O)C1=CC=C(C)C=C1 SYNVQASQYAMPQE-UHFFFAOYSA-N 0.000 description 4
• 239000000080 wetting agent Substances 0.000 description 4
• NWZSZGALRFJKBT-KNIFDHDWSA-N (2s)-2,6-diaminohexanoic acid;(2s)-2-hydroxybutanedioic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O.NCCCC[C@H](N)C(O)=O NWZSZGALRFJKBT-KNIFDHDWSA-N 0.000 description 3
• 125000004169 (C1-C6) alkyl group Chemical group 0.000 description 3
• WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 3
• KZPYGQFFRCFCPP-UHFFFAOYSA-N 1,1'-bis(diphenylphosphino)ferrocene Chemical compound [Fe+2].C1=CC=C[C-]1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=C[C-]1P(C=1C=CC=CC=1)C1=CC=CC=C1 KZPYGQFFRCFCPP-UHFFFAOYSA-N 0.000 description 3
• FUMZCJPYOAPLCV-UHFFFAOYSA-N 1-(2-azidoethoxymethyl)-3-(ethoxymethyl)benzene Chemical compound N(=[N+]=[N-])CCOCC1=CC(=CC=C1)COCC FUMZCJPYOAPLCV-UHFFFAOYSA-N 0.000 description 3
• ACMPWHBATYURCW-VOTSOKGWSA-N 1-(2-ethoxyethoxy)-3-[(E)-2-nitroethenyl]benzene Chemical compound C(C)OCCOC1=CC(=CC=C1)\C=C\[N+](=O)[O-] ACMPWHBATYURCW-VOTSOKGWSA-N 0.000 description 3
• WQSYYGAUFCXTMH-UHFFFAOYSA-N 1-azido-5-pentoxypentane Chemical compound N(=[N+]=[N-])CCCCCOCCCCC WQSYYGAUFCXTMH-UHFFFAOYSA-N 0.000 description 3
• MMYKTRPLXXWLBC-UHFFFAOYSA-N 1-bromo-2-ethoxyethane Chemical compound CCOCCBr MMYKTRPLXXWLBC-UHFFFAOYSA-N 0.000 description 3
• YZWKKMVJZFACSU-UHFFFAOYSA-N 1-bromopentane Chemical compound CCCCCBr YZWKKMVJZFACSU-UHFFFAOYSA-N 0.000 description 3
• PWTNRNHDJZLBCD-UHFFFAOYSA-N 2-(2-pentoxyethoxy)ethanol Chemical compound CCCCCOCCOCCO PWTNRNHDJZLBCD-UHFFFAOYSA-N 0.000 description 3
• PQAUQVAKAFVVLF-UHFFFAOYSA-N 2-(5-ethoxypentoxy)ethanol Chemical compound C(C)OCCCCCOCCO PQAUQVAKAFVVLF-UHFFFAOYSA-N 0.000 description 3
• UAXLZZFUDWQWGY-UHFFFAOYSA-N 2-[2-[2-(2-ethoxyethoxy)ethoxy]ethyl]isoindole-1,3-dione Chemical compound C1=CC=C2C(=O)N(CCOCCOCCOCC)C(=O)C2=C1 UAXLZZFUDWQWGY-UHFFFAOYSA-N 0.000 description 3
• KJBLUUMGFPNJIZ-UHFFFAOYSA-N 2-[3-(2-ethoxyethoxy)phenyl]-N-methylacetamide Chemical compound O(CC)CCOC1=CC=CC(CC(=O)NC)=C1 KJBLUUMGFPNJIZ-UHFFFAOYSA-N 0.000 description 3
• REJUOJZIMANUBC-UHFFFAOYSA-N 2-[[3-(ethoxymethyl)phenyl]methoxy]ethanol Chemical compound C(C)OCC=1C=C(COCCO)C=CC=1 REJUOJZIMANUBC-UHFFFAOYSA-N 0.000 description 3
• 125000006016 2-bromoethoxy group Chemical group 0.000 description 3
• QVQDALFNSIKMBH-UHFFFAOYSA-N 2-pentoxyethanol Chemical compound CCCCCOCCO QVQDALFNSIKMBH-UHFFFAOYSA-N 0.000 description 3
• LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 3
• HPHIRVJRSQIAIT-UHFFFAOYSA-N 3-(2-ethoxyethoxy)benzaldehyde Chemical compound CCOCCOC1=CC=CC(C=O)=C1 HPHIRVJRSQIAIT-UHFFFAOYSA-N 0.000 description 3
• MWDJROWZDUZXBP-UHFFFAOYSA-N 3-bromo-5-chloro-1h-pyrrolo[2,3-b]pyridine Chemical compound ClC1=CN=C2NC=C(Br)C2=C1 MWDJROWZDUZXBP-UHFFFAOYSA-N 0.000 description 3
• 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 description 3
• VWKBHXZKOVMZRQ-UHFFFAOYSA-N 5-(2-ethoxyethoxy)pentan-1-amine Chemical compound CCOCCOCCCCCN VWKBHXZKOVMZRQ-UHFFFAOYSA-N 0.000 description 3
• MOTBTNFJSAEUDU-UHFFFAOYSA-N 5-(2-ethoxyethoxy)pentan-1-ol Chemical compound C(C)OCCOCCCCCO MOTBTNFJSAEUDU-UHFFFAOYSA-N 0.000 description 3
• NBTQILYOTKPKRZ-UHFFFAOYSA-N 5-fluoro-1-(4-methylphenyl)sulfonyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrrolo[2,3-b]pyridine Chemical compound C1=CC(C)=CC=C1S(=O)(=O)N1C2=NC=C(F)C=C2C(B2OC(C)(C)C(C)(C)O2)=C1 NBTQILYOTKPKRZ-UHFFFAOYSA-N 0.000 description 3
• BALBNSFYMXBWNM-UHFFFAOYSA-N 5-fluoro-1h-pyrrolo[2,3-b]pyridine Chemical compound FC1=CN=C2NC=CC2=C1 BALBNSFYMXBWNM-UHFFFAOYSA-N 0.000 description 3
• WQSPIURCJCRCIF-UHFFFAOYSA-N 5-fluoro-3-iodopyridin-2-amine Chemical compound NC1=NC=C(F)C=C1I WQSPIURCJCRCIF-UHFFFAOYSA-N 0.000 description 3
• XJCHBJBYLCKVBA-UHFFFAOYSA-N 5-pentoxypentan-1-ol Chemical compound CCCCCOCCCCCO XJCHBJBYLCKVBA-UHFFFAOYSA-N 0.000 description 3
• FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 3
• QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 3
• NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical class [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 3
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 3
• 229920002134 Carboxymethyl cellulose Polymers 0.000 description 3
• 229920001661 Chitosan Polymers 0.000 description 3
• 229920002261 Corn starch Polymers 0.000 description 3
• 206010011224 Cough Diseases 0.000 description 3
• BUDQDWGNQVEFAC-UHFFFAOYSA-N Dihydropyran Chemical compound C1COC=CC1 BUDQDWGNQVEFAC-UHFFFAOYSA-N 0.000 description 3
• LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
• 206010019233 Headaches Diseases 0.000 description 3
• MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 3
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
• KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
• 102000011931 Nucleoproteins Human genes 0.000 description 3
• 108010061100 Nucleoproteins Proteins 0.000 description 3
• 239000005642 Oleic acid Substances 0.000 description 3
• ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 3
• 229910019142 PO4 Inorganic materials 0.000 description 3
• 235000021314 Palmitic acid Nutrition 0.000 description 3
• 229920003171 Poly (ethylene oxide) Polymers 0.000 description 3
• 239000004372 Polyvinyl alcohol Substances 0.000 description 3
• KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
• OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 3
• 102000004389 Ribonucleoproteins Human genes 0.000 description 3
• 108010081734 Ribonucleoproteins Proteins 0.000 description 3
• KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 3
• 241000282887 Suidae Species 0.000 description 3
• QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 3
• 108020000999 Viral RNA Proteins 0.000 description 3
• ZTODSBIWCZJPTF-UHFFFAOYSA-N [3-(ethoxymethyl)phenyl]methanol Chemical compound C(C)OCC=1C=C(C=CC=1)CO ZTODSBIWCZJPTF-UHFFFAOYSA-N 0.000 description 3
• 229940072056 alginate Drugs 0.000 description 3
• 125000001931 aliphatic group Chemical group 0.000 description 3
• 125000003277 amino group Chemical group 0.000 description 3
• 230000000890 antigenic effect Effects 0.000 description 3
• 238000013459 approach Methods 0.000 description 3
• 230000036760 body temperature Effects 0.000 description 3
• 239000000872 buffer Substances 0.000 description 3
• 235000019437 butane-1,3-diol Nutrition 0.000 description 3
• 235000010948 carboxy methyl cellulose Nutrition 0.000 description 3
• 239000008112 carboxymethyl-cellulose Substances 0.000 description 3
• 150000001768 cations Chemical class 0.000 description 3
• 235000010980 cellulose Nutrition 0.000 description 3
• 229920002678 cellulose Polymers 0.000 description 3
• 230000008859 change Effects 0.000 description 3
• 235000012000 cholesterol Nutrition 0.000 description 3
• 229940110456 cocoa butter Drugs 0.000 description 3
• 235000019868 cocoa butter Nutrition 0.000 description 3
• 239000012230 colorless oil Substances 0.000 description 3
• 239000008120 corn starch Substances 0.000 description 3
• 229940099112 cornstarch Drugs 0.000 description 3
• 238000002425 crystallisation Methods 0.000 description 3
• 230000008025 crystallization Effects 0.000 description 3
• 230000003111 delayed effect Effects 0.000 description 3
• UAOMVDZJSHZZME-UHFFFAOYSA-N diisopropylamine Chemical compound CC(C)NC(C)C UAOMVDZJSHZZME-UHFFFAOYSA-N 0.000 description 3
• 238000010790 dilution Methods 0.000 description 3
• 239000012895 dilution Substances 0.000 description 3
• 238000004090 dissolution Methods 0.000 description 3
• 239000006196 drop Substances 0.000 description 3
• GFQTZTQVDBODHC-BDAKNGLRSA-N ethyl (1R,4S)-bicyclo[2.2.2]octa-2,5-diene-2-carboxylate Chemical compound [C@H]12C(=C[C@H](C=C1)CC2)C(=O)OCC GFQTZTQVDBODHC-BDAKNGLRSA-N 0.000 description 3
• IZNHZTSKIYZKKP-UHFFFAOYSA-N ethyl 3-[2-(2-hydroxyethoxy)ethoxy]propanoate Chemical compound CCOC(=O)CCOCCOCCO IZNHZTSKIYZKKP-UHFFFAOYSA-N 0.000 description 3
• PGCDRCTVDGPPLF-UHFFFAOYSA-N ethyl 3-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]propanoate Chemical compound CCOC(=O)CCOCCOCCOCCO PGCDRCTVDGPPLF-UHFFFAOYSA-N 0.000 description 3
• GFBKGZRYCGBOJH-UHFFFAOYSA-N ethyl 3-[2-[2-[2-(oxan-2-yloxy)ethoxy]ethoxy]ethoxy]propanoate Chemical compound CCOC(=O)CCOCCOCCOCCOC1CCCCO1 GFBKGZRYCGBOJH-UHFFFAOYSA-N 0.000 description 3
• DCXHOFYCEKHYJP-UHFFFAOYSA-N ethyl 3-[2-[2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethoxy]ethoxy]ethoxy]propanoate Chemical compound CC(C)(OC(NCCOCCOCCOCCC(=O)OCC)=O)C DCXHOFYCEKHYJP-UHFFFAOYSA-N 0.000 description 3
• FQTIYMRSUOADDK-UHFFFAOYSA-N ethyl 3-bromopropanoate Chemical compound CCOC(=O)CCBr FQTIYMRSUOADDK-UHFFFAOYSA-N 0.000 description 3
• VRZVPALEJCLXPR-UHFFFAOYSA-N ethyl 4-methylbenzenesulfonate Chemical compound CCOS(=O)(=O)C1=CC=C(C)C=C1 VRZVPALEJCLXPR-UHFFFAOYSA-N 0.000 description 3
• IDVOXFXXSKWFQX-UHFFFAOYSA-N ethyl 5-(2-ethoxyethoxy)pentanoate Chemical compound C(C)OCCOCCCCC(=O)OCC IDVOXFXXSKWFQX-UHFFFAOYSA-N 0.000 description 3
• VBKXSLMPGROBMX-UHFFFAOYSA-N ethyl 5-pentoxypentanoate Chemical compound CCCCCOCCCCC(=O)OCC VBKXSLMPGROBMX-UHFFFAOYSA-N 0.000 description 3
• 239000007789 gas Substances 0.000 description 3
• 239000008187 granular material Substances 0.000 description 3
• 231100000869 headache Toxicity 0.000 description 3
• 230000036541 health Effects 0.000 description 3
• BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 3
• 238000009396 hybridization Methods 0.000 description 3
• 239000001257 hydrogen Substances 0.000 description 3
• 230000036039 immunity Effects 0.000 description 3
• 229960003971 influenza vaccine Drugs 0.000 description 3
• 230000005764 inhibitory process Effects 0.000 description 3
• 229910003480 inorganic solid Inorganic materials 0.000 description 3
• 150000002500 ions Chemical class 0.000 description 3
• QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 3
• 239000007951 isotonicity adjuster Substances 0.000 description 3
• 238000004519 manufacturing process Methods 0.000 description 3
• 239000002480 mineral oil Substances 0.000 description 3
• 235000010446 mineral oil Nutrition 0.000 description 3
• 150000007522 mineralic acids Chemical class 0.000 description 3
• 238000002156 mixing Methods 0.000 description 3
• MZRVEZGGRBJDDB-UHFFFAOYSA-N n-Butyllithium Substances [Li]CCCC MZRVEZGGRBJDDB-UHFFFAOYSA-N 0.000 description 3
• WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 3
• JCJFBKCQLFMABE-UHFFFAOYSA-N n-methylundecan-1-amine Chemical compound CCCCCCCCCCCNC JCJFBKCQLFMABE-UHFFFAOYSA-N 0.000 description 3
• 239000007922 nasal spray Substances 0.000 description 3
• LYGJENNIWJXYER-UHFFFAOYSA-N nitromethane Chemical compound C[N+]([O-])=O LYGJENNIWJXYER-UHFFFAOYSA-N 0.000 description 3
• 210000001331 nose Anatomy 0.000 description 3
• 239000002773 nucleotide Substances 0.000 description 3
• 125000003729 nucleotide group Chemical group 0.000 description 3
• 239000004006 olive oil Substances 0.000 description 3
• 150000007524 organic acids Chemical class 0.000 description 3
• 230000036961 partial effect Effects 0.000 description 3
• 235000019271 petrolatum Nutrition 0.000 description 3
• 235000021317 phosphate Nutrition 0.000 description 3
• 229920002451 polyvinyl alcohol Polymers 0.000 description 3
• 235000019422 polyvinyl alcohol Nutrition 0.000 description 3
• 235000011056 potassium acetate Nutrition 0.000 description 3
• 229910000027 potassium carbonate Inorganic materials 0.000 description 3
• NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 description 3
• 239000000047 product Substances 0.000 description 3
• 238000000746 purification Methods 0.000 description 3
• 239000000523 sample Substances 0.000 description 3
• 230000028327 secretion Effects 0.000 description 3
• 229910052708 sodium Inorganic materials 0.000 description 3
• 235000017557 sodium bicarbonate Nutrition 0.000 description 3
• 229910000030 sodium bicarbonate Inorganic materials 0.000 description 3
• FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 description 3
• 239000008247 solid mixture Substances 0.000 description 3
• 239000003765 sweetening agent Substances 0.000 description 3
• 238000010189 synthetic method Methods 0.000 description 3
• 125000004213 tert-butoxy group Chemical group [H]C([H])([H])C(O*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 3
• KTHYQDDQFDDNCI-UHFFFAOYSA-N tert-butyl 2-(5-ethoxypentoxy)acetate Chemical compound C(C)OCCCCCOCC(=O)OC(C)(C)C KTHYQDDQFDDNCI-UHFFFAOYSA-N 0.000 description 3
• MOLNWWXGGWYPSU-UHFFFAOYSA-N tert-butyl 2-[[3-(ethoxymethyl)phenyl]methoxy]acetate Chemical compound C(C)OCC=1C=C(COCC(=O)OC(C)(C)C)C=CC=1 MOLNWWXGGWYPSU-UHFFFAOYSA-N 0.000 description 3
• FMLOTGGIHAYZLW-UHFFFAOYSA-N tert-butyl n-[2-[2-(2-hydroxyethoxy)ethoxy]ethyl]carbamate Chemical compound CC(C)(C)OC(=O)NCCOCCOCCO FMLOTGGIHAYZLW-UHFFFAOYSA-N 0.000 description 3
• 238000012360 testing method Methods 0.000 description 3
• VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 3
• PBIMIGNDTBRRPI-UHFFFAOYSA-N trifluoro borate Chemical compound FOB(OF)OF PBIMIGNDTBRRPI-UHFFFAOYSA-N 0.000 description 3
• JBWKIWSBJXDJDT-UHFFFAOYSA-N triphenylmethyl chloride Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)(Cl)C1=CC=CC=C1 JBWKIWSBJXDJDT-UHFFFAOYSA-N 0.000 description 3
• JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 2
• 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 description 2
• HAPBRWUQJCOTFT-UHFFFAOYSA-N 1-azido-5-(2-ethoxyethoxy)pentane Chemical compound N(=[N+]=[N-])CCCCCOCCOCC HAPBRWUQJCOTFT-UHFFFAOYSA-N 0.000 description 2
• IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 2
• 238000005160 1H NMR spectroscopy Methods 0.000 description 2
• FPXSVYDNRKXHEZ-UHFFFAOYSA-N 2-(2-pentoxyethoxy)acetic acid Chemical compound CCCCCOCCOCC(O)=O FPXSVYDNRKXHEZ-UHFFFAOYSA-N 0.000 description 2
• POCDUYWFKNENLF-UHFFFAOYSA-N 2-(2-pentoxyethoxy)ethanamine Chemical compound CCCCCOCCOCCN POCDUYWFKNENLF-UHFFFAOYSA-N 0.000 description 2
• FLZNYQVBVKBNMC-UHFFFAOYSA-N 2-(5-ethoxypentoxy)acetic acid Chemical compound C(C)OCCCCCOCC(=O)O FLZNYQVBVKBNMC-UHFFFAOYSA-N 0.000 description 2
• VDPZDVSLMPQRIR-UHFFFAOYSA-N 2-[2-(2-ethoxyethoxy)ethoxy]-n-methylethanamine Chemical compound CCOCCOCCOCCNC VDPZDVSLMPQRIR-UHFFFAOYSA-N 0.000 description 2
• FYRBJJHCFFXENF-UHFFFAOYSA-N 2-[2-(2-ethoxyethoxy)ethoxy]acetic acid Chemical compound CCOCCOCCOCC(O)=O FYRBJJHCFFXENF-UHFFFAOYSA-N 0.000 description 2
• WWJVRDMJNJTOBL-UHFFFAOYSA-N 2-[2-(2-ethoxyethoxy)ethoxy]ethanamine Chemical compound CCOCCOCCOCCN WWJVRDMJNJTOBL-UHFFFAOYSA-N 0.000 description 2
• UTXKJPSLEXESKS-UHFFFAOYSA-N 2-[2-(2-ethoxyethoxy)ethoxy]ethanesulfonyl chloride Chemical compound CCOCCOCCOCCS(Cl)(=O)=O UTXKJPSLEXESKS-UHFFFAOYSA-N 0.000 description 2
• MJGDDYDIULQMTE-UHFFFAOYSA-N 2-[2-(2-ethoxyethoxy)ethoxy]ethanethiol Chemical compound CCOCCOCCOCCS MJGDDYDIULQMTE-UHFFFAOYSA-N 0.000 description 2
• WFSMVVDJSNMRAR-UHFFFAOYSA-N 2-[2-(2-ethoxyethoxy)ethoxy]ethanol Chemical compound CCOCCOCCOCCO WFSMVVDJSNMRAR-UHFFFAOYSA-N 0.000 description 2
• CPCUDERUJBARLD-UHFFFAOYSA-N 2-[2-(oxan-2-yloxy)ethoxy]ethanol Chemical compound OCCOCCOC1CCCCO1 CPCUDERUJBARLD-UHFFFAOYSA-N 0.000 description 2
• YNNUSGIPVFPVBX-UHFFFAOYSA-N 2-[2-[1-(4-chlorophenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidine Chemical compound CN1CCCC1CCOC(C)(C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 YNNUSGIPVFPVBX-UHFFFAOYSA-N 0.000 description 2
• GYQRUHMNSYHFAE-UHFFFAOYSA-N 2-[2-[2-(3-ethoxy-3-oxopropoxy)ethoxy]ethoxy]acetic acid Chemical compound O=C(CCOCCOCCOCC(=O)O)OCC GYQRUHMNSYHFAE-UHFFFAOYSA-N 0.000 description 2
• SHNBAYPXCLCGGZ-UHFFFAOYSA-N 2-[2-[2-(oxan-2-yloxy)ethoxy]ethoxy]ethanamine Chemical compound O1C(CCCC1)OCCOCCOCCN SHNBAYPXCLCGGZ-UHFFFAOYSA-N 0.000 description 2
• JBLOFIJEJSEJCB-UHFFFAOYSA-N 2-[2-[2-[2-(methylamino)ethoxy]ethoxy]ethoxy]ethanol Chemical compound CNCCOCCOCCOCCO JBLOFIJEJSEJCB-UHFFFAOYSA-N 0.000 description 2
• XUTYVMRXVARJFT-UHFFFAOYSA-N 2-[2-[2-[2-(oxan-2-yloxy)ethoxy]ethoxy]ethoxy]ethanol Chemical compound OCCOCCOCCOCCOC1CCCCO1 XUTYVMRXVARJFT-UHFFFAOYSA-N 0.000 description 2
• AWIUPDGEVFBSGD-UHFFFAOYSA-N 2-[2-[2-[2-(oxan-2-yloxy)ethoxy]ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate Chemical compound C1=CC(C)=CC=C1S(=O)(=O)OCCOCCOCCOCCOC1OCCCC1 AWIUPDGEVFBSGD-UHFFFAOYSA-N 0.000 description 2
• KXMLJKNVSYSACL-UHFFFAOYSA-N 2-[2-[2-[2-(oxan-2-yloxy)ethoxy]ethoxy]ethyl]isoindole-1,3-dione Chemical compound O1C(CCCC1)OCCOCCOCCN1C(C2=CC=CC=C2C1=O)=O KXMLJKNVSYSACL-UHFFFAOYSA-N 0.000 description 2
• NXZOSZJZNUYDSK-UHFFFAOYSA-N 2-[2-[2-[2-[2-(methylamino)ethoxy]ethoxy]ethoxy]ethyl]isoindole-1,3-dione Chemical compound CNCCOCCOCCOCCN1C(C2=CC=CC=C2C1=O)=O NXZOSZJZNUYDSK-UHFFFAOYSA-N 0.000 description 2
• BIGXRUYQZACYCX-UHFFFAOYSA-N 2-[2-[2-[2-[methyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]ethoxy]ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate Chemical compound CC1=CC=C(C=C1)S(=O)(=O)OCCOCCOCCOCCN(C(OC(C)(C)C)=O)C BIGXRUYQZACYCX-UHFFFAOYSA-N 0.000 description 2
• UCTJYJZMDLRPGZ-UHFFFAOYSA-N 2-[3-(2-ethoxyethoxy)phenyl]-N-methylethanamine Chemical compound C(C)OCCOC=1C=C(C=CC=1)CCNC UCTJYJZMDLRPGZ-UHFFFAOYSA-N 0.000 description 2
• UOVZNNFKZFPCDG-UHFFFAOYSA-N 2-[3-(2-ethoxyethoxy)phenyl]acetic acid Chemical compound CCOCCOC1=CC=CC(CC(O)=O)=C1 UOVZNNFKZFPCDG-UHFFFAOYSA-N 0.000 description 2
• HSFMEYGGXQXJLQ-UHFFFAOYSA-N 2-[3-(2-ethoxyethoxy)phenyl]ethanamine Chemical compound CCOCCOC1=CC=CC(CCN)=C1 HSFMEYGGXQXJLQ-UHFFFAOYSA-N 0.000 description 2
• ZGUCGSQXNKWVQZ-UHFFFAOYSA-N 2-[[3-(ethoxymethyl)phenyl]methoxy]-N-methylethanamine Chemical compound C(C)OCC=1C=C(COCCNC)C=CC=1 ZGUCGSQXNKWVQZ-UHFFFAOYSA-N 0.000 description 2
• FTTDLVIQHVCXCW-UHFFFAOYSA-N 2-[[3-(ethoxymethyl)phenyl]methoxy]acetic acid Chemical compound C(C)OCC=1C=C(COCC(=O)O)C=CC=1 FTTDLVIQHVCXCW-UHFFFAOYSA-N 0.000 description 2
• RIAJGPBLIYBNMY-UHFFFAOYSA-N 2-[[3-(ethoxymethyl)phenyl]methoxy]ethanamine Chemical compound C(C)OCC=1C=C(COCCN)C=CC=1 RIAJGPBLIYBNMY-UHFFFAOYSA-N 0.000 description 2
• DFLBFIHYZVVEGI-UHFFFAOYSA-N 2-[[3-(ethoxymethyl)phenyl]methoxy]ethyl 4-methylbenzenesulfonate Chemical compound CC1=CC=C(C=C1)S(=O)(=O)OCCOCC1=CC(=CC=C1)COCC DFLBFIHYZVVEGI-UHFFFAOYSA-N 0.000 description 2
• NTOWWABYYWPKKJ-UHFFFAOYSA-N 3-bromo-5-chloro-1-(4-methylphenyl)sulfonylpyrrolo[2,3-b]pyridine Chemical compound C1=CC(C)=CC=C1S(=O)(=O)N1C2=NC=C(Cl)C=C2C(Br)=C1 NTOWWABYYWPKKJ-UHFFFAOYSA-N 0.000 description 2
• RPGHTBGXIQCHJW-UHFFFAOYSA-N 5-(2-ethoxyethoxy)-n-methylpentan-1-amine Chemical compound CCOCCOCCCCCNC RPGHTBGXIQCHJW-UHFFFAOYSA-N 0.000 description 2
• ANRCFXCVXZBNRQ-UHFFFAOYSA-N 5-(2-ethoxyethoxy)pentanoic acid Chemical compound CCOCCOCCCCC(O)=O ANRCFXCVXZBNRQ-UHFFFAOYSA-N 0.000 description 2
• MFZQJIKENSPRSJ-UHFFFAOYSA-N 5-chloro-1h-pyrrolo[2,3-b]pyridine Chemical compound ClC1=CN=C2NC=CC2=C1 MFZQJIKENSPRSJ-UHFFFAOYSA-N 0.000 description 2
• ITZOUBOIAZVSGJ-UHFFFAOYSA-N 5-fluoro-3-(2-trimethylsilylethynyl)pyridin-2-amine Chemical compound C[Si](C)(C)C#CC1=CC(F)=CN=C1N ITZOUBOIAZVSGJ-UHFFFAOYSA-N 0.000 description 2
• 229920001817 Agar Polymers 0.000 description 2
• QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
• QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 2
• USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 description 2
• 239000005695 Ammonium acetate Substances 0.000 description 2
• 241000283690 Bos taurus Species 0.000 description 2
• OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
• VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
• 241000700199 Cavia porcellus Species 0.000 description 2
• HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
• KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 2
• 208000035473 Communicable disease Diseases 0.000 description 2
• FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
• ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 description 2
• 241000283073 Equus caballus Species 0.000 description 2
• JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 description 2
• QUSNBJAOOMFDIB-UHFFFAOYSA-N Ethylamine Chemical compound CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 description 2
• 241000282326 Felis catus Species 0.000 description 2
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
• DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
• AEMRFAOFKBGASW-UHFFFAOYSA-M Glycolate Chemical compound OCC([O-])=O AEMRFAOFKBGASW-UHFFFAOYSA-M 0.000 description 2
• 101710154606 Hemagglutinin Proteins 0.000 description 2
• 239000004705 High-molecular-weight polyethylene Substances 0.000 description 2
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
• 241000713196 Influenza B virus Species 0.000 description 2
• 241001661732 Isavirus Species 0.000 description 2
• 235000010643 Leucaena leucocephala Nutrition 0.000 description 2
• 240000007472 Leucaena leucocephala Species 0.000 description 2
• FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 2
• 229930195725 Mannitol Natural products 0.000 description 2
• BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 description 2
• 208000000112 Myalgia Diseases 0.000 description 2
• IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 2
• AMQJEAYHLZJPGS-UHFFFAOYSA-N N-Pentanol Chemical compound CCCCCO AMQJEAYHLZJPGS-UHFFFAOYSA-N 0.000 description 2
• XODLQCGJSMSLNU-UHFFFAOYSA-N N-benzyl-5-(2-ethoxyethoxy)pentanamide Chemical compound CCOCCOCCCCC(=O)NCC1=CC=CC=C1 XODLQCGJSMSLNU-UHFFFAOYSA-N 0.000 description 2
• 229910002651 NO3 Inorganic materials 0.000 description 2
• NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 2
• 206010068319 Oropharyngeal pain Diseases 0.000 description 2
• 241000712464 Orthomyxoviridae Species 0.000 description 2
• 241000283973 Oryctolagus cuniculus Species 0.000 description 2
• 101710093908 Outer capsid protein VP4 Proteins 0.000 description 2
• 101710135467 Outer capsid protein sigma-1 Proteins 0.000 description 2
• 101150003085 Pdcl gene Proteins 0.000 description 2
• 241001494479 Pecora Species 0.000 description 2
• 241000009328 Perro Species 0.000 description 2
• 239000004264 Petrolatum Substances 0.000 description 2
• 201000007100 Pharyngitis Diseases 0.000 description 2
• ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
• NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
• GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 description 2
• 229920002732 Polyanhydride Polymers 0.000 description 2
• 229920001710 Polyorthoester Polymers 0.000 description 2
• 241000288906 Primates Species 0.000 description 2
• 101710176177 Protein A56 Proteins 0.000 description 2
• RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 description 2
• 229910004298 SiO 2 Inorganic materials 0.000 description 2
• CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
• DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
• QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 2
• 241000282898 Sus scrofa Species 0.000 description 2
• 240000001068 Thogoto virus Species 0.000 description 2
• 206010047700 Vomiting Diseases 0.000 description 2
• 230000002378 acidificating effect Effects 0.000 description 2
• 150000007513 acids Chemical class 0.000 description 2
• 239000011149 active material Substances 0.000 description 2
• 235000010419 agar Nutrition 0.000 description 2
• 239000000783 alginic acid Substances 0.000 description 2
• 229960001126 alginic acid Drugs 0.000 description 2
• 150000004781 alginic acids Chemical class 0.000 description 2
• WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 2
• 150000001408 amides Chemical group 0.000 description 2
• 229940024606 amino acid Drugs 0.000 description 2
• 150000001413 amino acids Chemical class 0.000 description 2
• 229940043376 ammonium acetate Drugs 0.000 description 2
• 235000019257 ammonium acetate Nutrition 0.000 description 2
• 239000003242 anti bacterial agent Substances 0.000 description 2
• 230000000844 anti-bacterial effect Effects 0.000 description 2
• 239000003429 antifungal agent Substances 0.000 description 2
• 229940121375 antifungal agent Drugs 0.000 description 2
• 239000003963 antioxidant agent Substances 0.000 description 2
• 235000006708 antioxidants Nutrition 0.000 description 2
• 239000008346 aqueous phase Substances 0.000 description 2
• 229940072107 ascorbate Drugs 0.000 description 2
• 235000010323 ascorbic acid Nutrition 0.000 description 2
• 239000011668 ascorbic acid Substances 0.000 description 2
• 238000011914 asymmetric synthesis Methods 0.000 description 2
• 235000019445 benzyl alcohol Nutrition 0.000 description 2
• SESFRYSPDFLNCH-UHFFFAOYSA-N benzyl benzoate Chemical compound C=1C=CC=CC=1C(=O)OCC1=CC=CC=C1 SESFRYSPDFLNCH-UHFFFAOYSA-N 0.000 description 2
• WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
• 239000011230 binding agent Substances 0.000 description 2
• 229920002988 biodegradable polymer Polymers 0.000 description 2
• 239000004621 biodegradable polymer Substances 0.000 description 2
• 230000004071 biological effect Effects 0.000 description 2
• 230000008512 biological response Effects 0.000 description 2
• 230000005540 biological transmission Effects 0.000 description 2
• YNHIGQDRGKUECZ-UHFFFAOYSA-L bis(triphenylphosphine)palladium(ii) dichloride Chemical compound [Cl-].[Cl-].[Pd+2].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 YNHIGQDRGKUECZ-UHFFFAOYSA-L 0.000 description 2
• 229910000085 borane Inorganic materials 0.000 description 2
• 239000000337 buffer salt Substances 0.000 description 2
• 229910052791 calcium Inorganic materials 0.000 description 2
• 239000011575 calcium Substances 0.000 description 2
• 239000004359 castor oil Substances 0.000 description 2
• 239000003054 catalyst Substances 0.000 description 2
• 238000004113 cell culture Methods 0.000 description 2
• 239000001913 cellulose Substances 0.000 description 2
• 239000002738 chelating agent Substances 0.000 description 2
• 238000002512 chemotherapy Methods 0.000 description 2
• 229960004926 chlorobutanol Drugs 0.000 description 2
• 238000013375 chromatographic separation Methods 0.000 description 2
• 238000011260 co-administration Methods 0.000 description 2
• 239000011248 coating agent Substances 0.000 description 2
• 239000003086 colorant Substances 0.000 description 2
• 238000013270 controlled release Methods 0.000 description 2
• 235000012343 cottonseed oil Nutrition 0.000 description 2
• 230000008878 coupling Effects 0.000 description 2
• 238000010168 coupling process Methods 0.000 description 2
• 239000006071 cream Substances 0.000 description 2
• 239000013058 crude material Substances 0.000 description 2
• 239000012045 crude solution Substances 0.000 description 2
• NXQGGXCHGDYOHB-UHFFFAOYSA-L cyclopenta-1,4-dien-1-yl(diphenyl)phosphane;dichloropalladium;iron(2+) Chemical compound [Fe+2].Cl[Pd]Cl.[CH-]1C=CC(P(C=2C=CC=CC=2)C=2C=CC=CC=2)=C1.[CH-]1C=CC(P(C=2C=CC=CC=2)C=2C=CC=CC=2)=C1 NXQGGXCHGDYOHB-UHFFFAOYSA-L 0.000 description 2
• 230000000120 cytopathologic effect Effects 0.000 description 2
• 230000034994 death Effects 0.000 description 2
• 231100000517 death Toxicity 0.000 description 2
• 230000008021 deposition Effects 0.000 description 2
• 230000001627 detrimental effect Effects 0.000 description 2
• 238000011161 development Methods 0.000 description 2
• 229940039227 diagnostic agent Drugs 0.000 description 2
• 239000000032 diagnostic agent Substances 0.000 description 2
• 239000002612 dispersion medium Substances 0.000 description 2
• MOTZDAYCYVMXPC-UHFFFAOYSA-N dodecyl hydrogen sulfate Chemical compound CCCCCCCCCCCCOS(O)(=O)=O MOTZDAYCYVMXPC-UHFFFAOYSA-N 0.000 description 2
• 229940043264 dodecyl sulfate Drugs 0.000 description 2
• 239000008298 dragée Substances 0.000 description 2
• 238000012377 drug delivery Methods 0.000 description 2
• 241001493065 dsRNA viruses Species 0.000 description 2
• 238000002296 dynamic light scattering Methods 0.000 description 2
• 230000001804 emulsifying effect Effects 0.000 description 2
• 238000009505 enteric coating Methods 0.000 description 2
• 239000002702 enteric coating Substances 0.000 description 2
• BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 2
• GJXIZKUYTOODFK-OQSWDALSSA-N ethyl (2S,3S)-3-(2-chloropyrrolo[2,3-d]pyrimidin-7-yl)bicyclo[2.2.2]octane-2-carboxylate Chemical compound ClC=1N=CC2=C(N=1)N(C=C2)[C@@H]1[C@H](C2CCC1CC2)C(=O)OCC GJXIZKUYTOODFK-OQSWDALSSA-N 0.000 description 2
• AWOLZTYCSWKPGN-UHFFFAOYSA-N ethyl 3-[2-[2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethoxy]ethoxy]propanoate Chemical compound S(=O)(=O)(C1=CC=C(C)C=C1)OCCOCCOCCOCCC(=O)OCC AWOLZTYCSWKPGN-UHFFFAOYSA-N 0.000 description 2
• AFRWBGJRWRHQOV-UHFFFAOYSA-N ethyl 5-bromopentanoate Chemical compound CCOC(=O)CCCCBr AFRWBGJRWRHQOV-UHFFFAOYSA-N 0.000 description 2
• PQJJJMRNHATNKG-UHFFFAOYSA-N ethyl bromoacetate Chemical compound CCOC(=O)CBr PQJJJMRNHATNKG-UHFFFAOYSA-N 0.000 description 2
• MMXKVMNBHPAILY-UHFFFAOYSA-N ethyl laurate Chemical compound CCCCCCCCCCCC(=O)OCC MMXKVMNBHPAILY-UHFFFAOYSA-N 0.000 description 2
• PQVSTLUFSYVLTO-UHFFFAOYSA-N ethyl n-ethoxycarbonylcarbamate Chemical compound CCOC(=O)NC(=O)OCC PQVSTLUFSYVLTO-UHFFFAOYSA-N 0.000 description 2
• 238000001704 evaporation Methods 0.000 description 2
• 239000000945 filler Substances 0.000 description 2
• 238000001914 filtration Methods 0.000 description 2
• 239000012530 fluid Substances 0.000 description 2
• 235000003599 food sweetener Nutrition 0.000 description 2
• 238000004508 fractional distillation Methods 0.000 description 2
• 239000012458 free base Substances 0.000 description 2
• 210000001035 gastrointestinal tract Anatomy 0.000 description 2
• 239000007903 gelatin capsule Substances 0.000 description 2
• 239000008103 glucose Substances 0.000 description 2
• 125000005456 glyceride group Chemical group 0.000 description 2
• 239000000185 hemagglutinin Substances 0.000 description 2
• 230000036571 hydration Effects 0.000 description 2
• 238000006703 hydration reaction Methods 0.000 description 2
• 210000000987 immune system Anatomy 0.000 description 2
• 238000011065 in-situ storage Methods 0.000 description 2
• 230000002458 infectious effect Effects 0.000 description 2
• 239000007972 injectable composition Substances 0.000 description 2
• 229940102223 injectable solution Drugs 0.000 description 2
• 229940102213 injectable suspension Drugs 0.000 description 2
• 150000007529 inorganic bases Chemical class 0.000 description 2
• 210000000936 intestine Anatomy 0.000 description 2
• 239000002555 ionophore Substances 0.000 description 2
• 230000000236 ionophoric effect Effects 0.000 description 2
• 230000007794 irritation Effects 0.000 description 2
• 238000002955 isolation Methods 0.000 description 2
• 235000010445 lecithin Nutrition 0.000 description 2
• 239000000787 lecithin Substances 0.000 description 2
• 229940067606 lecithin Drugs 0.000 description 2
• 239000008297 liquid dosage form Substances 0.000 description 2
• 229940040692 lithium hydroxide monohydrate Drugs 0.000 description 2
• GLXDVVHUTZTUQK-UHFFFAOYSA-M lithium hydroxide monohydrate Substances [Li+].O.[OH-] GLXDVVHUTZTUQK-UHFFFAOYSA-M 0.000 description 2
• 238000011068 loading method Methods 0.000 description 2
• 239000006210 lotion Substances 0.000 description 2
• 239000008176 lyophilized powder Substances 0.000 description 2
• 229910052749 magnesium Inorganic materials 0.000 description 2
• 239000011777 magnesium Substances 0.000 description 2
• VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 description 2
• 239000000347 magnesium hydroxide Substances 0.000 description 2
• 229910001862 magnesium hydroxide Inorganic materials 0.000 description 2
• VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 2
• 239000000594 mannitol Substances 0.000 description 2
• 235000010355 mannitol Nutrition 0.000 description 2
• 230000007246 mechanism Effects 0.000 description 2
• 230000008384 membrane barrier Effects 0.000 description 2
• BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
• SJPVEARYNXPNKV-UHFFFAOYSA-N methyl 3-(2-chloropyrrolo[2,3-d]pyrimidin-7-yl)propanoate Chemical compound ClC=1N=CC2=C(N=1)N(C=C2)CCC(=O)OC SJPVEARYNXPNKV-UHFFFAOYSA-N 0.000 description 2
• 229920000609 methyl cellulose Polymers 0.000 description 2
• 235000010981 methylcellulose Nutrition 0.000 description 2
• 239000001923 methylcellulose Substances 0.000 description 2
• 239000000693 micelle Substances 0.000 description 2
• 208000013465 muscle pain Diseases 0.000 description 2
• IDDXBUMARGQVQF-UHFFFAOYSA-N n-methyl-5-pentoxypentan-1-amine Chemical compound CCCCCOCCCCCNC IDDXBUMARGQVQF-UHFFFAOYSA-N 0.000 description 2
• 210000002850 nasal mucosa Anatomy 0.000 description 2
• 229940097496 nasal spray Drugs 0.000 description 2
• 239000006199 nebulizer Substances 0.000 description 2
• 231100000417 nephrotoxicity Toxicity 0.000 description 2
• 230000007935 neutral effect Effects 0.000 description 2
• 239000012038 nucleophile Substances 0.000 description 2
• 238000010534 nucleophilic substitution reaction Methods 0.000 description 2
• 230000000474 nursing effect Effects 0.000 description 2
• 235000008390 olive oil Nutrition 0.000 description 2
• 210000000056 organ Anatomy 0.000 description 2
• 235000005985 organic acids Nutrition 0.000 description 2
• 235000006408 oxalic acid Nutrition 0.000 description 2
• PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 description 2
• VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 description 2
• 229940066842 petrolatum Drugs 0.000 description 2
• WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 2
• 239000010452 phosphate Substances 0.000 description 2
• NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
• 239000008363 phosphate buffer Substances 0.000 description 2
• 239000004632 polycaprolactone Substances 0.000 description 2
• 229920001610 polycaprolactone Polymers 0.000 description 2
• 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 2
• 229920001282 polysaccharide Polymers 0.000 description 2
• 239000005017 polysaccharide Substances 0.000 description 2
• 229920000053 polysorbate 80 Polymers 0.000 description 2
• 239000001267 polyvinylpyrrolidone Substances 0.000 description 2
• 229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
• 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
• NROKBHXJSPEDAR-UHFFFAOYSA-M potassium fluoride Chemical compound [F-].[K+] NROKBHXJSPEDAR-UHFFFAOYSA-M 0.000 description 2
• VBKNTGMWIPUCRF-UHFFFAOYSA-M potassium;fluoride;hydrofluoride Chemical compound F.[F-].[K+] VBKNTGMWIPUCRF-UHFFFAOYSA-M 0.000 description 2
• 230000003449 preventive effect Effects 0.000 description 2
• 238000005956 quaternization reaction Methods 0.000 description 2
• 238000001953 recrystallisation Methods 0.000 description 2
• 210000000664 rectum Anatomy 0.000 description 2
• 230000000241 respiratory effect Effects 0.000 description 2
• YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
• 239000008159 sesame oil Substances 0.000 description 2
• 235000011803 sesame oil Nutrition 0.000 description 2
• 239000000377 silicon dioxide Substances 0.000 description 2
• NDVLTYZPCACLMA-UHFFFAOYSA-N silver oxide Chemical compound [O-2].[Ag+].[Ag+] NDVLTYZPCACLMA-UHFFFAOYSA-N 0.000 description 2
• 229940126586 small molecule drug Drugs 0.000 description 2
• 239000012312 sodium hydride Substances 0.000 description 2
• 235000019333 sodium laurylsulphate Nutrition 0.000 description 2
• JQWHASGSAFIOCM-UHFFFAOYSA-M sodium periodate Chemical compound [Na+].[O-]I(=O)(=O)=O JQWHASGSAFIOCM-UHFFFAOYSA-M 0.000 description 2
• 235000010199 sorbic acid Nutrition 0.000 description 2
• 239000004334 sorbic acid Substances 0.000 description 2
• 229940075582 sorbic acid Drugs 0.000 description 2
• 238000001694 spray drying Methods 0.000 description 2
• 230000000087 stabilizing effect Effects 0.000 description 2
• KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 2
• 239000001797 sucrose acetate isobutyrate Substances 0.000 description 2
• 235000010983 sucrose acetate isobutyrate Nutrition 0.000 description 2
• UVGUPMLLGBCFEJ-SWTLDUCYSA-N sucrose acetate isobutyrate Chemical compound CC(C)C(=O)O[C@H]1[C@H](OC(=O)C(C)C)[C@@H](COC(=O)C(C)C)O[C@@]1(COC(C)=O)O[C@@H]1[C@H](OC(=O)C(C)C)[C@@H](OC(=O)C(C)C)[C@H](OC(=O)C(C)C)[C@@H](COC(C)=O)O1 UVGUPMLLGBCFEJ-SWTLDUCYSA-N 0.000 description 2
• 235000000346 sugar Nutrition 0.000 description 2
• 150000008163 sugars Chemical class 0.000 description 2
• 238000001308 synthesis method Methods 0.000 description 2
• 239000000454 talc Substances 0.000 description 2
• 229910052623 talc Inorganic materials 0.000 description 2
• 235000012222 talc Nutrition 0.000 description 2
• DYHSDKLCOJIUFX-UHFFFAOYSA-N tert-butoxycarbonyl anhydride Chemical compound CC(C)(C)OC(=O)OC(=O)OC(C)(C)C DYHSDKLCOJIUFX-UHFFFAOYSA-N 0.000 description 2
• PJAUJPHROOYXOX-UHFFFAOYSA-N tert-butyl N-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]-N-methylcarbamate Chemical compound N(C(=O)OC(C)(C)C)(CCOCCOCCOCCO)C PJAUJPHROOYXOX-UHFFFAOYSA-N 0.000 description 2
• UHKWRIMRDPOSEC-UHFFFAOYSA-N tert-butyl N-[2-[2-[2-(oxan-2-yloxy)ethoxy]ethoxy]ethyl]carbamate Chemical compound O1C(CCCC1)OCCOCCOCCNC(OC(C)(C)C)=O UHKWRIMRDPOSEC-UHFFFAOYSA-N 0.000 description 2
• DCKFELVJYTVQJV-UHFFFAOYSA-N tert-butyl N-[2-[2-[2-[2-(1,3-dioxoisoindol-2-yl)ethoxy]ethoxy]ethoxy]ethyl]-N-methylcarbamate Chemical compound N1(C(=O)C2=C(C1=O)C=CC=C2)CCOCCOCCOCCN(C)C(=O)OC(C)(C)C DCKFELVJYTVQJV-UHFFFAOYSA-N 0.000 description 2
• UWHCKJMYHZGTIT-UHFFFAOYSA-N tetraethylene glycol Chemical compound OCCOCCOCCOCCO UWHCKJMYHZGTIT-UHFFFAOYSA-N 0.000 description 2
• WGTYBPLFGIVFAS-UHFFFAOYSA-M tetramethylammonium hydroxide Chemical compound [OH-].C[N+](C)(C)C WGTYBPLFGIVFAS-UHFFFAOYSA-M 0.000 description 2
• 239000002562 thickening agent Substances 0.000 description 2
• RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 2
• 229940033663 thimerosal Drugs 0.000 description 2
• 125000005490 tosylate group Chemical group 0.000 description 2
• 230000032258 transport Effects 0.000 description 2
• GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 2
• 238000001665 trituration Methods 0.000 description 2
• 235000015112 vegetable and seed oil Nutrition 0.000 description 2
• 239000008158 vegetable oil Substances 0.000 description 2
• 238000005406 washing Methods 0.000 description 2
• 229920001285 xanthan gum Polymers 0.000 description 2
• 239000000230 xanthan gum Substances 0.000 description 2
• 235000010493 xanthan gum Nutrition 0.000 description 2
• 229940082509 xanthan gum Drugs 0.000 description 2
• 229910052725 zinc Inorganic materials 0.000 description 2
• 239000011701 zinc Substances 0.000 description 2
• 235000016804 zinc Nutrition 0.000 description 2
• LSPHULWDVZXLIL-UHFFFAOYSA-N (+/-)-Camphoric acid Chemical compound CC1(C)C(C(O)=O)CCC1(C)C(O)=O LSPHULWDVZXLIL-UHFFFAOYSA-N 0.000 description 1
• 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 description 1
• 102000040650 (ribonucleotides)n+m Human genes 0.000 description 1
• YFMFNYKEUDLDTL-UHFFFAOYSA-N 1,1,1,2,3,3,3-heptafluoropropane Chemical compound FC(F)(F)C(F)C(F)(F)F YFMFNYKEUDLDTL-UHFFFAOYSA-N 0.000 description 1
• LVGUZGTVOIAKKC-UHFFFAOYSA-N 1,1,1,2-tetrafluoroethane Chemical compound FCC(F)(F)F LVGUZGTVOIAKKC-UHFFFAOYSA-N 0.000 description 1
• DDMOUSALMHHKOS-UHFFFAOYSA-N 1,2-dichloro-1,1,2,2-tetrafluoroethane Chemical compound FC(F)(Cl)C(F)(F)Cl DDMOUSALMHHKOS-UHFFFAOYSA-N 0.000 description 1
• TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 description 1
• 229940058015 1,3-butylene glycol Drugs 0.000 description 1
• JKUVVDZNPRTKKI-UHFFFAOYSA-N 1-(2-azidoethoxy)-5-ethoxypentane Chemical compound N(=[N+]=[N-])CCOCCCCCOCC JKUVVDZNPRTKKI-UHFFFAOYSA-N 0.000 description 1
• MLHQPPYBHZSBCX-UHFFFAOYSA-N 1-(2-hydroxyethoxy)propan-2-ol Chemical compound CC(O)COCCO MLHQPPYBHZSBCX-UHFFFAOYSA-N 0.000 description 1
• GQMGRGFRBJPXTM-UHFFFAOYSA-N 1-[2-(2-azidoethoxy)ethoxy]pentane Chemical compound N(=[N+]=[N-])CCOCCOCCCCC GQMGRGFRBJPXTM-UHFFFAOYSA-N 0.000 description 1
• VYBQBSGDKAHCPI-UHFFFAOYSA-N 11-(methylamino)undecan-1-ol Chemical compound CNCCCCCCCCCCCO VYBQBSGDKAHCPI-UHFFFAOYSA-N 0.000 description 1
• XEZNGIUYQVAUSS-UHFFFAOYSA-N 18-crown-6 Chemical compound C1COCCOCCOCCOCCOCCO1 XEZNGIUYQVAUSS-UHFFFAOYSA-N 0.000 description 1
• BAXOFTOLAUCFNW-UHFFFAOYSA-N 1H-indazole Chemical group C1=CC=C2C=NNC2=C1 BAXOFTOLAUCFNW-UHFFFAOYSA-N 0.000 description 1
• CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 description 1
• OGIOQJAWGBVLDQ-UHFFFAOYSA-N 2-(5-ethoxypentoxy)-N-methylethanamine Chemical compound C(C)OCCCCCOCCNC OGIOQJAWGBVLDQ-UHFFFAOYSA-N 0.000 description 1
• CNIJRLOMBUTAFJ-UHFFFAOYSA-N 2-(5-ethoxypentoxy)ethanamine Chemical compound C(C)OCCCCCOCCN CNIJRLOMBUTAFJ-UHFFFAOYSA-N 0.000 description 1
• BLDFSDCBQJUWFG-UHFFFAOYSA-N 2-(methylamino)-1,2-diphenylethanol Chemical compound C=1C=CC=CC=1C(NC)C(O)C1=CC=CC=C1 BLDFSDCBQJUWFG-UHFFFAOYSA-N 0.000 description 1
• FGDJUEZBMFELRW-UHFFFAOYSA-N 2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate Chemical compound CC1=CC=C(S(=O)(=O)OCCOCCOCCOCCO)C=C1 FGDJUEZBMFELRW-UHFFFAOYSA-N 0.000 description 1
• JHAISJVRBDNCEZ-UHFFFAOYSA-N 2-[2-[2-[2-(oxan-2-yloxy)ethoxy]ethoxy]ethoxy]acetic acid Chemical compound OC(=O)COCCOCCOCCOC1CCCCO1 JHAISJVRBDNCEZ-UHFFFAOYSA-N 0.000 description 1
• LDLCZOVUSADOIV-UHFFFAOYSA-N 2-bromoethanol Chemical compound OCCBr LDLCZOVUSADOIV-UHFFFAOYSA-N 0.000 description 1
• HJOQGBBHVRYTDX-UHFFFAOYSA-N 2-chloro-7h-pyrrolo[2,3-d]pyrimidine Chemical compound ClC1=NC=C2C=CNC2=N1 HJOQGBBHVRYTDX-UHFFFAOYSA-N 0.000 description 1
• ZNQVEEAIQZEUHB-UHFFFAOYSA-N 2-ethoxyethanol Chemical compound CCOCCO ZNQVEEAIQZEUHB-UHFFFAOYSA-N 0.000 description 1
• 229940093475 2-ethoxyethanol Drugs 0.000 description 1
• LBLYYCQCTBFVLH-UHFFFAOYSA-M 2-methylbenzenesulfonate Chemical compound CC1=CC=CC=C1S([O-])(=O)=O LBLYYCQCTBFVLH-UHFFFAOYSA-M 0.000 description 1
• 229940080296 2-naphthalenesulfonate Drugs 0.000 description 1
• LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 description 1
• JHUUPUMBZGWODW-UHFFFAOYSA-N 3,6-dihydro-1,2-dioxine Chemical compound C1OOCC=C1 JHUUPUMBZGWODW-UHFFFAOYSA-N 0.000 description 1
• BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 description 1
• XAAFAPOSALSONG-UHFFFAOYSA-N 3-bromo-5-fluoro-1-(4-methylphenyl)sulfonylpyrrolo[2,3-b]pyridine Chemical compound C1=CC(C)=CC=C1S(=O)(=O)N1C2=NC=C(F)C=C2C(Br)=C1 XAAFAPOSALSONG-UHFFFAOYSA-N 0.000 description 1
• CRDINLYNEISYHP-UHFFFAOYSA-N 3-bromo-5-fluoro-1h-pyrrolo[2,3-b]pyridine Chemical compound FC1=CN=C2NC=C(Br)C2=C1 CRDINLYNEISYHP-UHFFFAOYSA-N 0.000 description 1
• ZRPLANDPDWYOMZ-UHFFFAOYSA-N 3-cyclopentylpropionic acid Chemical compound OC(=O)CCC1CCCC1 ZRPLANDPDWYOMZ-UHFFFAOYSA-N 0.000 description 1
• FVMDYYGIDFPZAX-UHFFFAOYSA-N 3-hydroxyphenylacetic acid Chemical compound OC(=O)CC1=CC=CC(O)=C1 FVMDYYGIDFPZAX-UHFFFAOYSA-N 0.000 description 1
• XMIIGOLPHOKFCH-UHFFFAOYSA-M 3-phenylpropionate Chemical compound [O-]C(=O)CCC1=CC=CC=C1 XMIIGOLPHOKFCH-UHFFFAOYSA-M 0.000 description 1
• OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
• NGKNMHFWZMHABQ-UHFFFAOYSA-N 4-chloro-2h-benzotriazole Chemical compound ClC1=CC=CC2=NNN=C12 NGKNMHFWZMHABQ-UHFFFAOYSA-N 0.000 description 1
• YJTXQLYMECWULH-UHFFFAOYSA-N 5-fluoropyridin-2-amine Chemical compound NC1=CC=C(F)C=N1 YJTXQLYMECWULH-UHFFFAOYSA-N 0.000 description 1
• SXZIYBMDMCKJPM-UHFFFAOYSA-N 5-pentoxypentan-1-amine Chemical compound CCCCCOCCCCCN SXZIYBMDMCKJPM-UHFFFAOYSA-N 0.000 description 1
• ZPLGDVRVTKEDGT-UHFFFAOYSA-N 5-pentoxypentanoic acid Chemical compound CCCCCOCCCCC(O)=O ZPLGDVRVTKEDGT-UHFFFAOYSA-N 0.000 description 1
• 101150025253 AFR1 gene Proteins 0.000 description 1
• 244000215068 Acacia senegal Species 0.000 description 1
• QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
• NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
• 206010067484 Adverse reaction Diseases 0.000 description 1
• 206010001540 Akathisia Diseases 0.000 description 1
• 108010088751 Albumins Proteins 0.000 description 1
• 102000009027 Albumins Human genes 0.000 description 1
• 201000004384 Alopecia Diseases 0.000 description 1
• 239000005995 Aluminium silicate Substances 0.000 description 1
• 102000004400 Aminopeptidases Human genes 0.000 description 1
• 108090000915 Aminopeptidases Proteins 0.000 description 1
• 241000272517 Anseriformes Species 0.000 description 1
• 235000017060 Arachis glabrata Nutrition 0.000 description 1
• 244000105624 Arachis hypogaea Species 0.000 description 1
• 235000010777 Arachis hypogaea Nutrition 0.000 description 1
• 235000018262 Arachis monticola Nutrition 0.000 description 1
• 239000004475 Arginine Substances 0.000 description 1
• 241000416162 Astragalus gummifer Species 0.000 description 1
• 241000271566 Aves Species 0.000 description 1
• 108010017384 Blood Proteins Proteins 0.000 description 1
• 102000004506 Blood Proteins Human genes 0.000 description 1
• 206010065553 Bone marrow failure Diseases 0.000 description 1
• BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 1
• FERIUCNNQQJTOY-UHFFFAOYSA-M Butyrate Chemical compound CCCC([O-])=O FERIUCNNQQJTOY-UHFFFAOYSA-M 0.000 description 1
• FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Natural products CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 1
• AFWTZXXDGQBIKW-UHFFFAOYSA-N C14 surfactin Natural products CCCCCCCCCCCC1CC(=O)NC(CCC(O)=O)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(CC(O)=O)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)O1 AFWTZXXDGQBIKW-UHFFFAOYSA-N 0.000 description 1
• 125000003601 C2-C6 alkynyl group Chemical group 0.000 description 1
• PCBZRNYXXCIELG-WYFCWLEVSA-N COC1=CC=C(C[C@H](NC(=O)OC2CCCC3(C2)OOC2(O3)C3CC4CC(C3)CC2C4)C(=O)N[C@@H]2[C@@H](CO)O[C@H]([C@@H]2O)N2C=NC3=C2N=CN=C3N(C)C)C=C1 Chemical compound COC1=CC=C(C[C@H](NC(=O)OC2CCCC3(C2)OOC2(O3)C3CC4CC(C3)CC2C4)C(=O)N[C@@H]2[C@@H](CO)O[C@H]([C@@H]2O)N2C=NC3=C2N=CN=C3N(C)C)C=C1 PCBZRNYXXCIELG-WYFCWLEVSA-N 0.000 description 1
• 241000282465 Canis Species 0.000 description 1
• BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
• 208000024172 Cardiovascular disease Diseases 0.000 description 1
• 241000282693 Cercopithecidae Species 0.000 description 1
• ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
• 102100032373 Coiled-coil domain-containing protein 85B Human genes 0.000 description 1
• 229920000858 Cyclodextrin Polymers 0.000 description 1
• FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
• FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
• RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 description 1
• 108020004414 DNA Proteins 0.000 description 1
• YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 description 1
• 229920002307 Dextran Polymers 0.000 description 1
• FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
• BWLUMTFWVZZZND-UHFFFAOYSA-N Dibenzylamine Chemical compound C=1C=CC=CC=1CNCC1=CC=CC=C1 BWLUMTFWVZZZND-UHFFFAOYSA-N 0.000 description 1
• 235000019739 Dicalciumphosphate Nutrition 0.000 description 1
• 239000004338 Dichlorodifluoromethane Substances 0.000 description 1
• 101100046553 Dictyostelium discoideum tnpo gene Proteins 0.000 description 1
• XBPCUCUWBYBCDP-UHFFFAOYSA-N Dicyclohexylamine Chemical compound C1CCCCC1NC1CCCCC1 XBPCUCUWBYBCDP-UHFFFAOYSA-N 0.000 description 1
• 206010052804 Drug tolerance Diseases 0.000 description 1
• 208000030453 Drug-Related Side Effects and Adverse reaction Diseases 0.000 description 1
• KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
• LVGKNOAMLMIIKO-UHFFFAOYSA-N Elaidinsaeure-aethylester Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC LVGKNOAMLMIIKO-UHFFFAOYSA-N 0.000 description 1
• 102100031780 Endonuclease Human genes 0.000 description 1
• 108010042407 Endonucleases Proteins 0.000 description 1
• 241000792859 Enema Species 0.000 description 1
• 239000001856 Ethyl cellulose Substances 0.000 description 1
• ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
• PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 description 1
• 208000027776 Extrapyramidal disease Diseases 0.000 description 1
• 206010016326 Feeling cold Diseases 0.000 description 1
• PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 1
• WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 1
• BDAGIHXWWSANSR-UHFFFAOYSA-M Formate Chemical compound [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 description 1
• VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 1
• 241000287828 Gallus gallus Species 0.000 description 1
• 208000005577 Gastroenteritis Diseases 0.000 description 1
• 206010017918 Gastroenteritis viral Diseases 0.000 description 1
• 206010059024 Gastrointestinal toxicity Diseases 0.000 description 1
• 241000206672 Gelidium Species 0.000 description 1
• ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 description 1
• 239000004471 Glycine Substances 0.000 description 1
• 108010007979 Glycocholic Acid Proteins 0.000 description 1
• AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Polymers OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 1
• 108060003393 Granulin Proteins 0.000 description 1
• 229920000084 Gum arabic Polymers 0.000 description 1
• 206010019851 Hepatotoxicity Diseases 0.000 description 1
• 101000868814 Homo sapiens Coiled-coil domain-containing protein 85B Proteins 0.000 description 1
• 108091006905 Human Serum Albumin Proteins 0.000 description 1
• 102000008100 Human Serum Albumin Human genes 0.000 description 1
• CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 1
• 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
• 208000002979 Influenza in Birds Diseases 0.000 description 1
• 206010022004 Influenza like illness Diseases 0.000 description 1
• 206010022714 Intestinal ulcer Diseases 0.000 description 1
• 201000003129 Kidney Papillary Necrosis Diseases 0.000 description 1
• AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 description 1
• ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
• CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
• KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
• JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
• 239000004166 Lanolin Substances 0.000 description 1
• 206010024264 Lethargy Diseases 0.000 description 1
• 229910010084 LiAlH4 Inorganic materials 0.000 description 1
• WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
• 239000004472 Lysine Substances 0.000 description 1
• 241000701076 Macacine alphaherpesvirus 1 Species 0.000 description 1
• OFOBLEOULBTSOW-UHFFFAOYSA-L Malonate Chemical compound [O-]C(=O)CC([O-])=O OFOBLEOULBTSOW-UHFFFAOYSA-L 0.000 description 1
• 240000003183 Manihot esculenta Species 0.000 description 1
• 235000016735 Manihot esculenta subsp esculenta Nutrition 0.000 description 1
• AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 1
• 108060004795 Methyltransferase Proteins 0.000 description 1
• 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
• GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 description 1
• FDQHRCKARMSEQL-UHFFFAOYSA-N N-benzyl-2-(2-pentoxyethoxy)ethanamine Chemical compound C(C1=CC=CC=C1)NCCOCCOCCCCC FDQHRCKARMSEQL-UHFFFAOYSA-N 0.000 description 1
• IUTYIWQTXPMORA-UHFFFAOYSA-N N-benzyl-2-(5-ethoxypentoxy)ethanamine Chemical compound C(C1=CC=CC=C1)NCCOCCCCCOCC IUTYIWQTXPMORA-UHFFFAOYSA-N 0.000 description 1
• OAGGXYKGDLMJIW-UHFFFAOYSA-N N-benzyl-2-[2-(2-ethoxyethoxy)ethoxy]ethanamine Chemical compound C(C1=CC=CC=C1)NCCOCCOCCOCC OAGGXYKGDLMJIW-UHFFFAOYSA-N 0.000 description 1
• UVMAHSPRYHGCIA-UHFFFAOYSA-N N-benzyl-5-(2-ethoxyethoxy)pentan-1-amine Chemical compound C(C1=CC=CC=C1)NCCCCCOCCOCC UVMAHSPRYHGCIA-UHFFFAOYSA-N 0.000 description 1
• HTLZVHNRZJPSMI-UHFFFAOYSA-N N-ethylpiperidine Chemical compound CCN1CCCCC1 HTLZVHNRZJPSMI-UHFFFAOYSA-N 0.000 description 1
• SRYCHSCJBMKWNK-UHFFFAOYSA-N N-methyl-2-(2-pentoxyethoxy)ethanamine Chemical compound N(C)CCOCCOCCCCC SRYCHSCJBMKWNK-UHFFFAOYSA-N 0.000 description 1
• KHTZWDWJHRVCEP-UHFFFAOYSA-N N-methyl-2-[2-[2-[2-(oxan-2-yloxy)ethoxy]ethoxy]ethoxy]ethanamine Chemical compound CNCCOCCOCCOCCOC1OCCCC1 KHTZWDWJHRVCEP-UHFFFAOYSA-N 0.000 description 1
• MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical compound CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 description 1
• 238000005481 NMR spectroscopy Methods 0.000 description 1
• 206010028735 Nasal congestion Diseases 0.000 description 1
• 206010028813 Nausea Diseases 0.000 description 1
• 206010029155 Nephropathy toxic Diseases 0.000 description 1
• 206010029350 Neurotoxicity Diseases 0.000 description 1
• PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 1
• 240000007817 Olea europaea Species 0.000 description 1
• 108020005187 Oligonucleotide Probes Proteins 0.000 description 1
• AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 description 1
• UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 description 1
• 241000282577 Pan troglodytes Species 0.000 description 1
• 235000019483 Peanut oil Nutrition 0.000 description 1
• 206010057249 Phagocytosis Diseases 0.000 description 1
• 241000286209 Phasianidae Species 0.000 description 1
• 206010035664 Pneumonia Diseases 0.000 description 1
• RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 1
• 239000004952 Polyamide Substances 0.000 description 1
• 239000004698 Polyethylene Substances 0.000 description 1
• 229920000954 Polyglycolide Polymers 0.000 description 1
• 229920001214 Polysorbate 60 Polymers 0.000 description 1
• XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 1
• 102000007327 Protamines Human genes 0.000 description 1
• 108010007568 Protamines Proteins 0.000 description 1
• 208000001431 Psychomotor Agitation Diseases 0.000 description 1
• 102000028391 RNA cap binding Human genes 0.000 description 1
• 108091000106 RNA cap binding Proteins 0.000 description 1
• 230000006819 RNA synthesis Effects 0.000 description 1
• 241000700159 Rattus Species 0.000 description 1
• 235000004443 Ricinus communis Nutrition 0.000 description 1
• 101000767160 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) Intracellular protein transport protein USO1 Proteins 0.000 description 1
• 235000019485 Safflower oil Nutrition 0.000 description 1
• 201000001880 Sexual dysfunction Diseases 0.000 description 1
• 229920002125 Sokalan® Polymers 0.000 description 1
• 235000002595 Solanum tuberosum Nutrition 0.000 description 1
• 244000061456 Solanum tuberosum Species 0.000 description 1
• 206010041349 Somnolence Diseases 0.000 description 1
• HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 1
• 101710172711 Structural protein Proteins 0.000 description 1
• FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
• 208000025371 Taste disease Diseases 0.000 description 1
• 206010044221 Toxic encephalopathy Diseases 0.000 description 1
• 206010070863 Toxicity to various agents Diseases 0.000 description 1
• 229920001615 Tragacanth Polymers 0.000 description 1
• YZCKVEUIGOORGS-NJFSPNSNSA-N Tritium Chemical compound [3H] YZCKVEUIGOORGS-NJFSPNSNSA-N 0.000 description 1
• 206010048302 Tubulointerstitial nephritis Diseases 0.000 description 1
• 208000036142 Viral infection Diseases 0.000 description 1
• TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
• 240000008042 Zea mays Species 0.000 description 1
• 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
• 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
• 101150037250 Zhx2 gene Proteins 0.000 description 1
• HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
• 102100025093 Zinc fingers and homeoboxes protein 2 Human genes 0.000 description 1
• JVVXZOOGOGPDRZ-SLFFLAALSA-N [(1R,4aS,10aR)-1,4a-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthren-1-yl]methanamine Chemical compound NC[C@]1(C)CCC[C@]2(C)C3=CC=C(C(C)C)C=C3CC[C@H]21 JVVXZOOGOGPDRZ-SLFFLAALSA-N 0.000 description 1
• 239000001089 [(2R)-oxolan-2-yl]methanol Substances 0.000 description 1
• ZBNRGEMZNWHCGA-PDKVEDEMSA-N [(2r)-2-[(2r,3r,4s)-3,4-bis[[(z)-octadec-9-enoyl]oxy]oxolan-2-yl]-2-hydroxyethyl] (z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H]1OC(=O)CCCCCCC\C=C/CCCCCCCC ZBNRGEMZNWHCGA-PDKVEDEMSA-N 0.000 description 1
• YWMLORGQOFONNT-UHFFFAOYSA-N [3-(hydroxymethyl)phenyl]methanol Chemical compound OCC1=CC=CC(CO)=C1 YWMLORGQOFONNT-UHFFFAOYSA-N 0.000 description 1
• 210000001015 abdomen Anatomy 0.000 description 1
• 239000002250 absorbent Substances 0.000 description 1
• 230000002745 absorbent Effects 0.000 description 1
• 239000003655 absorption accelerator Substances 0.000 description 1
• 239000003070 absorption delaying agent Substances 0.000 description 1
• 229940124532 absorption promoter Drugs 0.000 description 1
• 235000010489 acacia gum Nutrition 0.000 description 1
• 239000000205 acacia gum Substances 0.000 description 1
• DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
• 230000009471 action Effects 0.000 description 1
• 230000001154 acute effect Effects 0.000 description 1
• WNLRTRBMVRJNCN-UHFFFAOYSA-L adipate(2-) Chemical compound [O-]C(=O)CCCCC([O-])=O WNLRTRBMVRJNCN-UHFFFAOYSA-L 0.000 description 1
• 239000003463 adsorbent Substances 0.000 description 1
• 230000002411 adverse Effects 0.000 description 1
• 230000006838 adverse reaction Effects 0.000 description 1
• 239000004479 aerosol dispenser Substances 0.000 description 1
• 239000008272 agar Substances 0.000 description 1
• 238000005054 agglomeration Methods 0.000 description 1
• 230000002776 aggregation Effects 0.000 description 1
• 239000003513 alkali Substances 0.000 description 1
• 229910052783 alkali metal Inorganic materials 0.000 description 1
• 150000001340 alkali metals Chemical class 0.000 description 1
• 229910052784 alkaline earth metal Inorganic materials 0.000 description 1
• 150000001342 alkaline earth metals Chemical class 0.000 description 1
• 150000008055 alkyl aryl sulfonates Chemical class 0.000 description 1
• 150000008052 alkyl sulfonates Chemical class 0.000 description 1
• 208000026935 allergic disease Diseases 0.000 description 1
• 231100000360 alopecia Toxicity 0.000 description 1
• AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 description 1
• AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 1
• 229910052782 aluminium Inorganic materials 0.000 description 1
• XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
• PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
• 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
• 235000012211 aluminium silicate Nutrition 0.000 description 1
• CEGOLXSVJUTHNZ-UHFFFAOYSA-K aluminium tristearate Chemical compound [Al+3].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CEGOLXSVJUTHNZ-UHFFFAOYSA-K 0.000 description 1
• 229940063655 aluminum stearate Drugs 0.000 description 1
• 229910021529 ammonia Inorganic materials 0.000 description 1
• 235000019270 ammonium chloride Nutrition 0.000 description 1
• 230000003321 amplification Effects 0.000 description 1
• 238000004458 analytical method Methods 0.000 description 1
• 208000007502 anemia Diseases 0.000 description 1
• 230000000840 anti-viral effect Effects 0.000 description 1
• 230000005875 antibody response Effects 0.000 description 1
• 230000027645 antigenic variation Effects 0.000 description 1
• 239000004599 antimicrobial Substances 0.000 description 1
• 229940027983 antiseptic and disinfectant quaternary ammonium compound Drugs 0.000 description 1
• 239000008365 aqueous carrier Substances 0.000 description 1
• 239000008135 aqueous vehicle Substances 0.000 description 1
• ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
• 229960003121 arginine Drugs 0.000 description 1
• 125000003118 aryl group Chemical group 0.000 description 1
• 229940009098 aspartate Drugs 0.000 description 1
• 206010003549 asthenia Diseases 0.000 description 1
• 208000006673 asthma Diseases 0.000 description 1
• 239000012298 atmosphere Substances 0.000 description 1
• 206010064097 avian influenza Diseases 0.000 description 1
• 125000005334 azaindolyl group Chemical group N1N=C(C2=CC=CC=C12)* 0.000 description 1
• 244000052616 bacterial pathogen Species 0.000 description 1
• 229910052788 barium Inorganic materials 0.000 description 1
• DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 description 1
• 230000004888 barrier function Effects 0.000 description 1
• 235000013871 bee wax Nutrition 0.000 description 1
• 239000012166 beeswax Substances 0.000 description 1
• UPABQMWFWCMOFV-UHFFFAOYSA-N benethamine Chemical compound C=1C=CC=CC=1CNCCC1=CC=CC=C1 UPABQMWFWCMOFV-UHFFFAOYSA-N 0.000 description 1
• 239000000440 bentonite Substances 0.000 description 1
• 229910000278 bentonite Inorganic materials 0.000 description 1
• SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
• 229960000686 benzalkonium chloride Drugs 0.000 description 1
• JUHORIMYRDESRB-UHFFFAOYSA-N benzathine Chemical compound C=1C=CC=CC=1CNCCNCC1=CC=CC=C1 JUHORIMYRDESRB-UHFFFAOYSA-N 0.000 description 1
• 229940077388 benzenesulfonate Drugs 0.000 description 1
• SRSXLGNVWSONIS-UHFFFAOYSA-M benzenesulfonate Chemical compound [O-]S(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-M 0.000 description 1
• 229940050390 benzoate Drugs 0.000 description 1
• WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 1
• 229960002903 benzyl benzoate Drugs 0.000 description 1
• CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
• 239000003833 bile salt Substances 0.000 description 1
• 229940093761 bile salts Drugs 0.000 description 1
• 239000000227 bioadhesive Substances 0.000 description 1
• 238000004166 bioassay Methods 0.000 description 1
• 238000001574 biopsy Methods 0.000 description 1
• 125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 description 1
• 210000004369 blood Anatomy 0.000 description 1
• 239000008280 blood Substances 0.000 description 1
• 208000027499 body ache Diseases 0.000 description 1
• 210000001124 body fluid Anatomy 0.000 description 1
• 239000010839 body fluid Substances 0.000 description 1
• 210000000988 bone and bone Anatomy 0.000 description 1
• UWTDFICHZKXYAC-UHFFFAOYSA-N boron;oxolane Chemical compound [B].C1CCOC1 UWTDFICHZKXYAC-UHFFFAOYSA-N 0.000 description 1
• ZADPBFCGQRWHPN-UHFFFAOYSA-N boronic acid Chemical compound OBO ZADPBFCGQRWHPN-UHFFFAOYSA-N 0.000 description 1
• 239000012267 brine Substances 0.000 description 1
• 229910000019 calcium carbonate Inorganic materials 0.000 description 1
• 235000010216 calcium carbonate Nutrition 0.000 description 1
• AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 1
• FATUQANACHZLRT-KMRXSBRUSA-L calcium glucoheptonate Chemical compound [Ca+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)C([O-])=O FATUQANACHZLRT-KMRXSBRUSA-L 0.000 description 1
• 239000000920 calcium hydroxide Substances 0.000 description 1
• 229910001861 calcium hydroxide Inorganic materials 0.000 description 1
• 239000001506 calcium phosphate Substances 0.000 description 1
• CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
• 239000008116 calcium stearate Substances 0.000 description 1
• 235000013539 calcium stearate Nutrition 0.000 description 1
• MIOPJNTWMNEORI-UHFFFAOYSA-N camphorsulfonic acid Chemical compound C1CC2(CS(O)(=O)=O)C(=O)CC1C2(C)C MIOPJNTWMNEORI-UHFFFAOYSA-N 0.000 description 1
• 150000001720 carbohydrates Chemical class 0.000 description 1
• 235000014633 carbohydrates Nutrition 0.000 description 1
• 229960001631 carbomer Drugs 0.000 description 1
• 150000001721 carbon Chemical group 0.000 description 1
• 229910002091 carbon monoxide Inorganic materials 0.000 description 1
• 150000007942 carboxylates Chemical class 0.000 description 1
• 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 1
• 235000019438 castor oil Nutrition 0.000 description 1
• 230000015556 catabolic process Effects 0.000 description 1
• 230000003197 catalytic effect Effects 0.000 description 1
• 230000030833 cell death Effects 0.000 description 1
• 230000006037 cell lysis Effects 0.000 description 1
• 230000001413 cellular effect Effects 0.000 description 1
• 229920002301 cellulose acetate Polymers 0.000 description 1
• 229940081733 cetearyl alcohol Drugs 0.000 description 1
• 229960000541 cetyl alcohol Drugs 0.000 description 1
• 229910052729 chemical element Inorganic materials 0.000 description 1
• 238000004296 chiral HPLC Methods 0.000 description 1
• VDANGULDQQJODZ-UHFFFAOYSA-N chloroprocaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1Cl VDANGULDQQJODZ-UHFFFAOYSA-N 0.000 description 1
• 229960002023 chloroprocaine Drugs 0.000 description 1
• OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 1
• 229960001231 choline Drugs 0.000 description 1
• 231100000850 chronic interstitial nephritis Toxicity 0.000 description 1
• HGCIXCUEYOPUTN-UHFFFAOYSA-N cis-cyclohexene Natural products C1CCC=CC1 HGCIXCUEYOPUTN-UHFFFAOYSA-N 0.000 description 1
• 239000004927 clay Substances 0.000 description 1
• 229940075614 colloidal silicon dioxide Drugs 0.000 description 1
• 229940125782 compound 2 Drugs 0.000 description 1
• 230000001010 compromised effect Effects 0.000 description 1
• 230000009351 contact transmission Effects 0.000 description 1
• 238000011217 control strategy Methods 0.000 description 1
• 239000012050 conventional carrier Substances 0.000 description 1
• 238000007796 conventional method Methods 0.000 description 1
• 235000005822 corn Nutrition 0.000 description 1
• 239000002285 corn oil Substances 0.000 description 1
• 235000005687 corn oil Nutrition 0.000 description 1
• 239000002385 cottonseed oil Substances 0.000 description 1
• NLUNLVTVUDIHFE-UHFFFAOYSA-N cyclooctylcyclooctane Chemical group C1CCCCCCC1C1CCCCCCC1 NLUNLVTVUDIHFE-UHFFFAOYSA-N 0.000 description 1
• 238000006731 degradation reaction Methods 0.000 description 1
• 230000002939 deleterious effect Effects 0.000 description 1
• 238000002716 delivery method Methods 0.000 description 1
• 230000001419 dependent effect Effects 0.000 description 1
• 239000003599 detergent Substances 0.000 description 1
• 238000005881 detosylation reaction Methods 0.000 description 1
• 150000001975 deuterium Chemical class 0.000 description 1
• 229910052805 deuterium Inorganic materials 0.000 description 1
• 206010012601 diabetes mellitus Diseases 0.000 description 1
• 238000003745 diagnosis Methods 0.000 description 1
• NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 1
• 229940038472 dicalcium phosphate Drugs 0.000 description 1
• 229910000390 dicalcium phosphate Inorganic materials 0.000 description 1
• PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 description 1
• 235000019404 dichlorodifluoromethane Nutrition 0.000 description 1
• 229940042935 dichlorodifluoromethane Drugs 0.000 description 1
• 229940087091 dichlorotetrafluoroethane Drugs 0.000 description 1
• 235000005911 diet Nutrition 0.000 description 1
• 230000037213 diet Effects 0.000 description 1
• ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
• 229940043237 diethanolamine Drugs 0.000 description 1
• HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 description 1
• XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 description 1
• UGMCXQCYOVCMTB-UHFFFAOYSA-K dihydroxy(stearato)aluminium Chemical compound CCCCCCCCCCCCCCCCCC(=O)O[Al](O)O UGMCXQCYOVCMTB-UHFFFAOYSA-K 0.000 description 1
• LVTYICIALWPMFW-UHFFFAOYSA-N diisopropanolamine Chemical compound CC(O)CNCC(C)O LVTYICIALWPMFW-UHFFFAOYSA-N 0.000 description 1
• 229940043279 diisopropylamine Drugs 0.000 description 1
• GXGAKHNRMVGRPK-UHFFFAOYSA-N dimagnesium;dioxido-bis[[oxido(oxo)silyl]oxy]silane Chemical compound [Mg+2].[Mg+2].[O-][Si](=O)O[Si]([O-])([O-])O[Si]([O-])=O GXGAKHNRMVGRPK-UHFFFAOYSA-N 0.000 description 1
• ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 1
• 229910000396 dipotassium phosphate Inorganic materials 0.000 description 1
• 235000019797 dipotassium phosphate Nutrition 0.000 description 1
• LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
• 239000007884 disintegrant Substances 0.000 description 1
• BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
• 238000004821 distillation Methods 0.000 description 1
• 208000002173 dizziness Diseases 0.000 description 1
• POULHZVOKOAJMA-UHFFFAOYSA-M dodecanoate Chemical compound CCCCCCCCCCCC([O-])=O POULHZVOKOAJMA-UHFFFAOYSA-M 0.000 description 1
• 206010013781 dry mouth Diseases 0.000 description 1
• 229940112141 dry powder inhaler Drugs 0.000 description 1
• 239000003221 ear drop Substances 0.000 description 1
• 229940047652 ear drops Drugs 0.000 description 1
• 239000003792 electrolyte Substances 0.000 description 1
• 239000008387 emulsifying waxe Substances 0.000 description 1
• 238000003821 enantio-separation Methods 0.000 description 1
• 239000007920 enema Substances 0.000 description 1
• 229940095399 enema Drugs 0.000 description 1
• 238000005516 engineering process Methods 0.000 description 1
• 238000006911 enzymatic reaction Methods 0.000 description 1
• 210000000981 epithelium Anatomy 0.000 description 1
• 230000003628 erosive effect Effects 0.000 description 1
• CCIVGXIOQKPBKL-UHFFFAOYSA-M ethanesulfonate Chemical compound CCS([O-])(=O)=O CCIVGXIOQKPBKL-UHFFFAOYSA-M 0.000 description 1
• PAPZONBXFOMSDL-UHFFFAOYSA-N ethyl 2-[2-[2-[2-(oxan-2-yloxy)ethoxy]ethoxy]ethoxy]acetate Chemical compound CCOC(=O)COCCOCCOCCOC1CCCCO1 PAPZONBXFOMSDL-UHFFFAOYSA-N 0.000 description 1
• ATQWZAQCONFYRI-UHFFFAOYSA-N ethyl 3-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]propanoate Chemical compound C(C)OC(CCOCCOCCOCCN)=O ATQWZAQCONFYRI-UHFFFAOYSA-N 0.000 description 1
• GDZFHVQFPZZKMD-UHFFFAOYSA-N ethyl 3-[2-[2-(oxan-2-yloxy)ethoxy]ethoxy]propanoate Chemical compound O1C(CCCC1)OCCOCCOCCC(=O)OCC GDZFHVQFPZZKMD-UHFFFAOYSA-N 0.000 description 1
• DCQABPQBHZCFOJ-UHFFFAOYSA-N ethyl 3-[2-[2-[2-(methylamino)ethoxy]ethoxy]ethoxy]propanoate Chemical compound CNCCOCCOCCOCCC(=O)OCC DCQABPQBHZCFOJ-UHFFFAOYSA-N 0.000 description 1
• SMGUCCJSBIXBMY-UHFFFAOYSA-N ethyl 3-[6-(4-methylphenyl)sulfonyloxyhexoxy]propanoate Chemical compound CCOC(=O)CCOCCCCCCOS(=O)(=O)C1=CC=C(C=C1)C SMGUCCJSBIXBMY-UHFFFAOYSA-N 0.000 description 1
• 235000019325 ethyl cellulose Nutrition 0.000 description 1
• 229920001249 ethyl cellulose Polymers 0.000 description 1
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
• LVGKNOAMLMIIKO-QXMHVHEDSA-N ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 description 1
• 229940093471 ethyl oleate Drugs 0.000 description 1
• 230000008020 evaporation Effects 0.000 description 1
• 230000029142 excretion Effects 0.000 description 1
• 238000000605 extraction Methods 0.000 description 1
• 238000001125 extrusion Methods 0.000 description 1
• 239000003889 eye drop Substances 0.000 description 1
• 229940012356 eye drops Drugs 0.000 description 1
• 150000002191 fatty alcohols Chemical class 0.000 description 1
• 210000003608 fece Anatomy 0.000 description 1
• 235000019634 flavors Nutrition 0.000 description 1
• 238000004334 fluoridation Methods 0.000 description 1
• 238000003682 fluorination reaction Methods 0.000 description 1
• 239000011737 fluorine Substances 0.000 description 1
• 150000002222 fluorine compounds Chemical class 0.000 description 1
• 238000005187 foaming Methods 0.000 description 1
• 239000011888 foil Substances 0.000 description 1
• 235000019256 formaldehyde Nutrition 0.000 description 1
• 235000019253 formic acid Nutrition 0.000 description 1
• 150000002270 gangliosides Chemical class 0.000 description 1
• 238000004817 gas chromatography Methods 0.000 description 1
• 230000002496 gastric effect Effects 0.000 description 1
• 231100000414 gastrointestinal toxicity Toxicity 0.000 description 1
• 230000002068 genetic effect Effects 0.000 description 1
• 229940050410 gluconate Drugs 0.000 description 1
• ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
• 229960002449 glycine Drugs 0.000 description 1
• RFDAIACWWDREDC-FRVQLJSFSA-N glycocholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 RFDAIACWWDREDC-FRVQLJSFSA-N 0.000 description 1
• 150000002334 glycols Chemical class 0.000 description 1
• 230000012010 growth Effects 0.000 description 1
• 150000004820 halides Chemical class 0.000 description 1
• 230000026030 halogenation Effects 0.000 description 1
• 238000005658 halogenation reaction Methods 0.000 description 1
• 208000019622 heart disease Diseases 0.000 description 1
• 238000010438 heat treatment Methods 0.000 description 1
• CPBQJMYROZQQJC-UHFFFAOYSA-N helium neon Chemical compound [He].[Ne] CPBQJMYROZQQJC-UHFFFAOYSA-N 0.000 description 1
• 231100000304 hepatotoxicity Toxicity 0.000 description 1
• 230000007686 hepatotoxicity Effects 0.000 description 1
• MNWFXJYAOYHMED-UHFFFAOYSA-N heptanoic acid Chemical compound CCCCCCC(O)=O MNWFXJYAOYHMED-UHFFFAOYSA-N 0.000 description 1
• IPCSVZSSVZVIGE-UHFFFAOYSA-M hexadecanoate Chemical compound CCCCCCCCCCCCCCCC([O-])=O IPCSVZSSVZVIGE-UHFFFAOYSA-M 0.000 description 1
• FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 1
• 238000000265 homogenisation Methods 0.000 description 1
• 244000052637 human pathogen Species 0.000 description 1
• 230000008348 humoral response Effects 0.000 description 1
• 150000005828 hydrofluoroalkanes Chemical class 0.000 description 1
• XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
• QAOWNCQODCNURD-UHFFFAOYSA-M hydrogensulfate Chemical compound OS([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-M 0.000 description 1
• XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
• 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
• 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
• 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
• 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
• 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
• UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
• 230000002163 immunogen Effects 0.000 description 1
• 239000012535 impurity Substances 0.000 description 1
• 238000000338 in vitro Methods 0.000 description 1
• 229940060367 inert ingredients Drugs 0.000 description 1
• 239000012678 infectious agent Substances 0.000 description 1
• 230000002757 inflammatory effect Effects 0.000 description 1
• 208000037802 influenza A (H3N2) Diseases 0.000 description 1
• 238000001802 infusion Methods 0.000 description 1
• 238000002664 inhalation therapy Methods 0.000 description 1
• 239000007924 injection Substances 0.000 description 1
• 238000002347 injection Methods 0.000 description 1
• 238000003780 insertion Methods 0.000 description 1
• 230000037431 insertion Effects 0.000 description 1
• 238000007917 intracranial administration Methods 0.000 description 1
• 238000007918 intramuscular administration Methods 0.000 description 1
• 238000010255 intramuscular injection Methods 0.000 description 1
• 239000007927 intramuscular injection Substances 0.000 description 1
• 238000007919 intrasynovial administration Methods 0.000 description 1
• 238000007913 intrathecal administration Methods 0.000 description 1
• 238000005342 ion exchange Methods 0.000 description 1
• SUMDYPCJJOFFON-UHFFFAOYSA-N isethionic acid Chemical compound OCCS(O)(=O)=O SUMDYPCJJOFFON-UHFFFAOYSA-N 0.000 description 1
• NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
• 210000003734 kidney Anatomy 0.000 description 1
• 230000003907 kidney function Effects 0.000 description 1
• 230000002147 killing effect Effects 0.000 description 1
• 229940001447 lactate Drugs 0.000 description 1
• 229940099584 lactobionate Drugs 0.000 description 1
• JYTUSYBCFIZPBE-AMTLMPIISA-N lactobionic acid Chemical compound OC(=O)[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O JYTUSYBCFIZPBE-AMTLMPIISA-N 0.000 description 1
• 235000019388 lanolin Nutrition 0.000 description 1
• 229940039717 lanolin Drugs 0.000 description 1
• 229940070765 laurate Drugs 0.000 description 1
• 201000002364 leukopenia Diseases 0.000 description 1
• 231100001022 leukopenia Toxicity 0.000 description 1
• 230000000670 limiting effect Effects 0.000 description 1
• 238000004811 liquid chromatography Methods 0.000 description 1
• 239000006194 liquid suspension Substances 0.000 description 1
• 229910052744 lithium Inorganic materials 0.000 description 1
• 239000012280 lithium aluminium hydride Substances 0.000 description 1
• DLEDOFVPSDKWEF-UHFFFAOYSA-N lithium butane Chemical compound [Li+].CCC[CH2-] DLEDOFVPSDKWEF-UHFFFAOYSA-N 0.000 description 1
• 210000004185 liver Anatomy 0.000 description 1
• 230000003908 liver function Effects 0.000 description 1
• 230000007774 longterm Effects 0.000 description 1
• 231100000053 low toxicity Toxicity 0.000 description 1
• 229960003646 lysine Drugs 0.000 description 1
• 239000000391 magnesium silicate Substances 0.000 description 1
• 229940099273 magnesium trisilicate Drugs 0.000 description 1
• 229910000386 magnesium trisilicate Inorganic materials 0.000 description 1
• 235000019793 magnesium trisilicate Nutrition 0.000 description 1
• 206010025482 malaise Diseases 0.000 description 1
• 229940049920 malate Drugs 0.000 description 1
• 239000011976 maleic acid Substances 0.000 description 1
• BJEPYKJPYRNKOW-UHFFFAOYSA-N malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
• 238000005259 measurement Methods 0.000 description 1
• 238000002844 melting Methods 0.000 description 1
• 230000008018 melting Effects 0.000 description 1
• HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
• 230000004060 metabolic process Effects 0.000 description 1
• 235000019656 metallic taste Nutrition 0.000 description 1
• NQMRYBIKMRVZLB-UHFFFAOYSA-N methylamine hydrochloride Chemical compound [Cl-].[NH3+]C NQMRYBIKMRVZLB-UHFFFAOYSA-N 0.000 description 1
• 244000005700 microbiome Species 0.000 description 1
• 229940016286 microcrystalline cellulose Drugs 0.000 description 1
• 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
• 239000008108 microcrystalline cellulose Substances 0.000 description 1
• 239000003595 mist Substances 0.000 description 1
• 230000003020 moisturizing effect Effects 0.000 description 1
• CQDGTJPVBWZJAZ-UHFFFAOYSA-N monoethyl carbonate Chemical compound CCOC(O)=O CQDGTJPVBWZJAZ-UHFFFAOYSA-N 0.000 description 1
• 210000004877 mucosa Anatomy 0.000 description 1
• 230000035772 mutation Effects 0.000 description 1
• VCFMSZPEUJDWDN-UHFFFAOYSA-N n-benzylundecan-1-amine Chemical compound CCCCCCCCCCCNCC1=CC=CC=C1 VCFMSZPEUJDWDN-UHFFFAOYSA-N 0.000 description 1
• 239000002539 nanocarrier Substances 0.000 description 1
• 239000002105 nanoparticle Substances 0.000 description 1
• KVBGVZZKJNLNJU-UHFFFAOYSA-M naphthalene-2-sulfonate Chemical compound C1=CC=CC2=CC(S(=O)(=O)[O-])=CC=C21 KVBGVZZKJNLNJU-UHFFFAOYSA-M 0.000 description 1
• 201000009240 nasopharyngitis Diseases 0.000 description 1
• 230000008693 nausea Effects 0.000 description 1
• 238000002663 nebulization Methods 0.000 description 1
• 230000007694 nephrotoxicity Effects 0.000 description 1
• 230000007433 nerve pathway Effects 0.000 description 1
• 210000002569 neuron Anatomy 0.000 description 1
• 231100000228 neurotoxicity Toxicity 0.000 description 1
• 230000007135 neurotoxicity Effects 0.000 description 1
• 235000001968 nicotinic acid Nutrition 0.000 description 1
• 239000011664 nicotinic acid Substances 0.000 description 1
• 239000012457 nonaqueous media Substances 0.000 description 1
• 238000003199 nucleic acid amplification method Methods 0.000 description 1
• 230000000269 nucleophilic effect Effects 0.000 description 1
• GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 1
• QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
• 229940049964 oleate Drugs 0.000 description 1
• 239000002751 oligonucleotide probe Substances 0.000 description 1
• 229940041678 oral spray Drugs 0.000 description 1
• 239000000668 oral spray Substances 0.000 description 1
• 150000007530 organic bases Chemical class 0.000 description 1
• 229920000620 organic polymer Polymers 0.000 description 1
• 229960003104 ornithine Drugs 0.000 description 1
• 229960003752 oseltamivir Drugs 0.000 description 1
• NENPYTRHICXVCS-YNEHKIRRSA-N oseltamivir acid Chemical compound CCC(CC)O[C@@H]1C=C(C(O)=O)C[C@H](N)[C@H]1NC(C)=O NENPYTRHICXVCS-YNEHKIRRSA-N 0.000 description 1
• PGZUMBJQJWIWGJ-ONAKXNSWSA-N oseltamivir phosphate Chemical compound OP(O)(O)=O.CCOC(=O)C1=C[C@@H](OC(CC)CC)[C@H](NC(C)=O)[C@@H](N)C1 PGZUMBJQJWIWGJ-ONAKXNSWSA-N 0.000 description 1
• KJIFKLIQANRMOU-UHFFFAOYSA-N oxidanium;4-methylbenzenesulfonate Chemical compound O.CC1=CC=C(S(O)(=O)=O)C=C1 KJIFKLIQANRMOU-UHFFFAOYSA-N 0.000 description 1
• 238000010979 pH adjustment Methods 0.000 description 1
• 229910052763 palladium Inorganic materials 0.000 description 1
• FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
• 239000012188 paraffin wax Substances 0.000 description 1
• 239000006072 paste Substances 0.000 description 1
• 244000052769 pathogen Species 0.000 description 1
• 230000001575 pathological effect Effects 0.000 description 1
• 235000020232 peanut Nutrition 0.000 description 1
• 239000000312 peanut oil Substances 0.000 description 1
• 235000010987 pectin Nutrition 0.000 description 1
• 239000001814 pectin Substances 0.000 description 1
• 229920001277 pectin Polymers 0.000 description 1
• OEHZTKPGXHXRJL-UHFFFAOYSA-N pentan-1-amine Chemical compound [CH2]CCCCN OEHZTKPGXHXRJL-UHFFFAOYSA-N 0.000 description 1
• 239000002304 perfume Substances 0.000 description 1
• 230000000737 periodic effect Effects 0.000 description 1
• 230000035699 permeability Effects 0.000 description 1
• JRKICGRDRMAZLK-UHFFFAOYSA-L peroxydisulfate Chemical compound [O-]S(=O)(=O)OOS([O-])(=O)=O JRKICGRDRMAZLK-UHFFFAOYSA-L 0.000 description 1
• 230000008782 phagocytosis Effects 0.000 description 1
• 239000008024 pharmaceutical diluent Substances 0.000 description 1
• 229960003742 phenol Drugs 0.000 description 1
• WJCXADMLESSGRI-UHFFFAOYSA-N phenyl selenohypochlorite Chemical compound Cl[Se]C1=CC=CC=C1 WJCXADMLESSGRI-UHFFFAOYSA-N 0.000 description 1
• 239000002953 phosphate buffered saline Substances 0.000 description 1
• 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
• 229940075930 picrate Drugs 0.000 description 1
• OXNIZHLAWKMVMX-UHFFFAOYSA-M picrate anion Chemical compound [O-]C1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-M 0.000 description 1
• 229950010765 pivalate Drugs 0.000 description 1
• IUGYQRQAERSCNH-UHFFFAOYSA-N pivalic acid Chemical compound CC(C)(C)C(O)=O IUGYQRQAERSCNH-UHFFFAOYSA-N 0.000 description 1
• 229960000502 poloxamer Drugs 0.000 description 1
• 229920001983 poloxamer Polymers 0.000 description 1
• 229920001308 poly(aminoacid) Polymers 0.000 description 1
• 229920000747 poly(lactic acid) Polymers 0.000 description 1
• 229920002627 poly(phosphazenes) Polymers 0.000 description 1
• 229920000058 polyacrylate Polymers 0.000 description 1
• 229920002239 polyacrylonitrile Polymers 0.000 description 1
• 229920002647 polyamide Polymers 0.000 description 1
• 229920000728 polyester Polymers 0.000 description 1
• 229920000573 polyethylene Polymers 0.000 description 1
• 239000004626 polylactic acid Substances 0.000 description 1
• 229920005862 polyol Polymers 0.000 description 1
• 150000003077 polyols Chemical class 0.000 description 1
• 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
• 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 description 1
• 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 description 1
• 229920001451 polypropylene glycol Polymers 0.000 description 1
• 150000004804 polysaccharides Chemical class 0.000 description 1
• 229920000136 polysorbate Polymers 0.000 description 1
• 229940113124 polysorbate 60 Drugs 0.000 description 1
• 229940068968 polysorbate 80 Drugs 0.000 description 1
• 229920002689 polyvinyl acetate Polymers 0.000 description 1
• 239000011118 polyvinyl acetate Substances 0.000 description 1
• 239000011698 potassium fluoride Substances 0.000 description 1
• 235000003270 potassium fluoride Nutrition 0.000 description 1
• 159000000001 potassium salts Chemical class 0.000 description 1
• 239000004302 potassium sorbate Substances 0.000 description 1
• 235000010241 potassium sorbate Nutrition 0.000 description 1
• 229940069338 potassium sorbate Drugs 0.000 description 1
• LPNYRYFBWFDTMA-UHFFFAOYSA-N potassium tert-butoxide Chemical compound [K+].CC(C)(C)[O-] LPNYRYFBWFDTMA-UHFFFAOYSA-N 0.000 description 1
• 229920001592 potato starch Polymers 0.000 description 1
• 244000144977 poultry Species 0.000 description 1
• 239000002244 precipitate Substances 0.000 description 1
• 230000035935 pregnancy Effects 0.000 description 1
• MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
• 229960004919 procaine Drugs 0.000 description 1
• 229940002612 prodrug Drugs 0.000 description 1
• 239000000651 prodrug Substances 0.000 description 1
• 230000002035 prolonged effect Effects 0.000 description 1
• 230000001915 proofreading effect Effects 0.000 description 1
• 239000003380 propellant Substances 0.000 description 1
• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
• 235000013772 propylene glycol Nutrition 0.000 description 1
• 229950008679 protamine sulfate Drugs 0.000 description 1
• 230000001681 protective effect Effects 0.000 description 1
• 230000005180 public health Effects 0.000 description 1
• 150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
• 125000001453 quaternary ammonium group Chemical group 0.000 description 1
• 150000003254 radicals Chemical class 0.000 description 1
• 239000000376 reactant Substances 0.000 description 1
• 238000005215 recombination Methods 0.000 description 1
• 230000006798 recombination Effects 0.000 description 1
• 229940100618 rectal suppository Drugs 0.000 description 1
• 239000006215 rectal suppository Substances 0.000 description 1
• 238000010992 reflux Methods 0.000 description 1
• 230000001105 regulatory effect Effects 0.000 description 1
• 230000004044 response Effects 0.000 description 1
• 239000003813 safflower oil Substances 0.000 description 1
• 235000005713 safflower oil Nutrition 0.000 description 1
• 229960001860 salicylate Drugs 0.000 description 1
• YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
• 229960004889 salicylic acid Drugs 0.000 description 1
• 210000003296 saliva Anatomy 0.000 description 1
• 239000012047 saturated solution Substances 0.000 description 1
• HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
• 210000000582 semen Anatomy 0.000 description 1
• 230000008786 sensory perception of smell Effects 0.000 description 1
• 238000013207 serial dilution Methods 0.000 description 1
• 210000002966 serum Anatomy 0.000 description 1
• 208000018316 severe headache Diseases 0.000 description 1
• 231100000872 sexual dysfunction Toxicity 0.000 description 1
• SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical class CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 description 1
• 238000007873 sieving Methods 0.000 description 1
• 150000004760 silicates Chemical class 0.000 description 1
• 229910001923 silver oxide Inorganic materials 0.000 description 1
• 238000005549 size reduction Methods 0.000 description 1
• 238000001542 size-exclusion chromatography Methods 0.000 description 1
• AWUCVROLDVIAJX-GSVOUGTGSA-N sn-glycerol 3-phosphate Chemical compound OC[C@@H](O)COP(O)(O)=O AWUCVROLDVIAJX-GSVOUGTGSA-N 0.000 description 1
• 229910000029 sodium carbonate Inorganic materials 0.000 description 1
• 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
• 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
• 239000001509 sodium citrate Substances 0.000 description 1
• NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
• 235000009518 sodium iodide Nutrition 0.000 description 1
• AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
• 235000019345 sodium thiosulphate Nutrition 0.000 description 1
• HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
• ZNKXTIAQRUWLRL-UHFFFAOYSA-M sodium;sulfane;hydroxide Chemical compound O.[Na+].[SH-] ZNKXTIAQRUWLRL-UHFFFAOYSA-M 0.000 description 1
• 230000003381 solubilizing effect Effects 0.000 description 1
• 238000000527 sonication Methods 0.000 description 1
• 235000011076 sorbitan monostearate Nutrition 0.000 description 1
• 239000001587 sorbitan monostearate Substances 0.000 description 1
• 229940035048 sorbitan monostearate Drugs 0.000 description 1
• 239000000600 sorbitol Substances 0.000 description 1
• 239000003549 soybean oil Substances 0.000 description 1
• 235000012424 soybean oil Nutrition 0.000 description 1
• 230000006641 stabilisation Effects 0.000 description 1
• 238000011105 stabilization Methods 0.000 description 1
• 239000003381 stabilizer Substances 0.000 description 1
• 239000008223 sterile water Substances 0.000 description 1
• 239000003206 sterilizing agent Substances 0.000 description 1
• 238000007920 subcutaneous administration Methods 0.000 description 1
• 238000010254 subcutaneous injection Methods 0.000 description 1
• 239000007929 subcutaneous injection Substances 0.000 description 1
• 238000006467 substitution reaction Methods 0.000 description 1
• 239000000758 substrate Substances 0.000 description 1
• KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
• 239000001384 succinic acid Substances 0.000 description 1
• 150000005846 sugar alcohols Chemical class 0.000 description 1
• YBBRCQOCSYXUOC-UHFFFAOYSA-N sulfuryl dichloride Chemical compound ClS(Cl)(=O)=O YBBRCQOCSYXUOC-UHFFFAOYSA-N 0.000 description 1
• 235000011149 sulphuric acid Nutrition 0.000 description 1
• 238000004808 supercritical fluid chromatography Methods 0.000 description 1
• NJGWOFRZMQRKHT-UHFFFAOYSA-N surfactin Natural products CC(C)CCCCCCCCCC1CC(=O)NC(CCC(O)=O)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(CC(O)=O)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)O1 NJGWOFRZMQRKHT-UHFFFAOYSA-N 0.000 description 1
• NJGWOFRZMQRKHT-WGVNQGGSSA-N surfactin C Chemical compound CC(C)CCCCCCCCC[C@@H]1CC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O1 NJGWOFRZMQRKHT-WGVNQGGSSA-N 0.000 description 1
• 238000013269 sustained drug release Methods 0.000 description 1
• 238000013268 sustained release Methods 0.000 description 1
• 239000012730 sustained-release form Substances 0.000 description 1
• 210000004243 sweat Anatomy 0.000 description 1
• 239000006188 syrup Substances 0.000 description 1
• 235000020357 syrup Nutrition 0.000 description 1
• 238000012385 systemic delivery Methods 0.000 description 1
• 229940061367 tamiflu Drugs 0.000 description 1
• 230000008685 targeting Effects 0.000 description 1
• 239000011975 tartaric acid Substances 0.000 description 1
• 235000002906 tartaric acid Nutrition 0.000 description 1
• 235000019640 taste Nutrition 0.000 description 1
• 210000001138 tear Anatomy 0.000 description 1
• LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 1
• 238000010998 test method Methods 0.000 description 1
• CBXCPBUEXACCNR-UHFFFAOYSA-N tetraethylammonium Chemical compound CC[N+](CC)(CC)CC CBXCPBUEXACCNR-UHFFFAOYSA-N 0.000 description 1
• BSYVTEYKTMYBMK-UHFFFAOYSA-N tetrahydrofurfuryl alcohol Chemical compound OCC1CCCO1 BSYVTEYKTMYBMK-UHFFFAOYSA-N 0.000 description 1
• QEMXHQIAXOOASZ-UHFFFAOYSA-N tetramethylammonium Chemical compound C[N+](C)(C)C QEMXHQIAXOOASZ-UHFFFAOYSA-N 0.000 description 1
• 238000002560 therapeutic procedure Methods 0.000 description 1
• 206010043554 thrombocytopenia Diseases 0.000 description 1
• 210000001578 tight junction Anatomy 0.000 description 1
• JOXIMZWYDAKGHI-UHFFFAOYSA-M toluene-4-sulfonate Chemical compound CC1=CC=C(S([O-])(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-M 0.000 description 1
• 238000011200 topical administration Methods 0.000 description 1
• 239000012049 topical pharmaceutical composition Substances 0.000 description 1
• 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 description 1
• 231100000419 toxicity Toxicity 0.000 description 1
• 230000001988 toxicity Effects 0.000 description 1
• 210000003437 trachea Anatomy 0.000 description 1
• 235000010487 tragacanth Nutrition 0.000 description 1
• 239000000196 tragacanth Substances 0.000 description 1
• 229940116362 tragacanth Drugs 0.000 description 1
• 238000013518 transcription Methods 0.000 description 1
• 230000035897 transcription Effects 0.000 description 1
• 238000012546 transfer Methods 0.000 description 1
• CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
• 229940029284 trichlorofluoromethane Drugs 0.000 description 1
• ZIBGPFATKBEMQZ-UHFFFAOYSA-N triethylene glycol Chemical compound OCCOCCOCCO ZIBGPFATKBEMQZ-UHFFFAOYSA-N 0.000 description 1
• LFXVBWRMVZPLFK-UHFFFAOYSA-N trioctylalumane Chemical compound CCCCCCCC[Al](CCCCCCCC)CCCCCCCC LFXVBWRMVZPLFK-UHFFFAOYSA-N 0.000 description 1
• LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
• 229910052722 tritium Inorganic materials 0.000 description 1
• 229920001664 tyloxapol Polymers 0.000 description 1
• MDYZKJNTKZIUSK-UHFFFAOYSA-N tyloxapol Chemical compound O=C.C1CO1.CC(C)(C)CC(C)(C)C1=CC=C(O)C=C1 MDYZKJNTKZIUSK-UHFFFAOYSA-N 0.000 description 1
• 229960004224 tyloxapol Drugs 0.000 description 1
• 238000000108 ultra-filtration Methods 0.000 description 1
• ZDPHROOEEOARMN-UHFFFAOYSA-N undecanoic acid Chemical compound CCCCCCCCCCC(O)=O ZDPHROOEEOARMN-UHFFFAOYSA-N 0.000 description 1
• KJIOQYGWTQBHNH-UHFFFAOYSA-N undecanol Chemical compound CCCCCCCCCCCO KJIOQYGWTQBHNH-UHFFFAOYSA-N 0.000 description 1
• 210000002700 urine Anatomy 0.000 description 1
• NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical class CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 1
• 235000013311 vegetables Nutrition 0.000 description 1
• 230000008673 vomiting Effects 0.000 description 1
• 230000003313 weakening effect Effects 0.000 description 1
• 239000003871 white petrolatum Substances 0.000 description 1
• 239000011995 wilkinson's catalyst Substances 0.000 description 1
• UTODFRQBVUVYOB-UHFFFAOYSA-P wilkinson's catalyst Chemical compound [Cl-].C1=CC=CC=C1P(C=1C=CC=CC=1)(C=1C=CC=CC=1)[Rh+](P(C=1C=CC=CC=1)(C=1C=CC=CC=1)C=1C=CC=CC=1)P(C=1C=CC=CC=1)(C=1C=CC=CC=1)C1=CC=CC=C1 UTODFRQBVUVYOB-UHFFFAOYSA-P 0.000 description 1
• 238000010626 work up procedure Methods 0.000 description 1
• 239000000811 xylitol Substances 0.000 description 1
• HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
• 235000010447 xylitol Nutrition 0.000 description 1
• 229960002675 xylitol Drugs 0.000 description 1
• ARAIBEBZBOPLMB-UFGQHTETSA-N zanamivir Chemical compound CC(=O)N[C@@H]1[C@@H](N=C(N)N)C=C(C(O)=O)O[C@H]1[C@H](O)[C@H](O)CO ARAIBEBZBOPLMB-UFGQHTETSA-N 0.000 description 1
• UGZADUVQMDAIAO-UHFFFAOYSA-L zinc hydroxide Chemical compound [OH-].[OH-].[Zn+2] UGZADUVQMDAIAO-UHFFFAOYSA-L 0.000 description 1
• 229910021511 zinc hydroxide Inorganic materials 0.000 description 1
• 229940007718 zinc hydroxide Drugs 0.000 description 1