TWI778052B - 流感病毒複製之抑制劑 - Google Patents

流感病毒複製之抑制劑 Download PDF

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Publication number
TWI778052B
TWI778052B TW107113876A TW107113876A TWI778052B TW I778052 B TWI778052 B TW I778052B TW 107113876 A TW107113876 A TW 107113876A TW 107113876 A TW107113876 A TW 107113876A TW I778052 B TWI778052 B TW I778052B
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TW
Taiwan
Prior art keywords
alkyl
cycloalkyl
mmol
compound
pharmaceutically acceptable
Prior art date
Application number
TW107113876A
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English (en)
Chinese (zh)
Other versions
TW201839003A (zh
Inventor
艾琳納Ｃ 傑克布森
麥可 大衛 費斯
山姆Ｓｋ 李
Original Assignee
美商共結晶製藥公司
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Application filed by 美商共結晶製藥公司 filed Critical 美商共結晶製藥公司
Publication of TW201839003A publication Critical patent/TW201839003A/zh
Application granted granted Critical
Publication of TWI778052B publication Critical patent/TWI778052B/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Otolaryngology (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
TW107113876A 2017-04-24 2018-04-24 流感病毒複製之抑制劑 TWI778052B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762489167P 2017-04-24 2017-04-24
US62/489,167 2017-04-24

Publications (2)

Publication Number Publication Date
TW201839003A TW201839003A (zh) 2018-11-01
TWI778052B true TWI778052B (zh) 2022-09-21

Family

ID=62117141

Family Applications (1)

Application Number Title Priority Date Filing Date
TW107113876A TWI778052B (zh) 2017-04-24 2018-04-24 流感病毒複製之抑制劑

Country Status (21)

Country Link
US (1) US11014941B2 (https=)
EP (1) EP3615545B1 (https=)
JP (1) JP7165721B2 (https=)
KR (1) KR102598466B1 (https=)
CN (1) CN110637022B (https=)
AU (1) AU2018257778B2 (https=)
CA (1) CA3059449A1 (https=)
DK (1) DK3615545T3 (https=)
EA (1) EA039181B1 (https=)
ES (1) ES2901875T3 (https=)
IL (1) IL269900B (https=)
MX (1) MX393113B (https=)
MY (1) MY199746A (https=)
NZ (1) NZ757442A (https=)
PH (1) PH12019502376B1 (https=)
PL (1) PL3615545T3 (https=)
SG (1) SG11201909478UA (https=)
SM (1) SMT202100684T1 (https=)
TW (1) TWI778052B (https=)
WO (1) WO2018200425A1 (https=)
ZA (1) ZA201906327B (https=)

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ES2939148T3 (es) * 2018-10-17 2023-04-19 Cocrystal Pharma Inc Combinaciones de inhibidores de la replicación del virus de la influenza
BR112021009254A2 (pt) * 2018-11-13 2021-08-10 Cocrystal Pharma, Inc. formulações para produtos terapêuticos para influenza
KR102890026B1 (ko) * 2019-04-26 2025-11-24 닛산 가가쿠 가부시키가이샤 아릴술폰산 에스테르 화합물의 제조 방법
WO2022007966A1 (zh) * 2020-07-10 2022-01-13 四川海思科制药有限公司 Pb2抑制剂及其制备方法和用途
WO2022109495A1 (en) * 2020-11-23 2022-05-27 The Regents Of The University Of California Methods and compositions for linking rna stem loops

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WO2015073481A1 (en) * 2013-11-13 2015-05-21 Vertex Pharmaceuticals Incorporated Methods of preparing inhibitors of influenza viruses replication

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WO2010148197A1 (en) * 2009-06-17 2010-12-23 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
WO2015073481A1 (en) * 2013-11-13 2015-05-21 Vertex Pharmaceuticals Incorporated Methods of preparing inhibitors of influenza viruses replication

Also Published As

Publication number Publication date
WO2018200425A1 (en) 2018-11-01
NZ757442A (en) 2022-10-28
US11014941B2 (en) 2021-05-25
PL3615545T3 (pl) 2022-01-10
ZA201906327B (en) 2025-01-29
EA201992543A1 (ru) 2020-03-24
AU2018257778B2 (en) 2022-02-17
JP7165721B2 (ja) 2022-11-04
TW201839003A (zh) 2018-11-01
PH12019502376B1 (en) 2024-06-05
CA3059449A1 (en) 2018-11-01
CN110637022A (zh) 2019-12-31
MX393113B (es) 2025-03-24
KR20190140971A (ko) 2019-12-20
SG11201909478UA (en) 2019-11-28
EP3615545A1 (en) 2020-03-04
BR112019022307A2 (pt) 2020-05-26
EA039181B1 (ru) 2021-12-15
KR102598466B1 (ko) 2023-11-03
MY199746A (en) 2023-11-21
US20200123177A1 (en) 2020-04-23
AU2018257778A1 (en) 2019-10-10
DK3615545T3 (da) 2021-11-22
EP3615545B1 (en) 2021-09-01
ES2901875T3 (es) 2022-03-24
SMT202100684T1 (it) 2022-01-10
CN110637022B (zh) 2022-09-16
MX2019012759A (es) 2019-12-16
PH12019502376A1 (en) 2020-09-14
IL269900B (en) 2022-05-01
JP2020517738A (ja) 2020-06-18

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