SG11201909478UA - Pyrrolopyrimidine derivatives useful as inhibitors of influenza virus replication - Google Patents
Pyrrolopyrimidine derivatives useful as inhibitors of influenza virus replicationInfo
- Publication number
- SG11201909478UA SG11201909478UA SG11201909478UA SG11201909478UA SG 11201909478U A SG11201909478U A SG 11201909478UA SG 11201909478U A SG11201909478U A SG 11201909478UA SG 11201909478U A SG11201909478U A SG 11201909478UA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- patient
- pharmaceutically acceptable
- biological sample
- pct
- Prior art date
Links
- 241000712461 unidentified influenza virus Species 0.000 title abstract 4
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 150000004944 pyrrolopyrimidines Chemical class 0.000 title abstract 2
- 230000029812 viral genome replication Effects 0.000 title abstract 2
- 239000012472 biological sample Substances 0.000 abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 229920004482 WACKER® Polymers 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 206010022000 influenza Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000010076 replication Effects 0.000 abstract 1
- 102220240796 rs553605556 Human genes 0.000 abstract 1
- 239000003981 vehicle Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Otolaryngology (AREA)
- Dermatology (AREA)
- Dispersion Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762489167P | 2017-04-24 | 2017-04-24 | |
| PCT/US2018/028986 WO2018200425A1 (en) | 2017-04-24 | 2018-04-24 | Pyrrolopyrimidine derivatives useful as inhibitors of influenza virus replication |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201909478UA true SG11201909478UA (en) | 2019-11-28 |
Family
ID=62117141
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201909478U SG11201909478UA (en) | 2017-04-24 | 2018-04-24 | Pyrrolopyrimidine derivatives useful as inhibitors of influenza virus replication |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US11014941B2 (https=) |
| EP (1) | EP3615545B1 (https=) |
| JP (1) | JP7165721B2 (https=) |
| KR (1) | KR102598466B1 (https=) |
| CN (1) | CN110637022B (https=) |
| AU (1) | AU2018257778B2 (https=) |
| CA (1) | CA3059449A1 (https=) |
| DK (1) | DK3615545T3 (https=) |
| EA (1) | EA039181B1 (https=) |
| ES (1) | ES2901875T3 (https=) |
| IL (1) | IL269900B (https=) |
| MX (1) | MX393113B (https=) |
| MY (1) | MY199746A (https=) |
| NZ (1) | NZ757442A (https=) |
| PH (1) | PH12019502376B1 (https=) |
| PL (1) | PL3615545T3 (https=) |
| SG (1) | SG11201909478UA (https=) |
| SM (1) | SMT202100684T1 (https=) |
| TW (1) | TWI778052B (https=) |
| WO (1) | WO2018200425A1 (https=) |
| ZA (1) | ZA201906327B (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2939148T3 (es) * | 2018-10-17 | 2023-04-19 | Cocrystal Pharma Inc | Combinaciones de inhibidores de la replicación del virus de la influenza |
| BR112021009254A2 (pt) * | 2018-11-13 | 2021-08-10 | Cocrystal Pharma, Inc. | formulações para produtos terapêuticos para influenza |
| KR102890026B1 (ko) * | 2019-04-26 | 2025-11-24 | 닛산 가가쿠 가부시키가이샤 | 아릴술폰산 에스테르 화합물의 제조 방법 |
| WO2022007966A1 (zh) * | 2020-07-10 | 2022-01-13 | 四川海思科制药有限公司 | Pb2抑制剂及其制备方法和用途 |
| WO2022109495A1 (en) * | 2020-11-23 | 2022-05-27 | The Regents Of The University Of California | Methods and compositions for linking rna stem loops |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB278965A (en) | 1927-03-24 | 1927-10-20 | Gerhard Haar | Improved agricultural plough |
| US4131648A (en) | 1975-01-28 | 1978-12-26 | Alza Corporation | Structured orthoester and orthocarbonate drug delivery devices |
| US4180646A (en) | 1975-01-28 | 1979-12-25 | Alza Corporation | Novel orthoester polymers and orthocarbonate polymers |
| US4093709A (en) | 1975-01-28 | 1978-06-06 | Alza Corporation | Drug delivery devices manufactured from poly(orthoesters) and poly(orthocarbonates) |
| US4079038A (en) | 1976-03-05 | 1978-03-14 | Alza Corporation | Poly(carbonates) |
| GB2064336B (en) | 1979-12-06 | 1984-03-14 | Glaxo Group Ltd | Device for dispensing medicaments |
| US4304767A (en) | 1980-05-15 | 1981-12-08 | Sri International | Polymers of di- (and higher functionality) ketene acetals and polyols |
| US4353656A (en) | 1980-10-14 | 1982-10-12 | Xerox Corporation | Moving coil, multiple energy print hammer system including a closed loop servo |
| DE3274065D1 (de) | 1981-07-08 | 1986-12-11 | Draco Ab | Powder inhalator |
| US4778054A (en) | 1982-10-08 | 1988-10-18 | Glaxo Group Limited | Pack for administering medicaments to patients |
| GB2169265B (en) | 1982-10-08 | 1987-08-12 | Glaxo Group Ltd | Pack for medicament |
| GB2129691B (en) | 1982-10-08 | 1987-08-05 | Glaxo Group Ltd | Devices for administering medicaments to patients |
| US4501729A (en) | 1982-12-13 | 1985-02-26 | Research Corporation | Aerosolized amiloride treatment of retained pulmonary secretions |
| US4753788A (en) | 1985-01-31 | 1988-06-28 | Vestar Research Inc. | Method for preparing small vesicles using microemulsification |
| AU591152B2 (en) | 1985-07-30 | 1989-11-30 | Glaxo Group Limited | Devices for administering medicaments to patients |
| US4946931A (en) | 1989-06-14 | 1990-08-07 | Pharmaceutical Delivery Systems, Inc. | Polymers containing carboxy-ortho ester and ortho ester linkages |
| CA2070823C (en) | 1989-12-05 | 1999-01-12 | William H. Ii Frey | Neurologic agents for nasal administration to the brain |
| GB9004781D0 (en) | 1990-03-02 | 1990-04-25 | Glaxo Group Ltd | Device |
| US6413536B1 (en) | 1995-06-07 | 2002-07-02 | Southern Biosystems, Inc. | High viscosity liquid controlled delivery system and medical or surgical device |
| US5968543A (en) | 1996-01-05 | 1999-10-19 | Advanced Polymer Systems, Inc. | Polymers with controlled physical state and bioerodibility |
| US6956021B1 (en) | 1998-08-25 | 2005-10-18 | Advanced Inhalation Research, Inc. | Stable spray-dried protein formulations |
| AU6526100A (en) | 1999-08-06 | 2001-03-05 | Board Of Regents, The University Of Texas System | Drug releasing biodegradable fiber implant |
| US6749835B1 (en) | 1999-08-25 | 2004-06-15 | Advanced Inhalation Research, Inc. | Formulation for spray-drying large porous particles |
| US7678364B2 (en) | 1999-08-25 | 2010-03-16 | Alkermes, Inc. | Particles for inhalation having sustained release properties |
| US7252840B1 (en) | 1999-08-25 | 2007-08-07 | Advanced Inhalation Research, Inc. | Use of simple amino acids to form porous particles |
| US6632666B2 (en) | 2000-01-14 | 2003-10-14 | Biolife Solutions, Inc. | Normothermic, hypothermic and cryopreservation maintenance and storage of cells, tissues and organs in gel-based media |
| US6613355B2 (en) | 2000-05-11 | 2003-09-02 | A.P. Pharma, Inc. | Semi-solid delivery vehicle and pharmaceutical compositions |
| WO2002013897A2 (en) | 2000-08-14 | 2002-02-21 | Advanced Inhalation Research, Inc. | Inhalation device and method |
| JP2005504715A (ja) | 2000-12-29 | 2005-02-17 | アドバンスト インハレーション リサーチ，インコーポレイテッド | 持続放出特性を有する吸入用粒子 |
| US6766799B2 (en) | 2001-04-16 | 2004-07-27 | Advanced Inhalation Research, Inc. | Inhalation device |
| US6848197B2 (en) | 2001-04-18 | 2005-02-01 | Advanced Inhalation Research, Inc. | Control of process humidity to produce large, porous particles |
| KR100894167B1 (ko) | 2001-08-14 | 2009-04-22 | 토야마 케미칼 컴퍼니 리미티드 | 신규의 바이러스 증식저해 ·살바이러스방법 및 신규의피라진뉴클레오티드 ·피라진뉴클레오시드 유사체 |
| US6524606B1 (en) | 2001-11-16 | 2003-02-25 | Ap Pharma, Inc. | Bioerodible polyorthoesters containing amine groups |
| AU2002352836B2 (en) | 2001-11-20 | 2005-09-29 | Alkermes, Inc. | Improved particulate compositions for pulmonary delivery |
| US7008644B2 (en) | 2002-03-20 | 2006-03-07 | Advanced Inhalation Research, Inc. | Method and apparatus for producing dry particles |
| EP1673123A2 (en) | 2003-09-05 | 2006-06-28 | Kurve Technology, Inc. | Integrated nebulizer and particle dispersing chamber for delivery of medicament |
| ES2364340T3 (es) | 2004-03-30 | 2011-08-31 | Vertex Pharmaceuticals Incorporated | Azaindoles útiles como inhibidores de jak y otras proteína quinasas. |
| UA95940C2 (uk) | 2006-01-17 | 2011-09-26 | Вертекс Фармасьютикалс Інкорпорейтед | Азаіндоли як інгібітори кіназ януса |
| LT3141252T (lt) * | 2009-06-17 | 2018-11-12 | Vertex Pharmaceuticals Inc. | Gripo virusų replikacijos inhibitoriai |
| MD4496C1 (ro) | 2012-03-13 | 2018-02-28 | Gilead Sciences, Inc. | Analogi carba-nucleozidici 2'-substituiţi pentru tratament antiviral |
| JP6618901B2 (ja) | 2013-11-13 | 2019-12-11 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | インフルエンザウイルスの複製の阻害剤を調製する方法 |
| ES2860688T3 (es) | 2014-09-08 | 2021-10-05 | Janssen Sciences Ireland Uc | Pirrolopirimidinas para uso en la infección por el virus de la gripe |
| CN105524067A (zh) | 2014-09-28 | 2016-04-27 | 江苏柯菲平医药股份有限公司 | 4-取代吡咯并[2,3-d]嘧啶化合物及其用途 |
| FR3039227B1 (fr) | 2015-07-22 | 2019-12-27 | Safran Aircraft Engines | Aeronef comprenant un propulseur arriere carene avec stator d’entree a volets mobiles |
| SG11201804225PA (en) * | 2015-12-09 | 2018-06-28 | Sunshine Lake Pharma Co Ltd | Inhibitors of influenza virus replication, application methods and uses thereof |
| WO2017133664A1 (en) * | 2016-02-05 | 2017-08-10 | Savira Pharmaceuticals Gmbh | Bicyclic pyridine and pyrimidine derivatives and their use in the treatment， amelioration or prevention of influenza |
| WO2017133667A1 (en) * | 2016-02-05 | 2017-08-10 | Savira Pharmaceuticals Gmbh | Pyrimidine and pyridine derivatives and use in treatment, amelioration or prevention of influenza thereof |
| WO2017198122A1 (zh) * | 2016-05-19 | 2017-11-23 | 四川大学 | 抗流感小分子化合物及其制备方法和用途 |
| DE102017000989A1 (de) * | 2017-02-03 | 2018-08-09 | Evonik Degussa Gmbh | Verfahren zur Herstellung von Cyclododecanon |
-
2018
- 2018-04-24 TW TW107113876A patent/TWI778052B/zh active
- 2018-04-24 JP JP2020507515A patent/JP7165721B2/ja active Active
- 2018-04-24 KR KR1020197033668A patent/KR102598466B1/ko active Active
- 2018-04-24 DK DK18723298.8T patent/DK3615545T3/da active
- 2018-04-24 PL PL18723298T patent/PL3615545T3/pl unknown
- 2018-04-24 PH PH1/2019/502376A patent/PH12019502376B1/en unknown
- 2018-04-24 US US16/603,951 patent/US11014941B2/en active Active
- 2018-04-24 SG SG11201909478U patent/SG11201909478UA/en unknown
- 2018-04-24 AU AU2018257778A patent/AU2018257778B2/en active Active
- 2018-04-24 CA CA3059449A patent/CA3059449A1/en active Pending
- 2018-04-24 CN CN201880030665.3A patent/CN110637022B/zh active Active
- 2018-04-24 SM SM20210684T patent/SMT202100684T1/it unknown
- 2018-04-24 NZ NZ757442A patent/NZ757442A/en unknown
- 2018-04-24 ES ES18723298T patent/ES2901875T3/es active Active
- 2018-04-24 MX MX2019012759A patent/MX393113B/es unknown
- 2018-04-24 EP EP18723298.8A patent/EP3615545B1/en active Active
- 2018-04-24 MY MYPI2019005805A patent/MY199746A/en unknown
- 2018-04-24 EA EA201992543A patent/EA039181B1/ru unknown
- 2018-04-24 WO PCT/US2018/028986 patent/WO2018200425A1/en not_active Ceased
-
2019
- 2019-09-25 ZA ZA2019/06327A patent/ZA201906327B/en unknown
- 2019-10-07 IL IL269900A patent/IL269900B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2018200425A1 (en) | 2018-11-01 |
| NZ757442A (en) | 2022-10-28 |
| US11014941B2 (en) | 2021-05-25 |
| PL3615545T3 (pl) | 2022-01-10 |
| ZA201906327B (en) | 2025-01-29 |
| EA201992543A1 (ru) | 2020-03-24 |
| AU2018257778B2 (en) | 2022-02-17 |
| JP7165721B2 (ja) | 2022-11-04 |
| TW201839003A (zh) | 2018-11-01 |
| PH12019502376B1 (en) | 2024-06-05 |
| CA3059449A1 (en) | 2018-11-01 |
| CN110637022A (zh) | 2019-12-31 |
| MX393113B (es) | 2025-03-24 |
| KR20190140971A (ko) | 2019-12-20 |
| EP3615545A1 (en) | 2020-03-04 |
| BR112019022307A2 (pt) | 2020-05-26 |
| EA039181B1 (ru) | 2021-12-15 |
| KR102598466B1 (ko) | 2023-11-03 |
| MY199746A (en) | 2023-11-21 |
| US20200123177A1 (en) | 2020-04-23 |
| TWI778052B (zh) | 2022-09-21 |
| AU2018257778A1 (en) | 2019-10-10 |
| DK3615545T3 (da) | 2021-11-22 |
| EP3615545B1 (en) | 2021-09-01 |
| ES2901875T3 (es) | 2022-03-24 |
| SMT202100684T1 (it) | 2022-01-10 |
| CN110637022B (zh) | 2022-09-16 |
| MX2019012759A (es) | 2019-12-16 |
| PH12019502376A1 (en) | 2020-09-14 |
| IL269900B (en) | 2022-05-01 |
| JP2020517738A (ja) | 2020-06-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SG11201909478UA (en) | Pyrrolopyrimidine derivatives useful as inhibitors of influenza virus replication | |
| SG11202000325UA (en) | Selective inhibitors of nlrp3 inflammasome | |
| SG11201909325RA (en) | 2-amino-quinoline derivatives | |
| SG11201808003RA (en) | Bromodomain inhibitors | |
| SG11201908532UA (en) | Macrocyclic compounds as ros1 kinase inhibitors | |
| SG11201805645QA (en) | Lsd1 inhibitors | |
| SG11201809559UA (en) | Substituted pyridines as inhibitors of dnmt1 | |
| SG11201907544VA (en) | Jak inhibitors containing a 4-membered heterocyclic amide | |
| SG11201806863WA (en) | Tetracyclic pyridone compounds as antivirals | |
| SG11201906891RA (en) | Methods for the administration of certain vmat2 inhibitors | |
| SG11201901576QA (en) | Dosage regimen for a controlled-release pth compound | |
| SG11201806583XA (en) | Compositions containing tucaresol or its analogs | |
| SG11201908351TA (en) | Indole derivatives as efflux pump inhibitors | |
| SG11201906436VA (en) | Novel heterocyclic compound, its preparation method, and pharmaceutical composition comprising the same | |
| SG11201811209QA (en) | Oral gastroretentive formulations and uses thereof | |
| SG11201808237UA (en) | Substituted indole compound derivatives as dengue viral replication inhibitors | |
| SG11202000331YA (en) | Therapeutic modulators of the reverse mode of atp synthase | |
| SG11201902988UA (en) | Novel hpv16 non hla-restricted t-cell vaccines, compositions and methods of use thereof | |
| SG11201407337QA (en) | Cyclodextrin complexation methods for formulating peptide proteasome inhibitors | |
| SG11201806480UA (en) | Derivatives of pyrroloimidazole or analogues thereof which are useful for the treatment of inter alia cancer | |
| SG11201900558RA (en) | Spiro-lactam nmda receptor modulators and uses thereof | |
| SG11201908788YA (en) | Combinations of chk1- and wee1 - inhibitors | |
| SG11201901070YA (en) | Formulations for oral administration of active agents | |
| SG11201908568XA (en) | Therapeutic compounds and methods | |
| SG11201906164RA (en) | Bicyclic inhibitors of histone deacetylase |