|
US5527527A
(en)
|
1989-09-07 |
1996-06-18 |
Alkermes, Inc. |
Transferrin receptor specific antibody-neuropharmaceutical agent conjugates
|
|
US5260210A
(en)
|
1989-09-27 |
1993-11-09 |
Rubin Lee L |
Blood-brain barrier model
|
|
US5254342A
(en)
|
1991-09-30 |
1993-10-19 |
University Of Southern California |
Compositions and methods for enhanced transepithelial and transendothelial transport or active agents
|
|
FR2705194A1
(fr)
|
1993-05-21 |
1994-11-25 |
Transgene Sa |
Animal transgénique exprimant une transferrine d'origine humaine.
|
|
WO1999000150A2
(en)
|
1997-06-27 |
1999-01-07 |
Regents Of The University Of California |
Drug targeting of a peptide radiopharmaceutical through the primate blood-brain barrier in vivo with a monoclonal antibody to the human insulin receptor
|
|
US7241449B1
(en)
|
1999-04-12 |
2007-07-10 |
Aventis Pasteur Limited |
Transferrin receptor genes of moraxella
|
|
EP1285272A2
(en)
|
2000-02-08 |
2003-02-26 |
University of British Columbia |
Compositions and methods for screening therapeutic agents
|
|
JP2001238681A
(ja)
|
2000-03-03 |
2001-09-04 |
Japan Science & Technology Corp |
共培養による血液脳関門再構築モデル
|
|
AU2002236499A1
(en)
|
2000-11-30 |
2002-06-11 |
Uab Research Foundation |
Receptor-mediated uptake of peptides that bind the human transferrin receptor
|
|
AU2002315398A1
(en)
|
2001-06-29 |
2003-03-03 |
Wyeth |
Methods and compositions useful for the prediction of blood-brain barrier permeation
|
|
US20030074141A1
(en)
|
2001-10-15 |
2003-04-17 |
Camitro Corporation |
Meta-models for predicting blood brain barrier penetration based on simple physicochemical descriptors
|
|
US7592143B2
(en)
|
2003-04-18 |
2009-09-22 |
Cytovia, Inc. |
Methods of treating diseases responsive to induction of apoptosis and screening assays
|
|
WO2005076011A2
(en)
|
2004-01-30 |
2005-08-18 |
Xenoport, Inc. |
Use of glut1 transporter expressed in blood brain barrier cells for screening for pharmacologically active substances
|
|
GB0403490D0
(en)
|
2004-02-17 |
2004-03-24 |
Daniolabs Ltd |
Screening methods
|
|
FR2871162B1
(fr)
|
2004-06-02 |
2007-06-29 |
Univ Paris 7 Denis Diderot |
Materiau de surface modifiee, son procede de preparation et ses utilisations
|
|
ES2473587T3
(es)
*
|
2004-08-03 |
2014-07-07 |
Transtech Pharma, Inc. |
Proteínas de fusión de RAGE y métodos de uso
|
|
WO2006056879A1
(en)
|
2004-11-29 |
2006-06-01 |
Institut National De La Sante Et De La Recherche Medicale (Inserm) |
Human blood brain barrier model
|
|
US8900865B2
(en)
|
2005-12-14 |
2014-12-02 |
The Invention Science Fund I, Llc |
Blood brain barrier device
|
|
JP5113332B2
(ja)
|
2005-12-19 |
2013-01-09 |
正美 丹羽 |
血液脳関門インヴィトロ・モデル、病態血液脳関門インヴィトロ・モデル、及びこれを用いた薬物スクリーニング方法、病態血液脳関門機能解析方法、病因解析方法
|
|
WO2007094926A2
(en)
*
|
2006-02-09 |
2007-08-23 |
Transtech Pharma, Inc. |
Rage fusion proteins and methods of use
|
|
WO2007143711A2
(en)
|
2006-06-07 |
2007-12-13 |
Wisconsin Alumni Research Foundation |
Blood-brain barrier targeting antibodies
|
|
US20080044847A1
(en)
|
2006-06-23 |
2008-02-21 |
Shusta Eric V |
Blood-Brain Barrier Model
|
|
AU2007285763B2
(en)
|
2006-08-18 |
2011-12-15 |
Armagen Technologies, Inc. |
Agents for blood-brain barrier delivery
|
|
JP2010533170A
(ja)
|
2007-07-12 |
2010-10-21 |
プロセンサ テクノロジーズ ビー.ブイ. |
化合物を種々の選択された臓器、組織又は腫瘍細胞に標的化するための分子
|
|
WO2010014622A2
(en)
|
2008-07-28 |
2010-02-04 |
Fondazione Istituto Firc Di Oncologica Molecolare (Ifom) |
In vitro model for modulating the blood brain barrier and methods of screening
|
|
DK3241435T3
(da)
|
2009-07-08 |
2021-08-23 |
Kymab Ltd |
Dyremodeller og terapeutiske molekyler
|
|
US8417465B2
(en)
|
2009-11-04 |
2013-04-09 |
Cfd Research Corporation |
Synthetic microfluidic blood-brain barrier
|
|
US9255259B2
(en)
|
2010-02-09 |
2016-02-09 |
Sangamo Biosciences, Inc. |
Targeted genomic modification with partially single-stranded donor molecules
|
|
WO2012055891A1
(en)
|
2010-10-29 |
2012-05-03 |
F. Hoffmann-La Roche Ag |
Murine model of inflammation with il33 n-terminal domain deletion
|
|
CN103443125B
(zh)
|
2010-11-30 |
2019-05-03 |
霍夫曼-拉罗奇有限公司 |
低亲和力血脑屏障受体抗体及其用途
|
|
KR20140026372A
(ko)
|
2011-02-02 |
2014-03-05 |
이무노퓨처 아이앤씨. |
혈액-뇌 장벽을 투과하는 약물 전달체, 펩티드 및 이의 용도
|
|
RU2013150331A
(ru)
|
2011-04-20 |
2015-05-27 |
Рош Гликарт Аг |
СПОСОБ И УСТРОЙСТВА ДЛЯ рН-ЗАВИСИМОГО ПРОХОЖДЕНИЯ ГЕМАТОЭНЦЕФАЛИЧЕСКОГО БАРЬЕРА
|
|
EP2568051A1
(en)
*
|
2011-09-07 |
2013-03-13 |
Stallergenes S.A. |
Methods for identifying dendritic cell subsets, for determining if a patient is developing a regulatory or an effector immune response, and for determining response to immunotherapy
|
|
DK177327B1
(en)
|
2011-12-23 |
2013-01-14 |
Entomopharm Aps |
OPTIMIZED INSECT BASED EX VIVO MODEL FOR EXAMINATION OF BLOOD BRAIN BARRIER penetration and method of exposing the insect brain to chemical compounds
|
|
US9475840B2
(en)
|
2012-02-27 |
2016-10-25 |
Universitat De Barcelona |
Protease-resistant compounds useful as shuttles through the blood-brain barrier and shuttle-cargo constructs
|
|
WO2013177062A2
(en)
|
2012-05-21 |
2013-11-28 |
Genentech, Inc. |
Methods for improving safety of blood-brain barrier transport
|
|
US9513280B2
(en)
|
2012-08-28 |
2016-12-06 |
University Of Utah Research Foundation |
Microfluidic biological barrier model and associated method
|
|
MX367126B
(es)
|
2012-08-29 |
2019-08-06 |
Hoffmann La Roche |
Transporte para atravesar la barrera hematoencefálica.
|
|
US10590393B2
(en)
|
2012-11-08 |
2020-03-17 |
Wisconsin Alumni Research Foundation |
Retinoic acid enhanced human stem cell derived blood brain barrier model
|
|
US9932559B2
(en)
|
2012-11-16 |
2018-04-03 |
The Johns Hopkins University |
Platform for creating an artificial blood brain barrier
|
|
PT2978840T
(pt)
|
2013-03-26 |
2021-01-06 |
Univ Of Artois |
Um modelo de barreira hematoencefálica humana derivado de células estaminais
|
|
TWI523945B
(zh)
|
2013-03-29 |
2016-03-01 |
Nat Univ Chung Cheng |
Establishment of blood - brain barrier model in
|
|
SG11201509566RA
(en)
|
2013-05-20 |
2015-12-30 |
Genentech Inc |
Anti-transferrin receptor antibodies and methods of use
|
|
EA201600141A1
(ru)
|
2013-08-02 |
2016-09-30 |
Ф. Хоффманн-Ля Рош Аг |
Терапевтический слитый белок
|
|
WO2015101586A1
(en)
|
2014-01-03 |
2015-07-09 |
F. Hoffmann-La Roche Ag |
Bispecific anti-hapten/anti-blood brain barrier receptor antibodies, complexes thereof and their use as blood brain barrier shuttles
|
|
US9629801B2
(en)
|
2014-01-10 |
2017-04-25 |
Wisconsin Alumni Research Foundation |
Blood-brain barrier targeting antibodies
|
|
CN103897033A
(zh)
|
2014-03-31 |
2014-07-02 |
中国药科大学 |
转铁蛋白受体TfR特异性结合肽及其应用
|
|
ES2913205T3
(es)
*
|
2014-05-13 |
2022-06-01 |
Bioatla Inc |
Proteínas biológicas activas condicionalmente
|
|
EP2995949A1
(en)
|
2014-09-09 |
2016-03-16 |
Institut Pasteur |
New in vitro blood brain barrier model
|
|
CA2967830A1
(en)
*
|
2014-11-14 |
2016-05-19 |
Ossianix, Inc. |
Tfr selective binding compounds and related methods
|
|
EP3221361B1
(en)
*
|
2014-11-19 |
2021-04-21 |
Genentech, Inc. |
Anti-transferrin receptor / anti-bace1 multispecific antibodies and methods of use
|
|
JP6779876B2
(ja)
*
|
2014-11-19 |
2020-11-04 |
ジェネンテック, インコーポレイテッド |
抗トランスフェリン受容体抗体及びその使用方法
|
|
WO2016090486A1
(en)
|
2014-12-09 |
2016-06-16 |
National Research Council Of Canada |
Human blood brain barrier model
|
|
US9988454B2
(en)
*
|
2015-05-20 |
2018-06-05 |
Immunwork Inc. |
Peptide core-based multi-arm linkers for treating central nervous system diseases
|
|
WO2016202343A1
(en)
|
2015-06-19 |
2016-12-22 |
Aalborg Universitet |
A triple co-culture model of the blood-brain barrier using primary porcine brain endothelial cells, porcine pericytes and porcine astrocytes
|
|
JP7021955B2
(ja)
|
2015-06-24 |
2022-03-03 |
エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト |
Her2及び血液脳関門受容体に特異的な三重特異性抗体及び使用方法
|
|
AU2016282334B2
(en)
|
2015-06-24 |
2022-07-21 |
F. Hoffmann-La Roche Ag |
Anti-transferrin receptor antibodies with tailored affinity
|
|
CA2990785C
(en)
|
2015-06-24 |
2024-11-12 |
Jcr Pharmaceuticals Co., Ltd. |
ANTI-HUMAN TRANSFERRIN RECEPTOR ANTIBODIES CROSSING THE BLOOD-BRAIN BARRIER
|
|
HK1247933A1
(en)
|
2015-06-24 |
2018-10-05 |
Jcr Pharmaceuticals Co., Ltd. |
Fusion protein containing bdnf
|
|
WO2017035119A1
(en)
|
2015-08-24 |
2017-03-02 |
National University Of Singapore |
Blood brain barrier model in a 3d co-culture microfluidic system
|
|
TWI791006B
(zh)
|
2016-12-26 |
2023-02-01 |
日商Jcr製藥股份有限公司 |
包含bdnf之融合蛋白質
|
|
TWI833178B
(zh)
|
2016-12-26 |
2024-02-21 |
日商Jcr製藥股份有限公司 |
通過血腦障壁之新穎抗人類運鐵蛋白受體抗體
|
|
CA3053381A1
(en)
|
2017-02-17 |
2018-08-23 |
Denali Therapeutics Inc. |
Engineered polypeptides
|
|
EP4628586A3
(en)
|
2017-02-17 |
2026-01-14 |
Denali Therapeutics Inc. |
Transferrin receptor transgenic models
|