JP7577447B2 - 操作されたポリペプチド - Google Patents

操作されたポリペプチド Download PDF

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Publication number
JP7577447B2
JP7577447B2 JP2019545353A JP2019545353A JP7577447B2 JP 7577447 B2 JP7577447 B2 JP 7577447B2 JP 2019545353 A JP2019545353 A JP 2019545353A JP 2019545353 A JP2019545353 A JP 2019545353A JP 7577447 B2 JP7577447 B2 JP 7577447B2
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polypeptide
seq
sequence
tfr
identity
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Japanese (ja)
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JP2020508053A5 (enExample
JP2020508053A (ja
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シャオチェン チェン
ミハリス カリオリス
ロバート シー． ウェルズ
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Denali Therapeutics Inc
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Denali Therapeutics Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70582—CD71
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2019545353A 2017-02-17 2018-02-15 操作されたポリペプチド Active JP7577447B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023016182A JP2023058568A (ja) 2017-02-17 2023-02-06 操作されたポリペプチド

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201762460692P 2017-02-17 2017-02-17
US62/460,692 2017-02-17
US201762543658P 2017-08-10 2017-08-10
US201762543819P 2017-08-10 2017-08-10
US62/543,658 2017-08-10
US62/543,819 2017-08-10
US201762583426P 2017-11-08 2017-11-08
US201762583314P 2017-11-08 2017-11-08
US62/583,426 2017-11-08
US62/583,314 2017-11-08
PCT/US2018/018445 WO2018152375A2 (en) 2017-02-17 2018-02-15 Engineered polypeptides

Related Child Applications (1)

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JP2023016182A Division JP2023058568A (ja) 2017-02-17 2023-02-06 操作されたポリペプチド

Publications (3)

Publication Number Publication Date
JP2020508053A JP2020508053A (ja) 2020-03-19
JP2020508053A5 JP2020508053A5 (enExample) 2021-03-11
JP7577447B2 true JP7577447B2 (ja) 2024-11-05

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JP2019545353A Active JP7577447B2 (ja) 2017-02-17 2018-02-15 操作されたポリペプチド
JP2023016182A Pending JP2023058568A (ja) 2017-02-17 2023-02-06 操作されたポリペプチド

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JP2023016182A Pending JP2023058568A (ja) 2017-02-17 2023-02-06 操作されたポリペプチド

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US (2) US10457717B2 (enExample)
EP (1) EP3583119A2 (enExample)
JP (2) JP7577447B2 (enExample)
CN (1) CN110506054A (enExample)
CA (1) CA3053381A1 (enExample)
WO (1) WO2018152375A2 (enExample)

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CA3053381A1 (en) 2017-02-17 2018-08-23 Denali Therapeutics Inc. Engineered polypeptides
RS63818B1 (sr) 2017-02-17 2023-01-31 Denali Therapeutics Inc Konstruisani polipeptidi za vezivanje za receptor transferina
HUE062436T2 (hu) 2017-08-03 2023-11-28 Alector Llc Anti-trem2 antitestek és alkalmazási módszereik
WO2019032955A1 (en) * 2017-08-10 2019-02-14 Denali Therapeutics Inc. MODIFIED TRANSFERRIN RECEPTOR BINDING POLYPEPTIDES
IL253984A0 (en) * 2017-08-14 2017-09-28 Yeda Res & Dev Immunotherapy against aranviruses that bind through transferrin receptor 1 (tfr1
BR112020005271A2 (pt) 2017-10-02 2020-09-15 Denali Therapeutics Inc. proteína, polipeptídeo, polinucleotídeo, vetor, célula hospedeira, método para produção de um polipeptídeo, métodos de tratamento de um distúrbio, de diminuição do acúmulo, de monitoramento, de transporte de um agente e de tratamento de um lsd e composição farmacêutica
BR112020013921A2 (pt) * 2018-01-10 2020-12-01 Denali Therapeutics Inc. polipeptídeos de ligação ao receptor de transferrina e usos destes
CA3109763A1 (en) * 2018-08-16 2020-02-20 Denali Therapeutics Inc. Engineered bispecific proteins
KR20210100086A (ko) 2018-10-04 2021-08-13 유니버시티 오브 로체스터 혈장 오스몰농도 조작에 의한 글림프 전달의 개선
JP7543290B2 (ja) 2019-02-20 2024-09-02 デナリ セラピューティクス インコーポレイテッド 抗ｔｒｅｍ２抗体及びその使用方法
BR112022012230A2 (pt) 2019-12-23 2022-08-30 Denali Therapeutics Inc Variantes de progranulina
US11124567B2 (en) * 2020-01-13 2021-09-21 Denali Therapeutics Inc. Anti-TREM2 antibodies and methods of use thereof
CA3170338A1 (en) * 2020-02-19 2021-08-26 Denali Therapeutics Inc. Engineered anti-her2 bispecific proteins
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CN115785251B (zh) * 2021-07-16 2024-12-24 百奥赛图(北京)医药科技股份有限公司 Tfr1基因人源化非人动物及其构建方法和应用
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Publication number Publication date
WO2018152375A2 (en) 2018-08-23
JP2023058568A (ja) 2023-04-25
EP3583119A2 (en) 2019-12-25
WO2018152375A3 (en) 2018-09-27
US11732023B2 (en) 2023-08-22
US20180237496A1 (en) 2018-08-23
CA3053381A1 (en) 2018-08-23
US10457717B2 (en) 2019-10-29
CN110506054A (zh) 2019-11-26
US20200262890A1 (en) 2020-08-20
JP2020508053A (ja) 2020-03-19

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