CA3053381A1 - Engineered polypeptides - Google Patents

Engineered polypeptides Download PDF

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Publication number
CA3053381A1
CA3053381A1 CA3053381A CA3053381A CA3053381A1 CA 3053381 A1 CA3053381 A1 CA 3053381A1 CA 3053381 A CA3053381 A CA 3053381A CA 3053381 A CA3053381 A CA 3053381A CA 3053381 A1 CA3053381 A1 CA 3053381A1
Authority
CA
Canada
Prior art keywords
seq
sequence
polypeptide
tfr
identity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3053381A
Other languages
English (en)
French (fr)
Inventor
Xiaocheng Chen
Mihalis Kariolis
Robert C. Wells
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Denali Therapeutics Inc
Original Assignee
Denali Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Denali Therapeutics Inc filed Critical Denali Therapeutics Inc
Publication of CA3053381A1 publication Critical patent/CA3053381A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70582—CD71
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA3053381A 2017-02-17 2018-02-15 Engineered polypeptides Pending CA3053381A1 (en)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201762460692P 2017-02-17 2017-02-17
US62/460,692 2017-02-17
US201762543658P 2017-08-10 2017-08-10
US201762543819P 2017-08-10 2017-08-10
US62/543,658 2017-08-10
US62/543,819 2017-08-10
US201762583426P 2017-11-08 2017-11-08
US201762583314P 2017-11-08 2017-11-08
US62/583,426 2017-11-08
US62/583,314 2017-11-08
PCT/US2018/018445 WO2018152375A2 (en) 2017-02-17 2018-02-15 Engineered polypeptides

Publications (1)

Publication Number Publication Date
CA3053381A1 true CA3053381A1 (en) 2018-08-23

Family

ID=61628465

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3053381A Pending CA3053381A1 (en) 2017-02-17 2018-02-15 Engineered polypeptides

Country Status (6)

Country Link
US (2) US10457717B2 (enExample)
EP (1) EP3583119A2 (enExample)
JP (2) JP7577447B2 (enExample)
CN (1) CN110506054A (enExample)
CA (1) CA3053381A1 (enExample)
WO (1) WO2018152375A2 (enExample)

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RS63818B1 (sr) 2017-02-17 2023-01-31 Denali Therapeutics Inc Konstruisani polipeptidi za vezivanje za receptor transferina
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US11124567B2 (en) * 2020-01-13 2021-09-21 Denali Therapeutics Inc. Anti-TREM2 antibodies and methods of use thereof
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Also Published As

Publication number Publication date
WO2018152375A2 (en) 2018-08-23
JP2023058568A (ja) 2023-04-25
EP3583119A2 (en) 2019-12-25
WO2018152375A3 (en) 2018-09-27
US11732023B2 (en) 2023-08-22
US20180237496A1 (en) 2018-08-23
US10457717B2 (en) 2019-10-29
CN110506054A (zh) 2019-11-26
JP7577447B2 (ja) 2024-11-05
US20200262890A1 (en) 2020-08-20
JP2020508053A (ja) 2020-03-19

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