JP2018500009A5 - - Google Patents
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- Publication number
- JP2018500009A5 JP2018500009A5 JP2017524052A JP2017524052A JP2018500009A5 JP 2018500009 A5 JP2018500009 A5 JP 2018500009A5 JP 2017524052 A JP2017524052 A JP 2017524052A JP 2017524052 A JP2017524052 A JP 2017524052A JP 2018500009 A5 JP2018500009 A5 JP 2018500009A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- nucleic acid
- protein
- dna nucleic
- amino acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001184 polypeptide Polymers 0.000 claims 22
- 102000004196 processed proteins & peptides Human genes 0.000 claims 22
- 108090000765 processed proteins & peptides Proteins 0.000 claims 22
- 238000000034 method Methods 0.000 claims 20
- 125000003275 alpha amino acid group Chemical group 0.000 claims 17
- 150000001413 amino acids Chemical class 0.000 claims 15
- 108090000623 proteins and genes Proteins 0.000 claims 14
- 102000004169 proteins and genes Human genes 0.000 claims 14
- 210000004027 cell Anatomy 0.000 claims 11
- 239000002773 nucleotide Substances 0.000 claims 11
- 125000003729 nucleotide group Chemical group 0.000 claims 11
- 239000003814 drug Substances 0.000 claims 9
- 229940079593 drug Drugs 0.000 claims 9
- 108020004707 nucleic acids Proteins 0.000 claims 8
- 102000039446 nucleic acids Human genes 0.000 claims 8
- 150000007523 nucleic acids Chemical class 0.000 claims 8
- 101710112477 Phycobiliprotein ApcE Proteins 0.000 claims 7
- 210000003527 eukaryotic cell Anatomy 0.000 claims 7
- 229930004094 glycosylphosphatidylinositol Natural products 0.000 claims 7
- 230000002538 fungal effect Effects 0.000 claims 4
- 108020001507 fusion proteins Proteins 0.000 claims 3
- 102000037865 fusion proteins Human genes 0.000 claims 3
- 210000002472 endoplasmic reticulum Anatomy 0.000 claims 2
- 238000003780 insertion Methods 0.000 claims 2
- 230000037431 insertion Effects 0.000 claims 2
- 210000005253 yeast cell Anatomy 0.000 claims 2
- 108010058643 Fungal Proteins Proteins 0.000 claims 1
- 230000004989 O-glycosylation Effects 0.000 claims 1
- 230000002378 acidificating effect Effects 0.000 claims 1
- 238000004873 anchoring Methods 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 238000000684 flow cytometry Methods 0.000 claims 1
- 238000002703 mutagenesis Methods 0.000 claims 1
- 231100000350 mutagenesis Toxicity 0.000 claims 1
- 230000001323 posttranslational effect Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021041635A JP2021101712A (ja) | 2014-11-10 | 2021-03-15 | 細胞の表面上にポリペプチドを発現させるための組成物および方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462077756P | 2014-11-10 | 2014-11-10 | |
| US62/077,756 | 2014-11-10 | ||
| PCT/US2015/059787 WO2016077249A1 (en) | 2014-11-10 | 2015-11-09 | Compositions and methods for expressing polypeptides on the surface of cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021041635A Division JP2021101712A (ja) | 2014-11-10 | 2021-03-15 | 細胞の表面上にポリペプチドを発現させるための組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018500009A JP2018500009A (ja) | 2018-01-11 |
| JP2018500009A5 true JP2018500009A5 (enExample) | 2018-12-20 |
| JP7235436B2 JP7235436B2 (ja) | 2023-03-08 |
Family
ID=55954905
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017524052A Active JP7235436B2 (ja) | 2014-11-10 | 2015-11-09 | 細胞の表面上にポリペプチドを発現させるための組成物および方法 |
| JP2021041635A Pending JP2021101712A (ja) | 2014-11-10 | 2021-03-15 | 細胞の表面上にポリペプチドを発現させるための組成物および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021041635A Pending JP2021101712A (ja) | 2014-11-10 | 2021-03-15 | 細胞の表面上にポリペプチドを発現させるための組成物および方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US10829771B2 (enExample) |
| EP (1) | EP3218477A4 (enExample) |
| JP (2) | JP7235436B2 (enExample) |
| CN (1) | CN107075507B (enExample) |
| WO (1) | WO2016077249A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7356351B2 (ja) | 2016-12-12 | 2023-10-04 | エクセラ・バイオサイエンシーズ・インコーポレイテッド | マイクロキャピラリーアレイを使用したスクリーニングのための方法およびシステム |
| WO2018125832A1 (en) | 2016-12-30 | 2018-07-05 | xCella Biosciences, Inc. | Multi-stage sample recovery system |
| WO2018208877A1 (en) | 2017-05-09 | 2018-11-15 | Yale University | Basehit, a high-throughput assay to identify proteins involved in host-microbe interaction |
| KR102556494B1 (ko) * | 2017-10-31 | 2023-07-18 | 엔코디아, 인코포레이티드 | 핵산 암호화 및/또는 표지를 이용한 분석용 키트 |
| CN108085332B (zh) * | 2017-12-27 | 2020-11-27 | 中国科学院青岛生物能源与过程研究所 | 一种细胞表面展示有豆壳过氧化物酶的重组酵母菌及其构建方法与应用 |
| CA3113642A1 (en) | 2018-09-20 | 2020-03-26 | Washington University | Engineered microorganisms and methods of making and using same |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| ES3039910T3 (en) | 2018-12-06 | 2025-10-27 | Xcella Biosciences Inc | Lateral loading of microcapillary arrays |
| CN110551644A (zh) * | 2019-07-19 | 2019-12-10 | 天津科技大学 | 通过调控细胞壁组成蛋白构建的低产高级醇酿酒酵母菌株 |
| WO2021168388A1 (en) * | 2020-02-21 | 2021-08-26 | 3T Biosciences, Inc. | Yeast display libraries, associated compositions, and associated methods of use |
| IL302280A (en) * | 2020-10-28 | 2023-06-01 | Univ Leland Stanford Junior | Cd47 blockade and combination therapies thereof for reduction of vascular inflammation |
| WO2021115497A2 (zh) | 2020-12-08 | 2021-06-17 | 和铂医药(上海)有限责任公司 | 蛋白-药物偶联物和定点偶联方法 |
| IL309179A (en) * | 2021-06-10 | 2024-02-01 | Janssen Biotech Inc | Nucleic acid coding for KLK2-GPI fusion protein, recombinant cells and their uses |
| CN118546912A (zh) * | 2024-05-29 | 2024-08-27 | 浙江毓昌生物技术有限公司 | 一种高稳定性双碱基酶Kex2突变体的表达纯化方法 |
| CN118726441B (zh) * | 2024-06-20 | 2025-06-03 | 广州大学 | 一种灵芝表面展示系统及其制备方法和应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003235579A (ja) | 2002-02-19 | 2003-08-26 | Bio Energy Kk | 凝集タンパク質Ｆｌｏ１を用いる細胞表層発現系の最適化 |
| ATE437889T1 (de) * | 2005-12-02 | 2009-08-15 | Apceth Gmbh & Co Kg | Chemokin-mucin fusionsproteine mit einer gpi- ankerdomäne und deren verwendung als tumor-immun- adjuvanzien oder in der geweberegeneration |
| CA2673085C (en) | 2006-12-12 | 2013-10-15 | Biorexis Pharmaceutical Corporation | Transferrin fusion protein libraries |
| WO2008100816A2 (en) * | 2007-02-09 | 2008-08-21 | Medimmune, Llc | Antibody libray display by yeast cell plasma membrane |
| WO2010065407A2 (en) * | 2008-12-01 | 2010-06-10 | University Of Maryland Biotechnology Institute | High affinity recombinant sea lamprey antibodies selected by a yeast surface display platform |
| US8343752B2 (en) * | 2011-05-03 | 2013-01-01 | Verdezyne, Inc. | Biological methods for preparing adipic acid |
-
2015
- 2015-11-09 JP JP2017524052A patent/JP7235436B2/ja active Active
- 2015-11-09 CN CN201580059777.8A patent/CN107075507B/zh active Active
- 2015-11-09 EP EP15859426.7A patent/EP3218477A4/en not_active Ceased
- 2015-11-09 US US15/525,397 patent/US10829771B2/en active Active
- 2015-11-09 WO PCT/US2015/059787 patent/WO2016077249A1/en not_active Ceased
-
2021
- 2021-03-15 JP JP2021041635A patent/JP2021101712A/ja active Pending
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