JP2012511920A5 - - Google Patents
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- Publication number
- JP2012511920A5 JP2012511920A5 JP2011541376A JP2011541376A JP2012511920A5 JP 2012511920 A5 JP2012511920 A5 JP 2012511920A5 JP 2011541376 A JP2011541376 A JP 2011541376A JP 2011541376 A JP2011541376 A JP 2011541376A JP 2012511920 A5 JP2012511920 A5 JP 2012511920A5
- Authority
- JP
- Japan
- Prior art keywords
- host cell
- molecule
- binding site
- display
- polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 claims 42
- 229920001184 polypeptide Polymers 0.000 claims 17
- 108090000765 processed proteins & peptides Proteins 0.000 claims 17
- 102000004196 processed proteins & peptides Human genes 0.000 claims 17
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 239000003446 ligand Substances 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 101710186708 Agglutinin Proteins 0.000 claims 2
- 101710194180 Alcohol oxidase 1 Proteins 0.000 claims 2
- 101100327917 Caenorhabditis elegans chup-1 gene Proteins 0.000 claims 2
- 102000016359 Fibronectins Human genes 0.000 claims 2
- 108010067306 Fibronectins Proteins 0.000 claims 2
- 108010001498 Galectin 1 Proteins 0.000 claims 2
- 102100021736 Galectin-1 Human genes 0.000 claims 2
- 101710146024 Horcolin Proteins 0.000 claims 2
- 101710189395 Lectin Proteins 0.000 claims 2
- 101710179758 Mannose-specific lectin Proteins 0.000 claims 2
- 101710150763 Mannose-specific lectin 1 Proteins 0.000 claims 2
- 101710150745 Mannose-specific lectin 2 Proteins 0.000 claims 2
- 102000000470 PDZ domains Human genes 0.000 claims 2
- 108050008994 PDZ domains Proteins 0.000 claims 2
- 239000000910 agglutinin Substances 0.000 claims 2
- 210000004899 c-terminal region Anatomy 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 230000003248 secreting effect Effects 0.000 claims 2
- 101710167800 Capsid assembly scaffolding protein Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 101710130420 Probable capsid assembly scaffolding protein Proteins 0.000 claims 1
- 101710204410 Scaffold protein Proteins 0.000 claims 1
- 102000040945 Transcription factor Human genes 0.000 claims 1
- 108091023040 Transcription factor Proteins 0.000 claims 1
- 210000000170 cell membrane Anatomy 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 102000027450 oncoproteins Human genes 0.000 claims 1
- 108091008819 oncoproteins Proteins 0.000 claims 1
- 102000034285 signal transducing proteins Human genes 0.000 claims 1
- 108091006024 signal transducing proteins Proteins 0.000 claims 1
- 210000005253 yeast cell Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12291008P | 2008-12-16 | 2008-12-16 | |
| US61/122,910 | 2008-12-16 | ||
| PCT/EP2009/067066 WO2010069913A1 (en) | 2008-12-16 | 2009-12-14 | Yeast display systems |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012511920A JP2012511920A (ja) | 2012-05-31 |
| JP2012511920A5 true JP2012511920A5 (enExample) | 2012-12-06 |
| JP5985826B2 JP5985826B2 (ja) | 2016-09-06 |
Family
ID=42115977
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011541376A Active JP5985826B2 (ja) | 2008-12-16 | 2009-12-14 | 酵母ディスプレイ系 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US20110275535A1 (enExample) |
| EP (1) | EP2379718B2 (enExample) |
| JP (1) | JP5985826B2 (enExample) |
| KR (1) | KR20110104052A (enExample) |
| CN (1) | CN102245771B (enExample) |
| AU (1) | AU2009327189B2 (enExample) |
| CA (1) | CA2746840A1 (enExample) |
| EA (1) | EA201100943A1 (enExample) |
| ES (1) | ES2410579T5 (enExample) |
| MX (1) | MX2011006483A (enExample) |
| WO (1) | WO2010069913A1 (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
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| BRPI0417302A (pt) | 2003-12-05 | 2007-03-06 | Compound Therapeutics Inc | inibidores de receptores de fator de crescimento endotelial vascular do tipo 2 |
| AU2007325838B2 (en) | 2006-11-22 | 2013-09-19 | Bristol-Myers Squibb Company | Targeted therapeutics based on engineered proteins for tyrosine kinases receptors, including IGF-IR |
| EP2247615B1 (en) | 2008-02-14 | 2014-07-30 | Bristol-Myers Squibb Company | Targeted therapeutics based on engineered proteins that bind egfr |
| AR071874A1 (es) | 2008-05-22 | 2010-07-21 | Bristol Myers Squibb Co | Proteinas de dominio de armazon basadas en fibronectina multivalentes |
| TWI496582B (zh) | 2008-11-24 | 2015-08-21 | 必治妥美雅史谷比公司 | 雙重專一性之ｅｇｆｒ／ｉｇｆｉｒ結合分子 |
| TW201138808A (en) | 2010-05-03 | 2011-11-16 | Bristol Myers Squibb Co | Serum albumin binding molecules |
| EP3091028A1 (en) | 2010-05-26 | 2016-11-09 | Bristol-Myers Squibb Company | Fibronectin based scaffold proteins having improved stability |
| US20140038842A1 (en) * | 2010-12-28 | 2014-02-06 | Xoma Technology | Cell surface display using pdz domains |
| EP3415528B1 (en) | 2011-04-13 | 2021-05-26 | Bristol-Myers Squibb Company | Fc fusion proteins comprising novel linkers or arrangements |
| US20140187488A1 (en) | 2011-05-17 | 2014-07-03 | Bristol-Myers Squibb Company | Methods for maintaining pegylation of polypeptides |
| CN102276707B (zh) * | 2011-07-29 | 2013-09-25 | 华南理工大学 | 毕赤酵母壁蛋白Gcw19及其表面展示系统和构建方法 |
| CN102276702B (zh) * | 2011-07-29 | 2013-09-25 | 华南理工大学 | 毕赤酵母壁蛋白Gcw30及其表面展示系统和构建方法 |
| CN102260335B (zh) * | 2011-07-29 | 2013-09-25 | 华南理工大学 | 毕赤酵母壁蛋白Gcw3及其表面展示系统和构建方法 |
| CN102276703B (zh) * | 2011-07-29 | 2013-09-25 | 华南理工大学 | 毕赤酵母壁蛋白Gcw51及其表面展示系统和构建方法 |
| US9522951B2 (en) | 2011-10-31 | 2016-12-20 | Bristol-Myers Squibb Company | Fibronectin binding domains with reduced immunogenicity |
| PT2692865E (pt) | 2012-07-30 | 2015-02-06 | Nbe Therapeutics Llc | Identificação mediada por transposição de proteínas funcionais ou de ligação específicas |
| RS58801B1 (sr) | 2012-09-13 | 2019-07-31 | Bristol Myers Squibb Co | Skafold domenski proteini na bazi fibronektina koji se vezuju za miostatin |
| AU2013359469B2 (en) | 2012-12-10 | 2019-05-16 | Seattle Biomedical Research Institute | Cell-free biofragment compositions and related systems, devices, and methods |
| US20150361159A1 (en) | 2013-02-01 | 2015-12-17 | Bristol-Myers Squibb Company | Fibronectin based scaffold proteins |
| WO2014124017A1 (en) | 2013-02-06 | 2014-08-14 | Bristol-Myers Squibb Company | Fibronectin type iii domain proteins with enhanced solubility |
| US10065987B2 (en) | 2013-02-12 | 2018-09-04 | Bristol-Myers Squibb Company | High pH protein refolding methods |
| WO2015100058A1 (en) | 2013-12-23 | 2015-07-02 | Research Corporation Technologies, Inc. | Pichia pastoris surface display system |
| CN103834630A (zh) * | 2014-01-17 | 2014-06-04 | 中国药科大学 | 一种制备重组牛肠激酶催化亚基的方法 |
| AU2015231170B2 (en) | 2014-03-20 | 2019-10-03 | Bristol-Myers Squibb Company | Serum albumin-binding fibronectin type III domains |
| US10766946B2 (en) | 2015-09-23 | 2020-09-08 | Bristol-Myers Squibb Company | Fast-off rate serum albumin binding fibronectin type III domains |
| WO2018041740A1 (en) | 2016-09-01 | 2018-03-08 | Bayer Pharma Aktiengesellschaft | Non-covalent display system using fimgt/dsf |
| EP3551745A4 (en) * | 2016-12-12 | 2020-07-15 | Xcella Biosciences, Inc. | SCREENING METHODS AND SYSTEMS USING MICROCAPILLARY NETWORKS |
| EP3564358A4 (en) | 2016-12-27 | 2020-12-16 | Kagoshima University | SELECTIVE PROTEIN SECRETION TECHNOLOGY IN A MUSHROOM |
| CN110382439B (zh) | 2016-12-30 | 2026-07-21 | 埃克切拉生物科学公司 | 多级样品回收系统 |
| JP7194112B2 (ja) * | 2017-03-13 | 2022-12-21 | ラレマンド ハンガリー リクィディティー マネジメント エルエルシー | 細胞結合型異種タンパク質を発現する組換え酵母宿主細胞 |
| JP7287940B2 (ja) | 2017-03-24 | 2023-06-06 | ランケナウ・インスティテュート・フォー・メディカル・リサーチ | ハイブリドーマによって分泌されるモノクローナル免疫グロブリンの誘導性細胞外膜捕捉のための方法及び組成物 |
| DK3890876T3 (da) | 2018-12-06 | 2024-07-22 | Xcella Biosciences Inc | Lateral påfyldning af mikrokapillære arrays |
| CN113544275A (zh) * | 2019-03-05 | 2021-10-22 | 信达生物制药(苏州)有限公司 | 展示与分泌目的多肽的酵母展示系统及其用途 |
| CA3156776A1 (en) | 2019-11-08 | 2021-05-14 | xCella Biosciences, Inc. | Apparatus and methods for laser-based single cell recovery from microcapillary arrays |
| CN111378676B (zh) * | 2020-02-28 | 2021-08-20 | 武汉华美生物工程有限公司 | 一种pCUP1载体质粒的构建及其应用 |
| ES2955461B2 (es) | 2022-05-24 | 2024-12-27 | Univ Valencia Politecnica | Levadura y plasmido para la exposicion de proteinas en superficie |
| WO2024123891A1 (en) * | 2022-12-07 | 2024-06-13 | The University Of North Carolina At Chapel Hill Office Of Technology Commercialization | Engineered microorganism compositions and applications thereof |
| WO2026128734A1 (en) * | 2024-12-11 | 2026-06-18 | Bioventures, Llc | Methods of treating gastrointestinal disorders with engineered yeast |
Family Cites Families (52)
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|---|---|---|---|---|
| NZ201705A (en) | 1981-08-31 | 1986-03-14 | Genentech Inc | Recombinant dna method for production of hepatitis b surface antigen in yeast |
| US4486533A (en) | 1982-09-02 | 1984-12-04 | St. Louis University | Filamentous fungi functional replicating extrachromosomal element |
| US4599311A (en) | 1982-08-13 | 1986-07-08 | Kawasaki Glenn H | Glycolytic promotersfor regulated protein expression: protease inhibitor |
| US4870008A (en) | 1983-08-12 | 1989-09-26 | Chiron Corporation | Secretory expression in eukaryotes |
| US4931373A (en) | 1984-05-25 | 1990-06-05 | Zymogenetics, Inc. | Stable DNA constructs for expression of α-1 antitrypsin |
| US4766073A (en) | 1985-02-25 | 1988-08-23 | Zymogenetics Inc. | Expression of biologically active PDGF analogs in eucaryotic cells |
| US4882279A (en) | 1985-10-25 | 1989-11-21 | Phillips Petroleum Company | Site selective genomic modification of yeast of the genus pichia |
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| DE69233760D1 (de) | 1991-03-01 | 2009-06-25 | Dyax Corp | Inhibitoren der menschlichen Elastase von Neutrophilen |
| PT1024191E (pt) | 1991-12-02 | 2008-12-22 | Medical Res Council | Produção de auto-anticorpos a partir de reportórios de segmentos de anticorpo e exibidos em fagos |
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| US7309575B2 (en) | 2002-01-16 | 2007-12-18 | The University Of North Carolina At Chapel Hill | Protein purification and detection methods |
| WO2003066830A2 (en) | 2002-02-08 | 2003-08-14 | Genetastix Corporation | Human monoclonal antibodies against membrane proteins |
| DE10324447A1 (de) | 2003-05-28 | 2004-12-30 | Scil Proteins Gmbh | Generierung künstlicher Bindungsproteine auf der Grundlage von Ubiquitin |
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| WO2008031098A1 (en) | 2006-09-09 | 2008-03-13 | The University Of Chicago | Binary amino acid libraries for fibronectin type iii polypeptide monobodies |
| AU2007325838B2 (en) * | 2006-11-22 | 2013-09-19 | Bristol-Myers Squibb Company | Targeted therapeutics based on engineered proteins for tyrosine kinases receptors, including IGF-IR |
| EP2617827A1 (en) † | 2007-03-26 | 2013-07-24 | Celexion, LLC | Method for displaying engineered proteins on a cell surface |
| EA019595B1 (ru) * | 2007-04-17 | 2014-04-30 | Имклоун Элэлси | СПЕЦИФИЧНЫЕ ИНГИБИТОРЫ PDGFRβ |
| MX2009012343A (es) * | 2007-05-14 | 2010-02-10 | Biogen Idec Inc | Regiones fc (sc fc) de cadena sencilla, polipeptidos de enlace que comprenden las mismas, y metodos relacionados con ello. |
-
2009
- 2009-12-14 CN CN2009801503306A patent/CN102245771B/zh active Active
- 2009-12-14 US US13/139,332 patent/US20110275535A1/en not_active Abandoned
- 2009-12-14 EP EP09774904.8A patent/EP2379718B2/en active Active
- 2009-12-14 AU AU2009327189A patent/AU2009327189B2/en not_active Ceased
- 2009-12-14 ES ES09774904T patent/ES2410579T5/es active Active
- 2009-12-14 CA CA2746840A patent/CA2746840A1/en not_active Abandoned
- 2009-12-14 KR KR1020117016542A patent/KR20110104052A/ko not_active Ceased
- 2009-12-14 EA EA201100943A patent/EA201100943A1/ru unknown
- 2009-12-14 JP JP2011541376A patent/JP5985826B2/ja active Active
- 2009-12-14 MX MX2011006483A patent/MX2011006483A/es not_active Application Discontinuation
- 2009-12-14 WO PCT/EP2009/067066 patent/WO2010069913A1/en not_active Ceased
-
2016
- 2016-04-21 US US15/135,438 patent/US10041064B2/en active Active
-
2018
- 2018-07-24 US US16/043,936 patent/US10301616B2/en active Active
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