JP2010112955A5 - - Google Patents

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Publication number
JP2010112955A5
JP2010112955A5 JP2009267007A JP2009267007A JP2010112955A5 JP 2010112955 A5 JP2010112955 A5 JP 2010112955A5 JP 2009267007 A JP2009267007 A JP 2009267007A JP 2009267007 A JP2009267007 A JP 2009267007A JP 2010112955 A5 JP2010112955 A5 JP 2010112955A5
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JP
Japan
Prior art keywords
receptor
cell
protein
cells
group
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Application number
JP2009267007A
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English (en)
Japanese (ja)
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JP2010112955A (ja
JP5187910B2 (ja
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Publication of JP2010112955A publication Critical patent/JP2010112955A/ja
Publication of JP2010112955A5 publication Critical patent/JP2010112955A5/ja
Application granted granted Critical
Publication of JP5187910B2 publication Critical patent/JP5187910B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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JP2009267007A 2002-04-12 2009-11-25 膜貫通型タンパク質と相互作用する化合物の同定法 Expired - Lifetime JP5187910B2 (ja)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US37170402P 2002-04-12 2002-04-12
US60/371,704 2002-04-12
US37941902P 2002-05-13 2002-05-13
US60/379,419 2002-05-13
US38757002P 2002-06-12 2002-06-12
US60/387,570 2002-06-12
US42289102P 2002-11-01 2002-11-01
US60/422,891 2002-11-01
US44255603P 2003-01-27 2003-01-27
US60/442,556 2003-01-27

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2003584728A Division JP4542342B2 (ja) 2002-04-12 2003-04-11 膜貫通型タンパク質と相互作用する化合物の同定法

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2012273726A Division JP5870016B2 (ja) 2002-04-12 2012-12-14 膜貫通型タンパク質と相互作用する化合物の同定法

Publications (3)

Publication Number Publication Date
JP2010112955A JP2010112955A (ja) 2010-05-20
JP2010112955A5 true JP2010112955A5 (enExample) 2011-08-18
JP5187910B2 JP5187910B2 (ja) 2013-04-24

Family

ID=29255685

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2003584728A Expired - Lifetime JP4542342B2 (ja) 2002-04-12 2003-04-11 膜貫通型タンパク質と相互作用する化合物の同定法
JP2009267007A Expired - Lifetime JP5187910B2 (ja) 2002-04-12 2009-11-25 膜貫通型タンパク質と相互作用する化合物の同定法
JP2012273726A Expired - Lifetime JP5870016B2 (ja) 2002-04-12 2012-12-14 膜貫通型タンパク質と相互作用する化合物の同定法
JP2015190891A Expired - Lifetime JP6168669B2 (ja) 2002-04-12 2015-09-29 膜貫通型タンパク質と相互作用する化合物の同定法

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2003584728A Expired - Lifetime JP4542342B2 (ja) 2002-04-12 2003-04-11 膜貫通型タンパク質と相互作用する化合物の同定法

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2012273726A Expired - Lifetime JP5870016B2 (ja) 2002-04-12 2012-12-14 膜貫通型タンパク質と相互作用する化合物の同定法
JP2015190891A Expired - Lifetime JP6168669B2 (ja) 2002-04-12 2015-09-29 膜貫通型タンパク質と相互作用する化合物の同定法

Country Status (16)

Country Link
US (8) US7309576B2 (enExample)
EP (3) EP2339347A1 (enExample)
JP (4) JP4542342B2 (enExample)
CN (1) CN100399028C (enExample)
AT (1) ATE421697T1 (enExample)
AU (2) AU2003218586B2 (enExample)
CA (1) CA2521946C (enExample)
CY (1) CY1108997T1 (enExample)
DE (1) DE60325953D1 (enExample)
DK (1) DK1495330T3 (enExample)
ES (2) ES2321704T3 (enExample)
MX (1) MXPA04011134A (enExample)
NZ (2) NZ567458A (enExample)
PT (1) PT1495330E (enExample)
SI (1) SI1495330T1 (enExample)
WO (1) WO2003087836A1 (enExample)

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ES2342551T3 (es) * 2004-06-16 2010-07-08 Affinergy Inc Biomateriales interfaciales (ifbm) para promover la adhesion especifica de substancias a analizar.
CN1944647B (zh) * 2006-08-23 2010-05-12 华东师范大学 多巴胺受体新亚型d5b基因及编码的蛋白与应用
JP4929462B2 (ja) 2007-01-29 2012-05-09 国立大学法人高知大学 細胞膜上分子と相互作用する化合物の検出方法
CA2690627C (en) 2007-06-15 2014-12-02 Genelux Corporation Microorganisms for imaging and/or treatment of tumors
JP5230397B2 (ja) * 2008-12-18 2013-07-10 独立行政法人科学技術振興機構 抗膜貫通型タンパク質抗体の抗原結合部位を決定する方法
CN102580091B (zh) * 2011-01-12 2014-12-10 中国科学院上海生命科学研究院 增强阿片镇痛剂的镇痛作用的方法及试剂
US8643360B1 (en) * 2012-09-02 2014-02-04 George S. Cargill, III In-water voltage gradient detector
TWI472617B (zh) * 2012-09-17 2015-02-11 Nat Univ Chung Hsing 調控大分子進入細胞內之蛋白質及其調控大分子進入細胞內之方法
US10513711B2 (en) 2014-08-13 2019-12-24 Dupont Us Holding, Llc Genetic targeting in non-conventional yeast using an RNA-guided endonuclease
DK3597740T3 (da) 2014-11-06 2022-06-20 Dupont Us Holding Llc Peptidmedieret indføring af rna-styret endonuklease i celler
AU2016265560B2 (en) 2015-05-15 2022-07-28 Pioneer Hi-Bred International, Inc. Rapid characterization of Cas endonuclease systems, PAM sequences and guide RNA elements
KR102628801B1 (ko) 2015-10-12 2024-01-25 이아이디피, 인크. 세포내 유전자 변형 및 증가된 상동 재조합을 위한 보호 dna 주형 및 이용 방법
AU2016341041A1 (en) 2015-10-20 2018-03-15 Pioneer Hi-Bred International, Inc. Methods and compositions for marker-free genome modification
US20180258438A1 (en) 2015-11-06 2018-09-13 Pioneer Hi-Bred International, Inc. Generation of complex trait loci in soybean and methods of use
DK3387134T3 (da) 2015-12-11 2020-12-21 Danisco Us Inc Fremgangsmåder og sammensætninger til øget nukleasemedieret genommodifikation og reducerede virkninger uden for målstedet
EP3390631B1 (en) 2015-12-18 2020-04-08 Danisco US Inc. Methods and compositions for t-rna based guide rna expression
US11136589B2 (en) 2016-01-26 2021-10-05 Pioneer Hi-Bred International, Inc. Waxy corn
WO2017155717A1 (en) 2016-03-11 2017-09-14 Pioneer Hi-Bred International, Inc. Novel cas9 systems and methods of use
EP3699281A1 (en) 2016-03-11 2020-08-26 Pioneer Hi-Bred International, Inc. Novel cas9 systems and methods of use
WO2017155715A1 (en) 2016-03-11 2017-09-14 Pioneer Hi-Bred International, Inc. Novel cas9 systems and methods of use
EP3469077A1 (en) 2016-06-14 2019-04-17 Pioneer Hi-Bred International, Inc. Use of cpf1 endonuclease for plant genome modifications
US20190100745A1 (en) 2016-06-20 2019-04-04 Pioneer Hi-Bred International, Inc. Novel cas systems and methods of use
CN109844121A (zh) 2016-10-13 2019-06-04 先锋国际良种公司 产生北方叶枯病抗性玉蜀黍
JP7356351B2 (ja) * 2016-12-12 2023-10-04 エクセラ・バイオサイエンシーズ・インコーポレイテッド マイクロキャピラリーアレイを使用したスクリーニングのための方法およびシステム
CN110382439A (zh) 2016-12-30 2019-10-25 埃克切拉生物科学公司 多级样品回收系统
WO2018129440A1 (en) 2017-01-09 2018-07-12 University Of Massachusetts Complexes for gene deletion and editing
BR112020011011A2 (pt) 2017-12-15 2020-11-17 Danisco Us Inc. variantes de cas9 e métodos de uso
CN108178790B (zh) * 2018-01-18 2021-09-07 上海药明康德新药开发有限公司 一种将细胞膜分离以便对跨膜蛋白进行dna编码化合物库筛选的方法
US20220010293A1 (en) 2018-02-23 2022-01-13 Pioneer Hi-Bred International, Inc. Novel cas9 orthologs
US20220030788A1 (en) 2018-10-16 2022-02-03 Pioneer Hi-Bred International, Inc. Genome edited fine mapping and causal gene identification
EP3890876B1 (en) 2018-12-06 2024-05-01 Xcella Biosciences, Inc. Lateral loading of microcapillary arrays
BR112021011372A2 (pt) 2018-12-14 2021-08-31 Pioneer Hi-Bred International, Inc. Novos sistemas crispr-cas para edição de genoma
BR112021012685A2 (pt) 2019-01-11 2021-12-28 Omeros Corp Métodos para tratar câncer, para aumentar o nível de citocinas th1 nas células mononucleares de sangue periférico humanas, para realçar uma resposta imune antitumoral e para estimular e/ou amplificar uma resposta imune em um sujeito mamífero sofrendo de ou em risco de desenvolver câncer ou metástase de câncer, e, composição farmacêutica
WO2020206202A1 (en) 2019-04-05 2020-10-08 Danisco Us Inc Methods for integrating a donor dna sequence into the genome of bacillus using linear recombinant dna constructs and compositions thereof
WO2020206197A1 (en) 2019-04-05 2020-10-08 Danisco Us Inc Methods for polynucleotide integration into the genome of bacillus using dual circular recombinant dna constructs and compositions thereof
KR102329302B1 (ko) * 2019-09-30 2021-11-22 한국과학기술연구원 도파민 d1형 수용체의 활성 측정용 적색 형광 단백질 기반 바이오센서
US20250064032A1 (en) 2021-12-10 2025-02-27 Pig Improvement Company Uk Limited Editing tmprss2/4 for disease resistance in livestock
KR102833970B1 (ko) * 2022-02-23 2025-07-17 충남대학교산학협력단 핵수송 신호 펩타이드가 접합된 핵산 전달용 2세대 폴리아미도아민 덴드리머 고분자 유도체
WO2024013514A2 (en) 2022-07-15 2024-01-18 Pig Improvement Company Uk Limited Gene edited livestock animals having coronavirus resistance
WO2024118881A1 (en) 2022-12-01 2024-06-06 Genencor International Bv Iterative muliplex genome engineering in microbial cells using a bidirectional selection marker system
WO2024118876A1 (en) 2022-12-01 2024-06-06 Genencor International Bv Iterative multiplex genome engineering in microbial cells using a recombinant self-excisable selection marker system
EP4627077A1 (en) 2022-12-01 2025-10-08 Danisco US Inc. Iterative multiplex genome engineering in microbial cells using a selection marker swapping system
WO2024196921A1 (en) 2023-03-20 2024-09-26 Pioneer Hi-Bred International, Inc. Cas polypeptides with altered pam recognition

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US5891646A (en) 1997-06-05 1999-04-06 Duke University Methods of assaying receptor activity and constructs useful in such methods
US6383761B2 (en) * 1997-07-28 2002-05-07 The Regents Of The University Of California Methods and compositions for identifying modulators of G-protein-coupled receptors
CN1227265C (zh) * 2000-02-09 2005-11-16 人类基因组科学公司 抗ccr5的抗体
WO2002014475A2 (en) 2000-08-16 2002-02-21 The Trustees Of Columbia University In The City Of New York QUANTITATIVE ASSESSMENT OF erbB/HER RECEPTORS IN BIOLOGICAL FLUIDS
PT1495330E (pt) * 2002-04-12 2009-04-23 Brian F O'dowd Método de identificação de compostos que interagem com proteínas transmembranares

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