CN100399028C - 鉴定与跨膜蛋白相互作用的化合物的方法 - Google Patents

鉴定与跨膜蛋白相互作用的化合物的方法 Download PDF

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CN100399028C
CN100399028C CNB038082977A CN03808297A CN100399028C CN 100399028 C CN100399028 C CN 100399028C CN B038082977 A CNB038082977 A CN B038082977A CN 03808297 A CN03808297 A CN 03808297A CN 100399028 C CN100399028 C CN 100399028C
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protein
receptor
cell
amino acid
cells
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CN1646917A (zh
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布赖恩·F·奥当德
苏珊·R·乔治
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Omeros Co
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CNB038082977A 2002-04-12 2003-04-11 鉴定与跨膜蛋白相互作用的化合物的方法 Expired - Lifetime CN100399028C (zh)

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US37170402P 2002-04-12 2002-04-12
US60/371,704 2002-04-12
US37941902P 2002-05-13 2002-05-13
US60/379,419 2002-05-13
US38757002P 2002-06-12 2002-06-12
US60/387,570 2002-06-12
US42289102P 2002-11-01 2002-11-01
US60/422,891 2002-11-01
US44255603P 2003-01-27 2003-01-27
US60/442,556 2003-01-27

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI472617B (zh) * 2012-09-17 2015-02-11 Nat Univ Chung Hsing 調控大分子進入細胞內之蛋白質及其調控大分子進入細胞內之方法

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1495330T3 (da) * 2002-04-12 2009-05-18 Brian F O'dowd Fremgangsmåde til at identificere forbindelser, som påvirker transmembran-proteiner
DE602005020320D1 (de) * 2004-06-16 2010-05-12 Affinergy Inc Grenzflächenbiomaterialien zur förderung der anhaftung von zielanalyten
CN1944647B (zh) * 2006-08-23 2010-05-12 华东师范大学 多巴胺受体新亚型d5b基因及编码的蛋白与应用
JP4929462B2 (ja) 2007-01-29 2012-05-09 国立大学法人高知大学 細胞膜上分子と相互作用する化合物の検出方法
WO2008156655A2 (en) 2007-06-15 2008-12-24 Genelux Corporation Vaccinia virus vectors encoding a sodium-dependent transporter protein for imaging and/or treatment of tumors
JP5230397B2 (ja) * 2008-12-18 2013-07-10 独立行政法人科学技術振興機構 抗膜貫通型タンパク質抗体の抗原結合部位を決定する方法
CN102580091B (zh) * 2011-01-12 2014-12-10 中国科学院上海生命科学研究院 增强阿片镇痛剂的镇痛作用的方法及试剂
US8643360B1 (en) * 2012-09-02 2014-02-04 George S. Cargill, III In-water voltage gradient detector
US10513711B2 (en) 2014-08-13 2019-12-24 Dupont Us Holding, Llc Genetic targeting in non-conventional yeast using an RNA-guided endonuclease
WO2016073433A1 (en) 2014-11-06 2016-05-12 E. I. Du Pont De Nemours And Company Peptide-mediated delivery of rna-guided endonuclease into cells
BR112017024534A2 (pt) 2015-05-15 2018-07-24 Pioneer Hi Bred Int sistemas de rna-guia/endonuclease cas9 inovadores
EP4144844B1 (en) 2015-10-12 2025-09-10 DuPont US Holding, LLC Protected dna templates for gene modification and increased homologous recombination in cells and methods of use
US20180282763A1 (en) 2015-10-20 2018-10-04 Pioneer Hi-Bred International, Inc. Restoring function to a non-functional gene product via guided cas systems and methods of use
US20180258438A1 (en) 2015-11-06 2018-09-13 Pioneer Hi-Bred International, Inc. Generation of complex trait loci in soybean and methods of use
WO2017100158A1 (en) 2015-12-11 2017-06-15 Danisco Us Inc. Methods and compositions for enhanced nuclease-mediated genome modification and reduced off-target site effects
EP3390631B1 (en) 2015-12-18 2020-04-08 Danisco US Inc. Methods and compositions for t-rna based guide rna expression
BR112018015348A2 (pt) 2016-01-26 2018-12-18 Pioneer Hi Bred Int método para obter uma planta de milho ceroso, planta, semente, polinucleotídeo-guia e método para produzir uma planta híbrida de milho ceroso
EP3699281A1 (en) 2016-03-11 2020-08-26 Pioneer Hi-Bred International, Inc. Novel cas9 systems and methods of use
WO2017155717A1 (en) 2016-03-11 2017-09-14 Pioneer Hi-Bred International, Inc. Novel cas9 systems and methods of use
WO2017155715A1 (en) 2016-03-11 2017-09-14 Pioneer Hi-Bred International, Inc. Novel cas9 systems and methods of use
KR20190016970A (ko) 2016-06-14 2019-02-19 파이어니어 하이 부렛드 인터내쇼날 인코포레이팃드 식물 게놈 변형을 위한 cpf1 엔도뉴클레아제의 용도
WO2017222773A1 (en) 2016-06-20 2017-12-28 Pioneer Hi-Bred International, Inc. Novel cas systems and methods of use
EP3525578A1 (en) 2016-10-13 2019-08-21 Pioneer Hi-Bred International, Inc. Generating northern leaf blight resistant maize
US11473081B2 (en) 2016-12-12 2022-10-18 xCella Biosciences, Inc. Methods and systems for screening using microcapillary arrays
CA3048904A1 (en) 2016-12-30 2018-07-05 xCella Biosciences, Inc. Multi-stage sample recovery system
WO2018129440A1 (en) 2017-01-09 2018-07-12 University Of Massachusetts Complexes for gene deletion and editing
EP3707253A1 (en) 2017-12-15 2020-09-16 Danisco US Inc. Cas9 variants and methods of use
CN108178790B (zh) * 2018-01-18 2021-09-07 上海药明康德新药开发有限公司 一种将细胞膜分离以便对跨膜蛋白进行dna编码化合物库筛选的方法
WO2019165168A1 (en) 2018-02-23 2019-08-29 Pioneer Hi-Bred International, Inc. Novel cas9 orthologs
EP3866583A1 (en) 2018-10-16 2021-08-25 Pioneer Hi-Bred International, Inc. Genome edited fine mapping and causal gene identification
EP4371930B1 (en) 2018-12-06 2025-08-20 Xcella Biosciences, Inc. Lateral loading of microcapillary arrays
US12365888B2 (en) 2018-12-14 2025-07-22 Pioneer Hi-Bred International, Inc. CRISPR-Cas systems for genome editing
JOP20210164A1 (ar) 2019-01-11 2023-01-30 Omeros Corp طرق وتركيبات علاج السرطان
EP3947656A1 (en) 2019-04-05 2022-02-09 Danisco US Inc. Methods for polynucleotide integration into the genome of bacillus using dual circular recombinant dna constructs and compositions thereof
CA3136114A1 (en) 2019-04-05 2020-10-08 Danisco Us Inc. Methods for integrating a donor dna sequence into the genome of bacillus using linear recombinant dna constructs and compositions thereof
KR102329302B1 (ko) * 2019-09-30 2021-11-22 한국과학기술연구원 도파민 d1형 수용체의 활성 측정용 적색 형광 단백질 기반 바이오센서
WO2023105244A1 (en) 2021-12-10 2023-06-15 Pig Improvement Company Uk Limited Editing tmprss2/4 for disease resistance in livestock
KR102833970B1 (ko) * 2022-02-23 2025-07-17 충남대학교산학협력단 핵수송 신호 펩타이드가 접합된 핵산 전달용 2세대 폴리아미도아민 덴드리머 고분자 유도체
WO2024013514A2 (en) 2022-07-15 2024-01-18 Pig Improvement Company Uk Limited Gene edited livestock animals having coronavirus resistance
WO2024118881A1 (en) 2022-12-01 2024-06-06 Genencor International Bv Iterative muliplex genome engineering in microbial cells using a bidirectional selection marker system
EP4627076A1 (en) 2022-12-01 2025-10-08 Danisco Us Inc Iterative multiplex genome engineering in microbial cells using a recombinant self-excisable selection marker system
WO2024118882A1 (en) 2022-12-01 2024-06-06 Genencor International Bv Iterative multiplex genome engineering in microbial cells using a selection marker swapping system
AU2024239266A1 (en) 2023-03-20 2025-09-25 Pioneer Hi-Bred International, Inc. Cas polypeptides with altered pam recognition

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997048820A1 (en) * 1996-06-21 1997-12-24 Aurora Biosciences Corporation Promiscuous g-protein compositions and their use
WO1999005177A1 (en) * 1997-07-28 1999-02-04 The Regents Of The University Of California Methods and compositions for identifying modulators of g-protein-coupled receptors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030022277A1 (en) * 1995-05-05 2003-01-30 Daniel R. Soppet Human neuropeptide receptor
US5891646A (en) 1997-06-05 1999-04-06 Duke University Methods of assaying receptor activity and constructs useful in such methods
CA2399593A1 (en) * 2000-02-09 2001-08-16 Human Genome Sciences, Inc. Antibodies to ccr5
AU2001284974A1 (en) 2000-08-16 2002-02-25 The Trustees Of Columbia University In The City Of New York Quantitative assessment of erbb/her receptors in biological fluids
DK1495330T3 (da) 2002-04-12 2009-05-18 Brian F O'dowd Fremgangsmåde til at identificere forbindelser, som påvirker transmembran-proteiner

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997048820A1 (en) * 1996-06-21 1997-12-24 Aurora Biosciences Corporation Promiscuous g-protein compositions and their use
WO1999005177A1 (en) * 1997-07-28 1999-02-04 The Regents Of The University Of California Methods and compositions for identifying modulators of g-protein-coupled receptors

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
. 王冀姝等.生物化学与生物物理进展，第29卷第1期. 2002 *
CELLULAR SIGNALING BY AN AGONIST-ACTIVATEDRECEPTOR G(S)ALPHA FUSION PROTEIN. BERTIN B, FREISSMUTH M, JOCKERS R, STROSBERGAD, MARULLO S.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,Vol.91 No.19. 1994 *
Discovery of three novel G-protein-coupled receptor genes. O'Dowd BF, Nguyen T, Marchese A, Cheng R, Lynch KR,Heng HHQ, Kolakowski LF, George SR.GENOMICS,Vol.47 No.2. 1998 *
Extraction and quantification of daidzein and genistein in food. Liggins J, Bluck LJC, Coward WA, Bingham SA.ANALYTICAL BIOCHEMISTRY,Vol.264 No.1. 1998 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI472617B (zh) * 2012-09-17 2015-02-11 Nat Univ Chung Hsing 調控大分子進入細胞內之蛋白質及其調控大分子進入細胞內之方法

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