CY1108997T1 - Μεθοδος για τον προσδιορισμο ενωσεων που αλληλενεργουν με διαμεμβρανικη πρωτεϊνη - Google Patents
Μεθοδος για τον προσδιορισμο ενωσεων που αλληλενεργουν με διαμεμβρανικη πρωτεϊνηInfo
- Publication number
- CY1108997T1 CY1108997T1 CY20091100453T CY091100453T CY1108997T1 CY 1108997 T1 CY1108997 T1 CY 1108997T1 CY 20091100453 T CY20091100453 T CY 20091100453T CY 091100453 T CY091100453 T CY 091100453T CY 1108997 T1 CY1108997 T1 CY 1108997T1
- Authority
- CY
- Cyprus
- Prior art keywords
- cell
- protein
- distribution
- detectable moiety
- transmembrane protein
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 108090000623 proteins and genes Proteins 0.000 title abstract 4
- 102000004169 proteins and genes Human genes 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 108091005703 transmembrane proteins Proteins 0.000 abstract 4
- 102000035160 transmembrane proteins Human genes 0.000 abstract 4
- 238000001514 detection method Methods 0.000 abstract 1
- 230000004807 localization Effects 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G01N33/5035—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on sub-cellular localization
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5058—Neurological cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/09—Fusion polypeptide containing a localisation/targetting motif containing a nuclear localisation signal
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/60—Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/71—Assays involving receptors, cell surface antigens or cell surface determinants for growth factors; for growth regulators
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
- G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2458/00—Labels used in chemical analysis of biological material
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
- Organic Chemistry (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Neurosurgery (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37170402P | 2002-04-12 | 2002-04-12 | |
| US37941902P | 2002-05-13 | 2002-05-13 | |
| US38757002P | 2002-06-12 | 2002-06-12 | |
| US42289102P | 2002-11-01 | 2002-11-01 | |
| US44255603P | 2003-01-27 | 2003-01-27 | |
| EP03711772A EP1495330B1 (en) | 2002-04-12 | 2003-04-11 | Method of identifying transmembrane protein-interacting compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1108997T1 true CY1108997T1 (el) | 2014-07-02 |
Family
ID=29255685
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20091100453T CY1108997T1 (el) | 2002-04-12 | 2009-04-16 | Μεθοδος για τον προσδιορισμο ενωσεων που αλληλενεργουν με διαμεμβρανικη πρωτεϊνη |
Country Status (16)
| Country | Link |
|---|---|
| US (8) | US7309576B2 (enExample) |
| EP (3) | EP1495330B1 (enExample) |
| JP (4) | JP4542342B2 (enExample) |
| CN (1) | CN100399028C (enExample) |
| AT (1) | ATE421697T1 (enExample) |
| AU (2) | AU2003218586B2 (enExample) |
| CA (1) | CA2521946C (enExample) |
| CY (1) | CY1108997T1 (enExample) |
| DE (1) | DE60325953D1 (enExample) |
| DK (1) | DK1495330T3 (enExample) |
| ES (2) | ES2566487T3 (enExample) |
| MX (1) | MXPA04011134A (enExample) |
| NZ (2) | NZ536063A (enExample) |
| PT (1) | PT1495330E (enExample) |
| SI (1) | SI1495330T1 (enExample) |
| WO (1) | WO2003087836A1 (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1495330T3 (da) * | 2002-04-12 | 2009-05-18 | Brian F O'dowd | Fremgangsmåde til at identificere forbindelser, som påvirker transmembran-proteiner |
| DE602005020320D1 (de) * | 2004-06-16 | 2010-05-12 | Affinergy Inc | Grenzflächenbiomaterialien zur förderung der anhaftung von zielanalyten |
| CN1944647B (zh) * | 2006-08-23 | 2010-05-12 | 华东师范大学 | 多巴胺受体新亚型d5b基因及编码的蛋白与应用 |
| JP4929462B2 (ja) | 2007-01-29 | 2012-05-09 | 国立大学法人高知大学 | 細胞膜上分子と相互作用する化合物の検出方法 |
| JP5213075B2 (ja) * | 2007-06-15 | 2013-06-19 | ジェネラックス・コーポレイション | 腫瘍の画像化および／または処置のための微生物 |
| JP5230397B2 (ja) * | 2008-12-18 | 2013-07-10 | 独立行政法人科学技術振興機構 | 抗膜貫通型タンパク質抗体の抗原結合部位を決定する方法 |
| CN102580091B (zh) * | 2011-01-12 | 2014-12-10 | 中国科学院上海生命科学研究院 | 增强阿片镇痛剂的镇痛作用的方法及试剂 |
| US8643360B1 (en) * | 2012-09-02 | 2014-02-04 | George S. Cargill, III | In-water voltage gradient detector |
| TWI472617B (zh) * | 2012-09-17 | 2015-02-11 | Nat Univ Chung Hsing | 調控大分子進入細胞內之蛋白質及其調控大分子進入細胞內之方法 |
| US10513711B2 (en) | 2014-08-13 | 2019-12-24 | Dupont Us Holding, Llc | Genetic targeting in non-conventional yeast using an RNA-guided endonuclease |
| KR102424721B1 (ko) | 2014-11-06 | 2022-07-25 | 이 아이 듀폰 디 네모아 앤드 캄파니 | Rna-유도 엔도뉴클레아제의 세포 내로의 펩티드 매개성 전달 |
| EP3294877A1 (en) | 2015-05-15 | 2018-03-21 | Pioneer Hi-Bred International, Inc. | Rapid characterization of cas endonuclease systems, pam sequences and guide rna elements |
| FI4144844T3 (fi) | 2015-10-12 | 2025-11-24 | Dupont Us Holding Llc | Suojatut dna-templaatit geenimuokkaukseen ja homologisen rekombinaation lisäämiseen soluissa ja niiden käyttömenetelmät |
| WO2018071362A1 (en) | 2016-10-13 | 2018-04-19 | Pioneer Hi-Bred International, Inc. | Generating northern leaf blight resistant maize |
| KR20180069832A (ko) | 2015-10-20 | 2018-06-25 | 파이어니어 하이 부렛드 인터내쇼날 인코포레이팃드 | 유도 cas 시스템을 통한 비기능성 유전자 산물에 대한 기능 회복 및 이용 방법 |
| BR112018007796A2 (pt) | 2015-11-06 | 2018-10-30 | Du Pont | plantas de soja, partes de plantas de soja ou sementes de soja, método para selecionar uma célula de soja, métodos de seleção de uma célula de soja e de produção de um locus e molécula de ácido nucleico |
| EP3387134B1 (en) | 2015-12-11 | 2020-10-14 | Danisco US Inc. | Methods and compositions for enhanced nuclease-mediated genome modification and reduced off-target site effects |
| EP3390631B1 (en) | 2015-12-18 | 2020-04-08 | Danisco US Inc. | Methods and compositions for t-rna based guide rna expression |
| US11136589B2 (en) | 2016-01-26 | 2021-10-05 | Pioneer Hi-Bred International, Inc. | Waxy corn |
| EP3699280A3 (en) | 2016-03-11 | 2020-11-18 | Pioneer Hi-Bred International, Inc. | Novel cas9 systems and methods of use |
| US20190161742A1 (en) | 2016-03-11 | 2019-05-30 | Pioneer Hi-Bred International, Inc. | Novel cas9 systems and methods of use |
| WO2017155715A1 (en) | 2016-03-11 | 2017-09-14 | Pioneer Hi-Bred International, Inc. | Novel cas9 systems and methods of use |
| AU2017286122A1 (en) | 2016-06-14 | 2018-11-22 | Pioneer Hi-Bred International, Inc. | Use of Cpf1 endonuclease for plant genome modifications |
| CA3018430A1 (en) | 2016-06-20 | 2017-12-28 | Pioneer Hi-Bred International, Inc. | Novel cas systems and methods of use |
| JP7356351B2 (ja) | 2016-12-12 | 2023-10-04 | エクセラ・バイオサイエンシーズ・インコーポレイテッド | マイクロキャピラリーアレイを使用したスクリーニングのための方法およびシステム |
| WO2018125832A1 (en) | 2016-12-30 | 2018-07-05 | xCella Biosciences, Inc. | Multi-stage sample recovery system |
| US11519009B2 (en) | 2017-01-09 | 2022-12-06 | University Of Massachusetts | Complexes for gene deletion and editing |
| MX2020005726A (es) | 2017-12-15 | 2020-08-13 | Danisco Us Inc | Variantes de cas9 y metodos de uso. |
| CN108178790B (zh) * | 2018-01-18 | 2021-09-07 | 上海药明康德新药开发有限公司 | 一种将细胞膜分离以便对跨膜蛋白进行dna编码化合物库筛选的方法 |
| US12084676B2 (en) | 2018-02-23 | 2024-09-10 | Pioneer Hi-Bred International, Inc. | Cas9 orthologs |
| US20220030788A1 (en) | 2018-10-16 | 2022-02-03 | Pioneer Hi-Bred International, Inc. | Genome edited fine mapping and causal gene identification |
| ES3039910T3 (en) | 2018-12-06 | 2025-10-27 | Xcella Biosciences Inc | Lateral loading of microcapillary arrays |
| AU2019398351A1 (en) | 2018-12-14 | 2021-06-03 | Pioneer Hi-Bred International, Inc. | Novel CRISPR-Cas systems for genome editing |
| CA3126735A1 (en) | 2019-01-11 | 2020-07-16 | Omeros Corporation | Methods and compositions for treating cancer |
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| KR102329302B1 (ko) * | 2019-09-30 | 2021-11-22 | 한국과학기술연구원 | 도파민 d1형 수용체의 활성 측정용 적색 형광 단백질 기반 바이오센서 |
| WO2023105244A1 (en) | 2021-12-10 | 2023-06-15 | Pig Improvement Company Uk Limited | Editing tmprss2/4 for disease resistance in livestock |
| KR102833970B1 (ko) * | 2022-02-23 | 2025-07-17 | 충남대학교산학협력단 | 핵수송 신호 펩타이드가 접합된 핵산 전달용 2세대 폴리아미도아민 덴드리머 고분자 유도체 |
| WO2024013514A2 (en) | 2022-07-15 | 2024-01-18 | Pig Improvement Company Uk Limited | Gene edited livestock animals having coronavirus resistance |
| WO2024118882A1 (en) | 2022-12-01 | 2024-06-06 | Genencor International Bv | Iterative multiplex genome engineering in microbial cells using a selection marker swapping system |
| WO2024118881A1 (en) | 2022-12-01 | 2024-06-06 | Genencor International Bv | Iterative muliplex genome engineering in microbial cells using a bidirectional selection marker system |
| WO2024118876A1 (en) | 2022-12-01 | 2024-06-06 | Genencor International Bv | Iterative multiplex genome engineering in microbial cells using a recombinant self-excisable selection marker system |
| WO2024196921A1 (en) | 2023-03-20 | 2024-09-26 | Pioneer Hi-Bred International, Inc. | Cas polypeptides with altered pam recognition |
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| US20030022277A1 (en) * | 1995-05-05 | 2003-01-30 | Daniel R. Soppet | Human neuropeptide receptor |
| US6004808A (en) * | 1996-06-21 | 1999-12-21 | Aurora Biosciences Corporation | Promiscuous G-protein compositions and their use |
| US5891646A (en) | 1997-06-05 | 1999-04-06 | Duke University | Methods of assaying receptor activity and constructs useful in such methods |
| US6383761B2 (en) | 1997-07-28 | 2002-05-07 | The Regents Of The University Of California | Methods and compositions for identifying modulators of G-protein-coupled receptors |
| AU2001243145A1 (en) * | 2000-02-09 | 2001-08-20 | Human Genome Sciences, Inc. | Human g-protein chemokine receptor (ccr5) hdgnr10 |
| AU2001284974A1 (en) | 2000-08-16 | 2002-02-25 | The Trustees Of Columbia University In The City Of New York | Quantitative assessment of erbb/her receptors in biological fluids |
| DK1495330T3 (da) | 2002-04-12 | 2009-05-18 | Brian F O'dowd | Fremgangsmåde til at identificere forbindelser, som påvirker transmembran-proteiner |
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