JP2017534851A5 - - Google Patents
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- Publication number
- JP2017534851A5 JP2017534851A5 JP2017515812A JP2017515812A JP2017534851A5 JP 2017534851 A5 JP2017534851 A5 JP 2017534851A5 JP 2017515812 A JP2017515812 A JP 2017515812A JP 2017515812 A JP2017515812 A JP 2017515812A JP 2017534851 A5 JP2017534851 A5 JP 2017534851A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- targeting moiety
- renilla
- interest
- biosensor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000008685 targeting Effects 0.000 claims 30
- 241000242739 Renilla Species 0.000 claims 22
- 102000004169 proteins and genes Human genes 0.000 claims 21
- 108090000623 proteins and genes Proteins 0.000 claims 21
- 210000000170 cell membrane Anatomy 0.000 claims 12
- 239000005090 green fluorescent protein Substances 0.000 claims 12
- 210000004027 cell Anatomy 0.000 claims 11
- 239000003795 chemical substances by application Substances 0.000 claims 6
- 210000001163 endosome Anatomy 0.000 claims 6
- 238000000034 method Methods 0.000 claims 5
- 101100443626 Mus musculus Dner gene Proteins 0.000 claims 4
- 238000000225 bioluminescence resonance energy transfer Methods 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 108010001857 Cell Surface Receptors Proteins 0.000 claims 3
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 claims 3
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 claims 3
- 102000006240 membrane receptors Human genes 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 102000005962 receptors Human genes 0.000 claims 3
- 108020003175 receptors Proteins 0.000 claims 3
- 108010043121 Green Fluorescent Proteins Proteins 0.000 claims 2
- 102000004144 Green Fluorescent Proteins Human genes 0.000 claims 2
- 108010052090 Renilla Luciferases Proteins 0.000 claims 2
- 102000035181 adaptor proteins Human genes 0.000 claims 2
- 108091005764 adaptor proteins Proteins 0.000 claims 2
- 150000001413 amino acids Chemical group 0.000 claims 2
- 102000000072 beta-Arrestins Human genes 0.000 claims 2
- 108010080367 beta-Arrestins Proteins 0.000 claims 2
- 210000004899 c-terminal region Anatomy 0.000 claims 2
- 230000001413 cellular effect Effects 0.000 claims 2
- 150000001982 diacylglycerols Chemical class 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- PHEDXBVPIONUQT-RGYGYFBISA-N phorbol 13-acetate 12-myristate Chemical compound C([C@]1(O)C(=O)C(C)=C[C@H]1[C@@]1(O)[C@H](C)[C@H]2OC(=O)CCCCCCCCCCCCC)C(CO)=C[C@H]1[C@H]1[C@]2(OC(C)=O)C1(C)C PHEDXBVPIONUQT-RGYGYFBISA-N 0.000 claims 2
- 239000002644 phorbol ester Substances 0.000 claims 2
- 239000012474 protein marker Substances 0.000 claims 2
- 102000027426 receptor tyrosine kinases Human genes 0.000 claims 2
- 108091008598 receptor tyrosine kinases Proteins 0.000 claims 2
- 230000000638 stimulation Effects 0.000 claims 2
- 108091006027 G proteins Proteins 0.000 claims 1
- 102000030782 GTP binding Human genes 0.000 claims 1
- 108091000058 GTP-Binding Proteins 0.000 claims 1
- 101000759188 Homo sapiens Zinc finger FYVE domain-containing protein 16 Proteins 0.000 claims 1
- 102000010995 Pleckstrin homology domains Human genes 0.000 claims 1
- 108050001185 Pleckstrin homology domains Proteins 0.000 claims 1
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 1
- 102100027609 Rho-related GTP-binding protein RhoD Human genes 0.000 claims 1
- 102000014400 SH2 domains Human genes 0.000 claims 1
- 108050003452 SH2 domains Proteins 0.000 claims 1
- 102000000395 SH3 domains Human genes 0.000 claims 1
- 108050008861 SH3 domains Proteins 0.000 claims 1
- 210000004957 autophagosome Anatomy 0.000 claims 1
- 239000000470 constituent Substances 0.000 claims 1
- 210000004292 cytoskeleton Anatomy 0.000 claims 1
- 239000012636 effector Substances 0.000 claims 1
- 102000044289 human ZFYVE16 Human genes 0.000 claims 1
- 230000004807 localization Effects 0.000 claims 1
- 210000003712 lysosome Anatomy 0.000 claims 1
- 230000001868 lysosomic effect Effects 0.000 claims 1
- 230000002438 mitochondrial effect Effects 0.000 claims 1
- 230000007498 myristoylation Effects 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 230000026792 palmitoylation Effects 0.000 claims 1
- 210000002824 peroxisome Anatomy 0.000 claims 1
- 230000013823 prenylation Effects 0.000 claims 1
- 230000011664 signaling Effects 0.000 claims 1
- 102000030938 small GTPase Human genes 0.000 claims 1
- 108060007624 small GTPase Proteins 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462052738P | 2014-09-19 | 2014-09-19 | |
| US62/052,738 | 2014-09-19 | ||
| PCT/CA2015/050924 WO2016041093A1 (en) | 2014-09-19 | 2015-09-21 | Biosensors for monitoring biomolecule localization and trafficking in cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017534851A JP2017534851A (ja) | 2017-11-24 |
| JP2017534851A5 true JP2017534851A5 (enExample) | 2018-11-01 |
| JP6708633B2 JP6708633B2 (ja) | 2020-06-10 |
Family
ID=55532401
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017515812A Active JP6708633B2 (ja) | 2014-09-19 | 2015-09-21 | 細胞における生体分子の局在化及び輸送をモニタリングするためのバイオセンサー |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US10584159B2 (enExample) |
| EP (1) | EP3194960B1 (enExample) |
| JP (1) | JP6708633B2 (enExample) |
| CN (1) | CN107533049B (enExample) |
| AU (1) | AU2015318567B2 (enExample) |
| CA (1) | CA2960902C (enExample) |
| DK (1) | DK3194960T3 (enExample) |
| ES (1) | ES2774416T3 (enExample) |
| IL (1) | IL251158A0 (enExample) |
| NZ (1) | NZ730131A (enExample) |
| PL (1) | PL3194960T3 (enExample) |
| SG (1) | SG11201702133TA (enExample) |
| WO (1) | WO2016041093A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20200071724A (ko) * | 2017-10-18 | 2020-06-19 | 유니버시떼 드 몬트리얼 | G-단백질 활성화의 평가를 위한 시스템 및 방법 |
| JP7631187B2 (ja) * | 2018-08-17 | 2025-02-18 | ジェネンテック， インコーポレイテッド | Ｉｎ ｖｉｔｒｏトランスサイトーシスアッセイ |
| CA3127255C (en) * | 2019-01-22 | 2024-01-16 | Interax Biotech Ag | Beta-arrestin mutants |
| WO2021023813A1 (en) | 2019-08-06 | 2021-02-11 | Domain Therapeutics | 5-heteroaryl-pyridin-2-amine confounds as neuropeptide ff receptor antagonists |
| CN110981943B (zh) * | 2019-12-02 | 2021-08-03 | 清华大学 | 多肽及其在制备药物中的用途和药物 |
| CA3198508A1 (en) * | 2020-11-19 | 2022-05-27 | Bradley K. MCCONNELL | Monitoring membrane protein trafficking for drug discovery and drug development |
| CN114200128B (zh) * | 2021-11-24 | 2024-09-27 | 中国科学院生物物理研究所 | 二维蛋白纳米阵列作为免疫传感元件载体的制备和应用 |
| CN114767832B (zh) * | 2022-04-21 | 2025-05-16 | 深圳辰扬生物科技有限公司 | 多肽及其用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7109315B2 (en) * | 2000-03-15 | 2006-09-19 | Bruce J. Bryan | Renilla reniformis fluorescent proteins, nucleic acids encoding the fluorescent proteins and the use thereof in diagnostics, high throughput screening and novelty items |
| US20030157519A1 (en) * | 2001-10-15 | 2003-08-21 | Stratagene | Recombinant renilla reniformis system for bioluminescence resonance energy transfer |
| CA2607015C (en) | 2004-05-04 | 2016-07-05 | Universite De Montreal | Double brilliance beta-arrestin: a biosensor for monitoring the activity of receptors and signalling molecules, and method of using same |
| EP2382470B1 (en) * | 2009-01-29 | 2014-12-10 | Commonwealth Scientific and Industrial Research Organisation | Measuring g protein coupled receptor activation |
| CA2782090C (en) | 2009-12-02 | 2019-03-12 | Unilever Plc | Improved method for screening a potential modulator compound of a taste receptor |
| WO2011130540A1 (en) * | 2010-04-14 | 2011-10-20 | Duke University | Light stimulated protein interaction molecules and methods of use |
-
2015
- 2015-09-21 US US15/512,267 patent/US10584159B2/en active Active
- 2015-09-21 WO PCT/CA2015/050924 patent/WO2016041093A1/en not_active Ceased
- 2015-09-21 EP EP15841561.2A patent/EP3194960B1/en active Active
- 2015-09-21 PL PL15841561T patent/PL3194960T3/pl unknown
- 2015-09-21 AU AU2015318567A patent/AU2015318567B2/en active Active
- 2015-09-21 DK DK15841561.2T patent/DK3194960T3/da active
- 2015-09-21 JP JP2017515812A patent/JP6708633B2/ja active Active
- 2015-09-21 CA CA2960902A patent/CA2960902C/en active Active
- 2015-09-21 CN CN201580062566.XA patent/CN107533049B/zh active Active
- 2015-09-21 SG SG11201702133TA patent/SG11201702133TA/en unknown
- 2015-09-21 NZ NZ730131A patent/NZ730131A/en unknown
- 2015-09-21 ES ES15841561T patent/ES2774416T3/es active Active
-
2017
- 2017-03-14 IL IL251158A patent/IL251158A0/en active IP Right Grant
-
2020
- 2020-01-30 US US16/777,504 patent/US20200157184A1/en not_active Abandoned
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