JP6708633B2 - 細胞における生体分子の局在化及び輸送をモニタリングするためのバイオセンサー - Google Patents

細胞における生体分子の局在化及び輸送をモニタリングするためのバイオセンサー Download PDF

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JP6708633B2
JP6708633B2 JP2017515812A JP2017515812A JP6708633B2 JP 6708633 B2 JP6708633 B2 JP 6708633B2 JP 2017515812 A JP2017515812 A JP 2017515812A JP 2017515812 A JP2017515812 A JP 2017515812A JP 6708633 B2 JP6708633 B2 JP 6708633B2
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protein
rgfp
bret
rlucii
targeting moiety
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JP2017534851A5 (enExample
JP2017534851A (ja
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アラン ラポルト ステファヌ
アラン ラポルト ステファヌ
ナムグン ユン
ナムグン ユン
ブビエ ミシェル
ブビエ ミシェル
ルグイユ クリスチャン
ルグイユ クリスチャン
オーゲ ミレイユ
オーゲ ミレイユ
ルカシェバ ビクトリヤ
ルカシェバ ビクトリヤ
小林　弘幸
弘幸 小林
ドブロワ ドニ
ドブロワ ドニ
ドゥレット エティエンヌ
ドゥレット エティエンヌ
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Universite de Montreal
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Universite de Montreal
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5035—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on sub-cellular localization
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/60—Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2017515812A 2014-09-19 2015-09-21 細胞における生体分子の局在化及び輸送をモニタリングするためのバイオセンサー Active JP6708633B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462052738P 2014-09-19 2014-09-19
US62/052,738 2014-09-19
PCT/CA2015/050924 WO2016041093A1 (en) 2014-09-19 2015-09-21 Biosensors for monitoring biomolecule localization and trafficking in cells

Publications (3)

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JP2017534851A JP2017534851A (ja) 2017-11-24
JP2017534851A5 JP2017534851A5 (enExample) 2018-11-01
JP6708633B2 true JP6708633B2 (ja) 2020-06-10

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US (2) US10584159B2 (enExample)
EP (1) EP3194960B1 (enExample)
JP (1) JP6708633B2 (enExample)
CN (1) CN107533049B (enExample)
AU (1) AU2015318567B2 (enExample)
CA (1) CA2960902C (enExample)
DK (1) DK3194960T3 (enExample)
ES (1) ES2774416T3 (enExample)
IL (1) IL251158A0 (enExample)
NZ (1) NZ730131A (enExample)
PL (1) PL3194960T3 (enExample)
SG (1) SG11201702133TA (enExample)
WO (1) WO2016041093A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20200071724A (ko) * 2017-10-18 2020-06-19 유니버시떼 드 몬트리얼 G-단백질 활성화의 평가를 위한 시스템 및 방법
JP7631187B2 (ja) * 2018-08-17 2025-02-18 ジェネンテック， インコーポレイテッド Ｉｎ ｖｉｔｒｏトランスサイトーシスアッセイ
CA3127255C (en) * 2019-01-22 2024-01-16 Interax Biotech Ag Beta-arrestin mutants
WO2021023813A1 (en) 2019-08-06 2021-02-11 Domain Therapeutics 5-heteroaryl-pyridin-2-amine confounds as neuropeptide ff receptor antagonists
CN110981943B (zh) * 2019-12-02 2021-08-03 清华大学 多肽及其在制备药物中的用途和药物
CA3198508A1 (en) * 2020-11-19 2022-05-27 Bradley K. MCCONNELL Monitoring membrane protein trafficking for drug discovery and drug development
CN114200128B (zh) * 2021-11-24 2024-09-27 中国科学院生物物理研究所 二维蛋白纳米阵列作为免疫传感元件载体的制备和应用
CN114767832B (zh) * 2022-04-21 2025-05-16 深圳辰扬生物科技有限公司 多肽及其用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7109315B2 (en) * 2000-03-15 2006-09-19 Bruce J. Bryan Renilla reniformis fluorescent proteins, nucleic acids encoding the fluorescent proteins and the use thereof in diagnostics, high throughput screening and novelty items
US20030157519A1 (en) * 2001-10-15 2003-08-21 Stratagene Recombinant renilla reniformis system for bioluminescence resonance energy transfer
CA2607015C (en) 2004-05-04 2016-07-05 Universite De Montreal Double brilliance beta-arrestin: a biosensor for monitoring the activity of receptors and signalling molecules, and method of using same
EP2382470B1 (en) * 2009-01-29 2014-12-10 Commonwealth Scientific and Industrial Research Organisation Measuring g protein coupled receptor activation
CA2782090C (en) 2009-12-02 2019-03-12 Unilever Plc Improved method for screening a potential modulator compound of a taste receptor
WO2011130540A1 (en) * 2010-04-14 2011-10-20 Duke University Light stimulated protein interaction molecules and methods of use

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Publication number Publication date
AU2015318567B2 (en) 2020-11-05
CA2960902A1 (en) 2016-03-24
ES2774416T3 (es) 2020-07-21
EP3194960A1 (en) 2017-07-26
CN107533049B (zh) 2020-11-20
PL3194960T3 (pl) 2020-06-01
US20170313762A1 (en) 2017-11-02
IL251158A0 (en) 2017-04-30
DK3194960T3 (da) 2020-02-17
CN107533049A (zh) 2018-01-02
US20200157184A1 (en) 2020-05-21
EP3194960B1 (en) 2019-12-04
EP3194960A4 (en) 2018-03-07
JP2017534851A (ja) 2017-11-24
AU2015318567A1 (en) 2017-04-06
NZ730131A (en) 2023-05-26
US10584159B2 (en) 2020-03-10
SG11201702133TA (en) 2017-04-27
WO2016041093A1 (en) 2016-03-24
CA2960902C (en) 2023-10-24

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