JP2020505381A5 - - Google Patents
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- JP2020505381A5 JP2020505381A5 JP2019539814A JP2019539814A JP2020505381A5 JP 2020505381 A5 JP2020505381 A5 JP 2020505381A5 JP 2019539814 A JP2019539814 A JP 2019539814A JP 2019539814 A JP2019539814 A JP 2019539814A JP 2020505381 A5 JP2020505381 A5 JP 2020505381A5
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- JP
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- Prior art keywords
- alkyl
- pharmaceutically acceptable
- compound
- solvate
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 81
- 150000003839 salts Chemical class 0.000 claims 43
- 239000012453 solvate Substances 0.000 claims 41
- 125000000623 heterocyclic group Chemical group 0.000 claims 37
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 25
- 229910052736 halogen Inorganic materials 0.000 claims 23
- 150000002367 halogens Chemical class 0.000 claims 23
- 125000001072 heteroaryl group Chemical group 0.000 claims 23
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 20
- 125000003118 aryl group Chemical group 0.000 claims 18
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 14
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 14
- 229910052760 oxygen Inorganic materials 0.000 claims 14
- 229910052717 sulfur Inorganic materials 0.000 claims 14
- 125000004429 atom Chemical group 0.000 claims 11
- 201000010099 disease Diseases 0.000 claims 11
- 229910052757 nitrogen Inorganic materials 0.000 claims 10
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 9
- 229910052805 deuterium Inorganic materials 0.000 claims 9
- 208000035475 disorder Diseases 0.000 claims 9
- 229910052739 hydrogen Inorganic materials 0.000 claims 9
- 125000005842 heteroatom Chemical group 0.000 claims 8
- 229910052698 phosphorus Inorganic materials 0.000 claims 8
- 150000001345 alkine derivatives Chemical class 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 6
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 6
- 208000022993 cryopyrin-associated periodic syndrome Diseases 0.000 claims 5
- 208000011580 syndromic disease Diseases 0.000 claims 5
- 125000004043 oxo group Chemical group O=* 0.000 claims 4
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims 3
- 206010061598 Immunodeficiency Diseases 0.000 claims 3
- 208000029462 Immunodeficiency disease Diseases 0.000 claims 3
- 206010061218 Inflammation Diseases 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 230000007812 deficiency Effects 0.000 claims 3
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- 230000004054 inflammatory process Effects 0.000 claims 3
- 201000006417 multiple sclerosis Diseases 0.000 claims 3
- 230000009385 viral infection Effects 0.000 claims 3
- XTFIVUDBNACUBN-UHFFFAOYSA-N 1,3,5-trinitro-1,3,5-triazinane Chemical compound [O-][N+](=O)N1CN([N+]([O-])=O)CN([N+]([O-])=O)C1 XTFIVUDBNACUBN-UHFFFAOYSA-N 0.000 claims 2
- 102100026210 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 Human genes 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 201000001320 Atherosclerosis Diseases 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 208000009766 Blau syndrome Diseases 0.000 claims 2
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 claims 2
- 206010008690 Chondrocalcinosis pyrophosphate Diseases 0.000 claims 2
- 206010016207 Familial Mediterranean fever Diseases 0.000 claims 2
- 201000005569 Gout Diseases 0.000 claims 2
- 101000691589 Homo sapiens 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 Proteins 0.000 claims 2
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 claims 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 2
- 208000003456 Juvenile Arthritis Diseases 0.000 claims 2
- 206010059176 Juvenile idiopathic arthritis Diseases 0.000 claims 2
- 206010072219 Mevalonic aciduria Diseases 0.000 claims 2
- 208000003926 Myelitis Diseases 0.000 claims 2
- 102100022691 NACHT, LRR and PYD domains-containing protein 3 Human genes 0.000 claims 2
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- 125000006574 non-aromatic ring group Chemical group 0.000 claims 2
- 230000001575 pathological effect Effects 0.000 claims 2
- 230000000306 recurrent effect Effects 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 230000001568 sexual effect Effects 0.000 claims 2
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 2
- 230000009885 systemic effect Effects 0.000 claims 2
- 206010000748 Acute febrile neutrophilic dermatosis Diseases 0.000 claims 1
- 208000026326 Adult-onset Still disease Diseases 0.000 claims 1
- 208000022309 Alcoholic Liver disease Diseases 0.000 claims 1
- 208000007887 Alphavirus Infections Diseases 0.000 claims 1
- 206010053555 Arthritis bacterial Diseases 0.000 claims 1
- 208000011594 Autoinflammatory disease Diseases 0.000 claims 1
- 208000022715 Autoinflammatory syndrome Diseases 0.000 claims 1
- 208000035143 Bacterial infection Diseases 0.000 claims 1
- 201000003274 CINCA syndrome Diseases 0.000 claims 1
- 206010063094 Cerebral malaria Diseases 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 206010064568 Chronic infantile neurological cutaneous and articular syndrome Diseases 0.000 claims 1
- 208000034656 Contusions Diseases 0.000 claims 1
- 206010061788 Corneal infection Diseases 0.000 claims 1
- 201000003883 Cystic fibrosis Diseases 0.000 claims 1
- 206010012310 Dengue fever Diseases 0.000 claims 1
- 201000004624 Dermatitis Diseases 0.000 claims 1
- 208000007342 Diabetic Nephropathies Diseases 0.000 claims 1
- 241001475178 Dira Species 0.000 claims 1
- 208000021866 Dressler syndrome Diseases 0.000 claims 1
- 208000003556 Dry Eye Syndromes Diseases 0.000 claims 1
- 206010013774 Dry eye Diseases 0.000 claims 1
- 206010053776 Eosinophilic cellulitis Diseases 0.000 claims 1
- 206010054261 Flavivirus infection Diseases 0.000 claims 1
- 206010053759 Growth retardation Diseases 0.000 claims 1
- 208000031886 HIV Infections Diseases 0.000 claims 1
- 208000037357 HIV infectious disease Diseases 0.000 claims 1
- 101001076407 Homo sapiens Interleukin-1 receptor antagonist protein Proteins 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 229940119178 Interleukin 1 receptor antagonist Drugs 0.000 claims 1
- 102000051628 Interleukin-1 receptor antagonist Human genes 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010027253 Meningitis pneumococcal Diseases 0.000 claims 1
- 206010027476 Metastases Diseases 0.000 claims 1
- 208000026072 Motor neurone disease Diseases 0.000 claims 1
- 108091008099 NLRP3 inflammasome Proteins 0.000 claims 1
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- 206010031149 Osteitis Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010035664 Pneumonia Diseases 0.000 claims 1
- 206010065159 Polychondritis Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 208000006311 Pyoderma Diseases 0.000 claims 1
- 206010037660 Pyrexia Diseases 0.000 claims 1
- 108010001946 Pyrin Domain-Containing 3 Protein NLR Family Proteins 0.000 claims 1
- 206010063837 Reperfusion injury Diseases 0.000 claims 1
- 241000876474 Sapho Species 0.000 claims 1
- 201000010848 Schnitzler Syndrome Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 208000010265 Sweet syndrome Diseases 0.000 claims 1
- 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 claims 1
- 206010047115 Vasculitis Diseases 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 208000008526 Wells syndrome Diseases 0.000 claims 1
- 210000001015 abdomen Anatomy 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 230000001476 alcoholic effect Effects 0.000 claims 1
- 208000007502 anemia Diseases 0.000 claims 1
- 208000007474 aortic aneurysm Diseases 0.000 claims 1
- 239000010425 asbestos Substances 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 208000022362 bacterial infectious disease Diseases 0.000 claims 1
- 208000018339 bone inflammation disease Diseases 0.000 claims 1
- 230000006931 brain damage Effects 0.000 claims 1
- 231100000874 brain damage Toxicity 0.000 claims 1
- 208000029028 brain injury Diseases 0.000 claims 1
- 210000000748 cardiovascular system Anatomy 0.000 claims 1
- 210000003169 central nervous system Anatomy 0.000 claims 1
- 208000015114 central nervous system disease Diseases 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 208000020832 chronic kidney disease Diseases 0.000 claims 1
- 206010009887 colitis Diseases 0.000 claims 1
- 208000024858 congenital sideroblastic anemia-B-cell immunodeficiency-periodic fever-developmental delay syndrome Diseases 0.000 claims 1
- 208000010247 contact dermatitis Diseases 0.000 claims 1
- 230000009519 contusion Effects 0.000 claims 1
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- 208000025729 dengue disease Diseases 0.000 claims 1
- 208000033679 diabetic kidney disease Diseases 0.000 claims 1
- 208000016097 disease of metabolism Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000000750 endocrine system Anatomy 0.000 claims 1
- 208000030533 eye disease Diseases 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 1
- 210000004602 germ cell Anatomy 0.000 claims 1
- 231100000001 growth retardation Toxicity 0.000 claims 1
- 208000006454 hepatitis Diseases 0.000 claims 1
- 231100000283 hepatitis Toxicity 0.000 claims 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 1
- 210000000987 immune system Anatomy 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 206010022000 influenza Diseases 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 239000003407 interleukin 1 receptor blocking agent Substances 0.000 claims 1
- 229910052742 iron Inorganic materials 0.000 claims 1
- 208000012947 ischemia reperfusion injury Diseases 0.000 claims 1
- 230000003902 lesion Effects 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 208000019423 liver disease Diseases 0.000 claims 1
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- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 201000003265 lymphadenitis Diseases 0.000 claims 1
- 230000003211 malignant effect Effects 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 208000030159 metabolic disease Diseases 0.000 claims 1
- 230000009401 metastasis Effects 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 208000005264 motor neuron disease Diseases 0.000 claims 1
- 230000002956 necrotizing effect Effects 0.000 claims 1
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims 1
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 244000052769 pathogen Species 0.000 claims 1
- 230000001717 pathogenic effect Effects 0.000 claims 1
- 208000008494 pericarditis Diseases 0.000 claims 1
- 230000000737 periodic effect Effects 0.000 claims 1
- 208000025487 periodic fever syndrome Diseases 0.000 claims 1
- 201000001245 periodontitis Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 208000004593 pneumococcal meningitis Diseases 0.000 claims 1
- 208000005987 polymyositis Diseases 0.000 claims 1
- 210000005227 renal system Anatomy 0.000 claims 1
- 210000002345 respiratory system Anatomy 0.000 claims 1
- 208000023504 respiratory system disease Diseases 0.000 claims 1
- 229910052895 riebeckite Inorganic materials 0.000 claims 1
- 230000035807 sensation Effects 0.000 claims 1
- 201000005956 sideroblastic anemia with B-cell immunodeficiency, periodic fevers, and developmental delay Diseases 0.000 claims 1
- 230000037432 silent mutation Effects 0.000 claims 1
- 208000017520 skin disease Diseases 0.000 claims 1
- LXMSZDCAJNLERA-ZHYRCANASA-N spironolactone Chemical compound C([C@@H]1[C@]2(C)CC[C@@H]3[C@@]4(C)CCC(=O)C=C4C[C@H]([C@@H]13)SC(=O)C)C[C@@]21CCC(=O)O1 LXMSZDCAJNLERA-ZHYRCANASA-N 0.000 claims 1
- 208000026082 sterile multifocal osteomyelitis with periostitis and pustulosis Diseases 0.000 claims 1
- 150000003431 steroids Chemical class 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 210000004243 sweat Anatomy 0.000 claims 1
- 201000004595 synovitis Diseases 0.000 claims 1
- 102000003298 tumor necrosis factor receptor Human genes 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
- 230000029663 wound healing Effects 0.000 claims 1
- IYUXBZVMFGEWMU-ZTAGZOEFSA-N C/N=C\C(\S(NC(Nc1c(CCC2)c2cc2c1CCC2)=O)(=O)=O)=C(/NC1)\OC[C@@H]1OC Chemical compound C/N=C\C(\S(NC(Nc1c(CCC2)c2cc2c1CCC2)=O)(=O)=O)=C(/NC1)\OC[C@@H]1OC IYUXBZVMFGEWMU-ZTAGZOEFSA-N 0.000 description 1
- NGNWWCOPQFNQHT-UHFFFAOYSA-N O=C(Nc1c(CCC2)c2cc2c1CCC2)NS(c1c(C(CCC2)F)[n]2nc1)(=O)=O Chemical compound O=C(Nc1c(CCC2)c2cc2c1CCC2)NS(c1c(C(CCC2)F)[n]2nc1)(=O)=O NGNWWCOPQFNQHT-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762449431P | 2017-01-23 | 2017-01-23 | |
| US62/449,431 | 2017-01-23 | ||
| US201762492813P | 2017-05-01 | 2017-05-01 | |
| US62/492,813 | 2017-05-01 | ||
| PCT/US2018/014728 WO2018136890A1 (en) | 2017-01-23 | 2018-01-22 | Chemical compounds as inhibitors of interleukin-1 activity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020505381A JP2020505381A (ja) | 2020-02-20 |
| JP2020505381A5 true JP2020505381A5 (enExample) | 2021-03-04 |
| JP7163293B2 JP7163293B2 (ja) | 2022-10-31 |
Family
ID=61189525
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019539814A Active JP7163293B2 (ja) | 2017-01-23 | 2018-01-22 | インターロイキン－１活性の阻害剤としての化学化合物 |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US11040985B2 (enExample) |
| EP (2) | EP3571187B1 (enExample) |
| JP (1) | JP7163293B2 (enExample) |
| KR (1) | KR20190111068A (enExample) |
| CN (1) | CN110366549A (enExample) |
| AU (1) | AU2018210525B2 (enExample) |
| BR (1) | BR112019014549A2 (enExample) |
| CA (1) | CA3047336A1 (enExample) |
| CL (1) | CL2019001988A1 (enExample) |
| CO (1) | CO2019009036A2 (enExample) |
| CR (1) | CR20190356A (enExample) |
| IL (1) | IL267961B2 (enExample) |
| MA (2) | MA47308A (enExample) |
| MX (1) | MX2019008592A (enExample) |
| MY (1) | MY197636A (enExample) |
| PE (1) | PE20191615A1 (enExample) |
| PH (1) | PH12019501611A1 (enExample) |
| SG (1) | SG11201906373VA (enExample) |
| TW (1) | TW201837021A (enExample) |
| UA (1) | UA126675C2 (enExample) |
| WO (1) | WO2018136890A1 (enExample) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110366549A (zh) | 2017-01-23 | 2019-10-22 | 基因泰克公司 | 作为白介素-1活性抑制剂的化合物 |
| CA3059458A1 (en) | 2017-05-24 | 2018-11-29 | The University Of Queensland | Novel compounds and uses |
| MA56075A (fr) | 2017-07-07 | 2022-04-06 | Inflazome Ltd | Nouveaux composés de sulfonamide carboxamide |
| IL271259B2 (en) | 2017-07-24 | 2024-06-01 | Novartis Inflammasome Res Inc | Compounds and compositions for treating conditions associated with nlrp activity |
| UY37848A (es) | 2017-08-15 | 2019-03-29 | Inflazome Ltd | Sulfonilureas y sulfoniltioureas útiles como inhibidores de nlrp3 |
| WO2019034688A1 (en) * | 2017-08-15 | 2019-02-21 | Inflazome Limited | NOVEL CARBOXAMIDE SULFONAMIDE COMPOUNDS |
| EP3668601A1 (en) | 2017-08-15 | 2020-06-24 | Inflazome Limited | Novel sulfonamide carboxamide compounds |
| MA49903A (fr) | 2017-08-15 | 2020-06-24 | Inflazome Ltd | Sulfonylureés et sulfonylthioureés en tant qu'inhibiteurs de nlrp3 |
| WO2019034697A1 (en) * | 2017-08-15 | 2019-02-21 | Inflazome Limited | NOVEL CARBOXAMIDE SULFONAMIDE COMPOUNDS |
| WO2019034693A1 (en) * | 2017-08-15 | 2019-02-21 | Inflazome Limited | SULFONYLURATES AND SULFONYLTHIOURES AS INHIBITORS OF NLRP3 |
| SG11202003984UA (en) * | 2017-11-09 | 2020-05-28 | Inflazome Ltd | Novel sulfonamide carboxamide compounds |
| US12221434B2 (en) | 2017-11-09 | 2025-02-11 | Inflazome Limited | Sulfonamide carboxamide compounds |
| WO2019166633A1 (en) | 2018-03-02 | 2019-09-06 | Inflazome Limited | Sulfonamide derivates as nlrp3 inhibitors |
| WO2019166627A1 (en) | 2018-03-02 | 2019-09-06 | Inflazome Limited | Novel compounds |
| WO2019166619A1 (en) * | 2018-03-02 | 2019-09-06 | Inflazome Limited | Novel compounds |
| WO2019211463A1 (en) | 2018-05-04 | 2019-11-07 | Inflazome Limited | Novel compounds |
| WO2020018970A1 (en) * | 2018-07-20 | 2020-01-23 | Genentech, Inc. | Sulfonylurea compounds as inhibitors of interleukin-1 activity |
| KR20210034596A (ko) | 2018-07-20 | 2021-03-30 | 에프. 호프만-라 로슈 아게 | 인터류킨-1 활성의 저해제로서 술폰이미드아미드 화합물 |
| GB201902327D0 (en) | 2019-02-20 | 2019-04-03 | Inflazome Ltd | Novel compounds |
| BR112021002770A2 (pt) | 2018-08-15 | 2021-05-04 | Inflazome Limited | compostos inovadores de sulfonamidaurea |
| GB201817038D0 (en) * | 2018-10-19 | 2018-12-05 | Inflazome Ltd | Novel processes |
| JP2022505562A (ja) * | 2018-10-24 | 2022-01-14 | ノバルティス アーゲー | Ｎｌｒｐ活性に関連する状態を治療するための化合物及び組成物 |
| JP2022505525A (ja) * | 2018-10-24 | 2022-01-14 | ノバルティス アーゲー | Ｎｌｒｐ活性に関連する状態を治療するための化合物及び組成物 |
| JP2022506898A (ja) | 2018-11-13 | 2022-01-17 | ノバルティス アーゲー | Ｎｌｒｐ活性に関連する状態を処置するための化合物及び組成物 |
| CN113015730A (zh) | 2018-11-13 | 2021-06-22 | 诺华股份有限公司 | 用于治疗与nlrp活性相关的病症的化合物和组合物 |
| GB201819083D0 (en) * | 2018-11-23 | 2019-01-09 | Inflazome Ltd | Novel compounds |
| FI3911631T3 (fi) * | 2019-01-14 | 2025-02-03 | Zydus Lifesciences Ltd | Uusia substituoituja sulfonyyliureajohdannaisia |
| CN113195469B (zh) * | 2019-02-19 | 2024-05-24 | 四川科伦博泰生物医药股份有限公司 | 含氮并环化合物、其制备方法及用途 |
| GB201905265D0 (en) | 2019-04-12 | 2019-05-29 | Inflazome Ltd | Inflammasome inhibition |
| WO2020254697A1 (en) | 2019-06-21 | 2020-12-24 | Ac Immune Sa | Fused 1,2 thiazoles and 1,2 thiazines which act as nl3p3 modulators |
| KR20220064364A (ko) * | 2019-07-17 | 2022-05-18 | 조마젠 바이오사이언시즈 엘티디 | 다발성 경화증(ms)의 치료를 위한 nlpr3 조절제로서의 n-((1,2,3,5,6,7-헥사하이드로-s-인다센-4-일)카바모일)-4,5,6,7-테트라하이드로벤조푸란-2-설폰아미드 유도체 및 관련 화합물 |
| KR102852270B1 (ko) * | 2019-07-17 | 2025-08-29 | 조마젠 바이오사이언시즈 엘티디 | Nlrp3 조절제 |
| US20220289766A1 (en) | 2019-08-16 | 2022-09-15 | Inflazome Limited | Macrocyclic sulfonylurea derivatives useful as nlrp3 inhibitors |
| JP2022547882A (ja) | 2019-09-06 | 2022-11-16 | インフレイゾーム リミテッド | Ｎｌｒｐ３阻害剤 |
| AU2020383646B2 (en) * | 2019-11-12 | 2023-10-12 | Kangbaida (Sichuan) Biotechnology Co., Ltd. | Amide derivative and preparation method therefore and use thereof in medicine |
| IL294536A (en) * | 2020-01-22 | 2022-09-01 | Hoffmann La Roche | Sulfonimidamide compounds as nlrp3 modulators |
| WO2021165245A1 (en) | 2020-02-18 | 2021-08-26 | Inflazome Limited | Compounds |
| CN115605209B (zh) * | 2020-03-16 | 2024-12-17 | 祖玛珍生物科学有限公司 | Nlrp3调节剂 |
| WO2021203014A1 (en) | 2020-04-03 | 2021-10-07 | Vertex Pharmaceuticals Incorporated | Pyrano[4,3-b]l ndole derivatives as alpha-1 -antitrypsin modulators for treating alpha-1 -antitrypsin deficiency (aatd) |
| US20230183249A1 (en) * | 2020-04-30 | 2023-06-15 | Janssen Pharmaceutica Nv | New triazinoindole compounds |
| IL299084A (en) | 2020-06-19 | 2023-02-01 | Ac Immune Sa | History of dihydrooxazole and thiourea or urea modulating the NLRP3 inflammasome pathway |
| CN114516878B (zh) * | 2020-11-20 | 2024-02-02 | 上海拓界生物医药科技有限公司 | 三环化合物及其医药用途 |
| CN114539256B (zh) * | 2020-11-20 | 2024-02-02 | 上海拓界生物医药科技有限公司 | 三环化合物及其医药用途 |
| CN115894478B (zh) * | 2021-09-30 | 2025-04-04 | 杭州民生药物研究院有限公司 | 一种新型吡啶并吡唑类杂环化合物及其应用 |
| TW202333678A (zh) * | 2021-12-22 | 2023-09-01 | 大陸商瑞石生物醫藥有限公司 | 一種磺醯脲類化合物 |
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