|
AU2015360502A1
(en)
|
2014-12-10 |
2017-06-29 |
Regents Of The University Of Minnesota |
Genetically modified cells, tissues, and organs for treating disease
|
|
EP3294342A4
(en)
|
2015-05-08 |
2018-11-07 |
President and Fellows of Harvard College |
Universal donor stem cells and related methods
|
|
EA201891338A1
(ru)
|
2015-12-04 |
2018-12-28 |
Новартис Аг |
Композиции и способы для иммуноонкологии
|
|
CN110177869A
(zh)
*
|
2017-01-13 |
2019-08-27 |
加利福尼亚大学董事会 |
免疫改造的多能细胞
|
|
CN110637083A
(zh)
*
|
2017-03-20 |
2019-12-31 |
华盛顿大学 |
细胞及其使用和制备方法
|
|
WO2018175636A2
(en)
|
2017-03-22 |
2018-09-27 |
Novartis Ag |
Compositions and methods for immunooncology
|
|
CN120041380A
(zh)
|
2017-06-12 |
2025-05-27 |
西奈卫生系统公司 |
无需全身性免疫遏制的同种异体移植物耐受
|
|
US11866726B2
(en)
|
2017-07-14 |
2024-01-09 |
Editas Medicine, Inc. |
Systems and methods for targeted integration and genome editing and detection thereof using integrated priming sites
|
|
US20210308183A1
(en)
*
|
2018-07-17 |
2021-10-07 |
The Regents Of The University Of California |
Chimeric antigen receptor t cells derived from immunoengineered pluripotent stem cells
|
|
BR112021000637A2
(pt)
*
|
2018-07-17 |
2021-04-13 |
The Regents Of The University Of California |
Célula cardíaca hipoimune isolada, método para tratar um paciente que sofre de uma afecção ou doença cardíaca, método para produzir uma população de células cardíacas hipoimunes, célula endotelial hipoimune isolada, método para tratar um paciente que sofre de uma afecção ou doença vascular, método para produzir uma população de células endoteliais hipoimunes, neurônio dopaminérgico hipoimune isolado, método para tratar um paciente que sofre de uma doença ou afecção neurodegenerativa, método para produzir uma população de neurônios dopaminérgicos hipoimunes, célula de ilhota pancreática hipoimune isolada, método para tratar um paciente que sofre de diabetes, método para produzir uma população de células de ilhota pancreática hipoimunes, célula de epitélio pigmentado da retina (rpe) hipoimune isolada, método para tratar um paciente que sofre de uma afecção ocular, e método para produzir uma população de células de epitélio pigmentado da retina (rpe) hipoimunes
|
|
US12378572B2
(en)
|
2018-09-07 |
2025-08-05 |
Crispr Therapeutics Ag |
Universal donor cells
|
|
CN113195724A
(zh)
*
|
2018-09-26 |
2021-07-30 |
新加坡国立大学 |
低免疫原性的工程化人类间充质基质细胞,制备方法和试剂盒
|
|
UY38427A
(es)
*
|
2018-10-26 |
2020-05-29 |
Novartis Ag |
Métodos y composiciones para terapia con células oculares
|
|
CN111424016A
(zh)
*
|
2019-01-09 |
2020-07-17 |
复旦大学 |
降低细胞免疫原性的诱导型多能干细胞系及建立方法
|
|
KR20210128440A
(ko)
*
|
2019-02-15 |
2021-10-26 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
범용 공여자 줄기 세포 및 관련 방법
|
|
US11162079B2
(en)
|
2019-05-10 |
2021-11-02 |
The Regents Of The University Of California |
Blood type O Rh-hypo-immunogenic pluripotent cells
|
|
WO2020231882A2
(en)
*
|
2019-05-10 |
2020-11-19 |
The Regents Of The University Of California |
Modified pluripotent cells
|
|
US12391923B2
(en)
|
2019-06-26 |
2025-08-19 |
The Regents Of The University Of California |
SIRPα-silenced natural killer (NK) cells
|
|
TW202115245A
(zh)
*
|
2019-06-27 |
2021-04-16 |
丹麥商諾佛 儂迪克股份有限公司 |
安全免疫隱形細胞
|
|
EP4022037A1
(en)
|
2019-07-10 |
2022-07-06 |
Helmuth Heinrich Kunz |
Methods for deriving autologous and hypoimmunogenic hair follicle containing sheets in vitro
|
|
JP2022543112A
(ja)
*
|
2019-08-01 |
2022-10-07 |
サナ バイオテクノロジー,インコーポレイテッド |
Dux4発現細胞およびそれらの使用
|
|
AU2020336302A1
(en)
|
2019-08-23 |
2022-03-03 |
Sana Biotechnology, Inc. |
CD24 expressing cells and uses thereof
|
|
KR20220058579A
(ko)
|
2019-09-05 |
2022-05-09 |
크리스퍼 테라퓨틱스 아게 |
보편적 공여자 세포
|
|
US11104918B2
(en)
*
|
2019-09-05 |
2021-08-31 |
Crispr Therapeutics Ag |
Universal donor cells
|
|
CA3153700A1
(en)
*
|
2019-09-09 |
2021-03-18 |
Scribe Therapeutics Inc. |
Compositions and methods for use in immunotherapy
|
|
WO2021055985A1
(en)
*
|
2019-09-22 |
2021-03-25 |
Cellerant Therapeutics, Inc. |
Ipsc-derived, hypoimmunogenic, myeloid progenitor cells
|
|
JP2022551975A
(ja)
*
|
2019-10-15 |
2022-12-14 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
Fc封鎖を介する移植細胞保護
|
|
AU2021207810A1
(en)
|
2020-01-13 |
2022-08-04 |
Sana Biotechnology, Inc. |
Modification of blood type antigens
|
|
EP4585223A3
(en)
|
2020-01-15 |
2025-07-30 |
The Regents of the University of California |
Transplanted cell protection via inhibition of polymorphonuclear cells
|
|
CA3165076A1
(en)
*
|
2020-01-17 |
2021-07-22 |
Ryan Clarke |
Safety switches for regulation of gene expression
|
|
MX2022011831A
(es)
*
|
2020-03-25 |
2023-01-04 |
Sana Biotechnology Inc |
Células neurales hipoinmunogénicas para el tratamiento de trastornos y afecciones neurológicas.
|
|
EP4132544A4
(en)
*
|
2020-04-06 |
2024-10-23 |
Rxcell Inc. |
HYPOIMMUNOGENIC CELLS AND METHODS AND COMPOSITIONS FOR THEIR PRODUCTION
|
|
EP4138893A4
(en)
*
|
2020-04-21 |
2024-06-12 |
Intima Bioscience, Inc. |
CELLULAR VACCINE PLATFORM AND METHODS OF USE THEREOF
|
|
EP4149525A4
(en)
*
|
2020-05-15 |
2024-08-28 |
Rxcell Inc. |
HYPOIMMUNOGENIC CELLS AND THEIR USES IN IMMUNE RESPONSES
|
|
IL300516A
(en)
|
2020-08-13 |
2023-04-01 |
Sana Biotechnology Inc |
Methods for treating susceptible patients with hypoimmunogenic cells, and related methods and compounds
|
|
CN112342196A
(zh)
*
|
2020-08-18 |
2021-02-09 |
未来智人再生医学研究院(广州)有限公司 |
一种免疫兼容可逆的通用型多能干细胞及其应用
|
|
CA3194577A1
(en)
*
|
2020-10-09 |
2022-04-14 |
Sonja SCHREPFER |
Methods for triggering safety killing mechanisms using a cd47-sirp.alpha. blockade agent
|
|
EP4232468A4
(en)
*
|
2020-10-20 |
2025-03-19 |
Replay Holdings, Inc. |
Methods and compositions for cellular therapy
|
|
CN114457021A
(zh)
*
|
2020-10-30 |
2022-05-10 |
未来智人再生医学研究院(广州)有限公司 |
一种表达cd47抗体的多能干细胞及其衍生物与应用
|
|
CN114525255A
(zh)
*
|
2020-10-30 |
2022-05-24 |
未来智人再生医学研究院(广州)有限公司 |
一种表达il-11的多能干细胞衍生物及其应用
|
|
US11591381B2
(en)
|
2020-11-30 |
2023-02-28 |
Crispr Therapeutics Ag |
Gene-edited natural killer cells
|
|
AU2021392032A1
(en)
|
2020-12-03 |
2023-06-22 |
Century Therapeutics, Inc. |
Genetically engineered cells and uses thereof
|
|
US11661459B2
(en)
|
2020-12-03 |
2023-05-30 |
Century Therapeutics, Inc. |
Artificial cell death polypeptide for chimeric antigen receptor and uses thereof
|
|
CN114107211B
(zh)
*
|
2020-12-04 |
2025-09-30 |
未来智人再生医学研究院(广州)有限公司 |
一种多能干细胞及其衍生物
|
|
WO2022125439A2
(en)
*
|
2020-12-07 |
2022-06-16 |
The Regents Of The University Of California |
Innate immune cell silencing by sirp-alpha engager
|
|
WO2022144632A1
(en)
|
2020-12-30 |
2022-07-07 |
Crispr Therapeutics Ag |
Compositions and methods for differentiating stem cells into nk cells
|
|
KR20230146007A
(ko)
|
2020-12-31 |
2023-10-18 |
크리스퍼 테라퓨틱스 아게 |
범용 공여자 세포
|
|
CA3200509A1
(en)
|
2020-12-31 |
2022-07-07 |
Sonja SCHREPFER |
Methods and compositions for modulating car-t activity
|
|
CA3212370A1
(en)
|
2021-03-03 |
2022-09-09 |
Sana Biotechnology, Inc. |
Immunosuppressive therapies for use with cardiomyocyte cell therapies, and associated methods and compositions
|
|
TW202302839A
(zh)
*
|
2021-03-09 |
2023-01-16 |
國立研究開發法人理化學研究所 |
低免疫原性視網膜色素上皮細胞之製造方法
|
|
EP4313087A4
(en)
*
|
2021-03-30 |
2025-03-19 |
The Regents of the University of California |
PROTECTION OF TRANSPLANTED CELLS VIA MODIFIED FC RECEPTORS
|
|
WO2022221699A1
(en)
*
|
2021-04-16 |
2022-10-20 |
Beam Therapeutics, Inc. |
Genetic modification of hepatocytes
|
|
EP4347810A4
(en)
*
|
2021-05-24 |
2025-06-04 |
Sangamo Therapeutics, Inc. |
ZINC FINGER NUCLEASES TARGETING CIITA
|
|
AU2022283291A1
(en)
|
2021-05-27 |
2023-11-02 |
Sana Biotechnology, Inc. |
Hypoimmunogenic cells comprising engineered hla-e or hla-g
|
|
KR20240046319A
(ko)
|
2021-07-14 |
2024-04-08 |
사나 바이오테크놀로지, 인크. |
저면역원성 세포에서의 y 염색체-연결 항원의 변경된 발현
|
|
WO2023008918A1
(ko)
*
|
2021-07-28 |
2023-02-02 |
의료법인 성광의료재단 |
B2m 유전자의 발현이 저해된 유전적으로 조작된 줄기세포 및 이의 이용방법
|
|
WO2023019226A1
(en)
|
2021-08-11 |
2023-02-16 |
Sana Biotechnology, Inc. |
Genetically modified cells for allogeneic cell therapy
|
|
TW202321435A
(zh)
|
2021-08-11 |
2023-06-01 |
美商薩那生物科技公司 |
用於改變低免疫原性細胞中之基因表現之可誘導系統
|
|
KR20240073006A
(ko)
|
2021-08-11 |
2024-05-24 |
사나 바이오테크놀로지, 인크. |
동종이계 세포 요법을 위한 유전자 변형된 1차 세포
|
|
AU2022325231A1
(en)
|
2021-08-11 |
2024-02-08 |
Sana Biotechnology, Inc. |
Genetically modified cells for allogeneic cell therapy to reduce complement-mediated inflammatory reactions
|
|
JP2024535677A
(ja)
|
2021-08-11 |
2024-10-02 |
サナ バイオテクノロジー,インコーポレイテッド |
即時血液媒介性炎症反応を減少させるための同種細胞療法を目的とした遺伝子改変細胞
|
|
CN113801881B
(zh)
*
|
2021-08-27 |
2024-02-20 |
浙江大学 |
超级增强子基因序列在促进人b2m基因表达中的用途
|
|
WO2023069790A1
(en)
|
2021-10-22 |
2023-04-27 |
Sana Biotechnology, Inc. |
Methods of engineering allogeneic t cells with a transgene in a tcr locus and associated compositions and methods
|
|
MX2024007528A
(es)
|
2021-12-23 |
2024-08-30 |
Sana Biotechnology Inc |
Linfocitos t del receptor de antígeno quimérico (car) para el tratamiento de enfermedades autoinmunitarias y métodos asociados.
|
|
KR20240142624A
(ko)
*
|
2022-01-10 |
2024-09-30 |
사나 바이오테크놀로지, 인크. |
만능줄기세포에서 분화된 면역저하 베타세포 및 관련 용도 및 방법
|
|
WO2023154578A1
(en)
|
2022-02-14 |
2023-08-17 |
Sana Biotechnology, Inc. |
Methods of treating patients exhibiting a prior failed therapy with hypoimmunogenic cells
|
|
KR20240155390A
(ko)
|
2022-02-17 |
2024-10-28 |
사나 바이오테크놀로지, 인크. |
조작된 cd47 단백질 및 이의 용도
|
|
US20250101382A1
(en)
|
2022-03-11 |
2025-03-27 |
Sana Biotechnology, Inc. |
Genetically modified cells and compositions and uses thereof
|
|
WO2023183313A1
(en)
|
2022-03-22 |
2023-09-28 |
Sana Biotechnology, Inc. |
Engineering cells with a transgene in b2m or ciita locus and associated compositions and methods
|
|
CN114958768B
(zh)
*
|
2022-06-02 |
2023-03-24 |
健颐生物科技发展(山东)有限公司 |
Fgf10旁分泌通用型人成纤维细胞制剂的制备方法
|
|
CN117343962A
(zh)
*
|
2022-06-29 |
2024-01-05 |
中国科学院上海营养与健康研究所 |
免疫兼容型人多能干细胞、其制备方法及应用
|
|
EP4547825A1
(en)
|
2022-07-01 |
2025-05-07 |
Novo Nordisk A/S |
Enhancing neuronal differentiation of ventral midbrain neural progenitor cells
|
|
CN117384851B
(zh)
*
|
2022-07-11 |
2025-11-21 |
士泽生物医药(苏州)有限公司 |
一种表达faslg的通用型细胞及其制备方法
|
|
CN117431217A
(zh)
*
|
2022-07-12 |
2024-01-23 |
上海驯鹿生物技术有限公司 |
表达靶向cd5的嵌合抗原受体(car)的细胞及其应用
|
|
GB202211117D0
(en)
*
|
2022-07-29 |
2022-09-14 |
Replay Holdings Llc |
Compositions and methods for non-immunogenecity
|
|
GB202212144D0
(en)
*
|
2022-08-19 |
2022-10-05 |
Resolution Therapeutics Ltd |
Cells for therapy
|
|
WO2024097315A2
(en)
|
2022-11-02 |
2024-05-10 |
Sana Biotechnology, Inc. |
Cell therapy products and methods for producing same
|
|
WO2024107420A1
(en)
*
|
2022-11-15 |
2024-05-23 |
The Board Of Trustees Of The Leland Stanford Junior University |
Hypoallogenic-immunogenic pluripotent stem cells as anti-cancer vaccine
|
|
CN118147077B
(zh)
*
|
2022-12-07 |
2025-09-26 |
士泽生物医药(苏州)有限公司 |
一种表达gsn的通用型细胞及其制备方法
|
|
CN118207165B
(zh)
*
|
2022-12-07 |
2026-03-20 |
士泽生物医药(苏州)有限公司 |
一种表达stc1的通用型细胞及其制备方法
|
|
GB202218755D0
(en)
*
|
2022-12-13 |
2023-01-25 |
Replay Holdings Llc |
Compositions and methods for non-immunogenicity
|
|
JP2026501446A
(ja)
*
|
2022-12-16 |
2026-01-15 |
ゼルスマート バイオ‐ファーマシューティカル (スズホウ) シーオー., エルティーディー. |
ユニバーサル細胞及びその製造方法
|
|
WO2024151541A1
(en)
|
2023-01-09 |
2024-07-18 |
Sana Biotechnology, Inc. |
Type-1 diabetes autoimmune mouse
|
|
WO2024169917A1
(zh)
*
|
2023-02-16 |
2024-08-22 |
士泽生物医药(苏州)有限公司 |
通用型细胞及其制备方法
|
|
WO2024229302A1
(en)
|
2023-05-03 |
2024-11-07 |
Sana Biotechnology, Inc. |
Methods of dosing and administration of engineered islet cells
|
|
CN121604968A
(zh)
|
2023-05-22 |
2026-03-03 |
萨那生物科技公司 |
递送胰岛细胞的方法及相关方法
|
|
WO2025003393A1
(en)
|
2023-06-30 |
2025-01-02 |
Novo Nordisk A/S |
Enhancing neuronal differentiation of neural progenitor cells
|
|
KR102740042B1
(ko)
*
|
2023-07-12 |
2024-12-06 |
㈜바이오솔빅스 |
인간 전분화능 줄기세포로 유래된 심장 오가노이드 제조방법, 효능 및 독성 평가 기술
|
|
AU2024328949A1
(en)
|
2023-08-23 |
2026-03-12 |
Sana Biotechnology, Inc. |
Modified cd47 proteins and their uses
|
|
WO2025054202A1
(en)
|
2023-09-05 |
2025-03-13 |
Sana Biotechnology, Inc. |
Method of screening a sample comprising a transgene with a unique barcode
|
|
CN119351338B
(zh)
*
|
2023-09-15 |
2026-01-23 |
士泽生物医药(苏州)有限公司 |
一种表达cd300ld的低免疫原性细胞及其制备方法
|
|
WO2025096757A1
(en)
|
2023-11-01 |
2025-05-08 |
Sana Biotechnology, Inc. |
Hypoimmunogenic cd22-targeted car t cells for the treatment of relapsed and/or refractory b cell lymphomas
|
|
WO2025151838A1
(en)
|
2024-01-12 |
2025-07-17 |
Sana Biotechnology, Inc. |
Safety switches to control in vitro and in vivo proliferation of cell therapy products
|
|
WO2025230941A1
(en)
|
2024-04-30 |
2025-11-06 |
Satellite Biosciences, Inc. |
Hypoimmunogenic cell mixtures and methods of use thereof
|
|
WO2025230947A1
(en)
|
2024-04-30 |
2025-11-06 |
Satellite Biosciences, Inc. |
Engineered hepatocytes for secreting polypeptides
|
|
CN121006322A
(zh)
*
|
2024-05-22 |
2025-11-25 |
上海苹谱医疗科技有限公司 |
一种通用型工程化细胞及其制备方法与应用
|
|
WO2025259640A1
(en)
*
|
2024-06-14 |
2025-12-18 |
The Board Of Trustees Of The Leland Stanford Junior University |
Systems and methods for bioengineering hypoimmunogenic organs, tissues and cells
|