JP2024050597A5 - - Google Patents
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- Publication number
- JP2024050597A5 JP2024050597A5 JP2024001947A JP2024001947A JP2024050597A5 JP 2024050597 A5 JP2024050597 A5 JP 2024050597A5 JP 2024001947 A JP2024001947 A JP 2024001947A JP 2024001947 A JP2024001947 A JP 2024001947A JP 2024050597 A5 JP2024050597 A5 JP 2024050597A5
- Authority
- JP
- Japan
- Prior art keywords
- hla
- gene
- genes
- hypoimmunogenic
- expression
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862698973P | 2018-07-17 | 2018-07-17 | |
| US201862698984P | 2018-07-17 | 2018-07-17 | |
| US201862698978P | 2018-07-17 | 2018-07-17 | |
| US201862698965P | 2018-07-17 | 2018-07-17 | |
| US201862698981P | 2018-07-17 | 2018-07-17 | |
| US62/698,973 | 2018-07-17 | ||
| US62/698,981 | 2018-07-17 | ||
| US62/698,984 | 2018-07-17 | ||
| US62/698,965 | 2018-07-17 | ||
| US62/698,978 | 2018-07-17 | ||
| JP2021502525A JP2021530232A (ja) | 2018-07-17 | 2019-07-17 | 免疫改変された多能性細胞から分化させた細胞 |
| PCT/US2019/042117 WO2020018615A2 (en) | 2018-07-17 | 2019-07-17 | Cells differentiated from immunoengineered pluripotent cells |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021502525A Division JP2021530232A (ja) | 2018-07-17 | 2019-07-17 | 免疫改変された多能性細胞から分化させた細胞 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024050597A JP2024050597A (ja) | 2024-04-10 |
| JP2024050597A5 true JP2024050597A5 (https=) | 2024-05-31 |
Family
ID=69165113
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021502525A Pending JP2021530232A (ja) | 2018-07-17 | 2019-07-17 | 免疫改変された多能性細胞から分化させた細胞 |
| JP2024001947A Pending JP2024050597A (ja) | 2018-07-17 | 2024-01-10 | 免疫改変された多能性細胞から分化させた細胞 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021502525A Pending JP2021530232A (ja) | 2018-07-17 | 2019-07-17 | 免疫改変された多能性細胞から分化させた細胞 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20210292715A1 (https=) |
| EP (1) | EP3824074A4 (https=) |
| JP (2) | JP2021530232A (https=) |
| KR (1) | KR20210032454A (https=) |
| CN (2) | CN112639079A (https=) |
| AU (2) | AU2019305585A1 (https=) |
| BR (1) | BR112021000637A2 (https=) |
| CA (1) | CA3109078A1 (https=) |
| IL (2) | IL314721A (https=) |
| MX (2) | MX2021000614A (https=) |
| SG (1) | SG11202100157YA (https=) |
| WO (1) | WO2020018615A2 (https=) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019189640A1 (ja) * | 2018-03-28 | 2019-10-03 | 国立大学法人大阪大学 | 幹細胞由来涙腺組織の作製方法 |
| CA3109078A1 (en) * | 2018-07-17 | 2020-01-23 | The Regents Of The University Of California | Cells differentiated from immunoengineered pluripotent cells |
| US11162079B2 (en) | 2019-05-10 | 2021-11-02 | The Regents Of The University Of California | Blood type O Rh-hypo-immunogenic pluripotent cells |
| US12221622B2 (en) | 2019-05-10 | 2025-02-11 | The Regents Of The University Of California | Modified pluripotent cells |
| GB2584664B (en) * | 2019-06-10 | 2023-05-24 | Newcells Biotech Ltd | Improved retinal organoids and methods of making the same |
| JP7728747B2 (ja) | 2019-08-23 | 2025-08-25 | サナ バイオテクノロジー，インコーポレイテッド | Ｃｄ２４発現細胞およびそれらの用途 |
| WO2021146222A1 (en) * | 2020-01-13 | 2021-07-22 | Sana Biotechnology, Inc. | Modification of blood type antigens |
| WO2021146471A2 (en) * | 2020-01-15 | 2021-07-22 | The Regents Of The University Of California | Transplanted cell protection via inhibition of polymorphonuclear cells |
| KR20220158046A (ko) * | 2020-03-25 | 2022-11-29 | 사나 바이오테크놀로지, 인크. | 신경계 장애 및 병태의 치료를 위한 면역저하성 신경 세포 |
| AU2021262766A1 (en) * | 2020-04-27 | 2022-11-24 | Sana Biotechnology, Inc. | Repeat dosing of hypoimmunogenic cells |
| EP4149525A4 (en) * | 2020-05-15 | 2024-08-28 | Rxcell Inc. | HYPOIMMUNOGENIC CELLS AND THEIR USES IN IMMUNE RESPONSES |
| WO2022036150A1 (en) | 2020-08-13 | 2022-02-17 | Sana Biotechnology, Inc. | Methods of treating sensitized patients with hypoimmunogenic cells, and associated methods and compositions |
| US11459372B2 (en) | 2020-11-30 | 2022-10-04 | Crispr Therapeutics Ag | Gene-edited natural killer cells |
| WO2022125439A2 (en) * | 2020-12-07 | 2022-06-16 | The Regents Of The University Of California | Innate immune cell silencing by sirp-alpha engager |
| WO2022144632A1 (en) | 2020-12-30 | 2022-07-07 | Crispr Therapeutics Ag | Compositions and methods for differentiating stem cells into nk cells |
| JP2024501971A (ja) | 2020-12-31 | 2024-01-17 | サナ バイオテクノロジー，インコーポレイテッド | Ｃａｒ－ｔ活性を調節するための方法及び組成物 |
| WO2022187379A1 (en) | 2021-03-03 | 2022-09-09 | Sana Biotechnology, Inc. | Immunosuppressive therapies for use with cardiomyocyte cell therapies, and associated methods and compositions |
| US20240226164A1 (en) | 2021-05-27 | 2024-07-11 | Sana Biotechnology, Inc. | Hypoimmunogenic cells comprising engineered hla-e or hla-g |
| KR20240046319A (ko) | 2021-07-14 | 2024-04-08 | 사나 바이오테크놀로지, 인크. | 저면역원성 세포에서의 y 염색체-연결 항원의 변경된 발현 |
| AU2022327174A1 (en) | 2021-08-11 | 2024-02-15 | Sana Biotechnology, Inc. | Inducible systems for altering gene expression in hypoimmunogenic cells |
| JP2024535677A (ja) | 2021-08-11 | 2024-10-02 | サナ バイオテクノロジー，インコーポレイテッド | 即時血液媒介性炎症反応を減少させるための同種細胞療法を目的とした遺伝子改変細胞 |
| EP4384598A1 (en) | 2021-08-11 | 2024-06-19 | Sana Biotechnology, Inc. | Genetically modified cells for allogeneic cell therapy to reduce complement-mediated inflammatory reactions |
| US20240358761A1 (en) | 2021-08-11 | 2024-10-31 | Sana Biotechnology, Inc. | Genetically modified cells for allogeneic cell therapy |
| AU2022325232A1 (en) | 2021-08-11 | 2024-02-08 | Sana Biotechnology, Inc. | Genetically modified primary cells for allogeneic cell therapy |
| CN118159646A (zh) * | 2021-09-13 | 2024-06-07 | 富士胶片细胞动力公司 | 产生定向心脏祖细胞的方法 |
| WO2023047433A1 (en) * | 2021-09-23 | 2023-03-30 | The University Of Jordan | Dental pluripotent stem cells |
| CN115873797B (zh) * | 2021-09-29 | 2024-08-13 | 北京干细胞与再生医学研究院 | 一种视网膜色素上皮细胞的扩增培养基及培养方法 |
| WO2023069480A1 (en) * | 2021-10-20 | 2023-04-27 | Vascugen, Inc. | Hypoimmune vasculogenic cells |
| CN119072319A (zh) | 2021-12-23 | 2024-12-03 | 萨那生物技术股份有限公司 | 用于治疗自身免疫性疾病的嵌合抗原受体(car)t细胞及相关方法 |
| KR20240142624A (ko) * | 2022-01-10 | 2024-09-30 | 사나 바이오테크놀로지, 인크. | 만능줄기세포에서 분화된 면역저하 베타세포 및 관련 용도 및 방법 |
| US20250302953A1 (en) | 2022-02-14 | 2025-10-02 | Sana Biotechnology, Inc. | Methods of treating patients exhibiting a prior failed therapy with hypoimmunogenic cells |
| EP4479416A1 (en) | 2022-02-17 | 2024-12-25 | Sana Biotechnology, Inc. | Engineered cd47 proteins and uses thereof |
| WO2023173123A1 (en) | 2022-03-11 | 2023-09-14 | Sana Biotechnology, Inc. | Genetically modified cells and compositions and uses thereof |
| WO2023183313A1 (en) | 2022-03-22 | 2023-09-28 | Sana Biotechnology, Inc. | Engineering cells with a transgene in b2m or ciita locus and associated compositions and methods |
| CN116804185A (zh) | 2022-03-25 | 2023-09-26 | 士泽生物医药（苏州）有限公司 | 一种通用型细胞及其制备方法 |
| KR20250008812A (ko) * | 2022-04-07 | 2025-01-15 | 페이트 세러퓨틱스, 인코포레이티드 | 동종 세포 치료에 사용하기 위한 면역 인식 경로에 관여하는 스텔스 전략 |
| CN114958768B (zh) * | 2022-06-02 | 2023-03-24 | 健颐生物科技发展(山东)有限公司 | Fgf10旁分泌通用型人成纤维细胞制剂的制备方法 |
| US20260002124A1 (en) | 2022-07-01 | 2026-01-01 | Novo Nordisk A/S | Enhancing neuronal differentiation of ventral midbrain neural progenitor cells |
| WO2024030959A1 (en) | 2022-08-02 | 2024-02-08 | Sana Biotechnology, Inc. | Methods for differentiating cardiomyocytes |
| WO2024050349A2 (en) * | 2022-08-30 | 2024-03-07 | Emendobio Inc. | Strategies for knock-ins at b2m safe harbor sites |
| JP2026500455A (ja) * | 2022-10-25 | 2026-01-07 | ウィスコンシン アルムニ リサーチ ファンデイション | 幹細胞治療のための接着分子阻害 |
| EP4633658A1 (en) * | 2022-12-12 | 2025-10-22 | Proletariat Therapeutics, Inc. | Methods of treating cardiac injury |
| GB202218755D0 (en) * | 2022-12-13 | 2023-01-25 | Replay Holdings Llc | Compositions and methods for non-immunogenicity |
| WO2024151541A1 (en) | 2023-01-09 | 2024-07-18 | Sana Biotechnology, Inc. | Type-1 diabetes autoimmune mouse |
| AU2024264889A1 (en) | 2023-05-03 | 2025-11-13 | Sana Biotechnology, Inc. | Methods of dosing and administration of engineered islet cells |
| EP4716541A2 (en) | 2023-05-22 | 2026-04-01 | Sana Biotechnology, Inc. | Methods of delivery of islet cells and related methods |
| US12565639B2 (en) | 2023-06-13 | 2026-03-03 | Aspen Neuroscience, Inc. | Methods for differentiating dopaminergic neurons from stem cells |
| EP4735585A1 (en) | 2023-06-30 | 2026-05-06 | Novo Nordisk A/S | Enhancing neuronal differentiation of neural progenitor cells |
| KR102740042B1 (ko) * | 2023-07-12 | 2024-12-06 | ㈜바이오솔빅스 | 인간 전분화능 줄기세포로 유래된 심장 오가노이드 제조방법, 효능 및 독성 평가 기술 |
| IL326274A (en) * | 2023-08-02 | 2026-04-01 | Fate Therapeutics Inc | A targeted scaffold for solid tumors that promotes effector cell differentiation and function |
| WO2025043172A1 (en) | 2023-08-23 | 2025-02-27 | Sana Biotechnology, Inc. | Modified cd47 proteins and their uses |
| WO2025047921A1 (ja) * | 2023-09-01 | 2025-03-06 | 株式会社セル―ジョン | 拒絶反応に対する回避方法 |
| WO2025054202A1 (en) | 2023-09-05 | 2025-03-13 | Sana Biotechnology, Inc. | Method of screening a sample comprising a transgene with a unique barcode |
| WO2025075929A1 (en) * | 2023-10-02 | 2025-04-10 | Neurona Therapeutics Inc. | Methods of treating seizure activity |
| WO2025096757A1 (en) | 2023-11-01 | 2025-05-08 | Sana Biotechnology, Inc. | Hypoimmunogenic cd22-targeted car t cells for the treatment of relapsed and/or refractory b cell lymphomas |
| WO2025151838A1 (en) | 2024-01-12 | 2025-07-17 | Sana Biotechnology, Inc. | Safety switches to control in vitro and in vivo proliferation of cell therapy products |
| CN117919504B (zh) * | 2024-01-29 | 2024-12-20 | 山东第一医科大学附属省立医院(山东省立医院) | 一种ros响应微纳结构钛植入物纳米涂层及其制备方法与应用 |
| CN118345030B (zh) * | 2024-06-20 | 2024-08-16 | 羽铂精制生物技术(成都)有限公司 | iPSC诱导分化成为胰腺祖细胞修复胰腺的方法及应用 |
| CN119464205A (zh) * | 2025-01-16 | 2025-02-18 | 北京大学第三医院（北京大学第三临床医学院） | 干细胞来源的功能增强型间充质基质细胞及其制备方法和应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001011011A2 (en) * | 1999-08-05 | 2001-02-15 | Mcl Llc | Multipotent adult stem cells and methods for isolation |
| US8491883B2 (en) * | 2003-06-27 | 2013-07-23 | Advanced Technologies And Regenerative Medicine, Llc | Treatment of amyotrophic lateral sclerosis using umbilical derived cells |
| WO2006071778A2 (en) * | 2004-12-23 | 2006-07-06 | Ethicon Incorporated | Treatment of parkinson's disease and related disorders using postpartum derived cells |
| CA2771336C (en) * | 2009-09-15 | 2019-11-26 | The Board Of Trustees Of The Leland Stanford Junior University | Synergistic anti-cd47 therapy for hematologic cancers |
| WO2011130675A2 (en) * | 2010-04-16 | 2011-10-20 | The Mclean Hospital Corporation | Dopaminergic neurons differentiated from pluripotent stem cells and uses of thereof |
| WO2014078414A1 (en) * | 2012-11-13 | 2014-05-22 | Joseph Wu | Chemically defined production of cardiomyocytes from pluripotent stem cells |
| AU2014248167B2 (en) * | 2013-04-03 | 2019-10-10 | FUJIFILM Cellular Dynamics, Inc. | Methods and compositions for culturing endoderm progenitor cells in suspension |
| KR101696874B1 (ko) * | 2013-07-31 | 2017-01-16 | 한국생명공학연구원 | 직접 리프로그래밍을 통한 유도 도파민성 전구세포 제조방법 |
| WO2015042356A1 (en) * | 2013-09-19 | 2015-03-26 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Chemically defined culture medium for stem cell maintenance and differentiation |
| US20180243343A1 (en) * | 2015-02-26 | 2018-08-30 | The Mclean Hospital Corporation | Methods and compositions for the treatment or prevention of parkinson's disease |
| CN107921148A (zh) * | 2015-05-08 | 2018-04-17 | 哈佛学院校长同事会 | 通用供体干细胞和相关方法 |
| EP3344758B1 (en) * | 2015-09-01 | 2021-09-29 | Ncardia B.V. | An in vitro method of differentiating a human pluripotent stem cell population into a cardiomyocyte cell population |
| KR20250141836A (ko) * | 2015-11-04 | 2025-09-29 | 페이트 세러퓨틱스, 인코포레이티드 | 만능 세포의 유전자 조작 |
| JP2020505025A (ja) * | 2017-01-13 | 2020-02-20 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 免疫工学的な改変をした多能性細胞 |
| CN108048484B (zh) * | 2017-11-14 | 2021-07-06 | 海南一龄医疗产业发展有限公司 | 诱导性多能干细胞及其制备方法和应用 |
| CA3109078A1 (en) * | 2018-07-17 | 2020-01-23 | The Regents Of The University Of California | Cells differentiated from immunoengineered pluripotent cells |
| KR20220158046A (ko) * | 2020-03-25 | 2022-11-29 | 사나 바이오테크놀로지, 인크. | 신경계 장애 및 병태의 치료를 위한 면역저하성 신경 세포 |
-
2019
- 2019-07-17 CA CA3109078A patent/CA3109078A1/en active Pending
- 2019-07-17 JP JP2021502525A patent/JP2021530232A/ja active Pending
- 2019-07-17 KR KR1020217004402A patent/KR20210032454A/ko not_active Ceased
- 2019-07-17 EP EP19837257.5A patent/EP3824074A4/en active Pending
- 2019-07-17 CN CN201980056481.9A patent/CN112639079A/zh active Pending
- 2019-07-17 BR BR112021000637-0A patent/BR112021000637A2/pt unknown
- 2019-07-17 SG SG11202100157YA patent/SG11202100157YA/en unknown
- 2019-07-17 MX MX2021000614A patent/MX2021000614A/es unknown
- 2019-07-17 AU AU2019305585A patent/AU2019305585A1/en not_active Abandoned
- 2019-07-17 IL IL314721A patent/IL314721A/en unknown
- 2019-07-17 WO PCT/US2019/042117 patent/WO2020018615A2/en not_active Ceased
- 2019-07-17 US US17/260,224 patent/US20210292715A1/en not_active Abandoned
- 2019-07-17 CN CN202411496724.XA patent/CN119372151A/zh active Pending
-
2020
- 2020-12-30 IL IL279871A patent/IL279871A/en unknown
-
2021
- 2021-01-15 MX MX2025004255A patent/MX2025004255A/es unknown
-
2024
- 2024-01-10 JP JP2024001947A patent/JP2024050597A/ja active Pending
-
2025
- 2025-01-09 US US19/015,552 patent/US20250283051A1/en active Pending
- 2025-08-28 AU AU2025223802A patent/AU2025223802A1/en active Pending
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