MX2019008413A - Celulas pluripotentes inmunodiseñadas. - Google Patents

Celulas pluripotentes inmunodiseñadas.

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Publication number
MX2019008413A
MX2019008413A MX2019008413A MX2019008413A MX2019008413A MX 2019008413 A MX2019008413 A MX 2019008413A MX 2019008413 A MX2019008413 A MX 2019008413A MX 2019008413 A MX2019008413 A MX 2019008413A MX 2019008413 A MX2019008413 A MX 2019008413A
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MX
Mexico
Prior art keywords
pluripotent cells
avoid
provides
immunoengineered
rejection
Prior art date
Application number
MX2019008413A
Other languages
English (en)
Inventor
SCHREPFER Sonja
Deuse Tobias
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Univ California filed Critical Univ California
Publication of MX2019008413A publication Critical patent/MX2019008413A/es

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
    • A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
    • C—CHEMISTRY; METALLURGY
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/599—Cell markers; Cell surface determinants with CD designations not provided for elsewhere
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    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/005—Vectors comprising a special translation-regulating system cell cycle specific
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    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/007—Vectors comprising a special translation-regulating system cell or tissue specific
    • C—CHEMISTRY; METALLURGY
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    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
    • C12Y207/01021—Thymidine kinase (2.7.1.21)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/04—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amidines (3.5.4)
    • C12Y305/04001—Cytosine deaminase (3.5.4.1)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

La invención proporciona células pluripotentes que se usan terapéuticamente para regenerar tejidos que evitan el rechazo de los sujetos que las reciben. En particular, la invención proporciona células pluripotentes hipoinmunogénicas que evitan el rechazo inmune del huésped. Las células carecen de antígenos inmunes importantes que desencadenan respuestas inmunes y están diseñadas para evitar la endocitosis fagocítica. La invención proporciona además células pluripotentes "disponibles en el mercado" universalmente aceptables y derivados de las mismas para generar o regenerar tejidos y órganos específicos.
MX2019008413A 2017-01-13 2018-01-14 Celulas pluripotentes inmunodiseñadas. MX2019008413A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762445969P 2017-01-13 2017-01-13
PCT/US2018/013688 WO2018132783A1 (en) 2017-01-13 2018-01-14 Immunoengineered pluripotent cells

Publications (1)

Publication Number Publication Date
MX2019008413A true MX2019008413A (es) 2019-09-13

Family

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MX2019008413A MX2019008413A (es) 2017-01-13 2018-01-14 Celulas pluripotentes inmunodiseñadas.

Country Status (13)

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US (2) US20190376045A1 (es)
EP (1) EP3568464A1 (es)
JP (2) JP2020505025A (es)
KR (1) KR20190103373A (es)
CN (1) CN110177869A (es)
AU (1) AU2018207649A1 (es)
BR (1) BR112019014257A2 (es)
CA (1) CA3049766A1 (es)
EA (1) EA201991692A1 (es)
IL (1) IL267616A (es)
MX (1) MX2019008413A (es)
NZ (1) NZ754898A (es)
WO (1) WO2018132783A1 (es)

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AU2018207649A1 (en) 2019-07-11
KR20190103373A (ko) 2019-09-04
CN110177869A (zh) 2019-08-27
IL267616A (en) 2019-08-29
BR112019014257A2 (pt) 2020-04-28
JP2020505025A (ja) 2020-02-20
US20230348862A1 (en) 2023-11-02
CA3049766A1 (en) 2018-07-19
EA201991692A1 (ru) 2019-12-30
EP3568464A1 (en) 2019-11-20
WO2018132783A1 (en) 2018-07-19
NZ754898A (en) 2023-11-24
US20190376045A1 (en) 2019-12-12
JP2023052079A (ja) 2023-04-11

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