JP2023052079A5 - - Google Patents
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- JP2023052079A5 JP2023052079A5 JP2022208126A JP2022208126A JP2023052079A5 JP 2023052079 A5 JP2023052079 A5 JP 2023052079A5 JP 2022208126 A JP2022208126 A JP 2022208126A JP 2022208126 A JP2022208126 A JP 2022208126A JP 2023052079 A5 JP2023052079 A5 JP 2023052079A5
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- Japan
- Prior art keywords
- hypoimmunogenic
- cell
- cells
- hla
- genes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000004027 cell Anatomy 0.000 claims 306
- 108090000623 proteins and genes Proteins 0.000 claims 108
- 238000000034 method Methods 0.000 claims 87
- 230000014509 gene expression Effects 0.000 claims 52
- 239000008194 pharmaceutical composition Substances 0.000 claims 34
- 238000012239 gene modification Methods 0.000 claims 33
- 230000005017 genetic modification Effects 0.000 claims 33
- 235000013617 genetically modified food Nutrition 0.000 claims 33
- 101000868279 Homo sapiens Leukocyte surface antigen CD47 Proteins 0.000 claims 30
- 102100032913 Leukocyte surface antigen CD47 Human genes 0.000 claims 30
- 230000001939 inductive effect Effects 0.000 claims 22
- 102000011727 Caspases Human genes 0.000 claims 18
- 108010076667 Caspases Proteins 0.000 claims 18
- 230000001225 therapeutic effect Effects 0.000 claims 18
- 230000002163 immunogen Effects 0.000 claims 16
- 210000001685 thyroid gland Anatomy 0.000 claims 15
- 230000004077 genetic alteration Effects 0.000 claims 10
- 231100000118 genetic alteration Toxicity 0.000 claims 10
- 210000004413 cardiac myocyte Anatomy 0.000 claims 8
- 230000001332 colony forming effect Effects 0.000 claims 8
- 210000002889 endothelial cell Anatomy 0.000 claims 8
- 230000003511 endothelial effect Effects 0.000 claims 8
- 210000004153 islets of langerhan Anatomy 0.000 claims 8
- 210000003061 neural cell Anatomy 0.000 claims 8
- 210000000844 retinal pigment epithelial cell Anatomy 0.000 claims 8
- 210000000329 smooth muscle myocyte Anatomy 0.000 claims 8
- 210000000130 stem cell Anatomy 0.000 claims 8
- 230000004048 modification Effects 0.000 claims 7
- 238000012986 modification Methods 0.000 claims 7
- 239000013598 vector Substances 0.000 claims 7
- 101900095660 Escherichia coli Cytosine deaminase Proteins 0.000 claims 6
- 241000700584 Simplexvirus Species 0.000 claims 6
- 108020004440 Thymidine kinase Proteins 0.000 claims 6
- 239000000427 antigen Substances 0.000 claims 6
- 108091007433 antigens Proteins 0.000 claims 6
- 102000036639 antigens Human genes 0.000 claims 6
- XRECTZIEBJDKEO-UHFFFAOYSA-N flucytosine Chemical group NC1=NC(=O)NC=C1F XRECTZIEBJDKEO-UHFFFAOYSA-N 0.000 claims 6
- 229960004413 flucytosine Drugs 0.000 claims 6
- 210000002569 neuron Anatomy 0.000 claims 6
- 102000004169 proteins and genes Human genes 0.000 claims 6
- 108010075704 HLA-A Antigens Proteins 0.000 claims 4
- 108010058607 HLA-B Antigens Proteins 0.000 claims 4
- 108010052199 HLA-C Antigens Proteins 0.000 claims 4
- 108010010378 HLA-DP Antigens Proteins 0.000 claims 4
- 108010062347 HLA-DQ Antigens Proteins 0.000 claims 4
- 108010058597 HLA-DR Antigens Proteins 0.000 claims 4
- 101100382122 Homo sapiens CIITA gene Proteins 0.000 claims 4
- 108010017070 Zinc Finger Nucleases Proteins 0.000 claims 4
- 102000015736 beta 2-Microglobulin Human genes 0.000 claims 4
- 108010081355 beta 2-Microglobulin Proteins 0.000 claims 4
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims 4
- 101710163270 Nuclease Proteins 0.000 claims 3
- 108700019146 Transgenes Proteins 0.000 claims 3
- 238000006471 dimerization reaction Methods 0.000 claims 3
- IRSCQMHQWWYFCW-UHFFFAOYSA-N ganciclovir Chemical group O=C1NC(N)=NC2=C1N=CN2COC(CO)CO IRSCQMHQWWYFCW-UHFFFAOYSA-N 0.000 claims 3
- 229960002963 ganciclovir Drugs 0.000 claims 3
- 239000000411 inducer Substances 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 239000000126 substance Substances 0.000 claims 3
- 101150076800 B2M gene Proteins 0.000 claims 2
- 206010057249 Phagocytosis Diseases 0.000 claims 2
- 230000003213 activating effect Effects 0.000 claims 2
- 210000003663 amniotic stem cell Anatomy 0.000 claims 2
- 230000036755 cellular response Effects 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 210000001671 embryonic stem cell Anatomy 0.000 claims 2
- 210000000604 fetal stem cell Anatomy 0.000 claims 2
- 210000004185 liver Anatomy 0.000 claims 2
- 210000002540 macrophage Anatomy 0.000 claims 2
- 210000001178 neural stem cell Anatomy 0.000 claims 2
- 230000008782 phagocytosis Effects 0.000 claims 2
- 230000001177 retroviral effect Effects 0.000 claims 2
- 210000001988 somatic stem cell Anatomy 0.000 claims 2
- 108700028369 Alleles Proteins 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 206010016654 Fibrosis Diseases 0.000 claims 1
- 208000030836 Hashimoto thyroiditis Diseases 0.000 claims 1
- 241000711408 Murine respirovirus Species 0.000 claims 1
- 238000010459 TALEN Methods 0.000 claims 1
- 108010043645 Transcription Activator-Like Effector Nucleases Proteins 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 238000002659 cell therapy Methods 0.000 claims 1
- 230000007882 cirrhosis Effects 0.000 claims 1
- 208000019425 cirrhosis of liver Diseases 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000012636 effector Substances 0.000 claims 1
- 208000030533 eye disease Diseases 0.000 claims 1
- 210000002216 heart Anatomy 0.000 claims 1
- 210000003494 hepatocyte Anatomy 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 210000000496 pancreas Anatomy 0.000 claims 1
- 208000030613 peripheral artery disease Diseases 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 230000002103 transcriptional effect Effects 0.000 claims 1
- 239000013603 viral vector Substances 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025003516A JP2025069169A (ja) | 2017-01-13 | 2025-01-09 | 免疫工学的な改変をした多能性細胞 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762445969P | 2017-01-13 | 2017-01-13 | |
| US62/445,969 | 2017-01-13 | ||
| JP2019538202A JP2020505025A (ja) | 2017-01-13 | 2018-01-14 | 免疫工学的な改変をした多能性細胞 |
| PCT/US2018/013688 WO2018132783A1 (en) | 2017-01-13 | 2018-01-14 | Immunoengineered pluripotent cells |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019538202A Division JP2020505025A (ja) | 2017-01-13 | 2018-01-14 | 免疫工学的な改変をした多能性細胞 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025003516A Division JP2025069169A (ja) | 2017-01-13 | 2025-01-09 | 免疫工学的な改変をした多能性細胞 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023052079A JP2023052079A (ja) | 2023-04-11 |
| JP2023052079A5 true JP2023052079A5 (https=) | 2023-06-19 |
Family
ID=61148505
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019538202A Pending JP2020505025A (ja) | 2017-01-13 | 2018-01-14 | 免疫工学的な改変をした多能性細胞 |
| JP2022208126A Pending JP2023052079A (ja) | 2017-01-13 | 2022-12-26 | 免疫工学的な改変をした多能性細胞 |
| JP2025003516A Pending JP2025069169A (ja) | 2017-01-13 | 2025-01-09 | 免疫工学的な改変をした多能性細胞 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019538202A Pending JP2020505025A (ja) | 2017-01-13 | 2018-01-14 | 免疫工学的な改変をした多能性細胞 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025003516A Pending JP2025069169A (ja) | 2017-01-13 | 2025-01-09 | 免疫工学的な改変をした多能性細胞 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20190376045A1 (https=) |
| EP (1) | EP3568464A1 (https=) |
| JP (3) | JP2020505025A (https=) |
| KR (2) | KR20190103373A (https=) |
| CN (1) | CN110177869A (https=) |
| AU (2) | AU2018207649B2 (https=) |
| BR (1) | BR112019014257A2 (https=) |
| CA (1) | CA3049766A1 (https=) |
| EA (1) | EA201991692A1 (https=) |
| IL (1) | IL267616A (https=) |
| MX (1) | MX2019008413A (https=) |
| WO (1) | WO2018132783A1 (https=) |
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| CN107921148A (zh) | 2015-05-08 | 2018-04-17 | 哈佛学院校长同事会 | 通用供体干细胞和相关方法 |
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| JP2020505025A (ja) * | 2017-01-13 | 2020-02-20 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 免疫工学的な改変をした多能性細胞 |
| CA3094322A1 (en) * | 2017-03-20 | 2018-09-27 | Washington University | Cells and methods of uses and making the same |
| WO2018175636A2 (en) | 2017-03-22 | 2018-09-27 | Novartis Ag | Compositions and methods for immunooncology |
| IL270835B2 (en) | 2017-06-12 | 2025-01-01 | Sinai Health Sys | Allograft tolerance without the need for systemic immunosuppression |
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| GB8724885D0 (en) | 1987-10-23 | 1987-11-25 | Binns M M | Fowlpox virus promotors |
| DE19539493A1 (de) | 1995-10-24 | 1997-04-30 | Thomae Gmbh Dr K | Starker homologer Promotor aus Hamster |
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