BR112019014257A2 - método para gerar uma célula-tronco pluripotente hipoimunogênica, célula-tronco pluripotente hipoimunogênica humana, método para produzir uma célula pluripotente hipoimunogênica, e ss-2 microglobulina - Google Patents
método para gerar uma célula-tronco pluripotente hipoimunogênica, célula-tronco pluripotente hipoimunogênica humana, método para produzir uma célula pluripotente hipoimunogênica, e ss-2 microglobulina Download PDFInfo
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- BR112019014257A2 BR112019014257A2 BR112019014257-6A BR112019014257A BR112019014257A2 BR 112019014257 A2 BR112019014257 A2 BR 112019014257A2 BR 112019014257 A BR112019014257 A BR 112019014257A BR 112019014257 A2 BR112019014257 A2 BR 112019014257A2
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- DQVUCKSWFSCYJW-UHFFFAOYSA-N CC(C)C1CC#CCC1 Chemical compound CC(C)C1CC#CCC1 DQVUCKSWFSCYJW-UHFFFAOYSA-N 0.000 description 1
- MEBONNVPKOBPEA-UHFFFAOYSA-N CC1C(C)(C)CCCC1 Chemical compound CC1C(C)(C)CCCC1 MEBONNVPKOBPEA-UHFFFAOYSA-N 0.000 description 1
- PQXAPVOKLYINEI-UHFFFAOYSA-N CCC1CC(C)CC1 Chemical compound CCC1CC(C)CC1 PQXAPVOKLYINEI-UHFFFAOYSA-N 0.000 description 1
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
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- A—HUMAN NECESSITIES
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- A61K35/48—Reproductive organs
- A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
- A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
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- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/005—Vectors comprising a special translation-regulating system cell cycle specific
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- C12N2840/00—Vectors comprising a special translation-regulating system
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- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
- C12Y207/01021—Thymidine kinase (2.7.1.21)
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- C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
- C12Y305/04—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amidines (3.5.4)
- C12Y305/04001—Cytosine deaminase (3.5.4.1)
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
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- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Transplantation (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Reproductive Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Gynecology & Obstetrics (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762445969P | 2017-01-13 | 2017-01-13 | |
| US62/445,969 | 2017-01-13 | ||
| PCT/US2018/013688 WO2018132783A1 (en) | 2017-01-13 | 2018-01-14 | Immunoengineered pluripotent cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112019014257A2 true BR112019014257A2 (pt) | 2020-04-28 |
Family
ID=61148505
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112019014257-6A BR112019014257A2 (pt) | 2017-01-13 | 2018-01-14 | método para gerar uma célula-tronco pluripotente hipoimunogênica, célula-tronco pluripotente hipoimunogênica humana, método para produzir uma célula pluripotente hipoimunogênica, e ss-2 microglobulina |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20190376045A1 (https=) |
| EP (1) | EP3568464A1 (https=) |
| JP (3) | JP2020505025A (https=) |
| KR (2) | KR20240095477A (https=) |
| CN (1) | CN110177869A (https=) |
| AU (2) | AU2018207649B2 (https=) |
| BR (1) | BR112019014257A2 (https=) |
| CA (1) | CA3049766A1 (https=) |
| EA (1) | EA201991692A1 (https=) |
| IL (1) | IL267616A (https=) |
| MX (1) | MX2019008413A (https=) |
| WO (1) | WO2018132783A1 (https=) |
Families Citing this family (97)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2015360502A1 (en) | 2014-12-10 | 2017-06-29 | Regents Of The University Of Minnesota | Genetically modified cells, tissues, and organs for treating disease |
| EP3294342A4 (en) | 2015-05-08 | 2018-11-07 | President and Fellows of Harvard College | Universal donor stem cells and related methods |
| EA201891338A1 (ru) | 2015-12-04 | 2018-12-28 | Новартис Аг | Композиции и способы для иммуноонкологии |
| CN110177869A (zh) * | 2017-01-13 | 2019-08-27 | 加利福尼亚大学董事会 | 免疫改造的多能细胞 |
| CN110637083A (zh) * | 2017-03-20 | 2019-12-31 | 华盛顿大学 | 细胞及其使用和制备方法 |
| WO2018175636A2 (en) | 2017-03-22 | 2018-09-27 | Novartis Ag | Compositions and methods for immunooncology |
| CN120041380A (zh) | 2017-06-12 | 2025-05-27 | 西奈卫生系统公司 | 无需全身性免疫遏制的同种异体移植物耐受 |
| US11866726B2 (en) | 2017-07-14 | 2024-01-09 | Editas Medicine, Inc. | Systems and methods for targeted integration and genome editing and detection thereof using integrated priming sites |
| US20210308183A1 (en) * | 2018-07-17 | 2021-10-07 | The Regents Of The University Of California | Chimeric antigen receptor t cells derived from immunoengineered pluripotent stem cells |
| BR112021000637A2 (pt) * | 2018-07-17 | 2021-04-13 | The Regents Of The University Of California | Célula cardíaca hipoimune isolada, método para tratar um paciente que sofre de uma afecção ou doença cardíaca, método para produzir uma população de células cardíacas hipoimunes, célula endotelial hipoimune isolada, método para tratar um paciente que sofre de uma afecção ou doença vascular, método para produzir uma população de células endoteliais hipoimunes, neurônio dopaminérgico hipoimune isolado, método para tratar um paciente que sofre de uma doença ou afecção neurodegenerativa, método para produzir uma população de neurônios dopaminérgicos hipoimunes, célula de ilhota pancreática hipoimune isolada, método para tratar um paciente que sofre de diabetes, método para produzir uma população de células de ilhota pancreática hipoimunes, célula de epitélio pigmentado da retina (rpe) hipoimune isolada, método para tratar um paciente que sofre de uma afecção ocular, e método para produzir uma população de células de epitélio pigmentado da retina (rpe) hipoimunes |
| US12378572B2 (en) | 2018-09-07 | 2025-08-05 | Crispr Therapeutics Ag | Universal donor cells |
| CN113195724A (zh) * | 2018-09-26 | 2021-07-30 | 新加坡国立大学 | 低免疫原性的工程化人类间充质基质细胞,制备方法和试剂盒 |
| UY38427A (es) * | 2018-10-26 | 2020-05-29 | Novartis Ag | Métodos y composiciones para terapia con células oculares |
| CN111424016A (zh) * | 2019-01-09 | 2020-07-17 | 复旦大学 | 降低细胞免疫原性的诱导型多能干细胞系及建立方法 |
| KR20210128440A (ko) * | 2019-02-15 | 2021-10-26 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 범용 공여자 줄기 세포 및 관련 방법 |
| US11162079B2 (en) | 2019-05-10 | 2021-11-02 | The Regents Of The University Of California | Blood type O Rh-hypo-immunogenic pluripotent cells |
| WO2020231882A2 (en) * | 2019-05-10 | 2020-11-19 | The Regents Of The University Of California | Modified pluripotent cells |
| US12391923B2 (en) | 2019-06-26 | 2025-08-19 | The Regents Of The University Of California | SIRPα-silenced natural killer (NK) cells |
| TW202115245A (zh) * | 2019-06-27 | 2021-04-16 | 丹麥商諾佛 儂迪克股份有限公司 | 安全免疫隱形細胞 |
| EP4022037A1 (en) | 2019-07-10 | 2022-07-06 | Helmuth Heinrich Kunz | Methods for deriving autologous and hypoimmunogenic hair follicle containing sheets in vitro |
| JP2022543112A (ja) * | 2019-08-01 | 2022-10-07 | サナ バイオテクノロジー,インコーポレイテッド | Dux4発現細胞およびそれらの使用 |
| AU2020336302A1 (en) | 2019-08-23 | 2022-03-03 | Sana Biotechnology, Inc. | CD24 expressing cells and uses thereof |
| KR20220058579A (ko) | 2019-09-05 | 2022-05-09 | 크리스퍼 테라퓨틱스 아게 | 보편적 공여자 세포 |
| US11104918B2 (en) * | 2019-09-05 | 2021-08-31 | Crispr Therapeutics Ag | Universal donor cells |
| CA3153700A1 (en) * | 2019-09-09 | 2021-03-18 | Scribe Therapeutics Inc. | Compositions and methods for use in immunotherapy |
| WO2021055985A1 (en) * | 2019-09-22 | 2021-03-25 | Cellerant Therapeutics, Inc. | Ipsc-derived, hypoimmunogenic, myeloid progenitor cells |
| JP2022551975A (ja) * | 2019-10-15 | 2022-12-14 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | Fc封鎖を介する移植細胞保護 |
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| EP4585223A3 (en) | 2020-01-15 | 2025-07-30 | The Regents of the University of California | Transplanted cell protection via inhibition of polymorphonuclear cells |
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| EP4132544A4 (en) * | 2020-04-06 | 2024-10-23 | Rxcell Inc. | HYPOIMMUNOGENIC CELLS AND METHODS AND COMPOSITIONS FOR THEIR PRODUCTION |
| EP4138893A4 (en) * | 2020-04-21 | 2024-06-12 | Intima Bioscience, Inc. | CELLULAR VACCINE PLATFORM AND METHODS OF USE THEREOF |
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| EP4313087A4 (en) * | 2021-03-30 | 2025-03-19 | The Regents of the University of California | PROTECTION OF TRANSPLANTED CELLS VIA MODIFIED FC RECEPTORS |
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