KR20190103373A - 면역조작된 만능 세포 - Google Patents
면역조작된 만능 세포 Download PDFInfo
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- KR20190103373A KR20190103373A KR1020197023696A KR20197023696A KR20190103373A KR 20190103373 A KR20190103373 A KR 20190103373A KR 1020197023696 A KR1020197023696 A KR 1020197023696A KR 20197023696 A KR20197023696 A KR 20197023696A KR 20190103373 A KR20190103373 A KR 20190103373A
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
- A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/599—Cell markers; Cell surface determinants with CD designations not provided for elsewhere
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/005—Vectors comprising a special translation-regulating system cell cycle specific
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/007—Vectors comprising a special translation-regulating system cell or tissue specific
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
- C12Y207/01021—Thymidine kinase (2.7.1.21)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
- C12Y305/04—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amidines (3.5.4)
- C12Y305/04001—Cytosine deaminase (3.5.4.1)
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Transplantation (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Reproductive Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gynecology & Obstetrics (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020247020089A KR20240095477A (ko) | 2017-01-13 | 2018-01-14 | 면역조작된 만능 세포 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762445969P | 2017-01-13 | 2017-01-13 | |
| US62/445,969 | 2017-01-13 | ||
| PCT/US2018/013688 WO2018132783A1 (en) | 2017-01-13 | 2018-01-14 | Immunoengineered pluripotent cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020247020089A Division KR20240095477A (ko) | 2017-01-13 | 2018-01-14 | 면역조작된 만능 세포 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20190103373A true KR20190103373A (ko) | 2019-09-04 |
Family
ID=61148505
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020197023696A Ceased KR20190103373A (ko) | 2017-01-13 | 2018-01-14 | 면역조작된 만능 세포 |
| KR1020247020089A Pending KR20240095477A (ko) | 2017-01-13 | 2018-01-14 | 면역조작된 만능 세포 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020247020089A Pending KR20240095477A (ko) | 2017-01-13 | 2018-01-14 | 면역조작된 만능 세포 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20190376045A1 (https=) |
| EP (1) | EP3568464A1 (https=) |
| JP (3) | JP2020505025A (https=) |
| KR (2) | KR20190103373A (https=) |
| CN (1) | CN110177869A (https=) |
| AU (2) | AU2018207649B2 (https=) |
| BR (1) | BR112019014257A2 (https=) |
| CA (1) | CA3049766A1 (https=) |
| EA (1) | EA201991692A1 (https=) |
| IL (1) | IL267616A (https=) |
| MX (1) | MX2019008413A (https=) |
| WO (1) | WO2018132783A1 (https=) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20230020351A (ko) * | 2021-07-28 | 2023-02-10 | 의료법인 성광의료재단 | B2m 유전자의 발현이 저해된 유전적으로 조작된 줄기세포 및 이의 이용방법 |
| KR102740042B1 (ko) * | 2023-07-12 | 2024-12-06 | ㈜바이오솔빅스 | 인간 전분화능 줄기세포로 유래된 심장 오가노이드 제조방법, 효능 및 독성 평가 기술 |
Families Citing this family (95)
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| CN116059378A (zh) | 2014-12-10 | 2023-05-05 | 明尼苏达大学董事会 | 用于治疗疾病的遗传修饰的细胞、组织和器官 |
| CN107921148A (zh) | 2015-05-08 | 2018-04-17 | 哈佛学院校长同事会 | 通用供体干细胞和相关方法 |
| WO2017093969A1 (en) | 2015-12-04 | 2017-06-08 | Novartis Ag | Compositions and methods for immunooncology |
| JP2020505025A (ja) * | 2017-01-13 | 2020-02-20 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 免疫工学的な改変をした多能性細胞 |
| CA3094322A1 (en) * | 2017-03-20 | 2018-09-27 | Washington University | Cells and methods of uses and making the same |
| WO2018175636A2 (en) | 2017-03-22 | 2018-09-27 | Novartis Ag | Compositions and methods for immunooncology |
| IL270835B2 (en) | 2017-06-12 | 2025-01-01 | Sinai Health Sys | Allograft tolerance without the need for systemic immunosuppression |
| US11866726B2 (en) | 2017-07-14 | 2024-01-09 | Editas Medicine, Inc. | Systems and methods for targeted integration and genome editing and detection thereof using integrated priming sites |
| WO2020018620A1 (en) * | 2018-07-17 | 2020-01-23 | The Regents Of The University Of California | Chimeric antigen receptor t cells derived from immunoengineered pluripotent stem cells |
| CA3109078A1 (en) * | 2018-07-17 | 2020-01-23 | The Regents Of The University Of California | Cells differentiated from immunoengineered pluripotent cells |
| US12378572B2 (en) * | 2018-09-07 | 2025-08-05 | Crispr Therapeutics Ag | Universal donor cells |
| WO2020067993A1 (en) * | 2018-09-26 | 2020-04-02 | National University Of Singapore | Engineered human mesenchymal stromal cells with low immunogenicity, methods and kits of generating the same |
| UY38427A (es) * | 2018-10-26 | 2020-05-29 | Novartis Ag | Métodos y composiciones para terapia con células oculares |
| CN111424016A (zh) * | 2019-01-09 | 2020-07-17 | 复旦大学 | 降低细胞免疫原性的诱导型多能干细胞系及建立方法 |
| KR20210128440A (ko) * | 2019-02-15 | 2021-10-26 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 범용 공여자 줄기 세포 및 관련 방법 |
| US12221622B2 (en) * | 2019-05-10 | 2025-02-11 | The Regents Of The University Of California | Modified pluripotent cells |
| US11162079B2 (en) | 2019-05-10 | 2021-11-02 | The Regents Of The University Of California | Blood type O Rh-hypo-immunogenic pluripotent cells |
| CA3144621A1 (en) | 2019-06-26 | 2020-12-30 | The Regents Of The University Of California | Sirpalpha-silenced natural killer (nk) cells |
| TW202115245A (zh) * | 2019-06-27 | 2021-04-16 | 丹麥商諾佛 儂迪克股份有限公司 | 安全免疫隱形細胞 |
| US20220333082A1 (en) | 2019-07-10 | 2022-10-20 | Helmuth Heinrich Kunz | Methods for deriving autologous and hypoimmunogenic hair follicle containing sheets in vitro |
| US20220267732A1 (en) * | 2019-08-01 | 2022-08-25 | Sana Biotechnology, Inc. | Dux4 expressing cells and uses thereof |
| JP7728747B2 (ja) | 2019-08-23 | 2025-08-25 | サナ バイオテクノロジー,インコーポレイテッド | Cd24発現細胞およびそれらの用途 |
| PH12022550542A1 (en) | 2019-09-05 | 2023-03-20 | Crispr Therapeutics Ag | Universal donor cells |
| CA3150235A1 (en) * | 2019-09-05 | 2021-03-11 | Alireza Rezania | Universal donor cells |
| WO2021050601A1 (en) * | 2019-09-09 | 2021-03-18 | Scribe Therapeutics Inc. | Compositions and methods for use in immunotherapy |
| WO2021055985A1 (en) * | 2019-09-22 | 2021-03-25 | Cellerant Therapeutics, Inc. | Ipsc-derived, hypoimmunogenic, myeloid progenitor cells |
| CN114787351A (zh) * | 2019-10-15 | 2022-07-22 | 加利福尼亚大学董事会 | 通过Fc隔离的移植细胞保护 |
| WO2021146222A1 (en) | 2020-01-13 | 2021-07-22 | Sana Biotechnology, Inc. | Modification of blood type antigens |
| WO2021146471A2 (en) | 2020-01-15 | 2021-07-22 | The Regents Of The University Of California | Transplanted cell protection via inhibition of polymorphonuclear cells |
| KR20220142433A (ko) | 2020-01-17 | 2022-10-21 | 사나 바이오테크놀로지, 인크. | 유전자 발현 조절용 안전 스위치 |
| KR20220158046A (ko) * | 2020-03-25 | 2022-11-29 | 사나 바이오테크놀로지, 인크. | 신경계 장애 및 병태의 치료를 위한 면역저하성 신경 세포 |
| US20230374448A1 (en) * | 2020-04-06 | 2023-11-23 | Rxcell Inc. | Hypoimmunogenic Cells and Methods and Compositions for Their Production |
| EP4138893A4 (en) * | 2020-04-21 | 2024-06-12 | Intima Bioscience, Inc. | CELLULAR VACCINE PLATFORM AND METHODS OF USE THEREOF |
| EP4149525A4 (en) * | 2020-05-15 | 2024-08-28 | Rxcell Inc. | HYPOIMMUNOGENIC CELLS AND THEIR USES IN IMMUNE RESPONSES |
| WO2022036150A1 (en) | 2020-08-13 | 2022-02-17 | Sana Biotechnology, Inc. | Methods of treating sensitized patients with hypoimmunogenic cells, and associated methods and compositions |
| CN112342196A (zh) * | 2020-08-18 | 2021-02-09 | 未来智人再生医学研究院(广州)有限公司 | 一种免疫兼容可逆的通用型多能干细胞及其应用 |
| WO2022076928A1 (en) * | 2020-10-09 | 2022-04-14 | Sana Biotechnology, Inc. | METHODS FOR TRIGGERING SAFETY KILLING MECHANISMS USING A CD47-SIRPα BLOCKADE AGENT |
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| CN114525255A (zh) * | 2020-10-30 | 2022-05-24 | 未来智人再生医学研究院(广州)有限公司 | 一种表达il-11的多能干细胞衍生物及其应用 |
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| WO2022144855A1 (en) | 2020-12-31 | 2022-07-07 | Crispr Therapeutics Ag | Universal donor cells |
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| JPWO2022191216A1 (https=) * | 2021-03-09 | 2022-09-15 | ||
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20230020351A (ko) * | 2021-07-28 | 2023-02-10 | 의료법인 성광의료재단 | B2m 유전자의 발현이 저해된 유전적으로 조작된 줄기세포 및 이의 이용방법 |
| KR102740042B1 (ko) * | 2023-07-12 | 2024-12-06 | ㈜바이오솔빅스 | 인간 전분화능 줄기세포로 유래된 심장 오가노이드 제조방법, 효능 및 독성 평가 기술 |
| WO2025014149A1 (ko) * | 2023-07-12 | 2025-01-16 | ㈜바이오솔빅스 | 인간 전분화능 줄기세포로 유래된 심장 오가노이드 제조방법, 효능 및 독성 평가 기술 |
Also Published As
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| JP2025069169A (ja) | 2025-04-30 |
| WO2018132783A1 (en) | 2018-07-19 |
| MX2019008413A (es) | 2019-09-13 |
| EP3568464A1 (en) | 2019-11-20 |
| US20230348862A1 (en) | 2023-11-02 |
| US20190376045A1 (en) | 2019-12-12 |
| KR20240095477A (ko) | 2024-06-25 |
| BR112019014257A2 (pt) | 2020-04-28 |
| AU2018207649A1 (en) | 2019-07-11 |
| IL267616A (en) | 2019-08-29 |
| JP2020505025A (ja) | 2020-02-20 |
| CA3049766A1 (en) | 2018-07-19 |
| CN110177869A (zh) | 2019-08-27 |
| AU2024256086A1 (en) | 2024-11-28 |
| AU2018207649B2 (en) | 2024-08-01 |
| JP2023052079A (ja) | 2023-04-11 |
| EA201991692A1 (ru) | 2019-12-30 |
| NZ754898A (en) | 2023-11-24 |
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