|
US6156303A
(en)
|
1997-06-11 |
2000-12-05 |
University Of Washington |
Adeno-associated virus (AAV) isolates and AAV vectors derived therefrom
|
|
EP1030861A4
(en)
|
1997-10-31 |
2001-09-05 |
Maxygen Inc |
MODIFICATION OF VIRUSTROPISMIUS AND THE ECONOMIC SPECTRUM BY VIRAL GENOM MIXING
|
|
AU780231B2
(en)
|
1998-11-10 |
2005-03-10 |
University Of North Carolina At Chapel Hill, The |
Virus vectors and methods of making and administering the same
|
|
EP1026250A1
(en)
|
1998-12-02 |
2000-08-09 |
Aventis Behring GmbH |
DNA-constructs of blood clotting factors and P-selectin
|
|
EP1010762A1
(en)
|
1998-12-02 |
2000-06-21 |
Aventis Behring Gesellschaft mit beschränkter Haftung |
DNA constructs of blood clotting factors and P-Selectin
|
|
EP1048726B1
(en)
|
1999-04-27 |
2006-07-26 |
Négrier, Claude |
Modified factor VIII cDNA
|
|
EP1038959A1
(en)
|
1999-03-17 |
2000-09-27 |
Aventis Behring Gesellschaft mit beschränkter Haftung |
Factor VIII without B-domain, comprising one or more insertions of a truncated intron I of factor IX
|
|
CA2373110A1
(en)
|
2000-03-14 |
2001-09-20 |
Neurologix, Inc. |
Production of chimeric capsid vectors
|
|
US7749492B2
(en)
|
2001-01-05 |
2010-07-06 |
Nationwide Children's Hospital, Inc. |
AAV vectors and methods
|
|
WO2002053703A2
(en)
|
2001-01-05 |
2002-07-11 |
Children's Hospital, Inc. |
Aav2 vectors and methods
|
|
US6723551B2
(en)
|
2001-11-09 |
2004-04-20 |
The United States Of America As Represented By The Department Of Health And Human Services |
Production of adeno-associated virus in insect cells
|
|
MX359371B
(es)
|
2001-11-13 |
2018-09-25 |
Univ Pennsylvania |
Un metodo para detectar y/o identificar secuencias del virus adeno-asociado y aislamiento de secuencias novedosas identificadas de ese modo.
|
|
PT1453547T
(pt)
|
2001-12-17 |
2016-12-28 |
Univ Pennsylvania |
Sequências do vírus adeno-associado (aav) do serotipo 8, vetores contendo as mesmas, e utilizações destas
|
|
US7858367B2
(en)
|
2002-04-30 |
2010-12-28 |
Duke University |
Viral vectors and methods for producing and using the same
|
|
SI1633772T1
(sl)
|
2003-06-19 |
2016-06-30 |
Genzyme Corporation |
AAV virioni z zmanjšano imunoreaktivnostjo in uporaba za ta namen
|
|
US9441244B2
(en)
|
2003-06-30 |
2016-09-13 |
The Regents Of The University Of California |
Mutant adeno-associated virus virions and methods of use thereof
|
|
EP2345731B1
(en)
|
2003-09-30 |
2015-10-21 |
The Trustees of the University of Pennsylvania |
Adeno-associated virus (AAV) clades, sequences, vectors containing same, and uses thereof
|
|
US20060166363A1
(en)
|
2004-01-27 |
2006-07-27 |
Sergei Zolotukhin |
Modified baculovirus expression system for production of pseudotyped rAAV vector
|
|
JP5136766B2
(ja)
|
2004-12-15 |
2013-02-06 |
ユニバーシティ オブ ノース カロライナ アット チャペル ヒル |
キメラベクター
|
|
CA2610164A1
(en)
|
2005-05-31 |
2006-12-07 |
Neurologix, Inc. |
Novel glutamic acid decarboxylase (gad) chimera and methods of use
|
|
US7867484B2
(en)
|
2006-01-27 |
2011-01-11 |
University Of North Carolina At Chapel Hill |
Heparin and heparan sulfate binding chimeric vectors
|
|
US7588772B2
(en)
|
2006-03-30 |
2009-09-15 |
Board Of Trustees Of The Leland Stamford Junior University |
AAV capsid library and AAV capsid proteins
|
|
ES2528797T3
(es)
|
2006-08-21 |
2015-02-12 |
Genentech, Inc. |
Compuestos de aza-benzotiofenilo y métodos de uso
|
|
ES2714007T3
(es)
|
2007-04-09 |
2019-05-24 |
Univ Florida |
Composiciones de vectores rAAV que tienen proteínas de la cápside modificadas en tirosina y métodos para su uso
|
|
US9725485B2
(en)
|
2012-05-15 |
2017-08-08 |
University Of Florida Research Foundation, Inc. |
AAV vectors with high transduction efficiency and uses thereof for gene therapy
|
|
ES2602610T3
(es)
|
2007-05-31 |
2017-02-21 |
Medigene Ag |
Proteína estructural mutada de un parvovirus
|
|
WO2009137006A2
(en)
|
2008-04-30 |
2009-11-12 |
The University Of North Carolina At Chapel Hill |
Directed evolution and in vivo panning of virus vectors
|
|
WO2010093784A2
(en)
|
2009-02-11 |
2010-08-19 |
The University Of North Carolina At Chapel Hill |
Modified virus vectors and methods of making and using the same
|
|
ES2742180T3
(es)
|
2009-03-04 |
2020-02-13 |
Deutsches Krebsforsch |
Proteína activadora del ensamblaje (AAP) y su uso para la fabricación de partículas de parvovirus que consisten esencialmente en VP3
|
|
GB0911870D0
(en)
|
2009-07-08 |
2009-08-19 |
Ucl Business Plc |
Optimised coding sequence and promoter
|
|
ES2857773T5
(es)
|
2011-08-24 |
2024-06-04 |
Univ Leland Stanford Junior |
Nuevas proteínas de la cápside de AAV para la transferencia de ácidos nucleicos
|
|
CA2853482C
(en)
|
2011-10-28 |
2020-05-19 |
Joshua Grieger |
Cell line for production of adeno-associated virus
|
|
EP2900686B1
(en)
|
2012-09-28 |
2020-06-10 |
The University of North Carolina At Chapel Hill |
Aav vectors targeted to oligodendrocytes
|
|
AU2013336601B2
(en)
|
2012-10-26 |
2018-01-25 |
Vrije Universiteit Brussel |
Vector for liver-directed gene therapy of hemophilia and methods and use thereof
|
|
ES2667209T3
(es)
|
2013-03-14 |
2018-05-10 |
Asklepios Biopharmaceutical, Inc. |
Genes del receptor-1 de VEGF soluble modificado y vectores para terapia génica
|
|
ES2926774T3
(es)
|
2013-03-15 |
2022-10-28 |
Univ North Carolina Chapel Hill |
Métodos y composiciones para vectores AAV de doble unión de glicano
|
|
EP3492597A3
(en)
|
2013-05-21 |
2019-08-28 |
University of Florida Research Foundation, Inc. |
Capsid-modified, raav3 vector compositions and methods of use in gene therapy of human liver cancer
|
|
IL297919A
(en)
|
2013-07-22 |
2023-01-01 |
Childrens Hospital Philadelphia |
Variant aav and compositions, methods and uses for gene transfer to cells, organs and tissues
|
|
SI3702466T1
(sl)
|
2013-08-27 |
2023-04-28 |
Research Institute At Nationwide Children's Hospital |
Proizvodi in postopki za zdravljenje amiotrofične lateralne skleroze
|
|
CN106232618A
(zh)
*
|
2013-10-11 |
2016-12-14 |
马萨诸塞眼科耳科诊所 |
预测祖先病毒序列的方法及其用途
|
|
GB201403684D0
(en)
|
2014-03-03 |
2014-04-16 |
King S College London |
Vector
|
|
US20170007720A1
(en)
|
2014-02-21 |
2017-01-12 |
University Of Florida Research Foundation, Inc. |
Methods and compositions for gene delivery to on bipolar cells
|
|
EP3113787B1
(en)
|
2014-03-04 |
2019-12-04 |
University of Florida Research Foundation, Inc. |
Improved raav vectors and methods for transduction of photoreceptors and rpe cells
|
|
CN114395559A
(zh)
|
2014-04-25 |
2022-04-26 |
吉尼松公司 |
高胆红素血症的治疗
|
|
LT3137497T
(lt)
|
2014-05-02 |
2021-07-26 |
Genzyme Corporation |
Aav vektoriai, skirti tinklainės ir cns genų terapijai
|
|
EP3151866B1
(en)
|
2014-06-09 |
2023-03-08 |
Voyager Therapeutics, Inc. |
Chimeric capsids
|
|
CN107073051B
(zh)
|
2014-10-21 |
2021-08-24 |
马萨诸塞大学 |
重组aav变体及其用途
|
|
GB201420139D0
(en)
|
2014-11-12 |
2014-12-24 |
Ucl Business Plc |
Factor IX gene therapy
|
|
EP4344741A3
(en)
|
2014-11-21 |
2024-08-28 |
The University of North Carolina at Chapel Hill |
Aav vectors targeted to the central nervous system
|
|
GB201502137D0
(en)
|
2015-02-09 |
2015-03-25 |
Ucl Business Plc |
Treatment
|
|
WO2016133917A1
(en)
|
2015-02-16 |
2016-08-25 |
University Of Florida Research Foundation |
Raav vector compositions, methods for targeting vascular endothelial cells and use in treatment of type i diabetes
|
|
WO2016137949A1
(en)
|
2015-02-23 |
2016-09-01 |
Voyager Therapeutics, Inc. |
Regulatable expression using adeno-associated virus (aav)
|
|
US11021519B2
(en)
|
2015-03-02 |
2021-06-01 |
Adverum Biotechnologies, Inc. |
Compositions and methods for intravitreal delivery of polynucleotides to retinal cones
|
|
JP6836999B2
(ja)
|
2015-03-24 |
2021-03-03 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアThe Regents Of The University Of California |
アデノ随伴ウイルス変異体及びその使用方法
|
|
US10081659B2
(en)
|
2015-04-06 |
2018-09-25 |
The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services |
Adeno-associated vectors for enhanced transduction and reduced immunogenicity
|
|
EP3285788B1
(en)
|
2015-04-23 |
2024-12-18 |
University of Massachusetts |
Modulation of aav vector transgene expression
|
|
GB201508026D0
(en)
*
|
2015-05-11 |
2015-06-24 |
Ucl Business Plc |
Capsid
|
|
MX390848B
(es)
|
2015-06-23 |
2025-03-21 |
Childrens Hospital Philadelphia |
Factor ix modificado, y composiciones, metodos y usos para la transferencia de genes a celulas, organos y tejidos.
|
|
WO2017015102A1
(en)
|
2015-07-17 |
2017-01-26 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods for achieving high levels of transduction in human liver cells
|
|
US20190000940A1
(en)
|
2015-07-31 |
2019-01-03 |
Voyager Therapeutics, Inc. |
Compositions and methods for the treatment of aadc deficiency
|
|
ES2865487T3
(es)
|
2015-09-28 |
2021-10-15 |
Univ North Carolina Chapel Hill |
Métodos y composiciones para vectores virales que evaden los anticuerpos
|
|
WO2017066764A2
(en)
|
2015-10-16 |
2017-04-20 |
William Marsh Rice University |
Modification of n-terminal region of capsid proteins for enhanced properties of adeno-associated viruses
|
|
WO2017075335A1
(en)
|
2015-10-28 |
2017-05-04 |
Voyager Therapeutics, Inc. |
Regulatable expression using adeno-associated virus (aav)
|
|
MX2018004755A
(es)
|
2015-10-29 |
2018-12-19 |
Voyager Therapeutics Inc |
Entrega de polinucleotidos dirigidos al sistema nervioso central.
|
|
PE20231949A1
(es)
|
2015-10-30 |
2023-12-05 |
Spark Therapeutics Inc |
VARIANTES DEL FACTOR VIII REDUCIDO CON CpG, COMPOSICIONES Y METODOS Y USOS PARA EL TRATAMIENTO DE TRASTORNOS DE LA HEMOSTASIA
|
|
SG11201802408RA
(en)
|
2015-11-05 |
2018-05-30 |
Bamboo Therapeutics Inc |
Modified friedreich ataxia genes and vectors for gene therapy
|
|
EP3384034B1
(en)
|
2015-12-02 |
2020-07-08 |
The Board of Trustees of the Leland Stanford Junior University |
Novel recombinant adeno-associated virus capsids with enhanced human skeletal muscle tropism
|
|
US10406244B2
(en)
|
2015-12-02 |
2019-09-10 |
The Board Of Trustees Of The Leland Stanford Junior University |
AAV vectors with expanded packaging capacity
|
|
KR102423442B1
(ko)
|
2015-12-11 |
2022-07-20 |
캘리포니아 인스티튜트 오브 테크놀로지 |
아데노-관련 바이러스를 지시하기 위한 타겟팅 펩타이드
|
|
JP7406783B2
(ja)
|
2015-12-14 |
2023-12-28 |
ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル |
パルボウイルスベクターの高められた送達のための改変キャプシドタンパク質
|
|
JP6947739B2
(ja)
|
2016-02-16 |
2021-10-13 |
ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー |
既存のヒト中和抗体に対して耐性である新規組換えアデノ随伴ウイルスカプシド
|
|
WO2017161273A1
(en)
|
2016-03-18 |
2017-09-21 |
The Children's Hospital Of Philadelphia |
Therapeutic for treatment of diseases including the central nervous system
|
|
US11433116B2
(en)
|
2016-04-14 |
2022-09-06 |
Cedars-Sinai Medical Center |
GJA1 isoforms protect against metabolic stress
|
|
US20190224339A1
(en)
|
2016-04-29 |
2019-07-25 |
Voyager Therapeutics, Inc. |
Compositions for the treatment of disease
|
|
EP3448874A4
(en)
|
2016-04-29 |
2020-04-22 |
Voyager Therapeutics, Inc. |
COMPOSITIONS FOR TREATING A DISEASE
|
|
KR20240056729A
(ko)
|
2016-05-18 |
2024-04-30 |
보이저 테라퓨틱스, 인크. |
조절성 폴리뉴클레오티드
|
|
CN109843913B
(zh)
|
2016-06-16 |
2024-03-08 |
柏林夏洛特医科大学 |
神经肽表达载体以及用于治疗癫痫的方法
|
|
IL305149A
(en)
|
2016-07-26 |
2023-10-01 |
Biomarin Pharm Inc |
Novel adeno-associated virus capsid proteins
|
|
CA3033856A1
(en)
|
2016-08-15 |
2018-02-22 |
Genzyme Corporation |
Methods for detecting aav
|
|
JP7610923B2
(ja)
|
2016-09-02 |
2025-01-09 |
スパーク セラピューティクス インコーポレイテッド |
Cns障害を治療するための方法及びベクター
|
|
WO2018046774A1
(en)
|
2016-09-12 |
2018-03-15 |
Genethon |
Acid-alpha glucosidase variants and uses thereof
|
|
EP3293203A1
(en)
|
2016-09-12 |
2018-03-14 |
Genethon |
Acid-alpha glucosidase variants and uses thereof
|
|
EP3293259A1
(en)
|
2016-09-12 |
2018-03-14 |
Genethon |
Acid-alpha glucosidase variants and uses thereof
|
|
AU2017341849B2
(en)
|
2016-10-13 |
2024-03-21 |
University Of Massachusetts |
AAV capsid designs
|
|
AU2017347854B2
(en)
|
2016-10-27 |
2022-12-08 |
Intima Bioscience, Inc. |
Viral methods of T cell therapy
|
|
US11905312B2
(en)
|
2017-02-15 |
2024-02-20 |
The University Of North Carolina At Chapel Hill |
Methods and compositions for gene transfer across the vasculature
|
|
WO2018162748A1
(en)
|
2017-03-10 |
2018-09-13 |
Genethon |
Treatment of glycogen storage disease iii
|
|
NZ756587A
(en)
|
2017-03-15 |
2025-12-19 |
Univ North Carolina Chapel Hill |
Polyploid adeno-associated virus vectors and methods of making and using the same
|
|
EP3609542B1
(en)
|
2017-04-11 |
2023-02-22 |
Ruprecht-Karls-Universität Heidelberg |
Adeno-associated virus library
|
|
WO2018200419A1
(en)
|
2017-04-23 |
2018-11-01 |
The Trustees Of The University Of Pennsylvania |
Viral vectors comprising engineered aav capsids and compositions containing the same
|
|
JP2020518258A
(ja)
|
2017-05-05 |
2020-06-25 |
ボイジャー セラピューティクス インコーポレイテッドVoyager Therapeutics,Inc. |
筋萎縮性側索硬化症(als)治療組成物および方法
|
|
JP2020518259A
(ja)
|
2017-05-05 |
2020-06-25 |
ボイジャー セラピューティクス インコーポレイテッドVoyager Therapeutics,Inc. |
ハンチントン病治療組成物および方法
|
|
WO2018226887A1
(en)
|
2017-06-07 |
2018-12-13 |
Spark Therapeutics, Inc. |
ENHANCING AGENTS FOR IMPROVED CELL TRANSFECTION AND/OR rAAV VECTOR PRODUCTION
|
|
JOP20190269A1
(ar)
|
2017-06-15 |
2019-11-20 |
Voyager Therapeutics Inc |
بولي نوكليوتيدات aadc لعلاج مرض باركنسون
|
|
PE20200737A1
(es)
|
2017-06-30 |
2020-07-23 |
Spark Therapeutics Inc |
Metodos de purificacion de columna de vector aav
|
|
SG11202000840YA
(en)
|
2017-07-31 |
2020-02-27 |
Reflection Biotechnologies Ltd |
Cellular models of and therapies for ocular diseases
|
|
PE20200722A1
(es)
|
2017-08-01 |
2020-07-21 |
Spark Therapeutics Inc |
Metodos de terapia genica del factor viii (fviii)
|
|
EP3808849A1
(en)
|
2017-08-03 |
2021-04-21 |
Voyager Therapeutics, Inc. |
Compositions and methods for delivery of aav
|
|
EP3676284A1
(en)
|
2017-08-29 |
2020-07-08 |
Ruprecht-Karls-Universität Heidelberg |
Rationally designed virus-like particles for modulation of chimeric antigen receptor (car)-t-cell therapy
|
|
US20200377887A1
(en)
|
2017-09-22 |
2020-12-03 |
Voyager Therapeutics, Inc. |
Compositions and methods of treating huntington's disease
|
|
US12123027B2
(en)
|
2017-10-12 |
2024-10-22 |
Ascend Advanced Therapies Limited |
Life-cycle-defective adenovirus helper viruses, their production and use for producing rAAV
|