|
US1724052A
(en)
|
1928-06-13 |
1929-08-13 |
Luther S Swearengin |
Fire-door construction
|
|
US5034506A
(en)
|
1985-03-15 |
1991-07-23 |
Anti-Gene Development Group |
Uncharged morpholino-based polymers having achiral intersubunit linkages
|
|
US5283058A
(en)
|
1990-08-30 |
1994-02-01 |
The General Hospital Corporation |
Methods for inhibiting rejection of transplanted tissue
|
|
CA2092825A1
(en)
|
1991-07-30 |
1993-01-31 |
Ronald W. Dudek |
Foramenous implant
|
|
US7101543B2
(en)
|
2000-03-31 |
2006-09-05 |
Novarx |
Genetically modified cells expressing a TGFβ inhibitor, the cells being lung cancer cells
|
|
US7056502B2
(en)
|
2000-04-28 |
2006-06-06 |
The Trustees Of The University Of Pennsylvania |
Recombinant aav vectors with AAV5 capsids and AAV5 vectors pseudotyped in heterologous capsids
|
|
US20060222633A1
(en)
|
2000-05-11 |
2006-10-05 |
Yale University |
Prevention, decrease, and/or treatment of immunoreactivity by depleting and/or inactivating antigen presenting cells in the host
|
|
US6635750B1
(en)
|
2000-07-20 |
2003-10-21 |
Millennium Pharmaceuticals, Inc. |
B7-H2 nucleic acids, members of the B7 family
|
|
WO2003014313A2
(en)
|
2001-08-06 |
2003-02-20 |
Bresagen, Ltd. |
Alternative compositions and methods for the culture of stem cells
|
|
US20050266554A1
(en)
|
2004-04-27 |
2005-12-01 |
D Amour Kevin A |
PDX1 expressing endoderm
|
|
CN103898047B
(zh)
|
2003-12-23 |
2020-03-03 |
维亚希特公司 |
定形内胚层
|
|
US7541185B2
(en)
|
2003-12-23 |
2009-06-02 |
Cythera, Inc. |
Methods for identifying factors for differentiating definitive endoderm
|
|
US8586357B2
(en)
|
2003-12-23 |
2013-11-19 |
Viacyte, Inc. |
Markers of definitive endoderm
|
|
US7985585B2
(en)
|
2004-07-09 |
2011-07-26 |
Viacyte, Inc. |
Preprimitive streak and mesendoderm cells
|
|
US8187878B2
(en)
|
2004-08-13 |
2012-05-29 |
University Of Georgia Research Foundation, Inc. |
Methods for increasing definitive endoderm differentiation of pluripotent human embryonic stem cells with PI-3 kinase inhibitors
|
|
US8999944B2
(en)
|
2005-01-20 |
2015-04-07 |
University Of Rochester |
Thioredoxin interacting protein (TXNIP) as regulator of vascular function
|
|
WO2007051038A2
(en)
|
2005-10-27 |
2007-05-03 |
Cythera, Inc. |
Pdx1-expressing dorsal and ventral foregut endoderm
|
|
SG170021A1
(en)
|
2006-02-23 |
2011-04-29 |
Novocell Inc |
Compositions and methods useful for culturing differentiable cells
|
|
US7695965B2
(en)
|
2006-03-02 |
2010-04-13 |
Cythera, Inc. |
Methods of producing pancreatic hormones
|
|
JP6110048B2
(ja)
|
2006-03-02 |
2017-04-05 |
ヴィアサイト，インコーポレイテッド |
内分泌前駆細胞、膵臓ホルモン発現細胞及びそれらの製造方法
|
|
US7964402B2
(en)
|
2006-05-25 |
2011-06-21 |
Sanford-Burnham Medical Research Institute |
Methods for culture and production of single cell populations of human embryonic stem cells
|
|
DK2185693T3
(da)
|
2007-07-31 |
2019-09-23 |
Lifescan Inc |
Differentiering af humane embryoniske stamceller
|
|
US7695963B2
(en)
|
2007-09-24 |
2010-04-13 |
Cythera, Inc. |
Methods for increasing definitive endoderm production
|
|
US8623650B2
(en)
|
2007-10-19 |
2014-01-07 |
Viacyte, Inc. |
Methods and compositions for feeder-free pluripotent stem cell media containing human serum
|
|
CA2954431C
(en)
|
2007-11-27 |
2021-08-24 |
Lifescan, Inc. |
Differentiation of human embryonic stem cells to pancreatic cells
|
|
US8338170B2
(en)
|
2008-04-21 |
2012-12-25 |
Viacyte, Inc. |
Methods for purifying endoderm and pancreatic endoderm cells derived from human embryonic stem cells
|
|
US7939322B2
(en)
|
2008-04-24 |
2011-05-10 |
Centocor Ortho Biotech Inc. |
Cells expressing pluripotency markers and expressing markers characteristic of the definitive endoderm
|
|
US20120058105A1
(en)
|
2008-06-27 |
2012-03-08 |
Martin Kean Chong Ng |
Method of treatment of vascular complications
|
|
EP2350265B1
(en)
|
2008-10-31 |
2019-04-17 |
Janssen Biotech, Inc. |
Differentiation of human embryonic stem cells to the pancreatic endocrine lineage
|
|
US9234178B2
(en)
|
2008-10-31 |
2016-01-12 |
Janssen Biotech, Inc. |
Differentiation of human pluripotent stem cells
|
|
US8895300B2
(en)
|
2008-11-04 |
2014-11-25 |
Viacyte, Inc. |
Scalable primate pluripotent stem cell aggregate suspension culture and differentiation thereof
|
|
US8008075B2
(en)
|
2008-11-04 |
2011-08-30 |
Viacyte, Inc. |
Stem cell aggregate suspension compositions and methods of differentiation thereof
|
|
JP2012508584A
(ja)
|
2008-11-14 |
2012-04-12 |
ヴィアサイト，インコーポレイテッド |
ヒト多能性幹細胞由来膵臓細胞のカプセル化
|
|
US20100272710A1
(en)
|
2009-03-26 |
2010-10-28 |
Abdelhadi Rebbaa |
Compositions and methods for treating and preventing aging-associated diseases
|
|
US9109245B2
(en)
|
2009-04-22 |
2015-08-18 |
Viacyte, Inc. |
Cell compositions derived from dedifferentiated reprogrammed cells
|
|
EP2421957B1
(en)
|
2009-04-22 |
2020-11-18 |
Viacyte, Inc. |
Cell compositions derived from dedifferentiated reprogrammed cells
|
|
CN107603943B
(zh)
|
2009-04-27 |
2019-10-11 |
威盛细胞有限公司 |
支持多能细胞生长的小分子和其方法
|
|
CN103952372B
(zh)
|
2009-07-20 |
2016-10-05 |
詹森生物科技公司 |
人胚胎干细胞的分化
|
|
US8785184B2
(en)
|
2009-07-20 |
2014-07-22 |
Janssen Biotech, Inc. |
Differentiation of human embryonic stem cells
|
|
SG10201408552YA
(en)
|
2009-12-23 |
2015-02-27 |
Janssen Biotech Inc |
Differentiation of human embryonic stem cells
|
|
CN102712902B
(zh)
|
2009-12-23 |
2019-01-08 |
詹森生物科技公司 |
人胚胎干细胞的分化
|
|
PL2853589T3
(pl)
|
2010-08-31 |
2018-05-30 |
Janssen Biotech, Inc |
Różnicowanie ludzkich zarodkowych komórek macierzystych
|
|
CN103154237B
(zh)
|
2010-08-31 |
2016-03-16 |
詹森生物科技公司 |
多能干细胞的分化
|
|
ES2690663T3
(es)
|
2010-12-08 |
2018-11-21 |
Viacyte, Inc. |
Agentes y métodos para inhibir el crecimiento de células madre pluripotentes humanas
|
|
CA3205636A1
(en)
|
2011-04-20 |
2012-10-26 |
University Of Washington Through Its Center For Commercialization |
Beta-2 microglobulin-deficient cells
|
|
USD728095S1
(en)
|
2011-12-12 |
2015-04-28 |
Viacyte, Inc. |
Cell encapsulation device
|
|
USD726306S1
(en)
|
2011-12-12 |
2015-04-07 |
Viacyte, Inc. |
Cell encapsulation device
|
|
USD726307S1
(en)
|
2011-12-12 |
2015-04-07 |
Viacyte Inc. |
Cell encapsulation device
|
|
CA3018046A1
(en)
|
2011-12-16 |
2013-06-20 |
Moderna Therapeutics, Inc. |
Modified nucleoside, nucleotide, and nucleic acid compositions
|
|
FI2794857T3
(fi)
|
2011-12-22 |
2026-03-25 |
Janssen Biotech Inc |
Ihmisen alkion kantasolujen erilaistaminen yksittäisiksi hormonaalisiksi insuliinipositiivisiksi soluiksi
|
|
ES2615346T3
(es)
|
2012-04-25 |
2017-06-06 |
Deutsches Krebsforschungszentrum |
Inhibidores de la proteína que interacciona con tiorredoxina (TXNIP) para terapia
|
|
BR112014027783A2
(pt)
|
2012-05-07 |
2017-06-27 |
Janssen Biotech Inc |
diferenciação de células-tronco embrionárias humanas em endoderma pancreático
|
|
AU2013266968B2
(en)
|
2012-05-25 |
2017-06-29 |
Emmanuelle CHARPENTIER |
Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
|
|
USD734847S1
(en)
|
2012-05-31 |
2015-07-21 |
Viacyte, Inc. |
Cell encapsulation device
|
|
EP3450544A1
(en)
|
2012-06-08 |
2019-03-06 |
Janssen Biotech, Inc. |
Differentiation of human embryonic stem cells into pancreatic endodrine cells
|
|
EP2861723A4
(en)
|
2012-06-14 |
2016-01-20 |
Janssen Biotech Inc |
DIFFERENTIATION OF HUMAN EMBRYONAL STEM CELLS IN ENDOCRINE PANCREAS CELLS
|
|
IL239344B2
(en)
|
2012-12-12 |
2024-06-01 |
Broad Inst Inc |
Systems engineering, methods and optimal guiding components for sequence manipulation
|
|
BR112015015714A2
(pt)
|
2012-12-31 |
2017-07-11 |
Janssen Biotech Inc |
suspensão e aglomeração de células pluripotentes humanas para diferenciação em célu-las endócrinas pancreáticas
|
|
ES2837763T3
(es)
|
2012-12-31 |
2021-07-01 |
Janssen Biotech Inc |
Cultivo de células madre embrionarias humanas en la interconexión aire-líquido para la diferenciación en células endocrinas pancreáticas
|
|
US10370644B2
(en)
|
2012-12-31 |
2019-08-06 |
Janssen Biotech, Inc. |
Method for making human pluripotent suspension cultures and cells derived therefrom
|
|
DK2938723T3
(da)
|
2012-12-31 |
2023-02-20 |
Janssen Biotech Inc |
Differentiering af humane embryonale stamceller til pancreatiske endokrine celler under anvendelse af hb9-regulatorer
|
|
AU2014225352B2
(en)
|
2013-03-07 |
2017-02-09 |
Viacyte, Inc. |
3-dimensional large capacity cell encapsulation device assembly
|
|
USD720469S1
(en)
|
2013-03-07 |
2014-12-30 |
Viacyte, Inc. |
Cell encapsulation device
|
|
US8859286B2
(en)
|
2013-03-14 |
2014-10-14 |
Viacyte, Inc. |
In vitro differentiation of pluripotent stem cells to pancreatic endoderm cells (PEC) and endocrine cells
|
|
US9101597B2
(en)
|
2013-03-14 |
2015-08-11 |
The Administration Of The Tulane Educational Fund |
Immunoprotective primary mesenchymal stem cells and methods
|
|
AU2014277092B2
(en)
|
2013-06-03 |
2019-04-04 |
Theravectys |
Lentiviral vectors containing an MHC class I, MHC class II, or beta-2 microglobulin upstream promoter sequence
|
|
CN120796168A
(zh)
|
2013-06-11 |
2025-10-17 |
哈佛学院校长同事会 |
SC-β细胞以及用于产生其的组合物和方法
|
|
KR20140144964A
(ko)
|
2013-06-12 |
2014-12-22 |
한국생명공학연구원 |
티오레독신-결합 단백질을 유효성분으로 포함하는 약학적 조성물 및 이의 용도
|
|
MX374532B
(es)
|
2013-06-17 |
2025-03-06 |
Broad Inst Inc |
Suministro, uso y aplicaciones terapéuticas de los sistemas y composiciones crispr-cas, para actuar sobre trastornos y enfermedades utilizando componentes víricos.
|
|
WO2015065524A2
(en)
|
2013-11-01 |
2015-05-07 |
Janssen Biotech, Inc. |
Suspension and clustering of human pluripotent stem cells for differentiation into pancreatic endocrine cells
|
|
USD718472S1
(en)
|
2014-03-07 |
2014-11-25 |
Viacyte, Inc. |
3-dimensional large capacity cell encapsulation device
|
|
USD718469S1
(en)
|
2014-03-07 |
2014-11-25 |
Viacyte, Inc. |
3-dimensional large capacity cell encapsulation device
|
|
USD718466S1
(en)
|
2014-03-07 |
2014-11-25 |
Viacyte, Inc. |
3-Dimensional large capacity cell encapsulation device
|
|
USD718467S1
(en)
|
2014-03-07 |
2014-11-25 |
Viacyte, Inc. |
3-dimensional large capacity cell encapsulation device
|
|
USD718471S1
(en)
|
2014-03-07 |
2014-11-25 |
Viacyte, Inc. |
3-dimensional large capacity cell encapsulation device
|
|
USD718470S1
(en)
|
2014-03-07 |
2014-11-25 |
Viacyte, Inc. |
3-dimensional large capacity cell encapsulation device
|
|
USD718468S1
(en)
|
2014-03-07 |
2014-11-25 |
Viacyte, Inc. |
3-dimensional large capacity cell encapsulation device
|
|
USD714956S1
(en)
|
2014-03-07 |
2014-10-07 |
Viacyte, Inc. |
3-dimensional large capacity cell encapsulation device
|
|
JP6681837B2
(ja)
|
2014-03-11 |
2020-04-15 |
セレクティスＣｅｌｌｅｃｔｉｓ |
同種移植に適合するｔ細胞を作製するための方法
|
|
US20170274048A1
(en)
|
2014-03-28 |
2017-09-28 |
Buck Institute For Research On Aging |
Methods and compositions for modulating the imune system
|
|
USD734166S1
(en)
|
2014-04-16 |
2015-07-14 |
Viacyte, Inc. |
Fill pouch assembly for encapsulation device
|
|
USD760399S1
(en)
|
2014-04-16 |
2016-06-28 |
Viacyte, Inc. |
Case for an encapsulation device
|
|
USD761424S1
(en)
|
2014-04-16 |
2016-07-12 |
Viacyte, Inc. |
Deployment tool for an encapsulation device
|
|
USD761423S1
(en)
|
2014-04-16 |
2016-07-12 |
Viacyte, Inc. |
Sizing tool for an encapsulation device
|
|
WO2015175307A1
(en)
|
2014-05-16 |
2015-11-19 |
Janssen Biotech, Inc. |
Use of small molecules to enhance mafa expression in pancreatic endocrine cells
|
|
EP3215623A4
(en)
|
2014-11-06 |
2018-09-26 |
President and Fellows of Harvard College |
Cells lacking b2m surface expression and methods for allogeneic administration of such cells
|
|
EP3234109A4
(en)
|
2014-12-19 |
2018-06-27 |
Janssen Biotech, Inc. |
Suspension culturing of pluripotent stem cells
|
|
CN107921148A
(zh)
|
2015-05-08 |
2018-04-17 |
哈佛学院校长同事会 |
通用供体干细胞和相关方法
|
|
GB2592821B
(en)
|
2015-07-31 |
2022-01-12 |
Univ Minnesota |
Modified cells and methods of therapy
|
|
KR20250141836A
(ko)
|
2015-11-04 |
2025-09-29 |
페이트 세러퓨틱스, 인코포레이티드 |
만능 세포의 유전자 조작
|
|
MD4194548T2
(ro)
|
2016-06-21 |
2026-02-28 |
Janssen Biotech Inc |
Generarea de celule beta funcționale derivate din celule stem pluripotente umane care posedă respirație mitocondrială dependentă - de glucoză și răspuns la secreția de insulină în două faze
|
|
WO2018035387A1
(en)
|
2016-08-17 |
2018-02-22 |
The Broad Institute, Inc. |
Novel crispr enzymes and systems
|
|
US9982267B2
(en)
|
2016-10-12 |
2018-05-29 |
Feldan Bio Inc. |
Rationally-designed synthetic peptide shuttle agents for delivering polypeptide cargos from an extracellular space to the cytosol and/or nucleus of a target eukaryotic cell, uses thereof, methods and kits relating to same
|
|
CA3042495A1
(en)
|
2016-11-10 |
2018-05-17 |
Viacyte, Inc. |
Pdx1 pancreatic endoderm cells in cell delivery devices and methods thereof
|
|
JP2020505025A
(ja)
|
2017-01-13 |
2020-02-20 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
免疫工学的な改変をした多能性細胞
|
|
US11771703B2
(en)
|
2017-03-17 |
2023-10-03 |
The Johns Hopkins University |
Targeted epigenetic therapy against distal regulatory element of TGFβ2 expression
|
|
IL270835B2
(en)
|
2017-06-12 |
2025-01-01 |
Sinai Health Sys |
Allograft tolerance without the need for systemic immunosuppression
|
|
US10391156B2
(en)
|
2017-07-12 |
2019-08-27 |
Viacyte, Inc. |
University donor cells and related methods
|
|
KR20200075851A
(ko)
|
2017-10-19 |
2020-06-26 |
셀렉티스 |
개선된 면역 세포들 치료를 위한 nk 억제제들의 타겟인 유전자 통합
|
|
CN107723275B
(zh)
|
2017-10-20 |
2020-09-04 |
重庆精准生物技术有限公司 |
通用型car-t细胞及其制备方法和应用
|
|
MX2020005235A
(es)
|
2017-11-16 |
2020-08-24 |
Mogam Inst Biomedical Res |
Celula humana transformada y uso de la misma.
|
|
JP2021505131A
(ja)
|
2017-12-08 |
2021-02-18 |
フェイト セラピューティクス，インコーポレイテッド |
増強されたｉＰＳＣ由来のエフェクター細胞を用いた免疫療法
|
|
US20190223416A1
(en)
|
2018-01-23 |
2019-07-25 |
Cotyledon, LLC |
Canine genome editing
|
|
WO2019160077A1
(ja)
|
2018-02-16 |
2019-08-22 |
国立大学法人京都大学 |
低抗原性細胞の製造方法
|
|
US12378572B2
(en)
*
|
2018-09-07 |
2025-08-05 |
Crispr Therapeutics Ag |
Universal donor cells
|
|
SG11202104337PA
(en)
|
2018-11-26 |
2021-05-28 |
Massachusetts Inst Technology |
Compositions and methods for immune tolerance
|
|
US20220016181A1
(en)
|
2018-12-13 |
2022-01-20 |
Sinai Health System |
Immunomodulatory cells and uses thereof
|
|
US20220160751A1
(en)
|
2019-04-02 |
2022-05-26 |
Yale University |
Methods of treatment of diseases and disorders associated with increased tet level, increased h19 level, increased level of tgf signaling, or any combination thereof
|
|
US12221622B2
(en)
*
|
2019-05-10 |
2025-02-11 |
The Regents Of The University Of California |
Modified pluripotent cells
|
|
WO2020228039A1
(en)
|
2019-05-16 |
2020-11-19 |
Egenesis, Inc. |
Cells, tissues, organs, and/or animals having one or more modified genes for enhanced xenograft survival and/or tolerance
|
|
CN110373389A
(zh)
*
|
2019-06-10 |
2019-10-25 |
云南农业大学 |
一种适合胰岛细胞及皮肤等组织异种移植供体猪的构建方法
|
|
CA3150235A1
(en)
|
2019-09-05 |
2021-03-11 |
Alireza Rezania |
Universal donor cells
|
|
PH12022550542A1
(en)
|
2019-09-05 |
2023-03-20 |
Crispr Therapeutics Ag |
Universal donor cells
|
|
WO2022144855A1
(en)
|
2020-12-31 |
2022-07-07 |
Crispr Therapeutics Ag |
Universal donor cells
|