JP2020505023A5 - - Google Patents
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- Publication number
- JP2020505023A5 JP2020505023A5 JP2019538131A JP2019538131A JP2020505023A5 JP 2020505023 A5 JP2020505023 A5 JP 2020505023A5 JP 2019538131 A JP2019538131 A JP 2019538131A JP 2019538131 A JP2019538131 A JP 2019538131A JP 2020505023 A5 JP2020505023 A5 JP 2020505023A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- chain amino
- synthase
- branched chain
- microorganism
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108010000700 Acetolactate synthase Proteins 0.000 claims 11
- 150000001413 amino acids Chemical group 0.000 claims 8
- 244000005700 microbiome Species 0.000 claims 7
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 6
- 102000040430 polynucleotide Human genes 0.000 claims 5
- 108091033319 polynucleotide Proteins 0.000 claims 5
- 239000002157 polynucleotide Substances 0.000 claims 5
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 4
- 229960003136 leucine Drugs 0.000 claims 4
- 239000013598 vector Substances 0.000 claims 4
- 241000186216 Corynebacterium Species 0.000 claims 3
- 229940024606 amino acid Drugs 0.000 claims 3
- 235000001014 amino acid Nutrition 0.000 claims 3
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 3
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 2
- 241000186249 Corynebacterium sp. Species 0.000 claims 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 2
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 2
- 235000019454 L-leucine Nutrition 0.000 claims 2
- 239000004395 L-leucine Substances 0.000 claims 2
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 2
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 2
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 2
- 235000004279 alanine Nutrition 0.000 claims 2
- 229960001230 asparagine Drugs 0.000 claims 2
- 235000009582 asparagine Nutrition 0.000 claims 2
- 235000018417 cysteine Nutrition 0.000 claims 2
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 2
- 125000000404 glutamine group Chemical group N[C@@H](CCC(N)=O)C(=O)* 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 229960004295 valine Drugs 0.000 claims 2
- YUXKOWPNKJSTPQ-AXWWPMSFSA-N (2s,3r)-2-amino-3-hydroxybutanoic acid;(2s)-2-amino-3-hydroxypropanoic acid Chemical compound OC[C@H](N)C(O)=O.C[C@@H](O)[C@H](N)C(O)=O YUXKOWPNKJSTPQ-AXWWPMSFSA-N 0.000 claims 1
- 101710103719 Acetolactate synthase large subunit Proteins 0.000 claims 1
- 241000186226 Corynebacterium glutamicum Species 0.000 claims 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 235000018102 proteins Nutrition 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2017-0087978 | 2017-07-11 | ||
| KR1020170087978A KR101996129B1 (ko) | 2017-07-11 | 2017-07-11 | 아세토하이드록시산 신타아제 변이체, 이를 포함하는 미생물 또는 이를 이용하는 l-분지쇄 아미노산 생산 방법 |
| PCT/KR2018/007821 WO2019013532A2 (ko) | 2017-07-11 | 2018-07-10 | 아세토하이드록시산 신타아제 변이체, 이를 포함하는 미생물 또는 이를 이용하는 l-분지쇄 아미노산 생산 방법 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020505023A JP2020505023A (ja) | 2020-02-20 |
| JP2020505023A5 true JP2020505023A5 (https=) | 2020-04-16 |
| JP6794555B2 JP6794555B2 (ja) | 2020-12-02 |
Family
ID=65002267
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019538131A Active JP6794555B2 (ja) | 2017-07-11 | 2018-07-10 | アセトヒドロキシ酸シンターゼ変異体、これを含む微生物、またはこれを用いるｌ−分岐鎖アミノ酸の生産方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US10844359B2 (https=) |
| EP (1) | EP3553171B1 (https=) |
| JP (1) | JP6794555B2 (https=) |
| KR (1) | KR101996129B1 (https=) |
| CN (2) | CN110724679B (https=) |
| AU (1) | AU2018301879B2 (https=) |
| BR (1) | BR112019020183B1 (https=) |
| CA (1) | CA3064569C (https=) |
| ES (1) | ES2919345T3 (https=) |
| MX (1) | MX2019015056A (https=) |
| RU (1) | RU2743964C1 (https=) |
| WO (1) | WO2019013532A2 (https=) |
| ZA (1) | ZA201908353B (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102147381B1 (ko) * | 2019-11-22 | 2020-08-24 | 씨제이제일제당 주식회사 | 아세토하이드록시산 신타제 신규 변이체 및 이를 포함하는 미생물 |
| KR102311391B1 (ko) * | 2020-05-21 | 2021-10-12 | 씨제이제일제당 주식회사 | L- 분지쇄 아미노산 생산능이 강화된 미생물 및 이를 이용하여 l-분지쇄 아미노산을 생산하는 방법 |
| CN112195204B (zh) * | 2020-10-21 | 2022-04-15 | 通辽梅花生物科技有限公司 | 一种混菌发酵生产支链氨基酸的方法 |
| KR102619598B1 (ko) * | 2021-08-23 | 2023-12-29 | 씨제이제일제당 주식회사 | 신규한 아세토하이드록시산 신타아제 소단위체 변이체 및 이를 이용한 l-발린 생산 방법 |
| KR102935702B1 (ko) * | 2022-12-28 | 2026-03-09 | 씨제이제일제당 주식회사 | 신규한 아세토락테이트 합성효소 활성을 갖는 변이체 폴리펩티드 및 이를 이용한 l-글루탐산 생산 방법 |
| CN121532502A (zh) * | 2023-05-19 | 2026-02-13 | Cj第一制糖株式会社 | 变体多肽和使用其生产l-缬氨酸的方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6576455B1 (en) * | 1995-04-20 | 2003-06-10 | Basf Corporation | Structure-based designed herbicide resistant products |
| CA2380613C (en) * | 1999-08-02 | 2014-03-25 | Archer-Daniels-Midland Company | Production of l-lysine by corynebacterium strain having mutation in ilvbn operon |
| JP4623825B2 (ja) | 1999-12-16 | 2011-02-02 | 協和発酵バイオ株式会社 | 新規ポリヌクレオチド |
| EP1491634A1 (en) | 2003-06-26 | 2004-12-29 | Degussa AG | Feedback resistant acetohydroxy acid synthetase mutants |
| KR100671167B1 (ko) | 2005-09-12 | 2007-01-19 | 이상익 | 개인용 긴급 구난 벨트 |
| WO2007149069A2 (en) | 2006-06-15 | 2007-12-27 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Resistance to acetolactate synthase-inhibiting herbicides |
| RU2355763C2 (ru) * | 2006-09-13 | 2009-05-20 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) | Мутантная ацетолактатсинтаза и способ продукции разветвленных l-аминокислот |
| WO2008033001A1 (en) | 2006-09-15 | 2008-03-20 | Cj Cheiljedang Corporation | A corynebacteria having enhanced l-lysine productivity and a method of producing l-lysine using the same |
| CN108130336A (zh) | 2007-10-05 | 2018-06-08 | 赛布斯欧洲公司 | 芸苔属中突变的乙酰羟酸合酶基因 |
| US9169502B2 (en) * | 2010-06-15 | 2015-10-27 | Paik Kwang Industrial Co., Ltd. | Method of producing L-lysine using a Corynebacterium glutamicum microorganism |
| CN102286505B (zh) | 2011-05-26 | 2013-04-03 | 江南大学 | 用于发酵生产l-缬氨酸的重组dna、菌株及方法 |
| KR101117022B1 (ko) | 2011-08-16 | 2012-03-16 | 씨제이제일제당 (주) | Ｌ-발린 생산능이 향상된 미생물 및 이를 이용한 ｌ-발린 제조방법 |
| EP2749638A4 (en) | 2011-08-22 | 2015-04-22 | Res Inst Innovative Tech Earth | MEANS FOR TRANSFORMING CORYNEFORMER BACTERIA AND PROCESS FOR VALIN PRODUCTION THEREWITH |
| KR101721722B1 (ko) * | 2013-03-11 | 2017-04-10 | 씨제이제일제당 (주) | L-발린 생산능이 향상된 균주 및 이를 이용한 l-발린 생산방법 |
| ES2623161T3 (es) | 2013-06-03 | 2017-07-10 | Evonik Degussa Gmbh | Procedimiento para la preparación de L-valina utilizando corinebacterias recombinantes que contienen el operón ilvBN inducible por propionato |
| KR20150119785A (ko) | 2014-04-15 | 2015-10-26 | 삼성전자주식회사 | 라이프 로그 서비스 제공 시스템 및 그 서비스 방법 |
| KR101720836B1 (ko) * | 2014-08-05 | 2017-04-03 | 씨제이제일제당 (주) | 피드백 저항성 아세토하이드록시산 신타아제 변이체 및 이를 이용한 l-발린의 생산방법 |
| KR101796830B1 (ko) | 2015-08-25 | 2017-11-13 | 씨제이제일제당 (주) | Ｌ-류신 생산능을 가지는 미생물 및 이를 이용한 ｌ-류신의 제조방법 |
| CN106754807B (zh) * | 2016-12-29 | 2020-10-30 | 廊坊梅花生物技术开发有限公司 | 生产l-亮氨酸菌株和生产l-亮氨酸的方法 |
-
2017
- 2017-07-11 KR KR1020170087978A patent/KR101996129B1/ko active Active
-
2018
- 2018-07-10 EP EP18832634.2A patent/EP3553171B1/en active Active
- 2018-07-10 MX MX2019015056A patent/MX2019015056A/es unknown
- 2018-07-10 WO PCT/KR2018/007821 patent/WO2019013532A2/ko not_active Ceased
- 2018-07-10 AU AU2018301879A patent/AU2018301879B2/en active Active
- 2018-07-10 CA CA3064569A patent/CA3064569C/en active Active
- 2018-07-10 BR BR112019020183-1A patent/BR112019020183B1/pt active IP Right Grant
- 2018-07-10 ES ES18832634T patent/ES2919345T3/es active Active
- 2018-07-10 CN CN201911130496.3A patent/CN110724679B/zh active Active
- 2018-07-10 JP JP2019538131A patent/JP6794555B2/ja active Active
- 2018-07-10 CN CN201880015829.5A patent/CN110506112B/zh active Active
- 2018-07-10 US US16/479,813 patent/US10844359B2/en active Active
- 2018-07-10 RU RU2019138301A patent/RU2743964C1/ru active
-
2019
- 2019-12-13 ZA ZA2019/08353A patent/ZA201908353B/en unknown
-
2020
- 2020-10-21 US US17/076,057 patent/US11085029B2/en active Active
-
2021
- 2021-06-24 US US17/357,196 patent/US11345901B2/en active Active
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