WO2019013532A3 - 아세토하이드록시산 신타아제 변이체, 이를 포함하는 미생물 또는 이를 이용하는 l-분지쇄 아미노산 생산 방법 - Google Patents

아세토하이드록시산 신타아제 변이체, 이를 포함하는 미생물 또는 이를 이용하는 l-분지쇄 아미노산 생산 방법 Download PDF

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WO2019013532A3
WO2019013532A3 PCT/KR2018/007821 KR2018007821W WO2019013532A3 WO 2019013532 A3 WO2019013532 A3 WO 2019013532A3 KR 2018007821 W KR2018007821 W KR 2018007821W WO 2019013532 A3 WO2019013532 A3 WO 2019013532A3
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WIPO (PCT)
Prior art keywords
same
branched chain
chain amino
amino acid
producing microorganism
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PCT/KR2018/007821
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English (en)
French (fr)
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WO2019013532A2 (ko
Inventor
전애지
송병철
이지혜
김종현
김혜원
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씨제이제일제당 (주)
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Publication date
Priority to CN201880015829.5A priority Critical patent/CN110506112B/zh
Priority to MX2019015056A priority patent/MX2019015056A/es
Priority to AU2018301879A priority patent/AU2018301879B2/en
Priority to ES18832634T priority patent/ES2919345T3/es
Priority to RU2019138301A priority patent/RU2743964C1/ru
Priority to BR112019020183-1A priority patent/BR112019020183B1/pt
Priority to US16/479,813 priority patent/US10844359B2/en
Priority to EP18832634.2A priority patent/EP3553171B1/en
Application filed by 씨제이제일제당 (주) filed Critical 씨제이제일제당 (주)
Priority to CA3064569A priority patent/CA3064569C/en
Priority to JP2019538131A priority patent/JP6794555B2/ja
Publication of WO2019013532A2 publication Critical patent/WO2019013532A2/ko
Publication of WO2019013532A3 publication Critical patent/WO2019013532A3/ko
Priority to US16/692,558 priority patent/US11021697B2/en
Priority to ZA2019/08353A priority patent/ZA201908353B/en
Priority to US17/076,057 priority patent/US11085029B2/en
Priority to US17/225,756 priority patent/US11248220B2/en
Priority to US17/357,196 priority patent/US11345901B2/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1022—Transferases (2.) transferring aldehyde or ketonic groups (2.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/77—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/03—Oxo-acid-lyases (4.1.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y202/00—Transferases transferring aldehyde or ketonic groups (2.2)
    • C12Y202/01—Transketolases and transaldolases (2.2.1)
    • C12Y202/01006—Acetolactate synthase (2.2.1.6)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

본 출원은 신규한 아세토하이드록시산 신타아제 변이체, 이를 포함하는 미생물 또는 이를 이용하는 L-분지쇄 아미노산의 생산 방법에 관한 것이다.
PCT/KR2018/007821 2017-07-11 2018-07-10 아세토하이드록시산 신타아제 변이체, 이를 포함하는 미생물 또는 이를 이용하는 l-분지쇄 아미노산 생산 방법 WO2019013532A2 (ko)

Priority Applications (15)

Application Number Priority Date Filing Date Title
CA3064569A CA3064569C (en) 2017-07-11 2018-07-10 Acetohydroxy acid synthase variant, microorganism comprising the same, and method of producing l-branched-chain amino acid using the same
MX2019015056A MX2019015056A (es) 2017-07-11 2018-07-10 Variante de acetohidroxiacido sintasa, microorganismo que comprende la misma, y procedimiento de produccion de aminoacidos de cadena l-ramificada mediante el uso del mismo.
JP2019538131A JP6794555B2 (ja) 2017-07-11 2018-07-10 アセトヒドロキシ酸シンターゼ変異体、これを含む微生物、またはこれを用いるｌ−分岐鎖アミノ酸の生産方法
RU2019138301A RU2743964C1 (ru) 2017-07-11 2018-07-10 Вариант синтазы ацетогидроксикислот, микроорганизм, содержащий этот вариант, и способ получения L-аминокислоты с разветвленной цепью с использованием данного микроорганизма
BR112019020183-1A BR112019020183B1 (pt) 2017-07-11 2018-07-10 Variante de aceto-hidroxiácido sintase, micro-organismo que compreende a mesma e método de produção de aminoácido de cadeia ramificada l com o uso da mesma
US16/479,813 US10844359B2 (en) 2017-07-11 2018-07-10 Acetohydroxy acid synthase variant, microorganism comprising the same, and method of producing L-branched-chain amino acid using the same
EP18832634.2A EP3553171B1 (en) 2017-07-11 2018-07-10 Acetohydroxy acid synthase variant, microorganism comprising the same, and method of producing l-branched-chain amino acid using the same
CN201880015829.5A CN110506112B (zh) 2017-07-11 2018-07-10 乙酰羟酸合酶变体、包含其的微生物和用其生产l-支链氨基酸的方法
AU2018301879A AU2018301879B2 (en) 2017-07-11 2018-07-10 Acetohydroxy Acid Synthase Variant, Microorganism Comprising The Same, And Method Of Producing L-Branched-Chain Amino Acid Using The Same
ES18832634T ES2919345T3 (es) 2017-07-11 2018-07-10 Variante de la acetohidroxiácido sintasa, microorganismo que comprende la misma, y método para producir L-aminoácidos de cadena ramificada mediante el uso del mismo
US16/692,558 US11021697B2 (en) 2017-07-11 2019-11-22 Acetohydroxy acid synthase variant, microorganism comprising the same, and method of producing L-branched-chain amino acid using the same
ZA2019/08353A ZA201908353B (en) 2017-07-11 2019-12-13 Acetohydroxy acid synthase mutant and method for producing microorganism comprising same or l-branched chain amino acid using same
US17/076,057 US11085029B2 (en) 2017-07-11 2020-10-21 Acetohydroxy acid synthase variant, microorganism comprising the same, and method of producing L-branched-chain amino acid using the same
US17/225,756 US11248220B2 (en) 2017-07-11 2021-04-08 Acetohydroxy acid synthase variant, microorganism comprising the same, and method of producing l-branched-chain amino acid using the same
US17/357,196 US11345901B2 (en) 2017-07-11 2021-06-24 Acetohydroxy acid synthase variant and a microorganism comprising the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2017-0087978 2017-07-11
KR1020170087978A KR101996129B1 (ko) 2017-07-11 2017-07-11 아세토하이드록시산 신타아제 변이체, 이를 포함하는 미생물 또는 이를 이용하는 l-분지쇄 아미노산 생산 방법

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US16/479,813 A-371-Of-International US10844359B2 (en) 2017-07-11 2018-07-10 Acetohydroxy acid synthase variant, microorganism comprising the same, and method of producing L-branched-chain amino acid using the same
US16/692,558 Continuation US11021697B2 (en) 2017-07-11 2019-11-22 Acetohydroxy acid synthase variant, microorganism comprising the same, and method of producing L-branched-chain amino acid using the same
US17/076,057 Division US11085029B2 (en) 2017-07-11 2020-10-21 Acetohydroxy acid synthase variant, microorganism comprising the same, and method of producing L-branched-chain amino acid using the same

Publications (2)

Publication Number Publication Date
WO2019013532A2 WO2019013532A2 (ko) 2019-01-17
WO2019013532A3 true WO2019013532A3 (ko) 2019-04-04

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PCT/KR2018/007821 WO2019013532A2 (ko) 2017-07-11 2018-07-10 아세토하이드록시산 신타아제 변이체, 이를 포함하는 미생물 또는 이를 이용하는 l-분지쇄 아미노산 생산 방법

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US (3) US10844359B2 (ko)
EP (1) EP3553171B1 (ko)
JP (1) JP6794555B2 (ko)
KR (1) KR101996129B1 (ko)
CN (2) CN110724679B (ko)
AU (1) AU2018301879B2 (ko)
BR (1) BR112019020183B1 (ko)
CA (1) CA3064569C (ko)
ES (1) ES2919345T3 (ko)
MX (1) MX2019015056A (ko)
RU (1) RU2743964C1 (ko)
WO (1) WO2019013532A2 (ko)
ZA (1) ZA201908353B (ko)

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KR102147381B1 (ko) * 2019-11-22 2020-08-24 씨제이제일제당 주식회사 아세토하이드록시산 신타제 신규 변이체 및 이를 포함하는 미생물
CN112195204B (zh) * 2020-10-21 2022-04-15 通辽梅花生物科技有限公司 一种混菌发酵生产支链氨基酸的方法
KR102619598B1 (ko) * 2021-08-23 2023-12-29 씨제이제일제당 주식회사 신규한 아세토하이드록시산 신타아제 소단위체 변이체 및 이를 이용한 l-발린 생산 방법

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JP6794555B2 (ja) 2020-12-02
CN110724679A (zh) 2020-01-24
CA3064569C (en) 2023-03-14
ZA201908353B (en) 2021-04-28
AU2018301879A1 (en) 2020-01-16
KR101996129B1 (ko) 2019-07-04
ES2919345T3 (es) 2022-07-26
EP3553171B1 (en) 2022-05-04
EP3553171A4 (en) 2020-05-13
US11085029B2 (en) 2021-08-10
RU2743964C1 (ru) 2021-03-01
CN110506112B (zh) 2021-06-08
CN110506112A (zh) 2019-11-26
US20200263149A1 (en) 2020-08-20
CN110724679B (zh) 2022-01-11
KR20190007142A (ko) 2019-01-22
BR112019020183A2 (pt) 2020-06-02
JP2020505023A (ja) 2020-02-20
US20210324349A1 (en) 2021-10-21
MX2019015056A (es) 2020-08-03
US10844359B2 (en) 2020-11-24
EP3553171A2 (en) 2019-10-16
US11345901B2 (en) 2022-05-31
CA3064569A1 (en) 2019-01-17
AU2018301879B2 (en) 2022-02-17
WO2019013532A2 (ko) 2019-01-17
US20210040457A1 (en) 2021-02-11
BR112019020183B1 (pt) 2023-03-21

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